Antihypertensive drug telmisartan inhibits cell proliferation of gastrointestinal stromal tumor cells in vitro

  • Authors:
    • Hideki Kobara
    • Shintaro Fujihara
    • Hisakazu Iwama
    • Takanori Matsui
    • Ayako Fujimori
    • Taiga Chiyo
    • Shi Tingting
    • Nobuya Kobayashi
    • Noriko Nishiyama
    • Tatsuo Yachida
    • Tomoko Tadokoro
    • Kyoko Oura
    • Joji Tani
    • Koji Fujita
    • Takako Nomura
    • Hirohito Yoneyama
    • Asahiro Morishita
    • Keiichi Okano
    • Yasuyuki Suzuki
    • Hirohito Mori
    • Tsutomu Masaki
  • View Affiliations

  • Published online on: May 14, 2020     https://doi.org/10.3892/mmr.2020.11144
  • Pages: 1063-1071
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Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. The angiotensin II type 1 receptor blockers, telmisartan and candesartan, are widely used antihypertensive drugs that inhibits cancer cell proliferation; however, its underlying mechanisms in mesenchymal tumors, including GIST, remains unknown. The present study aimed to investigate the effect of telmisartan on GIST‑T1 cells and its underlying mechanism. Telmisartan and candesartan inhibited the proliferation of these cells by blocking the G0 to G1 cell cycle transition, which was accompanied by a decrease in cell cycle‑related proteins such as cyclin D1. Furthermore, telmisartan exposure significantly altered microRNA expression in vitro. In conclusion, telmisartan suppressed human GIST cell proliferation by inducing cell cycle arrest in vitro.

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August-2020
Volume 22 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Kobara, H., Fujihara, S., Iwama, H., Matsui, T., Fujimori, A., Chiyo, T. ... Masaki, T. (2020). Antihypertensive drug telmisartan inhibits cell proliferation of gastrointestinal stromal tumor cells in vitro. Molecular Medicine Reports, 22, 1063-1071. https://doi.org/10.3892/mmr.2020.11144
MLA
Kobara, H., Fujihara, S., Iwama, H., Matsui, T., Fujimori, A., Chiyo, T., Tingting, S., Kobayashi, N., Nishiyama, N., Yachida, T., Tadokoro, T., Oura, K., Tani, J., Fujita, K., Nomura, T., Yoneyama, H., Morishita, A., Okano, K., Suzuki, Y., Mori, H., Masaki, T."Antihypertensive drug telmisartan inhibits cell proliferation of gastrointestinal stromal tumor cells in vitro". Molecular Medicine Reports 22.2 (2020): 1063-1071.
Chicago
Kobara, H., Fujihara, S., Iwama, H., Matsui, T., Fujimori, A., Chiyo, T., Tingting, S., Kobayashi, N., Nishiyama, N., Yachida, T., Tadokoro, T., Oura, K., Tani, J., Fujita, K., Nomura, T., Yoneyama, H., Morishita, A., Okano, K., Suzuki, Y., Mori, H., Masaki, T."Antihypertensive drug telmisartan inhibits cell proliferation of gastrointestinal stromal tumor cells in vitro". Molecular Medicine Reports 22, no. 2 (2020): 1063-1071. https://doi.org/10.3892/mmr.2020.11144