Open Access

STK31 upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model

  • Authors:
    • Dong Hyuck Bae
    • Hee-Jin Kim
    • Byoung-Ha Yoon
    • Jong-Lyul Park
    • Mirang Kim
    • Seon-Kyu Kim
    • Seon-Young Kim
    • Sang-Il Lee
    • Kyu-Sang Song
    • Yong Sung Kim
  • View Affiliations

  • Published online on: February 23, 2021     https://doi.org/10.3892/or.2021.7993
  • Article Number: 42
  • Copyright: © Bae et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pathological changes in the epigenetic landscape of chromatin are hallmarks of cancer. Our previous study showed that global methylation of promoters may increase or decrease during the transition from gastric mucosa to intestinal metaplasia (IM) to gastric cancer (GC). Here, CpG hypomethylation of the serine/threonine kinase STK31 promoter in IM and GC was detected in a reduced representation bisulfite sequencing database. STK31 hypomethylation, which resulted in its upregulation in 120 cases of primary GC, was confirmed. Using public genome‑wide histone modification data, upregulation of STK31 promoter activity was detected in primary GC but not in normal mucosae, suggesting that STK31 may be repressed in gastric mucosa but activated in GC as a consequence of hypomethylation‑associated chromatin remodeling. STK31 knockdown suppressed the proliferation, colony formation and migration activities of GC cells in vitro, whereas stable overexpression of STK31 promoted the proliferation, colony formation, and migration activities of GC cells in vitro and tumorigenesis in nude mice. Patients with GC in which STK31 was upregulated exhibited significantly shorter survival times in a combined cohort. Thus, activation of STK31 by chromatin remodeling may be associated with gastric carcinogenesis and also may help predict GC prognosis.

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April-2021
Volume 45 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Bae DH, Kim H, Yoon B, Park J, Kim M, Kim S, Kim S, Lee S, Song K, Kim YS, Kim YS, et al: <em>STK31</em> upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model. Oncol Rep 45: 42, 2021
APA
Bae, D.H., Kim, H., Yoon, B., Park, J., Kim, M., Kim, S. ... Kim, Y.S. (2021). <em>STK31</em> upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model. Oncology Reports, 45, 42. https://doi.org/10.3892/or.2021.7993
MLA
Bae, D. H., Kim, H., Yoon, B., Park, J., Kim, M., Kim, S., Kim, S., Lee, S., Song, K., Kim, Y. S."<em>STK31</em> upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model". Oncology Reports 45.4 (2021): 42.
Chicago
Bae, D. H., Kim, H., Yoon, B., Park, J., Kim, M., Kim, S., Kim, S., Lee, S., Song, K., Kim, Y. S."<em>STK31</em> upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model". Oncology Reports 45, no. 4 (2021): 42. https://doi.org/10.3892/or.2021.7993