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The phenotypic reversion of cancer: Experimental evidences on cancer reversibility through epigenetic mechanisms (Review)

  • Authors:
    • Andrea Pensotti
    • Mariano Bizzarri
    • Marta Bertolaso
  • View Affiliations / Copyright

    Affiliations: Research Unit of Philosophy of Science and Human Development, University Campus Bio‑Medico of Rome, I‑00128 Rome, Italy, Systems Biology Group Lab, Department of Experimental Medicine, Sapienza University, I‑00185 Rome, Italy
    Copyright: © Pensotti et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 48
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    Published online on: January 23, 2024
       https://doi.org/10.3892/or.2024.8707
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Abstract

Different experimental models reveal that malignant cancer cells can be induced to change their phenotype into a benign one. This phenotypic transformation, confirmed both in vitro and in vivo, currently is known as ‘tumor reversion‘. This evidence raises a radical question among current cancer models: Is cancer reversible? How do genetic and epigenetic alterations hierarchically relate? Understanding the mechanisms of ‘tumor reversion’ represents a key point in order to evolve the actual cancer models and develop new heuristic models that can possibly lead to drugs that target epigenetic mechanisms, for example epigenetic drugs. Even though evidence of tumor reversion dates back to the 1950s, this remains a completely new field of research recently re‑discovered thanks to the interest in cell reprogramming research, developmental biology and the increasing understanding of epigenetic mechanisms. In the current review, a comprehensive review of all the main experimental models on tumor reversion was presented.
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1 

Recamier JCA: Recherches sur le Traitement du Cancer, etc. Chez Gabo; Paris: 1829

2 

Oberling CH: The Riddle of Cancer. Yale University Press; New Haven: pp. p1961944

3 

Oberling C: The riddle of cancer. Yale University Press; New Haven: pp. 26–27. 1946

4 

Müller J: Über den feinern Bau und die Formen der krankhaften Geschwülste. G. Reimer, Berlin. Nat Cancer Inst Mnogr Spontaneous Regression Cancer. 1976:441838.

5 

Virchow R: Editoral Archiv fuer pathologische Anatomie und Physiologie und fuer klinische. Medizin. 8:231855.

6 

Virchow R: Cellular Pathology. Hirschwald A: August Hirschwald; Berlin: 1858, PubMed/NCBI

7 

Durante F: Nesso fisiopatologico tra la struttura dei nei materni e la genesi di alcuni tumori maligni. Arch Memorie ed Osservazioni di Chirurgia Pratica. 1874:217–226. 1874.

8 

Cohnheim J: Congenitales, quergestreiftes muskelsarkon der nireren. Virchows Arch. 65:64–69. 1875. View Article : Google Scholar

9 

Wilms M: Die Mischgeschwuelste. Leipzing; Arthur Georgi: 1899

10 

Ribbert H: Ueber Rückbildung an Zellen und Geweben und über die Entstehung der Geschwülste. Erwin Nägele; Stuttgart: 1897

11 

Ribbert, op. cit., Rückbildung (note 51). pp42–43, idem, op. cit., Beiträge (note 51). pp8–13, See also Johach, op. cit. (note 11). pp246–267

12 

Soto AM, Maffini MV and Sonnenschein C: Neoplasia as development gone awry: The role of endocrine disruptors. Int J Androl. 31:288–293. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Askanazy M: Die Teratome nach ihrem Bau, ihrem Verlauf, ihrer Genese und im Vergleich zum experimentellen Teratoid. Verhandl Deutsch Pathol. 11:39–82. 1907.

