Open Access

Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling

  • Authors:
    • Minglei Zhang
    • Li Chen
    • Yang Liu
    • Minghui Chen
    • Shuang Zhang
    • Daliang Kong
  • View Affiliations

  • Published online on: May 19, 2020     https://doi.org/10.3892/or.2020.7614
  • Pages: 469-476
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteosarcoma (OS) has been demonstrated to be difficult to cure due to its potently malignant metastasis. Therefore, new therapeutic approaches blocking the metastatic potential of OS are urgently required to improve the outcomes for OS patients. In the present study, the anti‑metastatic capacity of sea cucumber (Cucumaria frondosa) fucoidan (Cf‑Fuc) was evaluated on osteosarcoma cells by cell adhesion assay, Transwell assay and U2OS cell migration assay. The underlying mechanism on the dynamic remodeling of the cytoskeleton was also explored. The present data indicated that Cf‑Fuc could block the U2OS osteosarcoma cell adhesion to fibronectin and significantly inhibit U2OS cell migration. Cf‑Fuc greatly impaired the migration capacity of U2OS cells, and the migrated distance and velocity of Cf‑Fuc‑treated cells were markedly reduced. Also, Cf‑Fuc could impair the dynamic remodeling of the cytoskeleton possibly by suppressing the phosphorylation of focal adhesion kinase and paxillin, as well as the activation of the Rac1/PAK1/LIMK1/cofilin signaling axis. Collectively, the present findings provide a novel therapeutic potential of C. frondosa fucoidan for osteosarcoma metastasis.

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August-2020
Volume 44 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Zhang, M., Chen, L., Liu, Y., Chen, M., Zhang, S., & Kong, D. (2020). Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling. Oncology Reports, 44, 469-476. https://doi.org/10.3892/or.2020.7614
MLA
Zhang, M., Chen, L., Liu, Y., Chen, M., Zhang, S., Kong, D."Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling". Oncology Reports 44.2 (2020): 469-476.
Chicago
Zhang, M., Chen, L., Liu, Y., Chen, M., Zhang, S., Kong, D."Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling". Oncology Reports 44, no. 2 (2020): 469-476. https://doi.org/10.3892/or.2020.7614