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Article Open Access

Integrated analysis of a lncRNA‑mRNA network reveals a potential mechanism underlying necrotizing enterocolitis

  • Authors:
    • Wenjuan Chen
    • Xiangyun Yan
    • Tian Tian
    • Ru Yan
    • Xingyun Wang
    • Zhangbin Yu
    • Yingzheng Li
    • Le Zhang
    • Shuping Han
  • View Affiliations / Copyright

    Affiliations: Department of Neonatology, Wuxi Children's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 423-435
    |
    Published online on: April 21, 2020
       https://doi.org/10.3892/mmr.2020.11083
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Abstract

Previous studies have shown that long non‑coding RNAs (lncRNAs) serve important roles in necrotizing enterocolitis (NEC). However, the underlying mechanisms remain largely unknown. In order to examine the potential role of lncRNAs in NEC, the present study investigated lncRNA and mRNA expression profiles in NEC lesions and adjacent intestinal tissues using Next Generation Sequencing. A total of 4,202 differentially expressed lncRNAs (fold‑change >2; P<0.05) and 7,860 differentially expressed mRNAs (fold‑change >2; P<0.05) were identified. Moreover, 5 dysregulated lncRNAs and 5 mRNAs were randomly selected, and further assessed by reverse transcription‑quantitative PCR in vitro. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses demonstrated that the differentially expressed lncRNAs were closely associated with NEC, and were enriched in ‘inflammatory response’, ‘Toll‑like receptor binding’, ‘PPAR signaling pathway’, ‘PI3K‑Akt signaling pathway’, ‘transforming growth factor‑β signaling pathway’ and ‘hypoxia‑inducible factor 1 signaling pathway’. In addition, co‑expression analysis demonstrated that these lncRNAs, including lncRNA ENST00000623580, lncRNA NONHSAT180418.1, lncRNA NONHSAT125636.2 and NONHSAT087855.2, may mediate the pathogenesis and development of NEC via lncRNA‑mRNA network interactions. Therefore, the present study provided a novel insight into the role of lncRNAs in NEC.
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1 

Fitzgibbons SC, Ching Y, Yu D, Carpenter J, Kenny M, Weldon C, Lillehei C, Valim C, Horbar JD and Jaksic T: Mortality of necrotizing enterocolitis expressed by birth weight categories. J Pediatr Surg. 44:1072–1076. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Kastenberg ZJ, Lee HC, Profit J, Gould JB and Sylvester KG: Effect of deregionalized care on mortality in very low-birth-weight infants with necrotizing enterocolitis. JAMA Pediatr. 169:26–32. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Dukleska K, Devin CL, Martin AE, Miller JM, Sullivan KM, Levy C, Prestowitz S, Flathers K, Vinocur CD and Berman L: Necrotizing enterocolitis totalis: High mortality in the absence of an aggressive surgical approach. Surgery. 165:1176–1181. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Lee JS and Polin RA: Treatment and prevention of necrotizing enterocolitis. Semin Neonatol. 8:449–459. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Shulhan J, Dicken B, Hartling L and Larsen BM: Current Knowledge of Necrotizing Enterocolitis in Preterm Infants and the Impact of Different Types of Enteral Nutrition Products. Adv Nutr. 8:80–91. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Kim ED and Sung S: Long noncoding RNA: Unveiling hidden layer of gene regulatory networks. Trends Plant Sci. 17:16–21. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Goff LA and Rinn JL: Linking RNA biology to lncRNAs. Genome Res. 25:1456–1465. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Han Y, Hong Y, Li L, Li T, Zhang Z, Wang J, Xia H, Tang Y, Shi Z, Han X, et al: A Transcriptome-Level Study Identifies Changing Expression Profiles for Ossification of the Ligamentum Flavum of the Spine. Mol Ther Nucleic Acids. 12:872–883. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Kim YJ, Hwang KC, Kim SW and Lee YC: Potential miRNA-target interactions for the screening of gastric carcinoma development in gastric adenoma/dysplasia. Int J Med Sci. 15:610–616. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Xiao L, Rao JN, Cao S, Liu L, Chung HK, Zhang Y, Zhang J, Liu Y, Gorospe M and Wang JY: Long noncoding RNA SPRY4-IT1 regulates intestinal epithelial barrier function by modulating the expression levels of tight junction proteins. Mol Biol Cell. 27:617–626. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Geng H, Bu HF, Liu F, Wu L, Pfeifer K, Chou PM, Wang X, Sun J, Lu L, Pandey A, et al: In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration. Gastroenterology. 155:144–155. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, Barton L and Brotherton T: Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg. 187:1–7. 1978. View Article : Google Scholar : PubMed/NCBI