14 

Stevens LC and Little CC: Spontaneous testicular teratomas in an inbred strain of mice. Proc Natl Acad Sci USA. 40:1080–1087. 1954. View Article : Google Scholar : PubMed/NCBI

15 

Pierce GB and Dixon FJ: Testicular teratomas: I. The demonstration of teratogenesis by metamorphosis of multipotent cells. Cancer. 12:573–583. 1959. View Article : Google Scholar : PubMed/NCBI

16 

Pierce GB and Verney EL: An in vitro and in vivo study of differentiation in teratocarcinomas. Cancer. 14:1017–1029. 1961. View Article : Google Scholar : PubMed/NCBI

17 

Brinster RL: The effect of cells transferred into the mouse blastocyst on subsequent development. J Exp Med. 140:1049–1056. 1974. View Article : Google Scholar : PubMed/NCBI

18 

Mintz B and Illmensee K: Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci USA. 72:3585–3589. 1975. View Article : Google Scholar : PubMed/NCBI

19 

Grobstein C: The differentiation of such tissues may depend on inductive interactions between embryonic components. 13th Symposium of the Society for Development and Growth. Rudnick D: Princeton University Press; Princeton, NJ: pp. 233–256. 1954

20 

Rous P: A Sarcoma of the Fowl Transmissible by an Agent Separable from the Tumor Cells. J Exp Med. 13:397–411. 1911. View Article : Google Scholar : PubMed/NCBI

21 

Macpherson I: Reversion in hamster cells transformed by Rous sarcoma virus. Science. 148:1731–1733. 1965. View Article : Google Scholar : PubMed/NCBI

22 

Pollack RE, Green H and Todaro GJ: Growth control in cultured cells: Selection of sublines with increased sensitivity to contact inhibition and decreased tumor-producing ability. Proc Natl Acad Sci USA. 60:126–133. 1968. View Article : Google Scholar : PubMed/NCBI

23 

Duran-Reynals F and Milford JJF: Growth of a chicken sarcoma virus in the chick embryo in the absence of neoplasia. Cancer Res. 3:578–584. 1943.

24 

Dolberg DS and Bissell MJ: Inability of Rous sarcoma virus to cause sarcomas in the avian embryo. Nature. 309:552–556. 1984. View Article : Google Scholar : PubMed/NCBI

25 

Braun AC: Bacterial and host factors concerned in determining tumor morphology in crown gall. Bot Gaz. 114:363–371. 1953. View Article : Google Scholar

26 

Braun AC: A Demonstration of the recovery of the crown-gall tumor cell with the use of complex tumors of single-cell origin. Proc Natl Acad Sci USA. 45:932–938. 1959. View Article : Google Scholar : PubMed/NCBI

27 

Rose SM: Epidermal dedifferentiation during blastema formation in regeneration limbs of Triturus viridescens. J Exp Zool. 108:337–362. 1948. View Article : Google Scholar : PubMed/NCBI

28 

Wallingford HM: Transformations of renal tumors to normal tissue in regenerating limbs of salamanders. Science. 107:4571948.PubMed/NCBI

29 

Gersch M: Zellentartung und Zellwucherung bei wirbellosen Tieren. Arch. Geschwulst-Forschung. 3:1–18. 1951.

30 

Waddington CH: Cancer and the theory of organizers. Nature. 135:606–608. 1935. View Article : Google Scholar

31 

Needham J: New advances in the chemistry and biology of organized growth. Proc R Soc London B Biol Sci. 29:1577–1626. 1936.PubMed/NCBI

32 

Seilern-Aspang F and Kratochwil K: Induction and differentiation of an epithelial tumour in the newt (Triturus cristatus). J Embryol Exp Morphol. 10:337–356. 1962.PubMed/NCBI

33 

McMichael H: Inhibition of growth of Shope rabbit papilloma by hypervitaminosis A. Cancer Res. 25:947–955. 1965.PubMed/NCBI

34 

Saffiotti J, Montesano R, Sellakumar AR and Borg SA: Experimental cancer of the lung, inhibition by vitamin a of the induction of tracheobronchial squamous metaplasia and squamous cell tumors. Cancer. 20:857–864. 1967. View Article : Google Scholar : PubMed/NCBI

