Open Access

Monoglucosyl‑rutin as a potential radioprotector in mammalian cells

  • Authors:
    • Shigeaki Sunada
    • Hiroshi Fujisawa
    • Ian M. Cartwright
    • Junko Maeda
    • Colleen A. Brents
    • Kazue Mizuno
    • Yasushi Aizawa
    • Takamitsu A. Kato
    • Mitsuru Uesaka
  • View Affiliations

  • Published online on: April 24, 2014     https://doi.org/10.3892/mmr.2014.2181
  • Pages: 10-14
  • Copyright: © Sunada et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

In the present study, the role of monoglucosyl‑rutin as a potential radioprotector was investigated using mammalian cell culture models. Cell survival and DNA damage were assessed using colony formation, sister chromatid exchange and γH2AX assays. It was demonstrated that monoglucosyl‑rutin was able to increase cell survival when exposed to ionizing radiation, possibly by decreasing the amount of base damage experienced by the cell. However, the present study also demonstrated that, despite monoglucosyl‑rutin exhibiting radioprotective effects at low doses, high doses of monoglucosyl‑rutin led to a decrease in plating efficiency and an increased doubling time. This effect may be due to double‑strand breaks caused by high concentrations of monoglucosyl‑rutin.
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July-2014
Volume 10 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Sunada S, Fujisawa H, Cartwright IM, Maeda J, Brents CA, Mizuno K, Aizawa Y, Kato TA and Uesaka M: Monoglucosyl‑rutin as a potential radioprotector in mammalian cells. Mol Med Rep 10: 10-14, 2014.
APA
Sunada, S., Fujisawa, H., Cartwright, I.M., Maeda, J., Brents, C.A., Mizuno, K. ... Uesaka, M. (2014). Monoglucosyl‑rutin as a potential radioprotector in mammalian cells. Molecular Medicine Reports, 10, 10-14. https://doi.org/10.3892/mmr.2014.2181
MLA
Sunada, S., Fujisawa, H., Cartwright, I. M., Maeda, J., Brents, C. A., Mizuno, K., Aizawa, Y., Kato, T. A., Uesaka, M."Monoglucosyl‑rutin as a potential radioprotector in mammalian cells". Molecular Medicine Reports 10.1 (2014): 10-14.
Chicago
Sunada, S., Fujisawa, H., Cartwright, I. M., Maeda, J., Brents, C. A., Mizuno, K., Aizawa, Y., Kato, T. A., Uesaka, M."Monoglucosyl‑rutin as a potential radioprotector in mammalian cells". Molecular Medicine Reports 10, no. 1 (2014): 10-14. https://doi.org/10.3892/mmr.2014.2181