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Zinc supplementation inhibits the high glucose‑induced EMT of peritoneal mesothelial cells by activating the Nrf2 antioxidant pathway

  • Authors:
    • Lili Gao
    • Yi Fan
    • Xiuli Zhang
    • Lina Yang
    • Wenyu Huang
    • Tianyu Hang
    • Mingyang Li
    • Shuyan Du
    • Jianfei Ma
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 655-663
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    Published online on: May 22, 2019
       https://doi.org/10.3892/mmr.2019.10260
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Abstract

The high glucose (HG)‑induced epithelial‑mesenchymal transition (EMT) of peritoneal mesothelial cells (PMCs) serves an important role in peritoneal fibrosis (PF) during peritoneal dialysis. Our previous study reported that zinc (Zn) supplementation prevented the HG‑induced EMT of rat PMCs in vitro. In the present study, the role of Zn in HG‑induced EMT was investigated in vivo using a rat model of PF. Additionally, the molecular mechanisms underlying HG‑induced EMT were studied in human PMCs (HPMCs). In the rat model of PF, HG treatment increased the glucose transfer capacity and decreased the ultrafiltration volume. Histopathological analysis revealed peritoneal thickening, increased expression of vimentin and decreased expression of E‑cadherin. ZnSO4 significantly ameliorated the aforementioned changes, whereas Zn inhibition by clioquinol significantly aggravated the effects of HG on rats. The effects of Zn on HPMCs was assessed using western blot analysis, Transwell assays and flow cytometry. It was revealed that Zn also significantly suppressed the extent of the EMT, and reduced reactive oxygen species production and the migratory ability of HG‑induced HPMCs, whereas Zn inhibition by N',N',N',N'‑tetrakis (2‑pyridylmethyl) ethylenediamine significantly potentiated the HG‑induced EMT of HPMCs. HG‑stimulated HPMCs exhibited increased expression of nuclear factor‑like 2 (Nrf2) in the nucleus, and total cellular NAD(P)H quinone dehydrogenase 1 (NQO1) and heme oxygenase-1 (HO‑1), the target proteins of the Nrf2 antioxidant pathway. Zn supplementation further promoted nuclear Nrf2 expression, and increased the expression of target proteins of the Nrf2 antioxidant pathway, whereas Zn depletion decreased nuclear Nrf2, NQO1 and HO‑1 expression compared with the HG group. In conclusion, Zn supplementation was proposed to suppress the effects of HG on the EMT by stimulating the Nrf2 antioxidant pathway and subsequently reducing oxidative stress in PMCs.
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1 

Prasad AS: Discovery of human zinc deficiency: Its impact on human health and diseas. Adv Nutr. 4:176–190. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Krediet RT and Struijk DG: Peritoneal changes in patients on long-term peritoneal dialysis. Nat Rev Nephrol. 9:419–429. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Yang CY, Chau YP, Chen A, Lee OK, Tarng DC and Yang AH: Targeting cannabinoid signaling for peritoneal dialysis-induced oxidative stress and fibrosis. World J Nephrol. 6:111–118. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Holmes CJ and Faict D: Peritoneal dialysis solution biocompatibility: Definitions and evaluation strategies. Kidney Int Suppl. S50–S56. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Yáñez-Mó M, Lara-Pezzi E, Selgas R, Ramírez-Huesca M, Domínguez-Jiménez C, Jiménez-Heffernan JA, Aguilera A, Sánchez-Tomero JA, Bajo MA, Alvarez V, et al: Peritoneal dialysis and Epithelial-To-Mesenchymal transition of mesothelial cells. N Engl J Med. 348:403–413. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Wu J, Xing C, Zhang L, Mao H, Chen X, Liang M, Wang F, Ren H, Cui H, Jiang A, et al: Autophagy promotes fibrosis and apoptosis in the peritoneum during long-term peritoneal dialysis. J Cell Mol Med. 22:1190–1201. 2018.PubMed/NCBI

7 

Kim YL: Update on mechanisms of ultrafiltration failure. Perit Dial Int. 29 (Suppl 2):S123–S127. 2009.PubMed/NCBI