35 

Davies RE: Effect of vitamin A on 7, 12-di-methylbenz(alpha) anthracene-induced papillomas in rhino mouse skin. Cancer Res. 27:237–241. 1967.PubMed/NCBI

36 

Coleman WB, Wennerberg AE, Smith GJ and Grisham JW: Regulation of the differentiation of diploid and some aneuploid rat liver epithelial (stemlike) cells by the hepatic microenvironment. Am J Pathol. 142:1373–1382. 1993.PubMed/NCBI

37 

Pierce GB: The cancer cell and its control by the embryo. Rous-Whipple Award lecture. Am J Pathol. 113:115–124. 1983.

38 

Pierce GB, Lewis SH, Miller GJ, Moritz E and Miller P: Tumorigenicity of embryonal carcinoma as an assay to study control of malignancy by the murine blastocyst. Proc Natl Acad Sci USA. 76:6649–6651. 1979. View Article : Google Scholar : PubMed/NCBI

39 

Pierce GB, Pantazis CG, Caldwell JE and Wells RS: Specificity of tumor formation by the blastocyst. Cancer Res. 42:1082–1087. 1982.PubMed/NCBI

40 

Wells RS: An in vitro assay for regulation of embryonal carcinoma by the blastocyst. Cancer Res. 42:2736–2741. 1982.PubMed/NCBI

41 

Podesta A, Beddington RSP, Wells RS and Pierce GB: The neurula stage mouse embryo in control of neuroblastoma. Proc Natl Acad Sci USA. 81:7608–7611. 1984. View Article : Google Scholar : PubMed/NCBI

42 

Podesta AN, Mullins J, Pierce GB and Sells RS: The neurula state mouse embryos in control of neuroblastomas. Proc Natl Acad Sci USA. 81:7608–7611. 1984. View Article : Google Scholar : PubMed/NCBI

43 

Gootwine E, Webb CG and Sachs L: Participation of myeloid leukaemia cells injected into embryos in haematopoietic differentiation in adult mice. Nature. 299:63–65. 1982. View Article : Google Scholar : PubMed/NCBI

44 

Gerschenson M, Graves K, Carson SD, Wells RS and Pierce GB: Regulation of melanoma by the embryonic skin. Proc Natl Acad Sci USA. 83:7307–7310. 1986. View Article : Google Scholar : PubMed/NCBI

45 

Pierce GB, Aguilar D, Hood G and Wells RS: Trophectoderm in control of murine embryonal carcinoma. Cancer Res. 44:3987–3996. 1984.PubMed/NCBI

46 

DeCosse JJ, Gossens CL, Kuzma JF and Unsworth BR: Breast cancer: Induction of differentiation by embryonic tissue. Science. 181:1057–1058. 1973. View Article : Google Scholar : PubMed/NCBI

47 

Biava PM, Fiorito A, Negro C and Mariani M: Effects of treatment with embryonic and uterine tissue homogenates on Lewis lung carcinoma development. Cancer Lett. 41:265–270. 1988. View Article : Google Scholar : PubMed/NCBI

48 

Biava PM, Bonsignorio D and Hosha M: Cell proliferation curves of different human tumor lines after in vitro treatment with Zebrafish embryonic extracts. J Tumor Marker Oncol. 16:195–201. 2001.

49 

Biava PM and Bonsignorio D: Cancer and cell differentiation: A model to explain malignancy. J Tumor Marker Oncol. 17:47–53. 2002.

