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Low molecular weight fucoidan attenuates experimental abdominal aortic aneurysm through interfering the leukocyte-endothelial cells interaction

  • Authors:
    • Min Zhou
    • Yong Ding
    • Liang Cai
    • Yonggang Wang
    • Changpo Lin
    • Zhenyu Shi
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, Shanghai 200032, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7089-7096
    |
    Published online on: March 16, 2018
       https://doi.org/10.3892/mmr.2018.8765
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Abstract

Low molecular weight fucoidan (LMWF) is a sulfated polysaccharide extracted from Saccharina Japonica that presents high affinity for P-selectin and abolish selectin-dependent recruitment of leukocytes. We hypothesized that dietary intake of LMWF, as a competitive binding agent of P‑selectin, could limit the inflammatory infiltration and aneurysmal growth in an Angiotensin II‑induced abdominal aortic aneurysm (AAA) mouse model. The Gene Expression Omnibus database was used for gene expressions and gene set enrichment analysis. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that focal adhesion was involved in the development of AAA. However, dietary intake of LMWF could limit the enlargement of AAA, decreasing maximal aortic diameter and preserving elastin lamellae. Although LMWF did not decrease the circulatory monocytes count and lower the expression of P‑selectin in endothelium, it reduced macrophages infiltration in media and adventitia. Furthermore, matrix metalloproteinase expression was markedly downregulated, accompanied with reduced expression of inflammatory mediators, including interleukin 1β, tumor necrosis factor‑α and monocyte chemotactic protein‑1. The present study revealed a novel target for the treatment of AAA and the anti‑inflammatory effects of LMWF.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou M, Ding Y, Cai L, Wang Y, Lin C and Shi Z: Low molecular weight fucoidan attenuates experimental abdominal aortic aneurysm through interfering the leukocyte-endothelial cells interaction. Mol Med Rep 17: 7089-7096, 2018.
APA
Zhou, M., Ding, Y., Cai, L., Wang, Y., Lin, C., & Shi, Z. (2018). Low molecular weight fucoidan attenuates experimental abdominal aortic aneurysm through interfering the leukocyte-endothelial cells interaction. Molecular Medicine Reports, 17, 7089-7096. https://doi.org/10.3892/mmr.2018.8765
MLA
Zhou, M., Ding, Y., Cai, L., Wang, Y., Lin, C., Shi, Z."Low molecular weight fucoidan attenuates experimental abdominal aortic aneurysm through interfering the leukocyte-endothelial cells interaction". Molecular Medicine Reports 17.5 (2018): 7089-7096.
Chicago
Zhou, M., Ding, Y., Cai, L., Wang, Y., Lin, C., Shi, Z."Low molecular weight fucoidan attenuates experimental abdominal aortic aneurysm through interfering the leukocyte-endothelial cells interaction". Molecular Medicine Reports 17, no. 5 (2018): 7089-7096. https://doi.org/10.3892/mmr.2018.8765
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou M, Ding Y, Cai L, Wang Y, Lin C and Shi Z: Low molecular weight fucoidan attenuates experimental abdominal aortic aneurysm through interfering the leukocyte-endothelial cells interaction. Mol Med Rep 17: 7089-7096, 2018.
APA
Zhou, M., Ding, Y., Cai, L., Wang, Y., Lin, C., & Shi, Z. (2018). Low molecular weight fucoidan attenuates experimental abdominal aortic aneurysm through interfering the leukocyte-endothelial cells interaction. Molecular Medicine Reports, 17, 7089-7096. https://doi.org/10.3892/mmr.2018.8765
MLA
Zhou, M., Ding, Y., Cai, L., Wang, Y., Lin, C., Shi, Z."Low molecular weight fucoidan attenuates experimental abdominal aortic aneurysm through interfering the leukocyte-endothelial cells interaction". Molecular Medicine Reports 17.5 (2018): 7089-7096.
Chicago
Zhou, M., Ding, Y., Cai, L., Wang, Y., Lin, C., Shi, Z."Low molecular weight fucoidan attenuates experimental abdominal aortic aneurysm through interfering the leukocyte-endothelial cells interaction". Molecular Medicine Reports 17, no. 5 (2018): 7089-7096. https://doi.org/10.3892/mmr.2018.8765
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