Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2021 Volume 24 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2021 Volume 24 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Resveratrol affects the expression of uric acid transporter by improving inflammation

  • Authors:
    • Xuemei Zhang
    • Qian Nie
    • Zhimei Zhang
    • Jing Zhao
    • Fengxiao Zhang
    • Chao Wang
    • Xing Wang
    • Guangyao Song
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050000, P.R. China, Department of Rheumatism and Immunology, Hebei General Hospital, Shijiazhuang, Hebei 050000, P.R. China, Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, Hebei 050000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 564
    |
    Published online on: June 7, 2021
       https://doi.org/10.3892/mmr.2021.12203
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Resveratrol (RSV), a polyphenol, non‑flavonoid plant‑derived antitoxin, ameliorates hyperuricemia and kidney inflammation. The present study aimed to establish a model of high‑fat diet (HFD)‑induced insulin resistance (IR) and to determine the specific mechanism of RSV to improve kidney inflammation and reduce uric acid (UA). C57BL/6J mice were fed a HFD for 12 weeks and their glucose tolerance was evaluated by intraperitoneal glucose tolerance testing. The mice were then administered RSV for 6 weeks, and blood and kidney samples were collected. Serum UA and insulin concentrations were determined using ELISA kits. Hematoxylin and eosin, periodic acid‑Schiff and Masson staining were performed to observe the pathological changes of the kidney, and electron microscopy was used to observe changes in the kidney ultrastructure. The renal concentrations of interleukin (IL)‑6, IL‑18, IL‑1β and tumor necrosis factor‑α (TNF‑α) were measured using ELISA kits, and western blotting evaluated changes in the protein expression levels of various indicators. RSV significantly ameliorated HFD‑induced IR and reduced blood UA levels. Long‑term IR can lead to lipid deposition, glycogen accumulation, inflammatory damage and fibrotic changes in the kidney of mice. This leads to a significant increase in the expression of UA transport‑related proteins, an increase in UA reabsorption and an increase in blood UA levels. Notably, RSV intervention was able to reverse this process. The effect of RSV may be achieved by inhibiting the NOD‑like receptor family, pyrin domain‑containing 3 (NLRP3) inflammasome and Toll‑like receptor 4 (TLR4)/myeloid differentiation factor 88/nuclear factor‑κB signaling pathway. In conclusion, RSV may improve kidney inflammation through TLR4 and NLRP3 signaling pathways, and reduce the expression of UA transporter proteins in the kidney of insulin‑resistant mice, thereby reducing blood UA levels.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

El Ridi R and Tallima H: Physiological functions and pathogenic potential of uric acid: A review. J Adv Res. 8:487–493. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Billiet L, Doaty S, Katz JD and Velasquez MT: Review of hyperuricemia as new marker for metabolic syndrome. ISRN Rheumatol. 2014:8529542014. View Article : Google Scholar : PubMed/NCBI

3 

Sharaf El Din UAA, Salem MM and Abdulazim DO: Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review. J Adv Res. 8:537–548. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Tan PK, Farrar JE, Gaucher EA and Miner JN: Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout. Mol Biol Evol. 33:2193–2200. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Ebert K, Ludwig M, Geillinger KE, Schoberth GC, Essenwanger J, Stolz J, Daniel H and Witt H: Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose Transporters. J Membr Biol. 250:171–182. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Yang Y, Zhang DM, Liu JH, Hu LS, Xue QC, Ding XQ and Kong LD: Wuling San protects kidney dysfunction by inhibiting renal TLR4/MyD88 signaling and NLRP3 inflammasome activation in high fructose-induced hyperuricemic mice. J Ethnopharmacol. 169:49–59. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Akira S, Takeda K and Kaisho T: Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat Immunol. 2:675–680. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Zeng XZ, Zhang YY, Yang Q, Wang S, Zou BH, Tan YH, Zou M, Liu SW and Li XJ: Artesunate attenuates LPS-induced osteoclastogenesis by suppressing TLR4/TRAF6 and PLCγ1-Ca2+-NFATc1 signaling pathway. Acta Pharmacol Sin. 41:229–236. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Shigeoka AA, Mueller JL, Kambo A, Mathison JC, King AJ, Hall WF, Correia JS, Ulevitch RJ, Hoffman HM and McKay DB: An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury. J Immunol. 185:6277–6285. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Thiel G and Rössler OG: Resveratrol regulates gene transcription via activation of stimulus-responsive transcription factors. Pharmacol Res. 117:166–176. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Cheng K, Song Z, Chen Y, Li S, Zhang Y, Zhang H, Zhang L, Wang C and Wang T: Resveratrol protects against renal damage via attenuation of inflammation and oxidative stress in high-fat-diet-induced obese mice. Inflammation. 42:937–945. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Saldanha JF, Leal VO, Stenvinkel P, Carraro-Eduardo JC and Mafra D: Resveratrol: Why is it a promising therapy for chronic kidney disease patients? Oxid Med Cell Longev. 2013:9632172013. View Article : Google Scholar : PubMed/NCBI

13 

Jørgensen MS, Tornqvist KS and Hvid H: Calculation of glucose dose for intraperitoneal glucose tolerance tests in lean and obese mice. J Am Assoc Lab Anim Sci. 56:95–97. 2017.

