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Article

Association of the PPARγ/PI3K/Akt pathway with the cardioprotective effects of tacrolimus in myocardial ischemic/reperfusion injury

  • Authors:
    • Xiufen Li
    • Aishan Bilali
    • Rui Qiao
    • Tuerxun Paerhati
    • Yan Yang
  • View Affiliations / Copyright

    Affiliations: Cardiac Care Unit, The Traditional Hospital Affiliated to Xinjiang Medical University, Ürümqi, Xinjiang 830001, P.R. China
  • Pages: 6759-6767
    |
    Published online on: February 27, 2018
       https://doi.org/10.3892/mmr.2018.8649
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Abstract

Myocardial ischemia/reperfusion injury (MIRI) induces severe arrhythmias and has a high risk of mortality. The aim of the present study was to investigate the effect of tacrolimus on arrhythmias, cardiac function, oxidative stress and myocardium apoptosis induced by MIRI, and to elucidate the underlying mechanism. The effects of MIRI and tacrolimus on arrhythmias, cardiac function parameters, myocardial oxidative stress and apoptosis were investigated in a rat model of MIRI. The phosphorylation of peroxisome proliferator‑activated receptor γ (PPARγ) and protein kinase B (Akt) was investigated via western blotting. After rats were treated with inhibitors of PPARγ/phosphoinositide 3‑kinase (PI3K)/Akt, cardiac function parameters were measured. The results demonstrated that the MIRI procedure induced arrhythmias and significant impairment of cardiac function, oxidative stress and apoptosis in cardiomyocytes (P<0.05). Tacrolimus significantly alleviated the arrhythmias and impairment of cardiac function and inhibited the oxidative stress and apoptosis in cardiomyocytes (P<0.05). The phosphorylation of PPARγ and Akt was significantly activated by tacrolimus, whereas inhibitors of PPARγ/PI3K/Akt significantly abolished the effects of tacrolimus (P<0.05). Together, these results suggest that tacrolimus may protect rats from MIRI through activation of the PPARγ/PI3K/Akt pathway.
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1 

Verheugt FW: Antithrombotic therapy to reduce ischemic events in acute coronary syndromes patients undergoing percutaneous coronary intervention. Interv Cardiol Clin. 6:131–140. 2017.PubMed/NCBI

2 

Helft G, Georges JL, Mouranche X, Loyeau A, Spaulding C, Caussin C, Benamer H, Garot P, Livarek B, Teiger E, et al: Outcomes of primary percutaneous coronary interventions in nonagenarians with acute myocardial infarction. Int J Cardiol. 192:24–29. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Yellon DM and Hausenloy DJ: Myocardial reperfusion injury. N Engl J Med. 357:1121–1135. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Hausenloy DJ and Yellon DM: New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the reperfusion injury salvage kinase (RISK)-pathway. Cardiovasc Res. 61:448–460. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Monassier JP: Reperfusion injury in acute myocardial infarction. From bench to cath lab. Part I: Basic considerations. Arch Cardiovasc Dis. 101:491–500. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Park JL and Lucchesi BR: Mechanisms of myocardial reperfusion injury. Ann Thorac Surg. 68:1905–1912. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Bozlu M, Eskandari G, Cayan S, Canpolat B, Akbay E and Atik U: The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury. J Urol. 169:1870–1873. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Ekhterae D, Hinmon R, Matsuzaki K, Noma M, Zhu W, Xiao RP, Gorman RC and Gorman JH III: Infarction induced myocardial apoptosis and ARC activation. J Surg Res. 166:59–67. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Kleinbongard P, Schulz R and Heusch G: TNFα in myocardial ischemia/reperfusion, remodeling and heart failure. Heart Fail Rev. 16:49–69. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Heusch G, Boengler K and Schulz R: Inhibition of mitochondrial permeability transition pore opening: The Holy Grail of cardioprotection. Basic Res Cardiol. 105:151–154. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Kroemer G and Reed JC: Mitochondrial control of cell death. Nat Med. 6:513–519. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Weiss JN, Korge P, Honda HM and Ping P: Role of the mitochondrial permeability transition in myocardial disease. Circ Res. 93:292–301. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Wallemacq PE and Reding R: FK506 (tacrolimus), a novel immunosuppressant in organ transplantation: Clinical, biomedical, and analytical aspects. Clin Chem. 39:2219–2228. 1993.PubMed/NCBI