13 

Mortazavi A, Williams BA, McCue K, Schaeffer L and Wold B: Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods. 5:621–628. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Liu M, Song S, Li H, Jiang X, Yin P, Wan C, Liu X, Liu F and Xu J: The protective effect of caffeic acid against inflammation injury of primary bovine mammary epithelial cells induced by lipopolysaccharide. J Dairy Sci. 97:2856–2865. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Robinson MD, McCarthy DJ and Smyth GK: edgeR: A Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Yazji I, Sodhi CP, Lee EK, Good M, Egan CE, Afrazi A, Neal MD, Jia H, Lin J, Ma C, et al: Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proc Natl Acad Sci USA. 110:9451–9456. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Pang Y, Du X, Xu X, Wang M and Li Z: Monocyte activation and inflammation can exacerbate Treg/Th17 imbalance in infants with neonatal necrotizing enterocolitis. Int Immunopharmacol. 59:354–360. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Good M, Siggers RH, Sodhi CP, Afrazi A, Alkhudari F, Egan CE, Neal MD, Yazji I, Jia H, Lin J, et al: Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Proc Natl Acad Sci USA. 109:11330–11335. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Jilling T, Simon D, Lu J, Meng FJ, Li D, Schy R, Thomson RB, Soliman A, Arditi M and Caplan MS: The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J Immunol. 177:3273–3282. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Sharma R, Tepas JJ III, Hudak ML, Mollitt DL, Wludyka PS, Teng RJ and Premachandra BR: Neonatal gut barrier and multiple organ failure: Role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitis. J Pediatr Surg. 42:454–461. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Bonora M, Wieckowsk MR, Chinopoulos C, Kepp O, Kroemer G, Galluzzi L and Pinton P: Molecular mechanisms of cell death: Central implication of ATP synthase in mitochondrial permeability transition. Oncogene. 34:16082015. View Article : Google Scholar : PubMed/NCBI

23 

Zhang L, Fan J, He J, Chen W, Jin W, Zhu Y, Sun H, Li Y, Shi Y, Jing Y, et al: Regulation of ROS-NF-κB axis by tuna backbone derived peptide ameliorates inflammation in necrotizing enterocolitis. J Cell Physiol. 234:14330–14338. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Good M, Sodhi CP, Egan CE, Afrazi A, Jia H, Yamaguchi Y, Lu P, Branca MF, Ma C, Prindle T Jr, et al: Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor. Mucosal Immunol. 8:1166–1179. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Wijendran V, Brenna JT, Wang DH, Zhu W, Meng D, Ganguli K, Kothapalli KS, Requena P, Innis S and Walker WA: Long-chain polyunsaturated fatty acids attenuate the IL-1β-induced proinflammatory response in human fetal intestinal epithelial cells. Pediatr Res. 78:626–633. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Feng Z, Zhou H, Ma S, Guan X, Chen L, Huang J, Gui H, Miao X, Yu S, Wang JH and Wang J: FTY720 attenuates intestinal injury and suppresses inflammation in experimental necrotizing enterocolitis via modulating CXCL5/CXCR2 axis. Biochem Biophys Res Commun. 505:1032–1037. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Chan KY, Leung FW, Lam HS, Tam YH, To KF, Cheung HM, Leung KT, Poon TC, Lee KH, Li K, et al: Immunoregulatory protein profiles of necrotizing enterocolitis versus spontaneous intestinal perforation in preterm infants. PLoS One. 7:e369772012. View Article : Google Scholar : PubMed/NCBI

