Open Access

Placenta-specific protein 1 promotes cell proliferation and invasion in non-small cell lung cancer

  • Authors:
    • Li Yang
    • Tian-Qi Zha
    • Xiang He
    • Liang Chen
    • Quan Zhu
    • Wei-Bing Wu
    • Feng-Qi Nie
    • Qian Wang
    • Chong-Shuang Zang
    • Mei-Ling Zhang
    • Jing He
    • Wei Li
    • Wen Jiang
    • Kai-Hua Lu
  • View Affiliations

  • Published online on: November 9, 2017     https://doi.org/10.3892/or.2017.6086
  • Pages:53-60
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pulmonary carcinoma-associated proteins have emerged as crucial players in governing fundamental biological processes such as cell proliferation, apoptosis and metastasis in human cancers. Placenta-specific protein 1 (PLAC1) is a cancer-related protein, which is activated and upregulated in a variety of malignant tissues, including prostate cancer, gastric adenocarcinoma, colorectal, epithelial ovarian and breast cancer. However, its biological role and clinical significance in non-small cell lung cancer (NSCLC) development and progression are still unknown. In the present study, we found that PLAC1 was significantly upregulated in NSCLC tissues, and its expression level was associated with advanced pathological stage and it was also correlated with shorter progression-free survival of lung cancer patients. Furthermore, knockdown of PLAC1 expression by siRNA inhibited cell proliferation, induced apoptosis and impaired invasive ability in NSCLC cells partly via regulation of epithelial-mesenchymal transition (EMT)-related protein expression. Our findings present that increased PLAC1 could be identified as a negative prognostic biomarker in NSCLC and regulate cell proliferation and invasion. Thus, we conclusively demonstrated that PLAC1 plays a key role in NSCLC development and progression, which may provide novel insights on the function of tumor-related gene-driven tumorigenesis.

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January 2018
Volume 39 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
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Copy and paste a formatted citation
APA
Yang, L., Zha, T., He, X., Chen, L., Zhu, Q., Wu, W. ... Lu, K. (2018). Placenta-specific protein 1 promotes cell proliferation and invasion in non-small cell lung cancer. Oncology Reports, 39, 53-60. https://doi.org/10.3892/or.2017.6086
MLA
Yang, L., Zha, T., He, X., Chen, L., Zhu, Q., Wu, W., Nie, F., Wang, Q., Zang, C., Zhang, M., He, J., Li, W., Jiang, W., Lu, K."Placenta-specific protein 1 promotes cell proliferation and invasion in non-small cell lung cancer". Oncology Reports 39.1 (2018): 53-60.
Chicago
Yang, L., Zha, T., He, X., Chen, L., Zhu, Q., Wu, W., Nie, F., Wang, Q., Zang, C., Zhang, M., He, J., Li, W., Jiang, W., Lu, K."Placenta-specific protein 1 promotes cell proliferation and invasion in non-small cell lung cancer". Oncology Reports 39, no. 1 (2018): 53-60. https://doi.org/10.3892/or.2017.6086