Open Access

Potassium channels as novel molecular targets in hepatocellular carcinoma (Review)

  • Authors:
    • Xingyue Chen
    • Li Zhang
    • Ling He
    • Liming Zheng
    • Biguang Tuo
  • View Affiliations

  • Published online on: August 24, 2023     https://doi.org/10.3892/or.2023.8622
  • Article Number: 185
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) poses a serious health burden worldwide. It is often not diagnosed until the patient is at an advanced stage of the disease, when treatment options are limited and the prognosis is poor. Therefore, novel treatment strategies are urgently required. Potassium (K+) channels have an important role in HCC, including regulating the proliferation, migration, invasion and drug resistance of HCC cells. The aim of the present review was therefore to survey the relevant publications that have investigated K+ channels not only as markers for the early diagnosis of HCC, but also as potential therapeutic targets for the treatment of HCC. Several of these channels have been indicated to be the sites of action for natural products previously known to inhibit HCC; however, more systematic studies are required to determine which K+ channels may be utilized for the clinical treatment of HCC, particularly in the advanced stages of the disease and in cases where patients are resistant to the existing drugs.
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October-2023
Volume 50 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Chen X, Zhang L, He L, Zheng L and Tuo B: Potassium channels as novel molecular targets in hepatocellular carcinoma (Review). Oncol Rep 50: 185, 2023
APA
Chen, X., Zhang, L., He, L., Zheng, L., & Tuo, B. (2023). Potassium channels as novel molecular targets in hepatocellular carcinoma (Review). Oncology Reports, 50, 185. https://doi.org/10.3892/or.2023.8622
MLA
Chen, X., Zhang, L., He, L., Zheng, L., Tuo, B."Potassium channels as novel molecular targets in hepatocellular carcinoma (Review)". Oncology Reports 50.4 (2023): 185.
Chicago
Chen, X., Zhang, L., He, L., Zheng, L., Tuo, B."Potassium channels as novel molecular targets in hepatocellular carcinoma (Review)". Oncology Reports 50, no. 4 (2023): 185. https://doi.org/10.3892/or.2023.8622