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Article

Expression levels of microRNA‑455 and its potential functions by targeting IGF‑1R in melanoma

  • Authors:
    • Hui Wang
    • Liang Yu
    • Xiujuan Shan
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of Clinical Laboratory, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China
  • Pages: 3852-3858
    |
    Published online on: April 12, 2017
       https://doi.org/10.3892/mmr.2017.6468
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Abstract

Melanoma has the highest fatality and malignancy of all skin cancers. In cancer, microRNAs (miRNAs) act as tumor suppressors or oncogenes, and inactivation of oncogenic miRNAs or restoration of tumor suppressor miRNAs has potential for cancer treatment. In the present study, miR‑455 expression levels were examined in melanoma tissues and cell lines, and miR‑455 was significantly downregulated in melanoma compared with matched normal tissues or normal epidermal melanocytes. In addition, increasing miR‑455 expression in melanoma cells reduced cell proliferation and invasion. Bioinformatic analysis revealed that insulin‑like growth factor 1 receptor (IGF‑1R) was a putative target of miR‑455. Luciferase reporter assays, reverse transcription‑quantitative polymerase chain reaction and western blot confirmed that miR‑455 targeted the 3'‑untranslated region of IGF‑1R and thus regulated the biological processes of melanoma cells. IGF‑1R knockdown resulted in similar effects as miR‑455 overexpression in melanoma cells. In summary, these findings indicated that miR‑455 was downregulated in melanoma, and inhibited proliferation and invasion of melanoma cells through directly targeting IGF‑1R. This also suggested that the restoration of miR‑455 may be worth investigation as a therapeutic treatment for patients with melanoma.
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1 

Miller AJ and Mihm MC Jr: Melanoma. N Engl J Med. 355:51–65. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Terando A, Sabel MS and Sondak VK: Melanoma: Adjuvant therapy and other treatment options. Curr Treat Options Oncol. 4:187–199. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Penna E, Orso F, Cimino D, Vercellino I, Grassi E, Quaglino E, Turco E and Taverna D: MiR-214 coordinates melanoma progression by upregulating ALCAM through TFAP2 and miR-148b downmodulation. Cancer Res. 73:4098–4111. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Baade P and Coory M: Trends in melanoma mortality in Australia: 1950–2002 and their implications for melanoma control. Aust N Z J Public Health. 29:383–386. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Coory M, Baade P, Aitken J, Smithers M, McLeod GR and Ring I: Trends for in situ and invasive melanoma in Queensland, Australia, 1982–2002. Cancer Causes Control. 17:21–27. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer statistics, 2008. CA Cancer J Clin. 58:71–96. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Sosman JA, Kim KB, Schuchter L, Gonzalez R, Pavlick AC, Weber JS, McArthur GA, Hutson TE, Moschos SJ, Flaherty KT, et al: Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med. 366:707–714. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, Cooper D, Gansler T, Lerro C, Fedewa S, et al: Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin. 62:220–241. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Wagle N, Emery C, Berger MF, Davis MJ, Sawyer A, Pochanard P, Kehoe SM, Johannessen CM, Macconaill LE, Hahn WC, et al: Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J Clin Oncol. 29:3085–3096. 2011. View Article : Google Scholar : PubMed/NCBI

10 

He L and Hannon GJ: MicroRNAs: Small RNAs with a big role in gene regulation. Nat Rev Genet. 5:522–531. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Lai EC: Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation. Nat Genet. 30:363–364. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Singh TR, Gupta A and Suravajhala P: Challenges in the miRNA research. Int J Bioinform Res Appl. 9:576–583. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Phuah NH and Nagoor NH: Regulation of microRNAs by natural agents: New strategies in cancer therapies. Biomed Res Int. 2014:8045102014. View Article : Google Scholar : PubMed/NCBI