50 

Lee LM, Seftor EA, Bonde G, Cornell RA and Hendrix MJ: The fate of human malignant melanoma cells transplanted into zebrafish embryos: Assessment of migration and cell division in the absence of tumour formation. Dev Dyn. 233:1560–1570. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Cucina A, Biava PM, D'Anselmi F, Coluccia P, Conti F, di Clemente R, Miccheli A, Frati L, Gulino A and Bizzarri M: Zebrafish embryo proteins induce apoptosis in human colon cancer cells (Caco2). Apoptosis. 11:1617–1628. 2006. View Article : Google Scholar : PubMed/NCBI

52 

Pierce GB and Johnson LD: Differentiation and cancer. In Vitro. 7:140–145. 1971. View Article : Google Scholar : PubMed/NCBI

53 

Pierce GB and Wallace C: Differentiation of malignant to benign cells. Cancer Res. 31:127–134. 1971.PubMed/NCBI

54 

Kenny PA and Bissell MJ: Tumor reversion: Correction of malignant behavior by microenvironmental cues. International J Cancer. 107:688–695. 2003. View Article : Google Scholar : PubMed/NCBI

55 

Camacho LH: Clinical application of retinoids in cancer medicine. J Biol Regul Homeost Agents. 17:98–114. 2003.PubMed/NCBI

56 

Pitha-Rowe I, Petty WJ, Kitareewan S and Dmitrovsky E: Retinoid target genes in acute promyelocytic leukemia. Leukemia. 17:1723–1730. 2003. View Article : Google Scholar : PubMed/NCBI

57 

Segalla S, Rinaldi L, Kilstrup-Nielsen C, Badaracco G, Minucci S, Pelicci PG and Landsberger N: Retinoic acid receptor alpha fusion to PML affects in transcriptional and chromatin-remodeling properties. Mol Cell Biol. 23:8795–808. 2003. View Article : Google Scholar : PubMed/NCBI

58 

Alcalay M, Meani N, Gelmetti V, Fantozzi A, Fagioli M, Orleth A, Riganelli D, Sebastiani C, Cappelli E, Casciari C, et al: Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair. J Clin Invest. 112:1751–1761. 2003. View Article : Google Scholar : PubMed/NCBI

59 

Strickland S and Madavi V: The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell. 15:393–403. 1978. View Article : Google Scholar : PubMed/NCBI

60 

Trump DL: Retinoids in bladder, testes and prostate cancer: Epidemiologic, preclinical and clinical observations. Leukemia. 8 (Suppl 3):S50–S54. 1994.PubMed/NCBI

61 

Breitman TR, Selonick SE and Collins SJ: Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc Natl Acad Sci USA. 77:2936–2940. 1980. View Article : Google Scholar : PubMed/NCBI

62 

Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L, Gu LJ and Wang ZY: Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood. 72:567–572. 1988. View Article : Google Scholar : PubMed/NCBI

63 

Dragnev KH, Petty WJ and Dmitrovsky E: Retinoid targets in cancer therapy and chemoprevention. Cancer Biol Ther. 2 (Suppl 1):S150–S156. 2003. View Article : Google Scholar : PubMed/NCBI

64 

Melnick A and Licht JD: Deconstruction a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood. 99:3167–3215. 1999. View Article : Google Scholar : PubMed/NCBI

65 

Warrell RP Jr, Frankel SR, Miller WH Jr, Scheinberg DA, Itri LM, Hittelman WN, Vyas R, Andreeff M, Tafuri A and Jakubowski A: Differention therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med. 324:1385–1393. 1991. View Article : Google Scholar : PubMed/NCBI

66 

Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA and Kinzler KW: Cancer genome landscapes. Science. 339:1546–1558. 6127. View Article : Google Scholar : PubMed/NCBI

67 

Bertolaso M: Philosophy of Cancer-A Dynamic and Relational View. Springer; New York, NY: 2016, PubMed/NCBI

68 

Rohdenburg GL: Fluctuations in the growth of malignant tumors in man, with especial reference to spontaneous regression. J Cancer Res. 3:192–221. 1918.

