Open Access

Baicalein induces cervical cancer apoptosis through the NF-κB signaling pathway

  • Authors:
    • Xiaolan Yu
    • Yuqing Liu
    • Yongzhou Wang
    • Xiguan Mao
    • Yujiao Zhang
    • Jiyi Xia
  • View Affiliations

  • Published online on: January 25, 2018     https://doi.org/10.3892/mmr.2018.8493
  • Pages: 5088-5094
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

To investigate the mechanism of baicalein in inducing human cervical cancer cell line C33A apoptosis. Baicalein (200 µM) was used to treat C33A cells. Cell proliferation was tested by the MTT assay. Cell apoptosis was detected by the TUNEL assay and caspase‑3 activity measurement. Cell cycle was determined by flow cytometry and associated gene expression at mRNA and protein levels. Nuclear factor (NF)‑κB activity was assessed by luciferase assay and western blotting. Baicalein suppressed cervical cancer cell C33A proliferation and induced cell apoptosis by activating caspase‑3 activity. Baicalein blocked cell cycle in G0/G1 phase through regulating the expression of associated genes. Baicalein inhibited NF‑κB activity by repressing nuclear translocation. Baicalein suppressed C33A proliferation and promoted cellular apoptosis by inhibiting NF‑κB signaling pathway. In conclusion, the results indicate that baicalein can inhibit cervical cancer cell proliferation and promote cell apoptosis by affecting NF-κB activity.
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April-2018
Volume 17 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Yu X, Liu Y, Wang Y, Mao X, Zhang Y and Xia J: Baicalein induces cervical cancer apoptosis through the NF-κB signaling pathway. Mol Med Rep 17: 5088-5094, 2018.
APA
Yu, X., Liu, Y., Wang, Y., Mao, X., Zhang, Y., & Xia, J. (2018). Baicalein induces cervical cancer apoptosis through the NF-κB signaling pathway. Molecular Medicine Reports, 17, 5088-5094. https://doi.org/10.3892/mmr.2018.8493
MLA
Yu, X., Liu, Y., Wang, Y., Mao, X., Zhang, Y., Xia, J."Baicalein induces cervical cancer apoptosis through the NF-κB signaling pathway". Molecular Medicine Reports 17.4 (2018): 5088-5094.
Chicago
Yu, X., Liu, Y., Wang, Y., Mao, X., Zhang, Y., Xia, J."Baicalein induces cervical cancer apoptosis through the NF-κB signaling pathway". Molecular Medicine Reports 17, no. 4 (2018): 5088-5094. https://doi.org/10.3892/mmr.2018.8493