Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December-2024 Volume 30 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2024 Volume 30 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

MUC1‑ND interacts with TRPV1 to promote corneal epithelial cell proliferation in diabetic dry eye mice by partly activating the AKT signaling pathway

  • Authors:
    • Haiqiong Li
    • Yu Zhang
    • Yuting Chen
    • Rong Zhu
    • Weikang Zou
    • Hui Chen
    • Jia Hu
    • Songfu Feng
    • Yanyan Zhong
    • Xiaohe Lu
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510220, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 213
    |
    Published online on: September 24, 2024
       https://doi.org/10.3892/mmr.2024.13337
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Although both mucin1 (MUC1) and transient receptor potential cation channel subfamily V member 1 (TRPV1) have been reported to be associated with dry eye (DE) disease, whether they interact and their regulatory roles in diabetic DE disease are unknown. Diabetic DE model mice were generated by streptozotocin induction and assessed by corneal fluorescein staining, tear ferning (TF) tests, phenol red thread tests, hematoxylin and eosin staining of corneal sections and periodic acid Schiff staining of conjunctival sections. Cell proliferation was measured by CCK8 assay. Western blotting was performed to measure protein expression. Primary mouse corneal epithelial cells (MCECs) were cultured after enzymatic digestion. Immunofluorescence staining of MCECs and frozen corneal sections was conducted to assess protein expression and colocalization. Coimmunoprecipitation was performed to detect protein‑protein interactions. It was found that, compared with control mice, diabetic DE mice exhibited increased corneal epithelial defects, reduced tear production, poorer TF pattern grades and impaired corneal and conjunctival tissues. In vivo and in vitro experiments showed that hyperglycemia impaired cell proliferation, accompanied by decreased levels of the MUC1 extracellular domain (MUC1‑ND) and TRPV1. Additionally, it was found that capsazepine (a TRPV1 antagonist) inhibited the proliferation of MCECs. Notably, MUC1‑ND was shown to interact with the TRPV1 protein in the control group but not in the diabetic DE group. It was also found that the AKT signaling pathway was attenuated in the diabetic DE mice and downstream of TRPV1. MUC1‑ND interacted with TRPV1, partly activating the AKT signaling pathway to promote MCEC proliferation. The present study found that the interaction of MUC1‑ND with TRPV1 promotes MCEC proliferation by partly activating the AKT signaling pathway, providing new insight into the pathogenesis of corneal epithelial dysfunction in diabetic DE disease.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Ogurtsova K, Guariguata L, Barengo NC, Ruiz PL, Sacre JW, Karuranga S, Sun H, Boyko EJ and Magliano DJ: IDF diabetes Atlas: Global estimates of undiagnosed diabetes in adults for 2021. Diabetes Res Clin Pract. 183:1091182022. View Article : Google Scholar : PubMed/NCBI

2 

Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS, Joo CK, Liu Z, Nelson JD, Nichols JJ, Tsubota K and Stapleton F: TFOS DEWS II definition and classification report. Ocul Surf. 15:276–283. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Stapleton F, Alves M, Bunya VY, Jalbert I, Lekhanont K, Malet F, Na KS, Schaumberg D, Uchino M, Vehof J, et al: TFOS DEWS II epidemiology report. Ocul Surf. 15:334–365. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Manaviat MR, Rashidi M, Afkhami-Ardekani M and Shoja MR: Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients. BMC Ophthalmol. 8:102008. View Article : Google Scholar : PubMed/NCBI

5 

Zhang X, Zhao L, Deng S, Sun X and Wang N: Dry eye syndrome in patients with diabetes mellitus: Prevalence, etiology, and clinical characteristics. J Ophthalmol. 2016:82010532016. View Article : Google Scholar : PubMed/NCBI

6 

Belmonte C, Nichols JJ, Cox SM, Brock JA, Begley CG, Bereiter DA, Dartt DA, Galor A, Hamrah P, Ivanusic JJ, et al: TFOS DEWS II pain and sensation report. Ocul Surf. 15:404–437. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Shih KC, Lam KS and Tong L: A systematic review on the impact of diabetes mellitus on the ocular surface. Nutr Diabetes. 7:e2512017. View Article : Google Scholar : PubMed/NCBI