14 

Kim HC, Hwang EA, Han SY, Park SB, Kim HT and Cho WH: Primary immunosuppression with tacrolimus in kidney transplantation: Three-year follow-up in a single center. Transplant Proc. 36:pp. 2082–2083. 2004; View Article : Google Scholar : PubMed/NCBI

15 

Jain A, Reyes J, Kashyap R, Rohal S, Abu-Elmagd K, Starzl T and Fung J: What have we learned about primary liver transplantation under tacrolimus immunosuppression? Long-term follow-up of the first 1000 patients. Ann Surg. 230:441–449. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Thomson AW, Bonham CA and Zeevi A: Mode of action of tacrolimus (FK506): Molecular and cellular mechanisms. Ther Drug Monit. 17:584–591. 1995. View Article : Google Scholar : PubMed/NCBI

17 

Ustundag UV, Sahin S, Ak K, Keskin I and Emekli-Alturfan E: The effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injury. Reprod Biol. 15:139–145. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Pratschke S, Bilzer M, Grützner U, Angele M, Tufman A, Jauch KW and Schauer RJ: Tacrolimus preconditioning of rat liver allografts impacts glutathione homeostasis and early reperfusion injury. J Surg Res. 176:309–316. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Badr R, Hashemi M, Javadi G, Movafagh A and Mahdian R: Assessment of global ischemic/reperfusion and Tacrolimus administration on CA1 region of hippocampus: Gene expression profiles of BAX and BCL2 genes. Bratisl Lek Listy. 117:358–362. 2016.PubMed/NCBI

20 

Chen K, Li JJ, Li SN, Feng J, Liu T, Wang F, Dai WQ, Xia YJ, Lu J, Zhou YQ and Guo CY: 15-Deoxy-Δ12,14-prostaglandin J2 alleviates hepatic ischemia-reperfusion injury in mice via inducing antioxidant response and inhibiting apoptosis and autophagy. Acta Pharmacol Sin. 38:672–687. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Stechschulte LA, Hinds TD Jr, Ghanem SS, Shou W, Najjar SM and Sanchez ER: FKBP51 reciprocally regulates GRα and PPARγ activation via the Akt-p38 pathway. Mol Endocrinol. 28:1254–1264. 2014. View Article : Google Scholar : PubMed/NCBI

22 

National Research Council: Division on Earth and Life StudiesInstitute for Laboratory Animal Research; Committee for the Update of the Guide for the Care and Use of Laboratory Animals: Guide for the Care and Use of Laboratory Animals. 8th. The National Academies Press; Washigton, DC: 2011

23 

Zhou C, Bai J, Jiang C, Ye L, Pan Y and Zhang H: Geranylgeranylacetone attenuates myocardium ischemic/reperfusion injury through HSP70 and Akt/GSK-3β/eNOS pathway. Am J Transl Res. 9:386–395. 2017.PubMed/NCBI

24 

Su HH, Chu YC, Liao JM, Wang YH, Jan MS, Lin CW, Wu CY, Tseng CY, Yen JC and Huang SS: Phellinus linteus mycelium alleviates myocardial ischemia-reperfusion injury through autophagic regulation. Front Pharmacol. 8:1752017. View Article : Google Scholar : PubMed/NCBI