28 

Sheng Q, Lv Z, Cai W, Song H, Qian L, Mu H, Shi J and Wang X: Human β-defensin-3 promotes intestinal epithelial cell migration and reduces the development of necrotizing enterocolitis in a neonatal rat model. Pediatr Res. 76:269–279. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Kandasamy J, Huda S, Ambalavanan N and Jilling T: Inflammatory signals that regulate intestinal epithelial renewal, differentiation, migration and cell death: Implications for necrotizing enterocolitis. Pathophysiology. 21:67–80. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Manoharan I, Suryawanshi A, Hong Y, Ranganathan P, Shanmugam A, Ahmad S, Swafford D, Manicassamy B, Ramesh G, Koni PA, et al: Homeostatic PPARalpha Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine. J Immunol. 196:4739–4749. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Shiou SR, Yu Y, Chen S, Ciancio MJ, Petrof EO, Sun J and Claud EC: Erythropoietin protects intestinal epithelial barrier function and lowers the incidence of experimental neonatal necrotizing enterocolitis. J Biol Chem. 286:12123–12132. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Fang C, Xie L, Liu C, Fu C, Ye W, Liu H and Zhang B: Berberine ameliorates neonatal necrotizing enterocolitis by activating the phosphoinositide 3-kinase/protein kinase B signaling pathway. Exp Ther Med. 15:3530–3536. 2018.PubMed/NCBI

33 

MohanKumar K, Namachivayam K, Chapalamadugu KC, Garzon SA, Premkumar MH, Tipparaju SM and Maheshwari A: Smad7 interrupts TGF-β signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis. Pediatr Res. 79:951–961. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Baregamian N, Rychahou PG, Hawkins HK, Evers BM and Chung DH: Phosphatidylinositol 3-kinase pathway regulates hypoxia-inducible factor-1 to protect from intestinal injury during necrotizing enterocolitis. Surgery. 142:295–302. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Günther W, Skaftnesmo KO, Arnold H, Bjerkvig R and Terzis AJ: Distribution patterns of the anti-angiogenic protein ADAMTS-1 during rat development. Acta Histochem. 107:121–131. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Hummitzsch L, Zitta K, Berndt R, Wong YL, Rusch R, Hess K, Wedel T, Gruenewald M, Cremer J, Steinfath M, et al: Remote ischemic preconditioning attenuates intestinal mucosal damage: Insight from a rat model of ischemia-reperfusion injury. J Transl Med. 17:1362019. View Article : Google Scholar : PubMed/NCBI

37 

Kardos J, Harmat V, Palló A, Barabás O, Szilágyi K, Gráf L, Náray-Szabó G, Goto Y, Závodszky P and Gál P: Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r. Mol Immunol. 45:1752–1760. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Kobayashi H, Albarracin L, Sato N, Kanmani P, Kober AK, Ikeda-Ohtsubo W, Suda Y, Nochi T, Aso H, Makino S, et al: Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937. Benef Microbes. 7:769–782. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Regard JB, Scheek S, Borbiev T, Lanahan AA, Schneider A, Demetriades AM, Hiemisch H, Barnes CA, Verin AD and Worley PF: Verge: a novel vascular early response gene. J Neurosci. 24:4092–4103. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Oakhill JS, Marritt SJ, Gareta EG, Cammack R and McKie AT: Functional characterization of human duodenal cytochrome B (Cybrd1): Redox properties in relation to iron and ascorbate metabolism. Biochim Biophys Acta. 1777:260–268. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Schlottmann F, Vera-Aviles M and Latunde-Dada GO: Duodenal cytochrome B (Cybrd1) ferric reductase functional studies in cells. Metallomics. 9:1389–1393. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Patel RM, Knezevic A, Shenvi N, Hinkes M, Keene S, Roback JD, Easley KA and Josephson CD: Association of Red Blood Cell Transfusion, Anemia, and Necrotizing Enterocolitis in Very Low-Birth-Weight Infants. JAMA. 315:889–897. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Glorieux C, Zamocky M, Sandoval JM, Verrax J and Calderon PB: Regulation of catalase expression in healthy and cancerous cells. Free Radic Biol Med. 87:84–97. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Ma L, Mondal AK, Murea M, Sharma NK, Tönjes A, Langberg KA, Das SK, Franks PW, Kovacs P, Antinozzi PA, et al: The effect of ACACB cis-variants on gene expression and metabolic traits. PLoS One. 6:e238602011. View Article : Google Scholar : PubMed/NCBI

45 

Chen G, Li Y, Su Y, Zhou L, Zhang H, Shen Q, Du C, Li H, Wen Z, Xia Y, et al: Identification of candidate genes for necrotizing enterocolitis based on microarray data. Gene. 661:152–159. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Caiado H, Conceição N, Tiago D, Marreiros A, Vicente S, Enriquez JL, Vaz AM, Antunes A, Guerreiro H, Caldeira P, et al: Evaluation of MGP gene expression in colorectal cancer. Gene. 723:1441202020. View Article : Google Scholar : PubMed/NCBI