8 

Han SB, Yang HK and Hyon JY: Influence of diabetes mellitus on anterior segment of the eye. Clin Interv Aging. 14:53–63. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Kaiserman I, Kaiserman N, Nakar S and Vinker S: Dry eye in diabetic patients. Am J Ophthalmol. 139:498–503. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Zhu L, Titone R and Robertson DM: The impact of hyperglycemia on the corneal epithelium: Molecular mechanisms and insight. Ocul Surf. 17:644–654. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Georgiev GA, Eftimov P and Yokoi N: Contribution of mucins towards the physical properties of the tear film: A modern update. Int J Mol Sci. 20:61322019. View Article : Google Scholar : PubMed/NCBI

12 

Ablamowicz AF and Nichols JJ: Ocular surface membrane-associated mucins. Ocul Surf. 14:331–341. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Shirai K and Saika S: Ocular surface mucins and local inflammation-studies in genetically modified mouse lines. BMC Ophthalmol. 15 (Suppl 1):S1542015. View Article : Google Scholar

14 

Martinez-Carrasco R, Argüeso P and Fini ME: Membrane-associated mucins of the human ocular surface in health and disease. Ocul Surf. 21:313–330. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Fini ME, Jeong S, Gong H, Martinez-Carrasco R, Laver NMV, Hijikata M, Keicho N and Argüeso P: Membrane-associated mucins of the ocular surface: New genes, new protein functions and new biological roles in human and mouse. Prog Retin Eye Res. 75:1007772020. View Article : Google Scholar : PubMed/NCBI

16 

Schroeder JA, Thompson MC, Gardner MM and Gendler SJ: Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland. J Biol Chem. 276:13057–13064. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Li Y, Ren J, Yu W, Li Q, Kuwahara H, Yin L, Carraway KL III and Kufe D: The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin. J Biol Chem. 276:35239–35242. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Morimoto Y, Yamashita N, Daimon T, Hirose H, Yamano S, Haratake N, Ishikawa S, Bhattacharya A, Fushimi A, Ahmad R, et al: MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells. J Immunother Cancer. 11:e0062382023. View Article : Google Scholar : PubMed/NCBI

19 

Thathiah A, Blobel CP and Carson DD: Tumor Necrosis Factor-alpha Converting Enzyme/ADAM 17 Mediates MUC1 Shedding. J Biol Chem. 278:3386–3394. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Thathiah A and Carson DD: MT1-MMP mediates MUC1 shedding independent of TACE/ADAM17. Biochem J. 382((Pt 1)): 363–373. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Miyazaki K, Kishimoto H, Kobayashi H, Suzuki A, Higuchi K, Shirasaka Y and Inoue K: The glycosylated N-terminal domain of MUC1 is involved in chemoresistance by modulating drug permeation across the plasma membrane. Mol Pharmacol. 103:166–175. 2023. View Article : Google Scholar : PubMed/NCBI

22 

Liu R, Chen L, Zhao X, Bao L, Wei R and Wu X: MUC1 promotes RIF by regulating macrophage ROS-SHP2 signaling pathway to up-regulate inflammatory response and inhibit angiogenesis. Aging (Albany NY). 16:3790–3802. 2024. View Article : Google Scholar : PubMed/NCBI

23 

Liu L, Zhou L, Wang L, Mao Z, Zheng P, Zhang F, Zhang H and Liu H: MUC1 attenuates neutrophilic airway inflammation in asthma by reducing NLRP3 inflammasome-mediated pyroptosis through the inhibition of the TLR4/MyD88/NF-κB pathway. Respir Res. 24:2552023. View Article : Google Scholar : PubMed/NCBI

24 

Comes N, Gasull X and Callejo G: Proton sensing on the ocular surface: Implications in eye pain. Front Pharmacol. 12:7738712021. View Article : Google Scholar : PubMed/NCBI

25 

Yang Y, Yang H, Wang Z, Okada Y, Saika S and Reinach PS: Wakayama symposium: Dependence of corneal epithelial homeostasis on transient receptor potential function. Ocul Surf. 11:8–11. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Yang XL, Wang X, Shao L, Jiang GT, Min JW, Mei XY, He XH, Liu WH, Huang WX and Peng BW: TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI). J Neuroinflammation. 16:1142019. View Article : Google Scholar : PubMed/NCBI

27 

Wang X, Yang XL, Kong WL, Zeng ML, Shao L, Jiang GT, Cheng JJ, Kong S, He XH, Liu WH, et al: TRPV1 translocated to astrocytic membrane to promote migration and inflammatory infiltration thus promotes epilepsy after hypoxic ischemia in immature brain. J Neuroinflammation. 16:2142019. View Article : Google Scholar : PubMed/NCBI