8 

Ha H, Yu MR and Lee HB: High glucose-induced PKC activation mediates TGF-beta 1 and fibronectin synthesis by peritoneal mesothelial cells. Kidney Int. 59:463–470. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Yao Q, Pawlaczyk K, Ayala ER, Styszynski A, Breborowicz A, Heimburger O, Qian JQ, Stenvinkel P, Lindholm B and Axelsson J: The role of the TGF/Smad signaling pathway in peritoneal fibrosis induced by peritoneal dialysis solutions. Nephron Exp Nephrol. 109:e71–e78. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Ksiazek K, Breborowicz A, Jorres A and Witowski J: Oxidative stress contributes to accelerated development of the senescent phenotype in human peritoneal mesothelial cells exposed to high glucose. Free Radic Biol Med. 42:636–641. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Noh H, Kim JS, Han KH, Lee GT, Song JS, Chung SH, Jeon JS, Ha H and Lee HB: Oxidative stress during peritoneal dialysis: Implications in functional and structural changes in the membrane. Kidney Int. 69:2022–2028. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Wellinghausen N and Rink L: The significance of zinc for leukocyte biology. J Leukoc Biol. 64:571–577. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Beyersmann D and Haase H: Functions of zinc in signaling, proliferation and differentiation of mammalian cells. Biometals. 14:331–341. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Cousins RJ, Blanchard RK, Moore JB, Cui L, Green CL, Liuzzi JP, Cao J and Bobo JA: Regulation of zinc metabolism and genomic outcomes. J Nutr. 133 (Suppl 1):1521S–1526S. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Honscheid A, Rink L and Haase H: T-lymphocytes: A target for stimulatory and inhibitory effects of zinc ions. Endocr Metab Immune Disord Drug Targets. 9:132–144. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Takahashi M, Saito H, Higashimoto M and Hibi T: Possible inhibitory effect of oral zinc supplementation on hepatic fibrosis through downregulation of TIMP-1: A pilot study. Hepatol Res. 37:405–409. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Wang L, Zhou Z, Saari JT and Kang YJ: Alcohol-induced myocardial fibrosis in metallothionein-null mice: Prevention by zinc supplementation. Am J Pathol. 167:337–344. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Gandhi MS, Deshmukh PA, Kamalov G, Zhao T, Zhao W, Whaley JT, Tichy JR, Bhattacharya SK, Ahokas RA and Sun Y: Causes and consequences of zinc dyshomeostasis in rats with chronic aldosteronism. J Cardiovasc Pharmacol. 52:245–252. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Van Biervliet S, Vande Velde S, Van Biervliet JP and Robberecht E: The effect of zinc supplements in cystic fibrosis patients. Ann Nutr Metab. 52:152–156. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Zhang X, Wang J, Fan Y, Yang L, Wang L and Ma J: Zinc supplementation attenuates high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelial cells. Biol Trace Elem Res. 150:229–235. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Duman S, Sen S, Gunal AI, Asci G, Akcicek F and Basci A: How can we standardize peritoneal thickness measurements in experimental studies in rats? Perit Dial Int. 21 (Suppl 3):S338–S341. 2001.PubMed/NCBI

22 

Rougier JP, Moullier P, Piedagnel R and Ronco PM: Hyperosmolality suppresses but TGF beta 1 increases MMP9 in human peritoneal mesothelial cells. Kidney Int. 51:337–347. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Zhang X, Liang D, Guo B, Sun L, Chi ZH, Cai Y, Wang L and Ma J: Zinc transporter 7 induced by high glucose attenuates epithelial-to-mesenchymal transition of peritoneal mesothelial cells. Biol Trace Elem Res. 151:138–147. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Zhang X, Liang D, Guo B, Yang L, Wang L and Ma J: Zinc inhibits high glucose-induced apoptosis in peritoneal mesothelial cells. Biol Trace Elem Res. 150:424–432. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Xiang S, Li M, Xie X, Xie Z, Zhou Q, Tian Y, Lin W, Zhang X, Jiang H, Shou Z and Chen J: Rapamycin inhibits epithelial-to-mesenchymal transition of peritoneal mesothelium cells through regulation of Rho GTPases. FEBS J. 283:2309–2325. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Thiery JP and Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol. 7:131–142. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Kovac S, Angelova PR, Holmstrom KM, Zhang Y, Dinkova-Kostova AT and Abramov AY: Nrf2 regulates ROS production by mitochondria and NADPH oxidase. Biochim Biophys Acta. 1850:794–801. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Kanlaya R, Khamchun S, Kapincharanon C and Thongboonkerd V: Protective effect of epigallocatechin-3-gallate (EGCG) via Nrf2 pathway against oxalate-induced epithelial mesenchymal transition (EMT) of renal tubular cells. Sci Rep. 6:302332016. View Article : Google Scholar : PubMed/NCBI

