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Article Open Access

Investigating the correlation between DNA methylation and immune‑associated genes of lung adenocarcinoma based on a competing endogenous RNA network

  • Authors:
    • Chun Chang
    • Wei Kong
    • Xiaoyang Mou
    • Shuaiqun Wang
  • View Affiliations / Copyright

    Affiliations: College of Information Engineering, Shanghai Maritime University, Shanghai 201306, P.R. China, Department of Biochemistry, Rowan University and Guava Medicine, Glassboro, NJ 08028, USA
    Copyright: © Chang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3173-3182
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    Published online on: August 19, 2020
       https://doi.org/10.3892/mmr.2020.11445
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Abstract

In recent years, there have been major breakthroughs in immunotherapies for the treatment of cancer. However, different patients have different responses to immunotherapy. Numerous studies have shown that the accumulation of epigenetic abnormalities, such as DNA methylation, serve an important role in the immune response of lung adenocarcinoma (LUAD). To investigate the effects of DNA methylation on tumor immunity with survival and prognosis, relevant studies can be performed based on the regulatory mechanisms of RNA molecules. For example, long non‑coding RNAs (lncRNAs), which regulate gene expression through epigenetic levels. By constructing an immune-associated competitive endogenous RNA (ceRNA) network, the present study identified the regulatory associations among 3 key immune‑associations mRNAs, 2 microRNAs (miRs) and 29 lncRNAs that were closely associated with the prognosis of patients with LUAD. The molecular biology analysis indicated that hypomethylation of the 1101320‑1104290 regions of chromosome 1 resulted in the low expression levels of LINC00337 and that LINC00337 may affect the expression levels of CHEK1 by competitively binding with human (has)‑miR‑373 and hsa‑miR‑195. Therefore, abnormal DNA methylation in lncRNA‑associated regions caused their abnormal expression levels, which further affected the interactions between RNA molecules. The interactions between these RNA molecules may have regulatory effects on tumor immunity and the prognosis of patients with LUAD.
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View References

1 

Sharma P, Wagner K, Wolchok JD and Allison JP: Novel cancer immunotherapy agents with survival benefit: Recent successes and next steps. Nat Rev Cancer. 11:3173–812. 2011. View Article : Google Scholar

2 

Pardoll DM: The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 12:252–264. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Carter BW, Halpenny DF, Ginsberg MS, Papadimitrakopoulou VA and de Groot PM: Immunotherapy in Non-small cell lung cancer treatment: Current status and the role of imaging. J Thorac Imaging. 32:300–312. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Di Giacomo AM, Calabrò L, Danielli R, Fonsatti E, Bertocci E, Pesce I, Fazio C, Cutaia O, Giannarelli D, Miracco C, et al: Long-term survival and immunological parameters in metastatic melanoma; patients who responded to ipilimumab 10 mg/kg within an expanded access; programme. Cancer Immunol Immunother. 62:1021–1028. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Prieto PA, Yang JC, Sherry RM, Hughes MS, Kammula US, White DE, Levy CL, Rosenberg SA and Phan GQ: CTLA-4 blockade with ipilimumab: Long-term follow-up of 177 patients with metastatic melanoma. Clin Cancer Res. 18:2039–2047. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Liu XS and Mardis ER: Applications of immunogenomics to cancer. Cell. 168:600–612. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Yang IV, Konigsberg I, Macphail K, Li L, Davidson EJ, Mroz PM, Hamzeh N, Gillespie M, Silveira LJ, Fingerlin TE and Maier LA: DNA methylation changes in lung immune cells are associated with granulomatous lung disease. Am J Respir Cell Mol Biol. 60:96–105. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Gudrun B, Rowley MJ, Kuciński J, Zhu Y, Amies I and Wierzbicki AT: RNA-directed DNA methylation requires stepwise binding of silencing factors to long non-coding RNA. Plant J Cell Mol Biol. 79:181–191. 2014. View Article : Google Scholar

9 

Hui Z, Shangwei N, Xiang L, Yuyun L, Wei W and Xia L: A novel reannotation strategy for dissecting DNA methylation patterns of human long intergenic non-coding RNAs in cancers. Nucleic Acids Res. 42:82582014. View Article : Google Scholar : PubMed/NCBI

10 

Bohne F, Langer D, Martiné U, Eider CS, Cencic R, Begemann M, Elbracht M, Bülow L, Eggermann T, Zechner U, et al: Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation. Clin Epigenetics. 8:472016. View Article : Google Scholar : PubMed/NCBI