69 

Cushing H and Wollbach S: The transformation of malignant paravertebral Sympathicoblastoma into a benign ganglioneuroma. Am J Pathol. 3:203–216.7. 1927.PubMed/NCBI

70 

Bumpus HC: The apparent disappearance of pulmonary metastasis in a case of hypernephroma following nephrectomy. J Urol. 20:185–191. 1927. View Article : Google Scholar

71 

Everson TC and Cole WH: Spontaneous Regression of Cancer. W.B Saunders; Philadelphia, PA: 1966, PubMed/NCBI

72 

Cole WH: Spontaneous regression of cancer and the importance of finding its cause. Nat Cancer Inst Mnogr. 44:5–9. 1976.PubMed/NCBI

73 

Challis GB and Stam HJ: The spontaneous regression of cancer. A review of cases from 1900 to 1987. Acta Oncol. 29:545–549. 1990. View Article : Google Scholar : PubMed/NCBI

74 

O'Regan B and Hirschberg C: Spontaneous Regression. An Annotated Bibliography Sausalito CA: Institute of Noetic Science; 1993

75 

Papac RJ: Spontaneous regression of cancer: Possible mechanisms. In Vivo. 12:571–578. 1998.PubMed/NCBI

76 

Livraghi T, Meloni F, Frosi A, Lazzaroni S, Bizzarri TM, Frati L and Biava PM: Treatment with stem cell differentiation stage factors of intermediate-advanced hepatocellular carcinoma: An open randomized clinical trial. Oncol Res. 15:399–408. 2005. View Article : Google Scholar : PubMed/NCBI

77 

Telerman A, Tuynder M, Dupressoir T, Robaye B, Sigaux F, Shaulian E, Oren M, Rommelaere J and Amson R: A model for tumor suppression using H-1 parvovirus. Proc Natl Acad Sci USA. 90:8702–8706. 1993. View Article : Google Scholar : PubMed/NCBI

78 

Tuynder M, Susini L, Prieur S, Besse S, Fiucci G, Amson R and Telerman A: Biological models and genes of tumor reversion: Cellular reprogramming through tpt1/TCTP and SIAH-1. Proc Natl Acad Sci USA. 99:14976–1481. 2002. View Article : Google Scholar : PubMed/NCBI

79 

Telerman A and Amson R: The molecular programme of tumour reversion: The steps beyond malignant transformation. Nat Rev Cancer. 9:206–216. 2009. View Article : Google Scholar : PubMed/NCBI

80 

Tuynder M, Fiucci G, Prieur S, Lespagnol A, Géant A, Beaucourt S, Duflaut D, Besse S, Susini L, Cavarelli J, et al: Translationally controlled tumor protein is a target of tumor reversion. Proc Natl Acad Sci USA. 101:15364–15369. 2004. View Article : Google Scholar : PubMed/NCBI

81 

Thaw P, Baxter NJ, Hounslow AM, Price C, Waltho JP and Craven CJ: Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones. Nat Struct Biol. 8:701–704. 2001. View Article : Google Scholar : PubMed/NCBI

82 

Proietti S, Cucina A, Pensotti A, Biava PM, Minini M, Monti N, Catizone A, Ricci G, Leonetti E, Harrath AH, et al: Active fraction from embryo fish extracts induces reversion of the malignant invasive phenotype in breast cancer through down-regulation of TCTP and modulation of E-cadherin/β-catenin pathway. Int J Mol Sci. 20:21512019. View Article : Google Scholar : PubMed/NCBI

83 

Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C and Bissell MJ: Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol. 137:231–245. 1997. View Article : Google Scholar : PubMed/NCBI

84 

Hendrix MJ, Seftor EA, Seftor RE, Kasemeier-Kulesa J, Kulesa PM and Postovit LM: Reprogramming metastatic tumour cells with embryonic microenvironments. Nat Rev Cancer. 7:246–255. 2007. View Article : Google Scholar : PubMed/NCBI

85 

Tabibzadeh S and Hemmati-Brivanlou A: Lefty at the crossroads of ‘stemness’ and differentiative events. Stem Cells. 24:1998–2006. 2006. View Article : Google Scholar : PubMed/NCBI