14 

Ling H, Fabbri M and Calin GA: MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov. 12:847–865. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Fabian MR, Sonenberg N and Filipowicz W: Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 79:351–379. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Blower PE, Verducci JS, Lin S, Zhou J, Chung JH, Dai Z, Liu CG, Reinhold W, Lorenzi PL, Kaldjian EP, et al: MicroRNA expression profiles for the NCI-60 cancer cell panel. Mol Cancer Ther. 6:1483–1491. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Sakurai E, Maesawa C, Shibazaki M, Yasuhira S, Oikawa H, Sato M, Tsunoda K, Ishikawa Y, Watanabe A, Takahashi K, et al: Downregulation of microRNA-211 is involved in expression of preferentially expressed antigen of melanoma in melanoma cells. Int J Oncol. 39:665–672. 2011.PubMed/NCBI

19 

Medina PP, Nolde M and Slack FJ: OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature. 467:86–90. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, et al: Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet. 43:371–378. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA and Jones PA: Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell. 9:435–443. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Liu R, Xie H, Luo C, Chen Z, Zhou X, Xia K, Chen X, Zhou M, Cao P, Cao K and Zhou J: Identification of FLOT2 as a novel target for microRNA-34a in melanoma. J Cancer Res Clin Oncol. 141:993–1006. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Du B, Wang Z, Zhang X, Feng S, Wang G, He J and Zhang B: MicroRNA-545 suppresses cell proliferation by targeting cyclin D1 and CDK4 in lung cancer cells. PLoS One. 9:e880222014. View Article : Google Scholar : PubMed/NCBI

27 

Huang F, Tang J, Zhuang X, Zhuang Y, Cheng W, Chen W, Yao H and Zhang S: MiR-196a promotes pancreatic cancer progression by targeting nuclear factor kappa-B-inhibitor alpha. PLoS One. 9:e878972014. View Article : Google Scholar : PubMed/NCBI

28 

Tao J, Wu D, Xu B, Qian W, Li P, Lu Q, Yin C and Zhang W: MicroRNA-133 inhibits cell proliferation, migration and invasion in prostate cancer cells by targeting the epidermal growth factor receptor. Oncol Rep. 27:1967–1975. 2012.PubMed/NCBI

29 

Ujifuku K, Mitsutake N, Takakura S, Matsuse M, Saenko V, Suzuki K, Hayashi K, Matsuo T, Kamada K, Nagata I and Yamashita S: MiR-195, miR-455-3p and miR-10a (*) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells. Cancer Lett. 296:241–248. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Hu Z, Shen WJ, Kraemer FB and Azhar S: MicroRNAs 125a and 455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class B type I in steroidogenic cells. Mol Cell Biol. 32:5035–5045. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Li X, Zhang G, Luo F, Ruan J, Huang D, Feng D, Xiao D, Zeng Z, Chen X and Wu W: Identification of aberrantly expressed miRNAs in rectal cancer. Oncol Rep. 28:77–84. 2012.PubMed/NCBI

32 

Swingler TE, Wheeler G, Carmont V, Elliott HR, Barter MJ, Abu-Elmagd M, Donell ST, Boot-Handford RP, Hajihosseini MK, Münsterberg A, et al: The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis Rheum. 64:1909–1919. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Chai J, Wang S, Han D, Dong W, Xie C and Guo H: MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase. Tumour Biol. 36:1313–1321. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Zhao X, Dou W, He L, Liang S, Tie J, Liu C, Li T, Lu Y, Mo P, Shi Y, et al: MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. Oncogene. 32:1363–1372. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Baserga R, Peruzzi F and Reiss K: The IGF-1 receptor in cancer biology. Int J Cancer. 107:873–877. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Cao Z, Liu LZ, Dixon DA, Zheng JZ, Chandran B and Jiang BH: Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells. Cell Signal. 19:1542–1553. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Christopoulos PF, Msaouel P and Koutsilieris M: The role of the insulin-like growth factor-1 system in breast cancer. Mol Cancer. 14:432015. View Article : Google Scholar : PubMed/NCBI