11 

Vennin C, Spruyt N, Robin YM, Chassat T, Le Bourhis X and Adriaenssens E: The long non-coding RNA 91H increases aggressive phenotype of breast cancer cells and up-regulates H19/IGF2 expression through epigenetic modifications. Cancer Lett. 385:198–206. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Yu F, Chen B, Dong P and Zheng J: HOTAIR epigenetically modulates PTEN expression via MicroRNA-29b: A novel mechanism in regulation of liver fibrosis. Mol Ther. 25:205–217. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Gregory MC and Loeb DM: Hypoxia-sensitive epigenetic regulation of an antisense-oriented lncRNA controls WT1 expression in myeloid leukemia cells. PLoS One. 10:e01198372015. View Article : Google Scholar : PubMed/NCBI

14 

Tianyi G, Bangshun H, Yuqin P, Yeqiong X, Rui L, Qiwen D, Huilin S and Shukui W: Long non-coding RNA 91H contributes to the occurrence and progression of esophageal squamous cell carcinoma by inhibiting IGF2 expression. Chinese J Clin Lab Sci. 54:359–367. 2015.

15 

Ruscio AD, Ebralidze AK, Benoukraf T, Amabile G, Goff LA, Terragni J, Figueroa ME, Pontes LLDF, Alberich-Jorda M, Zhang P, et al: DNMT1-interacting RNAs block gene-specific DNA methylation. Nature. 503:371–376. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Salmena L, Poliseno L, Tay Y, Kats L and Pandolfi PP: ceRNA hypothesis: The Rosetta stone of a hidden RNA language? Cell. 146:353–358. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Li B and Dewey CN: RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics. 12:323. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Zhi H, Li X, Wang P, Gao Y, Gao B, Zhou D, Zhang Y, Guo M, Yue M, Shen W, et al: Lnc2Meth: A manually curated database of regulatory relationships between long non-coding RNAs and DNA methylation associated with human disease. Nucleic Acids Res. 46:D133–D138. 2017. View Article : Google Scholar

19 

Love MI, Wolfgang H and Simon A: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15:5502014. View Article : Google Scholar : PubMed/NCBI

20 

Li B, Severson E, Pignon JC, Zhao H, Li T, Novak J, Peng J, Hui S, Aster JC, Rodig S, et al: Comprehensive analyses of tumor immunity: Implications for cancer immunotherapy. Genome Biol. 17:1742016. View Article : Google Scholar : PubMed/NCBI

21 

Li B and Li JZ: A general framework for analyzing tumor subclonality using SNP array and DNA sequencing data. Genome Biol. 15:4732014. View Article : Google Scholar : PubMed/NCBI

22 

Chao C, Kay G, Judith B, Dandan Z, Elliot G, Li J and Chunyu L: Removing batch effects in analysis of expression microarray data: An evaluation of six batch adjustment methods. PLoS One. 6:e172382011. View Article : Google Scholar : PubMed/NCBI

23 

Ashwini J, Marks DS and Erik L: miRcode: A map of putative microRNA target sites in the long non-coding transcriptome. Bioinformatics. 28:2062–2063. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Li JH, Liu S, Zhou H, Qu LH and Yang JH: starBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 42((Database Issue)): D92–D97. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. Elife. 4:e050052015. View Article : Google Scholar

26 

Chou CH, Shrestha S, Yang CD, Chang NW, Lin YL, Liao KW, Huang WC, Sun TH, Tu SJ, Lee WH, et al: miRTarBase update 2018: A resource for experimentally validated microRNA-target interactions. Nucleic Acids Res. 46:D296–D302. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Wong N and Wang X: miRDB: An online resource for microRNA target prediction and functional annotations. Nucleic Acids Res. 43((Database Issue)): D146–D152. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Gill RD: Censoring and stochastic integrals. Statistica Neerlandica. 34:124. 1980. View Article : Google Scholar

30 

Fox J: Cox proportional-hazards regression for survival data. See Also. 371–372. 2012.

31 

Huang DW, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Zhang W, Cui Q, Qu W, Ding X, Jiang D and Liu H: TRIM58/cg26157385 methylation is associated with eight prognostic genes in lung squamous cell carcinoma. Oncol Rep. 40:206–216. 2018.PubMed/NCBI

33 

Nakayama K, Rahman MT, Rahman M, Nakamura K, Ishikawa M, Katagiri H, Sato E, Ishibashi T, Iida K, Ishikawa N and Kyo S: CCNE1amplification is associated with aggressive potential in endometrioid endometrial carcinomas. Int J Oncol. 48:506–516. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Yao Y, Luo J, Sun Q, Xu T, Sun S, Chen M, Lin X, Qian Q, Zhang Y, Cao L, et al: HOXC13 promotes proliferation of lung adenocarcinoma via modulation of CCND1 and CCNE1. Am J Cancer Res. 7:1820–1834. 2017.PubMed/NCBI