86 

Postovit LM, Margaryan NV, Seftor EA, Kirschmann DA, Lipavsky A, Wheaton WW, Abbott DE, Seftor RE and Hendrix MJ: Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells. Proc Natl Acad Sci USA. 105:4329–4334. 2008. View Article : Google Scholar : PubMed/NCBI

87 

Topczewska JM, Postovit LM, Margaryan NV, Sam A, Hess AR, Wheaton WW, Nickoloff BJ, Topczewski J and Hendrix MJ: Embryonic and tumorigenic pathways converge via Nodal signaling: Role in melanoma aggressiveness. Nat Med. 12:925–932. 2006. View Article : Google Scholar : PubMed/NCBI

88 

Costa FF: Non-coding RNAs: Lost in translation? Gene. 386:1–10. 2007. View Article : Google Scholar : PubMed/NCBI

89 

Garzon R, Fabbri M, Cimmino A, Calin GA and Croce CM: MicroRNA expression and function in cancer. Trends Mol Med. 12:580–587. 2006. View Article : Google Scholar : PubMed/NCBI

90 

Costa FF, Seftor EA, Bischof JM, Kirschmann DA, Strizzi L, Arndt K, Bonaldo Mde F, Soares MB and Hendrix MJ: Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment. Epigenomics. 1:387–398. 2009. View Article : Google Scholar : PubMed/NCBI

91 

Card DA, Hebbar PB, Li L, Trotter KW, Komatsu Y, Mishina Y and Archer TK: Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol Cell Biol. 28:6426–6438. 2008. View Article : Google Scholar : PubMed/NCBI

92 

Krebs LT, Iwai N, Nonaka S, Welsh IC, Lan Y, Jiang R, Saijoh Y, O'Brien TP, Hamada H and Gridley T: Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev. 17:1207–1212. 2003. View Article : Google Scholar : PubMed/NCBI

93 

Morgan DO: Cyclin-dependent kinases: Engines, clocks, and microprocessors. Annu Rev Cell Dev Biol. 13:261–291. 1997. View Article : Google Scholar : PubMed/NCBI

94 

Giuffrida D, Rogers IM, Nagy A, Calogero AE, Brown TJ and Casper RF: Human embryonic stem cells secrete soluble factors that inhibit cancer cell growth. Cell Prolif. 42:788–798. 2009. View Article : Google Scholar : PubMed/NCBI

95 

Novak P, Jensen TJ, Garbe JC, Stampfer MR and Futscher BW: Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization. Cancer Res. 69:5251–5258. 2009. View Article : Google Scholar : PubMed/NCBI

96 

Hinshelwood RA and Clark SJ: Breast cancer epigenetics: Normal human mammary epithelial cells as a model system. J Mol Med. 86:1315–1328. 2008. View Article : Google Scholar : PubMed/NCBI

97 

Allegrucci C, Rushton MD, Dixon JE, Sottile V, Shah M, Kumari R, Watson S, Alberio R and Johnson AD: Epigenetic reprogramming of breast cancer cells with oocyte extracts. Mol Cancer. 10:72011. View Article : Google Scholar : PubMed/NCBI

98 

Saad N, Alberio R, Johnson AD, Emes RD, Giles TC, Clarke P, Grabowska AM and Allegrucci C: Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy. Oncotarget. 9:16008–16027. 2018. View Article : Google Scholar : PubMed/NCBI

99 

Tripathi A, Kashyap A, Tripathi G, Yadav J, Bibban R, Aggarwal N, Thakur K, Chhokar A, Jadli M, Sah AK, et al: Tumor reversion: A dream or a reality. Biomark Res. 9:312021. View Article : Google Scholar : PubMed/NCBI

100 

Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K and Yamanaka S: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 131:861–872. 2007. View Article : Google Scholar : PubMed/NCBI