25 

Curtis MJ, Hancox JC, Farkas A, Wainwright CL, Stables CL, Saint DA, Clements-Jewery H, Lambiase PD, Billman GE, Janse MJ, et al: The Lambeth Conventions (II): Guidelines for the study of animal and human ventricular and supraventricular arrhythmias. Pharmacol Ther. 139:213–248. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Sivasinprasasn S, Tanajak P, Pongkan W, Pratchayasakul W, Chattipakorn SC and Chattipakorn N: DPP-4 inhibitor and estrogen share similar efficacy against cardiac ischemic-reperfusion injury in obese-insulin resistant and estrogen-deprived female rats. Sci Rep. 7:443062017. View Article : Google Scholar : PubMed/NCBI

27 

Weng D, Lu Y, Wei Y, Liu Y and Shen P: The role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in mice. Toxicology. 232:15–23. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Levine RL, Wehr N, Williams JA, Stadtman ER and Shacter E: Determination of carbonyl groups in oxidized proteins. Methods Mol Biol. 99:15–24. 2000.PubMed/NCBI

29 

Umemura T, Tasaki M, Kijima A, Okamura T, Inoue T, Ishii Y, Suzuki Y, Masui N, Nohmi T and Nishikawa A: Possible participation of oxidative stress in causation of cell proliferation and in vivo mutagenicity in kidneys of gpt delta rats treated with potassium bromate. Toxicology. 257:46–52. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Musman J, Pons S, Barau C, Caccia C, Leoni V, Berdeaux A, Ghaleh B and Morin D: Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia-reperfusion in wild-type and ob/ob mice. Free Radic Biol Med. 101:317–324. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Bernier M, Manning AS and Hearse DJ: Reperfusion arrhythmias: Dose-related protection by anti-free radical interventions. Am J Physiol. 256:H1344–H1352. 1989.PubMed/NCBI

32 

Yamazaki S, Fujibayashi Y, Rajagopalan RE, Meerbaum S and Corday E: Effects of staged versus sudden reperfusion after acute coronary occlusion in the dog. J Am Coll Cardiol. 7:564–572. 1986. View Article : Google Scholar : PubMed/NCBI

33 

Motloch LJ and Akar FG: Gene therapy to restore electrophysiological function in heart failure. Expert Opin Biol Ther. 15:803–817. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Donahue JK: Gene therapy for ventricular tachyarrhythmias. Gene Ther. 19:600–605. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Neri M, Fineschi V, Di Paolo M, Pomara C, Riezzo I, Turillazzi E and Cerretani D: Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction. Curr Vasc Pharmacol. 13:26–36. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Mughal W, Dhingra R and Kirshenbaum LA: Striking a balance: Autophagy, apoptosis, and necrosis in a normal and failing heart. Curr Hypertens Rep. 14:540–547. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Pan F, Cheng YX, Zhu CL, Tao FH, Li ZH, Tao HY, He B, Yu L, Ji P and Tang H: Tacolimus postconditioning alleviates apoptotic cell death in rats after spinal cord ischemia-reperfusion injury via up-regulating protein-serine-threonine kinases phosphorylation. J Huazhong Univ Sci Technolog Med Sci. 33:852–856. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Love S, Mudasir MA, Bhardwaj SC, Singh G and Tasduq SA: Long-term administration of tacrolimus and everolimus prevents high cholesterol-high fructose-induced steatosis in C57BL/6J mice by inhibiting de-novo lipogenesis. Oncotarget. 8:113403–113417. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Jin J, Jin L, Lim SW and Yang CW: Klotho deficiency aggravates tacrolimus-induced renal injury via the phosphatidylinositol 3-kinase-Akt-forkhead box protein O pathway. Am J Nephrol. 43:357–365. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Li H, Lu W, Cai WW, Wang PJ, Zhang N, Yu CP, Wang DL, Liu BC and Sun W: Telmisartan attenuates monocrotaline-induced pulmonary artery endothelial dysfunction through a PPAR gamma-dependent PI3K/Akt/eNOS pathway. Pulm Pharmacol Ther. 28:17–24. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Yuen CY, Wong WT, Tian XY, Wong SL, Lau CW, Yu J, Tomlinson B, Yao X and Huang Y: Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthase. Cardiovasc Res. 90:122–129. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Maejima Y, Okada H, Haraguchi G, Onai Y, Kosuge H, Suzuki J and Isobe M: Telmisartan, a unique ARB, improves left ventricular remodeling of infarcted heart by activating PPAR gamma. Lab Invest. 91:932–944. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Mullonkal CJ and Toledo-Pereyra LH: Akt in ischemia and reperfusion. J Invest Surg. 20:195–203. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Matsui T, Tao J, del Monte F, Lee KH, Li L, Picard M, Force TL, Franke TF, Hajjar RJ and Rosenzweig A: Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation. 104:330–335. 2001. View Article : Google Scholar : PubMed/NCBI

