Osteoprotective effects of flavonoids: Evidence from in vivo and in vitro studies (Review)

  • Authors:
    • Lili Cao
    • Jiawei Wang
    • Yujuan Zhang
    • Feng Tian
    • Chunfang Wang
  • View Affiliations

  • Published online on: April 26, 2022     https://doi.org/10.3892/mmr.2022.12716
  • Article Number: 200
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Abstract

Osteoporosis is a systemic bone disease characterized by decreased bone mass and quality and bone micro‑architecture degradation. Its primary cause is disorder of bone metabolism: Over‑formation of osteoclasts, resulting in increased bone resorption and insufficient osteogenesis. Traditional herbal flavonoids can be used as alternative drugs to prevent and treat osteoporosis due to their wide range of sources, structural diversity and less adverse effects. The present paper reviewed six flavonoids, including quercetin, icariin, hesperitin, naringin, chrysin and pueraria, that promote bone formation and have been widely studied in the literature over the past five years, with the aim of providing novel ideas for the development of drugs for bone‑associated disease.
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June-2022
Volume 25 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Cao L, Wang J, Zhang Y, Tian F and Wang C: Osteoprotective effects of flavonoids: Evidence from <em>in vivo</em> and <em>in vitro</em> studies (Review). Mol Med Rep 25: 200, 2022
APA
Cao, L., Wang, J., Zhang, Y., Tian, F., & Wang, C. (2022). Osteoprotective effects of flavonoids: Evidence from <em>in vivo</em> and <em>in vitro</em> studies (Review). Molecular Medicine Reports, 25, 200. https://doi.org/10.3892/mmr.2022.12716
MLA
Cao, L., Wang, J., Zhang, Y., Tian, F., Wang, C."Osteoprotective effects of flavonoids: Evidence from <em>in vivo</em> and <em>in vitro</em> studies (Review)". Molecular Medicine Reports 25.6 (2022): 200.
Chicago
Cao, L., Wang, J., Zhang, Y., Tian, F., Wang, C."Osteoprotective effects of flavonoids: Evidence from <em>in vivo</em> and <em>in vitro</em> studies (Review)". Molecular Medicine Reports 25, no. 6 (2022): 200. https://doi.org/10.3892/mmr.2022.12716