Open Access

Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)

  • Authors:
    • Qiongrong Xia
    • Dingding Zhang
  • View Affiliations

  • Published online on: March 19, 2024     https://doi.org/10.3892/mmr.2024.13207
  • Article Number: 82
  • Copyright: © Xia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glaucoma is a group of progressive optic nerve disorders characterized by the loss of retinal ganglion cells, a thinner retinal nerve fibre layer and cupping of the optic disk. Apoptosis is a physiological cell death process regulated by genes and plays a crucial role in maintaining tissue homeostasis, ensuring the natural development and immune defence of organisms. Apoptosis has been associated with glaucoma and inhibiting apoptosis by activating phosphatidylinositol 3-kinase‑protein kinase B or other medicines can rescue pathological changes in glaucoma. Due to the complex crosstalk of apoptosis pathways, the pathophysiological mechanism of apoptosis in glaucoma needs to be fully elucidated. The present review aimed to discuss the mechanism of cell apoptosis in glaucoma, improve the understanding of the pathophysiology of glaucoma, summarize new directions for the treatment of glaucoma and lay the foundation for new treatment strategies for glaucoma.
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May-2024
Volume 29 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Xia Q and Zhang D: Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review). Mol Med Rep 29: 82, 2024.
APA
Xia, Q., & Zhang, D. (2024). Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review). Molecular Medicine Reports, 29, 82. https://doi.org/10.3892/mmr.2024.13207
MLA
Xia, Q., Zhang, D."Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)". Molecular Medicine Reports 29.5 (2024): 82.
Chicago
Xia, Q., Zhang, D."Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)". Molecular Medicine Reports 29, no. 5 (2024): 82. https://doi.org/10.3892/mmr.2024.13207