28 

Lu MJ, Chen YS, Huang HS and Ma MC: Hypoxic preconditioning protects rat hearts against ischemia-reperfusion injury via the arachidonate12-lipoxygenase/transient receptor potential vanilloid 1 pathway. Basic Res Cardiol. 109:4142014. View Article : Google Scholar : PubMed/NCBI

29 

Yang H, Wang Z, Capó-Aponte JE, Zhang F, Pan Z and Reinach PS: Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses in corneal epithelial cells. Exp Eye Res. 91:462–471. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Nie M, Bal MS, Yang Z, Liu J, Rivera C, Wenzel A, Beck BB, Sakhaee K, Marciano DK and Wolf MT: Mucin-1 Increases Renal TRPV5 activity in vitro, and urinary level associates with calcium nephrolithiasis in patients. J Am Soc Nephrol. 27:3447–3458. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Al-Bataineh MM, Kinlough CL, Marciszyn A, Lam T, Ye L, Kidd K, Maggiore JC, Poland PA, Kmoch S, Bleyer A, et al: Influence of glycoprotein MUC1 on trafficking of the Ca2+-selective ion channels, TRPV5 and TRPV6, and on in vivo calcium homeostasis. J Biol Chem. 299:1029252023. View Article : Google Scholar : PubMed/NCBI

32 

The Association for Research in Vision and Ophthalmology:ARVO Statement for the Use of Animals in Ophthalmic and Vision Research. The Association for Research in Vision and Ophthalmology; Rockville, MD: 2021

33 

Masmali AM, Murphy PJ and Purslow C: Development of a new grading scale for tear ferning. Cont Lens Anterior Eye. 37:178–184. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Rahman MM, Kim DH, Park CK and Kim YH: Experimental models, induction protocols, and measured parameters in dry eye disease: Focusing on practical implications for experimental research. Int J Mol Sci. 22:121022021. View Article : Google Scholar : PubMed/NCBI

35 

Zhu J, Inomata T, Shih KC, Okumura Y, Fujio K, Huang T, Nagino K, Akasaki Y, Fujimoto K, Yanagawa A, et al: Application of animal models in interpreting dry eye disease. Front Med (Lausanne). 9:8305922022. View Article : Google Scholar : PubMed/NCBI

36 

Qu M, Wan L, Dong M, Wang Y, Xie L and Zhou Q: Hyperglycemia-induced severe mitochondrial bioenergetic deficit of lacrimal gland contributes to the early onset of dry eye in diabetic mice. Free Radic Biol Med. 166:313–323. 2021. View Article : Google Scholar : PubMed/NCBI

37 

Bai J, Fu H, Bazinet L, Birsner AE and D'Amato RJ: A method for developing novel 3D Cornea-on-a-Chip using primary murine corneal epithelial and endothelial cells. Front Pharmacol. 11:4532020. View Article : Google Scholar : PubMed/NCBI

38 

Corrales RM, Narayanan S, Fernández I, Mayo A, Galarreta DJ, Fuentes-Páez G, Chaves FJ, Herreras JM and Calonge M: Ocular mucin gene expression levels as biomarkers for the diagnosis of dry eye syndrome. Invest Ophthalmol Vis Sci. 52:8363–8369. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Spurr-Michaud S, Argüeso P and Gipson I: Assay of mucins in human tear fluid. Exp Eye Res. 84:939–950. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Zhai K, Liskova A, Kubatka P and Büsselberg D: Calcium Entry through TRPV1: A potential target for the regulation of proliferation and apoptosis in cancerous and healthy cells. Int J Mol Sci. 21:41772020. View Article : Google Scholar : PubMed/NCBI

41 

Sumioka T, Okada Y, Reinach PS, Shirai K, Miyajima M, Yamanaka O and Saika S: Impairment of corneal epithelial wound healing in a TRPV1-deficient mouse. Invest Ophthalmol Vis Sci. 55:3295–3302. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Okada Y, Reinach PS, Shirai K, Kitano A, Kao WW, Flanders KC, Miyajima M, Liu H, Zhang J and Saika S: TRPV1 involvement in inflammatory tissue fibrosis in mice. Am J Pathol. 178:2654–2664. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Nidegawa-Saitoh Y, Sumioka T, Okada Y, Reinach PS, Flanders KC, Liu CY, Yamanaka O, Kao WW and Saika S: Impaired healing of cornea incision injury in a TRPV1-deficient mouse. Cell Tissue Res. 374:329–338. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Pan Z, Wang Z, Yang H, Zhang F and Reinach PS: TRPV1 activation is required for hypertonicity-stimulated inflammatory cytokine release in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 52:485–493. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Reinach PS, Mergler S, Okada Y and Saika S: Ocular transient receptor potential channel function in health and disease. BMC Ophthalmol. 15 (Suppl 1):S1532015. View Article : Google Scholar