45 

Li L, Zhou Y, Li Y, Wang L, Sun L, Zhou L, Arai H, Qi Y and Xu Y: Aqueous extract of Cortex Dictamni protects H9c2 cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress and apoptosis by PI3K/Akt signaling pathway. Biomed Pharmacother. 89:233–244. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Tang L, Mo Y, Li Y, Zhong Y, He S, Zhang Y, Tang Y, Fu S, Wang X and Chen A: Urolithin A alleviates myocardial ischemia/reperfusion injury via PI3K/Akt pathway. Biochem Biophys Res Commun. 486:774–780. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Bilali A, Qiao R, Paerhati T and Yang Y: Association of the PPARγ/PI3K/Akt pathway with the cardioprotective effects of tacrolimus in myocardial ischemic/reperfusion injury. Mol Med Rep 17: 6759-6767, 2018.
APA
Li, X., Bilali, A., Qiao, R., Paerhati, T., & Yang, Y. (2018). Association of the PPARγ/PI3K/Akt pathway with the cardioprotective effects of tacrolimus in myocardial ischemic/reperfusion injury. Molecular Medicine Reports, 17, 6759-6767. https://doi.org/10.3892/mmr.2018.8649
MLA
Li, X., Bilali, A., Qiao, R., Paerhati, T., Yang, Y."Association of the PPARγ/PI3K/Akt pathway with the cardioprotective effects of tacrolimus in myocardial ischemic/reperfusion injury". Molecular Medicine Reports 17.5 (2018): 6759-6767.
Chicago
Li, X., Bilali, A., Qiao, R., Paerhati, T., Yang, Y."Association of the PPARγ/PI3K/Akt pathway with the cardioprotective effects of tacrolimus in myocardial ischemic/reperfusion injury". Molecular Medicine Reports 17, no. 5 (2018): 6759-6767. https://doi.org/10.3892/mmr.2018.8649
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Bilali A, Qiao R, Paerhati T and Yang Y: Association of the PPARγ/PI3K/Akt pathway with the cardioprotective effects of tacrolimus in myocardial ischemic/reperfusion injury. Mol Med Rep 17: 6759-6767, 2018.
APA
Li, X., Bilali, A., Qiao, R., Paerhati, T., & Yang, Y. (2018). Association of the PPARγ/PI3K/Akt pathway with the cardioprotective effects of tacrolimus in myocardial ischemic/reperfusion injury. Molecular Medicine Reports, 17, 6759-6767. https://doi.org/10.3892/mmr.2018.8649
MLA
Li, X., Bilali, A., Qiao, R., Paerhati, T., Yang, Y."Association of the PPARγ/PI3K/Akt pathway with the cardioprotective effects of tacrolimus in myocardial ischemic/reperfusion injury". Molecular Medicine Reports 17.5 (2018): 6759-6767.
Chicago
Li, X., Bilali, A., Qiao, R., Paerhati, T., Yang, Y."Association of the PPARγ/PI3K/Akt pathway with the cardioprotective effects of tacrolimus in myocardial ischemic/reperfusion injury". Molecular Medicine Reports 17, no. 5 (2018): 6759-6767. https://doi.org/10.3892/mmr.2018.8649
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