101 

Feinberg AP: Phenotypic plasticity and the epigenetics of human disease. Nature. 447:433–440. 2007. View Article : Google Scholar : PubMed/NCBI

102 

Redmer T, Diecke S, Grigoryan T, Quiroga-Negreira A, Birchmeier W and Besser D: E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming. EMBO Rep. 12:720–726. 2011. View Article : Google Scholar : PubMed/NCBI

103 

Feng B, Ng JH, Heng JC and Ng HH: Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell. 4:301–312. 2009. View Article : Google Scholar : PubMed/NCBI

104 

Smith ZD, Sindhu C and Meissner A: Molecular features of cellular reprogramming and development. Nat Rev Mol Cell Biol. 17:139–154. 2016. View Article : Google Scholar : PubMed/NCBI

105 

Yoo J and Kim J, Baek S, Park Y, Im H and Kim J: Cell reprogramming into the pluripotent state using graphene based substrates. Biomaterials. 35:8321–8329. 2014. View Article : Google Scholar : PubMed/NCBI

106 

Bizzarri M, Palombo A and Cucina A: Theoretical aspects of systems biology. Prog Biophys Mol Biol. 112:33–43. 2013. View Article : Google Scholar : PubMed/NCBI

107 

Nieto MA, Huang RY, Jackson RA and Thiery JP: EMT: 2016. Cell. 166:21–45. 2016. View Article : Google Scholar : PubMed/NCBI

108 

Abad M, Mosteiro L, Pantoja C, Cañamero M, Rayon T, Ors I, Graña O, Megías D, Domínguez O, Martínez D, et al: Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature. 502:340–345. 2013. View Article : Google Scholar : PubMed/NCBI

109 

Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, et al: Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell. 156:663–677. 2014. View Article : Google Scholar : PubMed/NCBI

110 

Inman JL, Robertson C, Mott JD and Bissell MJ: Mammary gland development: Cell fate specification, stem cells and the microenvironment. Development. 142:1028–1042. 2015. View Article : Google Scholar : PubMed/NCBI

111 

Bizzarri M and Giuliani A: Representing cancer cell trajectories in a phase-space diagram: Switching cellular states by biological phase transitions. Applied Statistics for Network Biology: Methods in Systems Biology. Dehmer M, Emmert-Streib F, Graber A and Salvador A: Wiley-VCH Verlag GmbH & Co.; pp. 377–403. 2011, View Article : Google Scholar

112 

Lin SL, Chang DC, Chang-Lin S, Lin CH, Wu DT, Chen DT and Ying SY: Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. RNA. 14:2115–2124. 2008. View Article : Google Scholar : PubMed/NCBI

113 

Utikal J, Maherali N, Kulalert W and Hochedlinger K: Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J Cell Sci. 122:3502–3510. 2009. View Article : Google Scholar : PubMed/NCBI

114 

Rapino F, Robles EF, Richter-Larrea JA, Kallin EM, Martinez-Climent JA and Graf T: C/EBPα induces highly efficient macrophage transdifferentiation of B lymphoma and leukemia cell lines and impairs their tumorigenicity. Cell Rep. 3:1153–1163. 2013. View Article : Google Scholar : PubMed/NCBI

115 

Huang P, Zhang L, Gao Y, He Z, Yao D, Wu Z, Cen J, Chen X, Liu C, Hu Y, et al: Direct reprogramming of human fibroblasts to functional and expandable hepatocytes. Cell Stem Cell. 14:370–384. 2014. View Article : Google Scholar : PubMed/NCBI

116 

McClellan JS, Dove C, Gentles AJ, Ryan CE and Majeti R: Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages. Proc Natl Acad Sci USA. 112:4074–4079. 2015. View Article : Google Scholar : PubMed/NCBI