35 

Han Z, Zhang Y, Yang Q, Liu B, Wu J, Zhang Y, Yang C and Jiang Y: miR-497 and miR-34a retard lung cancer growth by co-inhibiting cyclin E1 (CCNE1). Oncotarget. 6:13149–13163. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Chen H, Eisenberg R, et al: xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression. Oncogene. 37:5007–5019. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Simner C, Novakovic B, Lillycrop KA, Bell CG, Harvey NC, Cooper C, Saffery R, Lewis RM and Cleal JK: DNA methylation of amino acid transporter genes in the human placenta. Placenta. 60:64–73. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Cohen AS, Khalil FK, Welsh EA, Schabath MB, Enkemann SA, Davis A, Zhou JM, Boulware DC, Kim J, Haura EB and Morse DL: Cell-surface marker discovery for lung cancer. Oncotarget. 8:113373–113402. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Ben L, Jinli Q, Fangxiu X, Yan G, Yu W, Herbert Y and Biyun Q: MiR-195 suppresses non-small cell lung cancer by targeting CHEK1. Oncotarget. 6:9445–9456. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Lakomy R, Sana J, Hankeova S, Fadrus P, Kren L, Lzicarova E, Svoboda M, Dolezelova H, Smrcka M, Vyzula R, et al: MiR-195, miR-196b, miR-181c, miR-21 expression levels and O-6-methylguanine-DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients. Cancer Sci. 102:2186–2190. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Wang Y, Hu Y, Wu G, Yang Y, Tang Y, Zhang W, Wang K, Liu Y, Wang X and Li T: Long noncoding RNA PCAT-14 induces proliferation and invasion by hepatocellular carcinoma cells by inducing methylation of miR-372. Oncotarget. 8:34429–34441. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Lai JH, She TF, Juang YM, Tsay YG, Huang AH, Yu SL, Chen JJW and Lai CC: Comparative proteomic profiling of human lung adenocarcinoma cells (CL 1-0) expressing miR-372. Electrophoresis. 33:675–688. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Sun H and Gao D: Propofol suppresses growth, migration and invasion of A549 cells by down-regulation of miR-372. BMC Cancer. 18:12522018. View Article : Google Scholar : PubMed/NCBI

44 

Chen Z, Li JL, Lin S, Cao C, Gimbrone NT, Yang R, Fu DA, Carper MB, Haura EB, Schabath MB, et al: cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth. J Clin Invest. 126:2267–2279. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chang C, Kong W, Mou X and Wang S: Investigating the correlation between DNA methylation and immune‑associated genes of lung adenocarcinoma based on a competing endogenous RNA network. Mol Med Rep 22: 3173-3182, 2020.
APA
Chang, C., Kong, W., Mou, X., & Wang, S. (2020). Investigating the correlation between DNA methylation and immune‑associated genes of lung adenocarcinoma based on a competing endogenous RNA network. Molecular Medicine Reports, 22, 3173-3182. https://doi.org/10.3892/mmr.2020.11445
MLA
Chang, C., Kong, W., Mou, X., Wang, S."Investigating the correlation between DNA methylation and immune‑associated genes of lung adenocarcinoma based on a competing endogenous RNA network". Molecular Medicine Reports 22.4 (2020): 3173-3182.
Chicago
Chang, C., Kong, W., Mou, X., Wang, S."Investigating the correlation between DNA methylation and immune‑associated genes of lung adenocarcinoma based on a competing endogenous RNA network". Molecular Medicine Reports 22, no. 4 (2020): 3173-3182. https://doi.org/10.3892/mmr.2020.11445
Copy and paste a formatted citation
x
Spandidos Publications style
Chang C, Kong W, Mou X and Wang S: Investigating the correlation between DNA methylation and immune‑associated genes of lung adenocarcinoma based on a competing endogenous RNA network. Mol Med Rep 22: 3173-3182, 2020.
APA
Chang, C., Kong, W., Mou, X., & Wang, S. (2020). Investigating the correlation between DNA methylation and immune‑associated genes of lung adenocarcinoma based on a competing endogenous RNA network. Molecular Medicine Reports, 22, 3173-3182. https://doi.org/10.3892/mmr.2020.11445
MLA
Chang, C., Kong, W., Mou, X., Wang, S."Investigating the correlation between DNA methylation and immune‑associated genes of lung adenocarcinoma based on a competing endogenous RNA network". Molecular Medicine Reports 22.4 (2020): 3173-3182.
Chicago
Chang, C., Kong, W., Mou, X., Wang, S."Investigating the correlation between DNA methylation and immune‑associated genes of lung adenocarcinoma based on a competing endogenous RNA network". Molecular Medicine Reports 22, no. 4 (2020): 3173-3182. https://doi.org/10.3892/mmr.2020.11445
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