29 

Oyama TM, Ishida S, Okano Y, Seo H and Oyama Y: Clioquinol-induced increase and decrease in the intracellular Zn2+ level in rat thymocytes. Life Sci. 91:1216–1220. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Priel T, Aricha-Tamir B and Sekler I: Clioquinol attenuates zinc-dependent beta-cell death and the onset of insulitis and hyperglycemia associated with experimental type I diabetes in mice. Eur J Pharmacol. 565:232–239. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Kim JH, Jang BG, Choi BY, Kwon LM, Sohn M, Song HK and Suh SW: Zinc chelation reduces hippocampal neurogenesis after pilocarpine-induced seizure. PLoS One. 7:E485432012. View Article : Google Scholar : PubMed/NCBI

32 

Nitzan YB, Sekler I, Frederickson CJ, Coulter DA, Balaji RV, Liang SL, Margulis A, Hershfinkel M and Silverman WF: Clioquinol effects on tissue chelatable zinc in mice. J Mol Med (Berl). 81:637–464. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Wang T, Wang CY, Shan ZY, Teng WP and Wang ZY: Clioquinol reduces zinc accumulation in neuritic plaques and inhibits the amyloidogenic pathway in AβPP/PS1 transgenic mouse brain. J Alzheimers Dis. 29:549–559. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, et al: Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron. 30:665–676. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Kang M, Zhao L, Ren M, Deng M and Li C: Reduced metallothionein expression induced by Zinc deficiency results in apoptosis in hepatic stellate cell line LX-2. Int J Clin Exp Med. 8:20603–20609. 2015.PubMed/NCBI

36 

Yang H, Keen CL and Lanoue L: Influence of intracellular zinc on cultures of rat cardiac neural crest cells. Birth Defects Res B Dev Reprod Toxicol. 104:11–22. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Lopez-Cabrera M: Mesenchymal conversion of mesothelial cells is a key event in the pathophysiology of the peritoneum during peritoneal dialysis. Adv Med. 2014:4731342014. View Article : Google Scholar : PubMed/NCBI

38 

Liu J, Zeng L, Zhao Y, Zhu B, Ren W and Wu C: Selenium suppresses lipopolysaccharide-induced fibrosis in peritoneal mesothelial cells through inhibition of epithelial-to-mesenchymal transition. Biol Trace Elem Res. 161:202–209. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Strippoli R, Moreno-Vicente R, Battistelli C, Cicchini C, Noce V, Amicone L, Marchetti A, Del Pozo MA and Tripodi M: Molecular mechanisms underlying peritoneal EMT and fibrosis. Stem Cells Int. 2016:35436782016. View Article : Google Scholar : PubMed/NCBI

40 

Lee JM, Dedhar S, Kalluri R and Thompson EW: The epithelial-mesenchymal transition: New insights in signaling, development, and disease. J Cell Biol. 172:973–981. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Aroeira LS, Aguilera A, Sanchez-Tomero JA, Bajo MA, del Peso G, Jimenez-Heffernan JA, Selgas R and Lopez-Cabrera M: Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: Pathologic significance and potential therapeutic interventions. J Am Soc Nephrol. 18:2004–2013. 2004. View Article : Google Scholar

43 

Hsieh HL, Chi PL, Lin CC, Yang CC and Yang CM: Up-regulation of ROS-dependent matrix metalloproteinase-9 from high-glucose-challenged astrocytes contributes to the neuronal apoptosis. Mol Neurobiol. 50:520–533. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Lee HB, Yu MR, Song JS and Ha H: Reactive oxygen species amplify protein kinase C signaling in high glucose-induced fibronectin expression by human peritoneal mesothelial cells. Kidney Int. 65:1170–1179. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Oteiza PI, Olin KL, Fraga CG and Keen CL: Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes. J Nutr. 125:823–829. 1995.PubMed/NCBI