47 

Dauphinee SM, Clayton A, Hussainkhel A, Yang C, Park YJ, Fuller ME, Blonder J, Veenstra TD and Karsan A: SASH1 is a scaffold molecule in endothelial TLR4 signaling. J Immunol. 191:892–901. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Coulombe P, Paliouras GN, Clayton A, Hussainkhel A, Fuller M, Jovanovic V, Dauphinee S, Umlandt P, Xiang P, Kyle AH, et al: Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling. Cell Rep. 27:1769–1780.e1764. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Um SH, Kim JS, Kim K, Kim N, Cho HS and Ha NC: Structural basis for the inhibition of human lysozyme by PliC from Brucella abortus. Biochemistry. 52:9385–9393. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Singh SB, Wilson M, Ritz N and Lin HC: Autophagy Genes of Host Responds to Disruption of Gut Microbial Community by Antibiotics. Dig Dis Sci. 62:1486–1497. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Kallen AN, Zhou XB, Xu J, Qiao C, Ma J, Yan L, Lu L, Liu C, Yi JS, Zhang H, et al: The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell. 52:101–112. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Fan Z, Gao S, Chen Y, Xu B, Yu C, Yue M and Tan X: Integrative analysis of competing endogenous RNA networks reveals the functional lncRNAs in heart failure. J Cell Mol Med. 22:4818–4829. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen W, Yan X, Tian T, Yan R, Wang X, Yu Z, Li Y, Zhang L and Han S: Integrated analysis of a lncRNA‑mRNA network reveals a potential mechanism underlying necrotizing enterocolitis. Mol Med Rep 22: 423-435, 2020.
APA
Chen, W., Yan, X., Tian, T., Yan, R., Wang, X., Yu, Z. ... Han, S. (2020). Integrated analysis of a lncRNA‑mRNA network reveals a potential mechanism underlying necrotizing enterocolitis. Molecular Medicine Reports, 22, 423-435. https://doi.org/10.3892/mmr.2020.11083
MLA
Chen, W., Yan, X., Tian, T., Yan, R., Wang, X., Yu, Z., Li, Y., Zhang, L., Han, S."Integrated analysis of a lncRNA‑mRNA network reveals a potential mechanism underlying necrotizing enterocolitis". Molecular Medicine Reports 22.1 (2020): 423-435.
Chicago
Chen, W., Yan, X., Tian, T., Yan, R., Wang, X., Yu, Z., Li, Y., Zhang, L., Han, S."Integrated analysis of a lncRNA‑mRNA network reveals a potential mechanism underlying necrotizing enterocolitis". Molecular Medicine Reports 22, no. 1 (2020): 423-435. https://doi.org/10.3892/mmr.2020.11083
Copy and paste a formatted citation
x
Spandidos Publications style
Chen W, Yan X, Tian T, Yan R, Wang X, Yu Z, Li Y, Zhang L and Han S: Integrated analysis of a lncRNA‑mRNA network reveals a potential mechanism underlying necrotizing enterocolitis. Mol Med Rep 22: 423-435, 2020.
APA
Chen, W., Yan, X., Tian, T., Yan, R., Wang, X., Yu, Z. ... Han, S. (2020). Integrated analysis of a lncRNA‑mRNA network reveals a potential mechanism underlying necrotizing enterocolitis. Molecular Medicine Reports, 22, 423-435. https://doi.org/10.3892/mmr.2020.11083
MLA
Chen, W., Yan, X., Tian, T., Yan, R., Wang, X., Yu, Z., Li, Y., Zhang, L., Han, S."Integrated analysis of a lncRNA‑mRNA network reveals a potential mechanism underlying necrotizing enterocolitis". Molecular Medicine Reports 22.1 (2020): 423-435.
Chicago
Chen, W., Yan, X., Tian, T., Yan, R., Wang, X., Yu, Z., Li, Y., Zhang, L., Han, S."Integrated analysis of a lncRNA‑mRNA network reveals a potential mechanism underlying necrotizing enterocolitis". Molecular Medicine Reports 22, no. 1 (2020): 423-435. https://doi.org/10.3892/mmr.2020.11083
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