38 

Gryko M, Kiśluk J, Cepowicz D, Zińczuk J, Kamocki Z, Guzińska-Ustymowicz K, Pryczynicz A, Czyżewska J, Kemona A and Kędra B: Expression of insulin-like growth factor receptor type 1 correlate with lymphatic metastases in human gastric cancer. Pol J Pathol. 65:135–140. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Wang YH, Wang ZX, Qiu Y, Xiong J, Chen YX, Miao DS and De W: Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion and enhances radiosensitivity in human osteosarcoma cells. Mol Cell Biochem. 327:257–266. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Wang YH, Han XD, Qiu Y, Xiong J, Yu Y, Wang B, Zhu ZZ, Qian BP, Chen YX, Wang SF, et al: Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma. J Surg Oncol. 105:235–243. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Scharf JG and Braulke T: The role of the IGF axis in hepatocarcinogenesis. Horm Metab Res. 35:685–693. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Kanter-Lewensohn L, Dricu A, Wang M, Wejde J, Kiessling R and Larsson O: Expression of the insulin-like growth factor-1 receptor and its anti-apoptotic effect in malignant melanoma: A potential therapeutic target. Melanoma Res. 8:389–397. 1998. View Article : Google Scholar : PubMed/NCBI

43 

Luo M, Shen D, Zhou X, Chen X and Wang W: MicroRNA-497 is a potential prognostic marker in human cervical cancer and functions as a tumor suppressor by targeting the insulin-like growth factor 1 receptor. Surgery. 153:836–847. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Xu JW, Wang TX, You L, Zheng LF, Shu H, Zhang TP and Zhao YP: Insulin-like growth factor 1 receptor (IGF-1R) as a target of MiR-497 and plasma IGF-1R levels associated with TNM stage of pancreatic cancer. PLoS One. 9:e928472014. View Article : Google Scholar : PubMed/NCBI

45 

Lian HW, Zhou Y, Jian ZH and Liu RZ: MiR-323-5p acts as a tumor suppressor by targeting the insulin-like growth factor 1 receptor in human glioma cells. Asian Pac J Cancer Prev. 15:10181–10185. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Shi ZM, Wang XF, Qian X, Tao T, Wang L, Chen QD, Wang XR, Cao L, Wang YY, Zhang JX, et al: MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas. RNA. 19:552–560. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Zhang W, Liu K, Liu S, Ji B, Wang Y and Liu Y: MicroRNA-133a functions as a tumor suppressor by targeting IGF-1R in hepatocellular carcinoma. Tumour Biol. 36:9779–9788. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Yu L and Shan X: Expression levels of microRNA‑455 and its potential functions by targeting IGF‑1R in melanoma. Mol Med Rep 15: 3852-3858, 2017.
APA
Wang, H., Yu, L., & Shan, X. (2017). Expression levels of microRNA‑455 and its potential functions by targeting IGF‑1R in melanoma. Molecular Medicine Reports, 15, 3852-3858. https://doi.org/10.3892/mmr.2017.6468
MLA
Wang, H., Yu, L., Shan, X."Expression levels of microRNA‑455 and its potential functions by targeting IGF‑1R in melanoma". Molecular Medicine Reports 15.6 (2017): 3852-3858.
Chicago
Wang, H., Yu, L., Shan, X."Expression levels of microRNA‑455 and its potential functions by targeting IGF‑1R in melanoma". Molecular Medicine Reports 15, no. 6 (2017): 3852-3858. https://doi.org/10.3892/mmr.2017.6468
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Yu L and Shan X: Expression levels of microRNA‑455 and its potential functions by targeting IGF‑1R in melanoma. Mol Med Rep 15: 3852-3858, 2017.
APA
Wang, H., Yu, L., & Shan, X. (2017). Expression levels of microRNA‑455 and its potential functions by targeting IGF‑1R in melanoma. Molecular Medicine Reports, 15, 3852-3858. https://doi.org/10.3892/mmr.2017.6468
MLA
Wang, H., Yu, L., Shan, X."Expression levels of microRNA‑455 and its potential functions by targeting IGF‑1R in melanoma". Molecular Medicine Reports 15.6 (2017): 3852-3858.
Chicago
Wang, H., Yu, L., Shan, X."Expression levels of microRNA‑455 and its potential functions by targeting IGF‑1R in melanoma". Molecular Medicine Reports 15, no. 6 (2017): 3852-3858. https://doi.org/10.3892/mmr.2017.6468
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