Open Access

Diabetic‑induced alterations in hepatic glucose and lipid metabolism: The role of type 1 and type 2 diabetes mellitus (Review)

  • Authors:
    • Saizhi Jiang
    • Jamie L. Young
    • Kai Wang
    • Yan Qian
    • Lu Cai
  • View Affiliations

  • Published online on: May 22, 2020     https://doi.org/10.3892/mmr.2020.11175
  • Pages: 603-611
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diabetes mellitus (DM) is a growing health concern in society. Type 1 and type 2 DM are the two main types of diabetes; both types are chronic diseases that affect glucose metabolism in the body and the impaired regulation of glucose and lipid metabolism promotes the development and progression of DM. During the physiological metabolism process, the liver serves a unique role in glucose and lipid metabolism. The present article aimed to review the association between DM and glucose metabolism in the liver and discuss the changes of the following hepatic glucose fluxes: Gluconeogenesis, glucose/glucose 6‑phosphate cycling, glycogenolysis, glycogenesis and the pentose phosphate pathway. Moreover, the incidence of fatty liver in DM was also investigated.

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August-2020
Volume 22 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Jiang, S., Young, J.L., Wang, K., Qian, Y., & Cai, L. (2020). Diabetic‑induced alterations in hepatic glucose and lipid metabolism: The role of type 1 and type 2 diabetes mellitus (Review). Molecular Medicine Reports, 22, 603-611. https://doi.org/10.3892/mmr.2020.11175
MLA
Jiang, S., Young, J. L., Wang, K., Qian, Y., Cai, L."Diabetic‑induced alterations in hepatic glucose and lipid metabolism: The role of type 1 and type 2 diabetes mellitus (Review)". Molecular Medicine Reports 22.2 (2020): 603-611.
Chicago
Jiang, S., Young, J. L., Wang, K., Qian, Y., Cai, L."Diabetic‑induced alterations in hepatic glucose and lipid metabolism: The role of type 1 and type 2 diabetes mellitus (Review)". Molecular Medicine Reports 22, no. 2 (2020): 603-611. https://doi.org/10.3892/mmr.2020.11175