117 

Zhou S, Abdouh M, Arena V, Arena M and Arena GO: Reprogramming malignant cancer cells toward a benign phenotype following expo-sure to human embryonic stem cell microenvironment. PLoS One. 12:e01698992017. View Article : Google Scholar : PubMed/NCBI

118 

Ishay-Ronen D, Diepenbruck M, Kalathur RKR, Sugiyama N, Tiede S, Ivanek R, Bantug G, Morini MF, Wang J, Hess C and Christofori G: Gain fat-lose metastasis: Converting invasive breast cancer cells into adipocytes inhibits cancer metastasis. Cancer Cell. 35:17–32.e6. 2019. View Article : Google Scholar : PubMed/NCBI

119 

Cheng Z, He Z, Cai Y, Zhang C, Fu G, Li H, Sun W, Liu C, Cui X, Ning B, et al: Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors. Cell Res. 29:124–135. 2019. View Article : Google Scholar : PubMed/NCBI

120 

Li Y, Agrawal I and Gong Z: Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene-expressing transgenic zebrafish model. Dis Model Mech. 12:dmm0395782019. View Article : Google Scholar : PubMed/NCBI

121 

Pensotti A, Bertolaso M and Bizzarri M: Is cancer reversible? Rethinking carcinogenesis models-a new epistemological tool. Biomolecules. 13:7332023. View Article : Google Scholar : PubMed/NCBI

122 

Longo G, Miquel PA, Sonnenschein C and Soto AM: Is information a proper observable for biological organization? Prog Biophys Mol Biol. 109:108–114. 2012. View Article : Google Scholar : PubMed/NCBI

123 

Kholodenko BN, Kolch W and Rukhlenko OS: Reversing pathological cell states: The road less travelled can extend the therapeutic horizon. Trends Cell Biol. 33:913–923. 2023. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Pensotti A, Bizzarri M and Bertolaso M: The phenotypic reversion of cancer: Experimental evidences on cancer reversibility through epigenetic mechanisms (Review). Oncol Rep 51: 48, 2024.
APA
Pensotti, A., Bizzarri, M., & Bertolaso, M. (2024). The phenotypic reversion of cancer: Experimental evidences on cancer reversibility through epigenetic mechanisms (Review). Oncology Reports, 51, 48. https://doi.org/10.3892/or.2024.8707
MLA
Pensotti, A., Bizzarri, M., Bertolaso, M."The phenotypic reversion of cancer: Experimental evidences on cancer reversibility through epigenetic mechanisms (Review)". Oncology Reports 51.3 (2024): 48.
Chicago
Pensotti, A., Bizzarri, M., Bertolaso, M."The phenotypic reversion of cancer: Experimental evidences on cancer reversibility through epigenetic mechanisms (Review)". Oncology Reports 51, no. 3 (2024): 48. https://doi.org/10.3892/or.2024.8707
Copy and paste a formatted citation
x
Spandidos Publications style
Pensotti A, Bizzarri M and Bertolaso M: The phenotypic reversion of cancer: Experimental evidences on cancer reversibility through epigenetic mechanisms (Review). Oncol Rep 51: 48, 2024.
APA
Pensotti, A., Bizzarri, M., & Bertolaso, M. (2024). The phenotypic reversion of cancer: Experimental evidences on cancer reversibility through epigenetic mechanisms (Review). Oncology Reports, 51, 48. https://doi.org/10.3892/or.2024.8707
MLA
Pensotti, A., Bizzarri, M., Bertolaso, M."The phenotypic reversion of cancer: Experimental evidences on cancer reversibility through epigenetic mechanisms (Review)". Oncology Reports 51.3 (2024): 48.
Chicago
Pensotti, A., Bizzarri, M., Bertolaso, M."The phenotypic reversion of cancer: Experimental evidences on cancer reversibility through epigenetic mechanisms (Review)". Oncology Reports 51, no. 3 (2024): 48. https://doi.org/10.3892/or.2024.8707
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