46 

Jeon BH, Yoo YM, Jung EM and Jeung EB: Dexamethasone treatment increases the intracellular calcium level through TRPV6 in A549 cells. Int J Mol Sci. 21:10502020. View Article : Google Scholar : PubMed/NCBI

47 

Manning BD and Toker A: AKT/PKB Signaling: Navigating the network. Cell. 169:381–405. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Li Y, Li J, Zhao C, Yang L, Qi X, Wang X, Zhou Q and Shi W: Hyperglycemia-reduced NAD+ biosynthesis impairs corneal epithelial wound healing in diabetic mice. Metabolism. 114:1544022021. View Article : Google Scholar : PubMed/NCBI

49 

Pham TH, Jin SW, Lee GH, Park JS, Kim JY, Thai TN, Han EH and Jeong HG: Sesamin induces endothelial nitric oxide synthase activation via transient receptor potential vanilloid type 1. J Agric Food Chem. 68:3474–3484. 2020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li H, Zhang Y, Chen Y, Zhu R, Zou W, Chen H, Hu J, Feng S, Zhong Y, Lu X, Lu X, et al: MUC1‑ND interacts with TRPV1 to promote corneal epithelial cell proliferation in diabetic dry eye mice by partly activating the AKT signaling pathway. Mol Med Rep 30: 213, 2024.
APA
Li, H., Zhang, Y., Chen, Y., Zhu, R., Zou, W., Chen, H. ... Lu, X. (2024). MUC1‑ND interacts with TRPV1 to promote corneal epithelial cell proliferation in diabetic dry eye mice by partly activating the AKT signaling pathway. Molecular Medicine Reports, 30, 213. https://doi.org/10.3892/mmr.2024.13337
MLA
Li, H., Zhang, Y., Chen, Y., Zhu, R., Zou, W., Chen, H., Hu, J., Feng, S., Zhong, Y., Lu, X."MUC1‑ND interacts with TRPV1 to promote corneal epithelial cell proliferation in diabetic dry eye mice by partly activating the AKT signaling pathway". Molecular Medicine Reports 30.6 (2024): 213.
Chicago
Li, H., Zhang, Y., Chen, Y., Zhu, R., Zou, W., Chen, H., Hu, J., Feng, S., Zhong, Y., Lu, X."MUC1‑ND interacts with TRPV1 to promote corneal epithelial cell proliferation in diabetic dry eye mice by partly activating the AKT signaling pathway". Molecular Medicine Reports 30, no. 6 (2024): 213. https://doi.org/10.3892/mmr.2024.13337
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Zhang Y, Chen Y, Zhu R, Zou W, Chen H, Hu J, Feng S, Zhong Y, Lu X, Lu X, et al: MUC1‑ND interacts with TRPV1 to promote corneal epithelial cell proliferation in diabetic dry eye mice by partly activating the AKT signaling pathway. Mol Med Rep 30: 213, 2024.
APA
Li, H., Zhang, Y., Chen, Y., Zhu, R., Zou, W., Chen, H. ... Lu, X. (2024). MUC1‑ND interacts with TRPV1 to promote corneal epithelial cell proliferation in diabetic dry eye mice by partly activating the AKT signaling pathway. Molecular Medicine Reports, 30, 213. https://doi.org/10.3892/mmr.2024.13337
MLA
Li, H., Zhang, Y., Chen, Y., Zhu, R., Zou, W., Chen, H., Hu, J., Feng, S., Zhong, Y., Lu, X."MUC1‑ND interacts with TRPV1 to promote corneal epithelial cell proliferation in diabetic dry eye mice by partly activating the AKT signaling pathway". Molecular Medicine Reports 30.6 (2024): 213.
Chicago
Li, H., Zhang, Y., Chen, Y., Zhu, R., Zou, W., Chen, H., Hu, J., Feng, S., Zhong, Y., Lu, X."MUC1‑ND interacts with TRPV1 to promote corneal epithelial cell proliferation in diabetic dry eye mice by partly activating the AKT signaling pathway". Molecular Medicine Reports 30, no. 6 (2024): 213. https://doi.org/10.3892/mmr.2024.13337
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team