14 

Bhatt JK, Thomas S and Nanjan MJ: Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr Res. 32:537–541. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Shu L, Hou G, Zhao H, Huang W, Song G and Ma H: Resveratrol improves high-fat diet-induced insulin resistance in mice by downregulating the lncRNA NONMMUT008655.2. Am J Transl Res. 12:1–18. 2020.PubMed/NCBI

16 

Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G and Quon MJ: Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 85:2402–2410. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Brenner C, Simmonds RE, Wood S, Rose V, Feldmann M and Turner J: TLR signalling and adapter utilization in primary human in vitro differentiated adipocytes. Scand J Immunol. 76:359–370. 2012. View Article : Google Scholar : PubMed/NCBI

18 

O'Neill LA, Dunne A, Edjeback M, Gray P, Jefferies C and Wietek C: Mal and MyD88: Adapter proteins involved in signal transduction by Toll-like receptors. J Endotoxin Res. 9:55–59. 2003. View Article : Google Scholar

19 

Verstak B, Nagpal K, Bottomley SP, Golenbock DT, Hertzog PJ and Mansell A: MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses. J Biol Chem. 284:24192–24203. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, et al: Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 127:1109–1122. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Zhao J, Wang H, Dai C, Wang H, Zhang H, Huang Y, Wang S, Gaskin F, Yang N and Fu SM: P2X7 blockade attenuates murine lupus nephritis by inhibiting activation of the NLRP3/ASC/caspase 1 pathway. Arthritis Rheum. 65:3176–3185. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Zhou R, Yazdi AS, Menu P and Tschopp J: A role for mitochondria in NLRP3 inflammasome activation. Nature. 469:221–225. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Roger T, David J, Glauser MP and Calandra T: MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature. 414:920–924. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Albert D, Scudder PN, Bagley P and Saag KG: Vascular consequences of hyperuricemia and hypouricemia. Rheum Dis Clin North Am. 45:453–464. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Kostka-Jeziorny K, Widecka K and Tykarski A: Study of epidemiological aspects of hyperuricemia in Poland. Cardiol J. 26:241–252. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Zhang S, Wang Y, Cheng J, Huangfu N, Zhao R, Xu Z, Zhang F, Zheng W and Zhang D: Hyperuricemia and Cardiovascular Disease. Curr Pharm Des. 25:700–709. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Doualla M, Halle MP, Moutchia J, Tegang S and Ashuntantang G: Determinants of hyperuricemia in non-dialysed chronic kidney disease patients in three hospitals in Cameroon. BMC Nephrol. 19:1692018. View Article : Google Scholar : PubMed/NCBI

28 

Yang H, Bai W, Gao L, Jiang J, Tang Y, Niu Y, Lin H and Li L: Mangiferin alleviates hypertension induced by hyperuricemia via increasing nitric oxide releases. J Pharmacol Sc. 137:154–161. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Sha J, Sui B, Su X, Meng Q and Zhang C: Alteration of oxidative stress and inflammatory cytokines induces apoptosis in diabetic nephropathy. Mol Med Rep. 16:7715–7723. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Mount PF and Juncos LA: Obesity-Related CKD: When kidneys get the munchies. J Am Soc Nephrol. 28:3429–3432. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Wang MX, Zhao XJ, Chen TY, Liu YL, Jiao RQ, Zhang JH, Ma CH, Liu JH, Pan Y and Kong LD: Nuciferine alleviates renal injury by inhibiting inflammatory responses in fructose-fed rats. J Agric Food Chem. 64:7899–7910. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Hu QH, Wang C, Li JM, Zhang DM and Kong LD: Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: Renal organic ion transporter involvement. Am J Physiol Renal Physiol. 297:F1080–F1091. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Nie Q, Zhang Z, Zhao J, Zhang F, Wang C, Wang X and Song G: Resveratrol affects the expression of uric acid transporter by improving inflammation. Mol Med Rep 24: 564, 2021.
APA
Zhang, X., Nie, Q., Zhang, Z., Zhao, J., Zhang, F., Wang, C. ... Song, G. (2021). Resveratrol affects the expression of uric acid transporter by improving inflammation. Molecular Medicine Reports, 24, 564. https://doi.org/10.3892/mmr.2021.12203
MLA
Zhang, X., Nie, Q., Zhang, Z., Zhao, J., Zhang, F., Wang, C., Wang, X., Song, G."Resveratrol affects the expression of uric acid transporter by improving inflammation". Molecular Medicine Reports 24.2 (2021): 564.
Chicago
Zhang, X., Nie, Q., Zhang, Z., Zhao, J., Zhang, F., Wang, C., Wang, X., Song, G."Resveratrol affects the expression of uric acid transporter by improving inflammation". Molecular Medicine Reports 24, no. 2 (2021): 564. https://doi.org/10.3892/mmr.2021.12203
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Nie Q, Zhang Z, Zhao J, Zhang F, Wang C, Wang X and Song G: Resveratrol affects the expression of uric acid transporter by improving inflammation. Mol Med Rep 24: 564, 2021.
APA
Zhang, X., Nie, Q., Zhang, Z., Zhao, J., Zhang, F., Wang, C. ... Song, G. (2021). Resveratrol affects the expression of uric acid transporter by improving inflammation. Molecular Medicine Reports, 24, 564. https://doi.org/10.3892/mmr.2021.12203
MLA
Zhang, X., Nie, Q., Zhang, Z., Zhao, J., Zhang, F., Wang, C., Wang, X., Song, G."Resveratrol affects the expression of uric acid transporter by improving inflammation". Molecular Medicine Reports 24.2 (2021): 564.
Chicago
Zhang, X., Nie, Q., Zhang, Z., Zhao, J., Zhang, F., Wang, C., Wang, X., Song, G."Resveratrol affects the expression of uric acid transporter by improving inflammation". Molecular Medicine Reports 24, no. 2 (2021): 564. https://doi.org/10.3892/mmr.2021.12203
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team