Astaxanthin reduces isoflurane-induced neuroapoptosis via the PI3K/Akt pathway

  • Authors:
    • Chun‑Mei  Wang
    • Xiao‑Lan  Cai
    • Qing‑Ping  Wen
  • View Affiliations

  • Published online on: March 21, 2016     https://doi.org/10.3892/mmr.2016.5035
  • Pages: 4073-4078
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Astaxanthin is an oxygen-containing derivative of carotenoids that effectively suppresses reactive oxygen and has nutritional and medicinal value. The mechanisms underlying the effects of astaxanthin on isoflurane‑induced neuroapoptosis remain to be fully understood. The present study was conducted to evaluate the protective effect of astaxanthin to reduce isoflurane‑induced neuroapoptosis and to investigate the underlying mechanisms. The results demonstrated that isoflurane induced brain damage, increased caspase‑3 activity and suppressed the phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (Akt) signaling pathway in an in vivo model. However, treatment with astaxanthin significantly inhibited brain damage, suppressed caspase‑3 activity and upregulated the PI3K/Akt pathway in the isoflurane‑induced rats. Furthermore, isoflurane suppressed cell growth, induced cell apoptosis, enhanced caspase‑3 activity and downregulated the PI3K/Akt pathway in organotypic hippocampal slice culture. Administration of astaxanthin significantly promoted cell growth, reduced cell apoptosis and caspase‑3 activity, and upregulated the PI3K/Akt pathway and isoflurane‑induced neuroapoptosis. The present study demonstrated that downregulation of the PI3K/Akt pathway reduced the effect of astaxanthin to protect against isoflurane‑induced neuroapoptosis in the in vitro model. The results of the current study suggested that the protective effect of astaxanthin reduces the isoflurane-induced neuroapoptosis via activation of the PI3K/Akt signaling pathway.
View Figures
View References

Related Articles

Journal Cover

May-2016
Volume 13 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang CM, Cai XL and Wen QP: Astaxanthin reduces isoflurane-induced neuroapoptosis via the PI3K/Akt pathway. Mol Med Rep 13: 4073-4078, 2016.
APA
Wang, C., Cai, X., & Wen, Q. (2016). Astaxanthin reduces isoflurane-induced neuroapoptosis via the PI3K/Akt pathway. Molecular Medicine Reports, 13, 4073-4078. https://doi.org/10.3892/mmr.2016.5035
MLA
Wang, C., Cai, X., Wen, Q."Astaxanthin reduces isoflurane-induced neuroapoptosis via the PI3K/Akt pathway". Molecular Medicine Reports 13.5 (2016): 4073-4078.
Chicago
Wang, C., Cai, X., Wen, Q."Astaxanthin reduces isoflurane-induced neuroapoptosis via the PI3K/Akt pathway". Molecular Medicine Reports 13, no. 5 (2016): 4073-4078. https://doi.org/10.3892/mmr.2016.5035