46 

Ho E and Ames BN: Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Proc Natl Acad Sci USA. 99:16770–16775. 2002. View Article : Google Scholar : PubMed/NCBI

47 

Prasad AS: Clinical, immunological, anti-inflammatory and antioxidant roles of zinc. Exp Gerontol. 43:370–377. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Bao B, Prasad AS, Beck FW, Snell D, Suneja A, Sarkar FH, Doshi N, Fitzgerald JT and Swerdlow P: Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients. Transl Res. 152:67–80. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Taguchi K, Motohashi H and Yamamoto M: Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells. 16:123–140. 2011. View Article : Google Scholar : PubMed/NCBI

50 

McMahon M, Lamont DJ, Beattie KA and Hayes JD: Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals. Proc Natl Acad Sci USA. 107:18838–18843. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Wang R, Paul VJ and Luesch H: Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway. Free Radic Biol Med. 57:141–153. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Kim HJ and Vaziri ND: Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. Am J Physiol Renal Physiol. 298:F662–F671. 2010. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Gao L, Fan Y, Zhang X, Yang L, Huang W, Hang T, Li M, Du S and Ma J: Zinc supplementation inhibits the high glucose‑induced EMT of peritoneal mesothelial cells by activating the Nrf2 antioxidant pathway . Mol Med Rep 20: 655-663, 2019.
APA
Gao, L., Fan, Y., Zhang, X., Yang, L., Huang, W., Hang, T. ... Ma, J. (2019). Zinc supplementation inhibits the high glucose‑induced EMT of peritoneal mesothelial cells by activating the Nrf2 antioxidant pathway . Molecular Medicine Reports, 20, 655-663. https://doi.org/10.3892/mmr.2019.10260
MLA
Gao, L., Fan, Y., Zhang, X., Yang, L., Huang, W., Hang, T., Li, M., Du, S., Ma, J."Zinc supplementation inhibits the high glucose‑induced EMT of peritoneal mesothelial cells by activating the Nrf2 antioxidant pathway ". Molecular Medicine Reports 20.1 (2019): 655-663.
Chicago
Gao, L., Fan, Y., Zhang, X., Yang, L., Huang, W., Hang, T., Li, M., Du, S., Ma, J."Zinc supplementation inhibits the high glucose‑induced EMT of peritoneal mesothelial cells by activating the Nrf2 antioxidant pathway ". Molecular Medicine Reports 20, no. 1 (2019): 655-663. https://doi.org/10.3892/mmr.2019.10260
Copy and paste a formatted citation
x
Spandidos Publications style
Gao L, Fan Y, Zhang X, Yang L, Huang W, Hang T, Li M, Du S and Ma J: Zinc supplementation inhibits the high glucose‑induced EMT of peritoneal mesothelial cells by activating the Nrf2 antioxidant pathway . Mol Med Rep 20: 655-663, 2019.
APA
Gao, L., Fan, Y., Zhang, X., Yang, L., Huang, W., Hang, T. ... Ma, J. (2019). Zinc supplementation inhibits the high glucose‑induced EMT of peritoneal mesothelial cells by activating the Nrf2 antioxidant pathway . Molecular Medicine Reports, 20, 655-663. https://doi.org/10.3892/mmr.2019.10260
MLA
Gao, L., Fan, Y., Zhang, X., Yang, L., Huang, W., Hang, T., Li, M., Du, S., Ma, J."Zinc supplementation inhibits the high glucose‑induced EMT of peritoneal mesothelial cells by activating the Nrf2 antioxidant pathway ". Molecular Medicine Reports 20.1 (2019): 655-663.
Chicago
Gao, L., Fan, Y., Zhang, X., Yang, L., Huang, W., Hang, T., Li, M., Du, S., Ma, J."Zinc supplementation inhibits the high glucose‑induced EMT of peritoneal mesothelial cells by activating the Nrf2 antioxidant pathway ". Molecular Medicine Reports 20, no. 1 (2019): 655-663. https://doi.org/10.3892/mmr.2019.10260
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