β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein

  • Authors:
    • Hang Zhang
    • Feng Xu
    • Tian Xie
    • Hongchuan Jin
    • Liyun Shi
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  • Published online on: September 11, 2012     https://doi.org/10.3892/or.2012.2022
  • Pages: 2083-2090
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Abstract

β-elemene, extracted from the ginger plant, possesses antitumor activity against a broad range of cancers clinically. However, the mechanism underlying β-elemene-induced cytotoxicity remains incompletely understood. Here, we show that β-elemene promoted apoptotic cell death in human glioma cells, downregulated survivin gene expression, and induced caspase-9, -3 and -7 activities. Induction of apoptosis was associated with inhibition of survivin gene expression, and restoration of survivin levels remarkably attenuated β-elemene-induced glioma cell death. Moreover, we found that the interaction between surviving and HBXIP, a critical regulator of caspase-9 activity, was impaired by β-elemene treatment. The results, therefore, reveal a caspase-mediated apoptotic pathway induced by β-elemene in human glioma cells, which is associated with downregulation of survivin itself and the interaction between survivin and HBXP.
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November 2012
Volume 28 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Zhang, H., Xu, F., Xie, T., Jin, H., & Shi, L. (2012). β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein. Oncology Reports, 28, 2083-2090. https://doi.org/10.3892/or.2012.2022
MLA
Zhang, H., Xu, F., Xie, T., Jin, H., Shi, L."β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein". Oncology Reports 28.6 (2012): 2083-2090.
Chicago
Zhang, H., Xu, F., Xie, T., Jin, H., Shi, L."β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein". Oncology Reports 28, no. 6 (2012): 2083-2090. https://doi.org/10.3892/or.2012.2022