Anti-inflammatory effect of bee venom in an allergic chronic rhinosinusitis mouse model

  • Authors:
    • Seung‑Heon Shin
    • Mi‑Kyung Ye
    • Sung‑Yong Choi
    • Kwan‑Kyu Park
  • View Affiliations

  • Published online on: March 9, 2018     https://doi.org/10.3892/mmr.2018.8720
  • Pages:6632-6638
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Abstract

Bee venom (BV) has long been used as anti-inflammatory agent in traditional oriental medicine; however, the effect of BV on chronic rhinosinusitis (CRS) is not commonly studied. The aim of the present study was to determine the anti-inflammatory effect of BV on an allergic CRS mouse model. An allergic CRS mouse model was established following the administration of ovalbumin with Staphylococcus aureus enterotoxin B (SEB) into the nose. A total of 0.5 or 5 ng/ml of BV were intranasally applied 3 times a week for 8 weeks. Histopathological alterations were observed using hematoxylin and eosin, and Periodic acid Schiff staining. The levels of inflammatory cell infiltration, interleukin (IL)‑4, IL‑10 and interferon (INF)‑γ in nasal lavage fluid (NLF) were measured. Nuclear factor (NF)‑κB and activator protein (AP)‑1 expressions were also determined by immunohistochemical staining. The group treated with BV had significantly decreased inflammatory cell infiltration and PAS‑positive cells. The levels of INF‑γ, and neutrophil and eosinophil counts in NLF were significantly decreased, and the SEB‑induced NF‑κB and AP‑1 expressions in mouse nasal mucosa were significantly suppressed by 0.5 and 5 ng/ml BV. Thus, BV exerted significant anti‑inflammatory effects in an allergic CRS mouse model and may have potential value for the treatment of CRS.

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May 2018
Volume 17 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Shin, S., Ye, M., Choi, S., & Park, K. (2018). Anti-inflammatory effect of bee venom in an allergic chronic rhinosinusitis mouse model. Molecular Medicine Reports, 17, 6632-6638. https://doi.org/10.3892/mmr.2018.8720
MLA
Shin, S., Ye, M., Choi, S., Park, K."Anti-inflammatory effect of bee venom in an allergic chronic rhinosinusitis mouse model". Molecular Medicine Reports 17.5 (2018): 6632-6638.
Chicago
Shin, S., Ye, M., Choi, S., Park, K."Anti-inflammatory effect of bee venom in an allergic chronic rhinosinusitis mouse model". Molecular Medicine Reports 17, no. 5 (2018): 6632-6638. https://doi.org/10.3892/mmr.2018.8720