Expression profile of circular RNAs in the peripheral blood of neonates with hypoxic‑ischemic encephalopathy

  • Authors:
    • Xiaohua Dong
    • Sisi Zhuang
    • Yun Huang
    • Xiaojing Yang
    • Yanrong Fu
    • Lingling Yu
    • Yingmin Zhao
  • View Affiliations

  • Published online on: April 23, 2020     https://doi.org/10.3892/mmr.2020.11091
  • Pages: 87-96
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNAs (circRNAs) are a class of non-coding RNAs that participate in various biological processes. However, the function of circRNAs in neonatal hypoxic‑ischemic encephalopathy (HIE) is not fully understood. In the present study, the differentially expressed circRNAs in the peripheral blood of neonates with HIE and control samples were characterized by a microarray assay. A total of 456 circRNAs were significantly differentially expressed in the peripheral blood of neonates with HIE, with 250 upregulated and 206 downregulated circRNAs in HIE compared with the control samples. Reverse transcription‑quantitative PCR was used to investigate specific circRNAs. Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes pathway analyses were used to determine the function of the parent genes of the dysregulated circRNAs. In addition, microRNAs that may be associated with specific circRNAs were predicted using miRanda. Collectively, the present results indicated the potential importance of circRNAs in the peripheral blood of neonates with HIE.
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July 2020
Volume 22 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Dong, X., Zhuang, S., Huang, Y., Yang, X., Fu, Y., Yu, L., & Zhao, Y. (2020). Expression profile of circular RNAs in the peripheral blood of neonates with hypoxic‑ischemic encephalopathy. Molecular Medicine Reports, 22, 87-96. https://doi.org/10.3892/mmr.2020.11091
MLA
Dong, X., Zhuang, S., Huang, Y., Yang, X., Fu, Y., Yu, L., Zhao, Y."Expression profile of circular RNAs in the peripheral blood of neonates with hypoxic‑ischemic encephalopathy". Molecular Medicine Reports 22.1 (2020): 87-96.
Chicago
Dong, X., Zhuang, S., Huang, Y., Yang, X., Fu, Y., Yu, L., Zhao, Y."Expression profile of circular RNAs in the peripheral blood of neonates with hypoxic‑ischemic encephalopathy". Molecular Medicine Reports 22, no. 1 (2020): 87-96. https://doi.org/10.3892/mmr.2020.11091