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Article

Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes

  • Authors:
    • Chang Taek Oh
    • Yu‑Jin Jang
    • Tae‑Rin Kwon
    • Songi Im
    • Soon Re Kim
    • Joon Seok
    • Gun‑Yong Kim
    • Young‑Heui Kim
    • Seog Kyun Mun
    • Beom Joon Kim
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Chung‑Ang University College of Medicine, Seoul 156‑755, Republic of Korea, Department of Biotechnology R&D, SK Bioland Corporation, Cheongju, North Chungcheong ASI/KR/KS001, Republic of Korea, Department of Otolaryngology Head and Neck Surgery, Chung‑Ang University College of Medicine, Seoul 156‑755, Republic of Korea
  • Pages: 2681-2688
    |
    Published online on: March 9, 2017
       https://doi.org/10.3892/mmr.2017.6306
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Abstract

The present study aimed to investigate the anti‑inflammatory effect and mechanism of action of isosecotanapartholide (ISTP), isolated from Artemisia princeps Pampanini extract (APE). The effects of ISTP and APE on the proliferation of human keratinocytes following stimulation by tumor necrosis factor‑α/interferon‑γ were assessed. ISTP and APE downregulated the expression levels of signal transducer and activator of transcription‑1 (STAT‑1), and reduced interleukin‑33 (IL‑33) production. ISTP and APE inhibited the mRNA expression levels of thymus and activation‑regulated chemokine (TARC/CCL17) in a dose‑dependent manner. Western blot analysis demonstrated that ISTP and APE dose‑dependently inhibited protein expression levels of intercellular adhesion molecule‑1 and phosphorylation of STAT‑1. The results of the present study indicate that ISTP may inhibit TARC/CCL17 production in human epidermal keratinocytes via the STAT‑1 signaling pathway and may be associated with the inhibition of IL‑33 production. The current study indicated that ISTP is an active component in APE and may be a potential therapeutic agent for the treatment of inflammatory skin disorders.
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Copy and paste a formatted citation
Spandidos Publications style
Oh CT, Jang YJ, Kwon TR, Im S, Kim SR, Seok J, Kim GY, Kim YH, Mun SK, Kim BJ, Kim BJ, et al: Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes. Mol Med Rep 15: 2681-2688, 2017.
APA
Oh, C.T., Jang, Y., Kwon, T., Im, S., Kim, S.R., Seok, J. ... Kim, B.J. (2017). Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes. Molecular Medicine Reports, 15, 2681-2688. https://doi.org/10.3892/mmr.2017.6306
MLA
Oh, C. T., Jang, Y., Kwon, T., Im, S., Kim, S. R., Seok, J., Kim, G., Kim, Y., Mun, S. K., Kim, B. J."Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes". Molecular Medicine Reports 15.5 (2017): 2681-2688.
Chicago
Oh, C. T., Jang, Y., Kwon, T., Im, S., Kim, S. R., Seok, J., Kim, G., Kim, Y., Mun, S. K., Kim, B. J."Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes". Molecular Medicine Reports 15, no. 5 (2017): 2681-2688. https://doi.org/10.3892/mmr.2017.6306
Copy and paste a formatted citation
x
Spandidos Publications style
Oh CT, Jang YJ, Kwon TR, Im S, Kim SR, Seok J, Kim GY, Kim YH, Mun SK, Kim BJ, Kim BJ, et al: Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes. Mol Med Rep 15: 2681-2688, 2017.
APA
Oh, C.T., Jang, Y., Kwon, T., Im, S., Kim, S.R., Seok, J. ... Kim, B.J. (2017). Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes. Molecular Medicine Reports, 15, 2681-2688. https://doi.org/10.3892/mmr.2017.6306
MLA
Oh, C. T., Jang, Y., Kwon, T., Im, S., Kim, S. R., Seok, J., Kim, G., Kim, Y., Mun, S. K., Kim, B. J."Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes". Molecular Medicine Reports 15.5 (2017): 2681-2688.
Chicago
Oh, C. T., Jang, Y., Kwon, T., Im, S., Kim, S. R., Seok, J., Kim, G., Kim, Y., Mun, S. K., Kim, B. J."Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes". Molecular Medicine Reports 15, no. 5 (2017): 2681-2688. https://doi.org/10.3892/mmr.2017.6306
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