Open Access

HELQ as a DNA helicase: Its novel role in normal cell function and tumorigenesis (Review)

  • Authors:
    • Nan Tang
    • Weilun Wen
    • Zhihe Liu
    • Xifeng Xiong
    • Yanhua Wu
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  • Published online on: November 2, 2023     https://doi.org/10.3892/or.2023.8657
  • Article Number: 220
  • Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Helicase POLQ‑like (HELQ or Hel308), is a highly conserved, 3'‑5' superfamily II DNA helicase that contributes to diverse DNA processes, including DNA repair, unwinding, and strand annealing. HELQ deficiency leads to subfertility, due to its critical role in germ cell stability. In addition, the abnormal expression of HELQ has been observed in multiple tumors and a number of molecular pathways, including the nucleotide excision repair, checkpoint kinase 1‑DNA repair protein RAD51 homolog 1 and ATM/ATR pathways, have been shown to be involved in HELQ. In the present review, the structure and characteristics of HELQ, as well as its major functions in DNA processing, were described. Molecular mechanisms involving HELQ in the context of tumorigenesis were also described. It was deduced that HELQ biology warrants investigation, and that its critical roles in the regulation of various DNA processes and participation in tumorigenesis are clinically relevant.
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December-2023
Volume 50 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Tang N, Wen W, Liu Z, Xiong X and Wu Y: HELQ as a DNA helicase: Its novel role in normal cell function and tumorigenesis (Review). Oncol Rep 50: 220, 2023
APA
Tang, N., Wen, W., Liu, Z., Xiong, X., & Wu, Y. (2023). HELQ as a DNA helicase: Its novel role in normal cell function and tumorigenesis (Review). Oncology Reports, 50, 220. https://doi.org/10.3892/or.2023.8657
MLA
Tang, N., Wen, W., Liu, Z., Xiong, X., Wu, Y."HELQ as a DNA helicase: Its novel role in normal cell function and tumorigenesis (Review)". Oncology Reports 50.6 (2023): 220.
Chicago
Tang, N., Wen, W., Liu, Z., Xiong, X., Wu, Y."HELQ as a DNA helicase: Its novel role in normal cell function and tumorigenesis (Review)". Oncology Reports 50, no. 6 (2023): 220. https://doi.org/10.3892/or.2023.8657