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MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer

  • Authors:
    • Lijun Tian
    • Mingtong Chen
    • Qiang He
    • Qiuliang Yan
    • Chunbao Zhai
  • View Affiliations / Copyright

    Affiliations: Department of Colorectal and Anus Surgery, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030001, P.R. China, Department of Gastroenterology, Jinhua People's Hospital, Jinhua, Zhejiang 321000, P.R. China, Department of General Surgery, Jinhua People's Hospital, Jinhua, Zhejiang 321000, P.R. China
    Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2307-2317
    |
    Published online on: July 10, 2020
       https://doi.org/10.3892/mmr.2020.11323
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Abstract

As a member of the integrin family, integrin α3β1 (ITGA3) has been linked to intercellular communication and serves an important role in the signaling among cells and the extracellular matrix. MicroRNA (miR)‑199a‑5p has been demonstrated to be related to the pathogenesis and progression of multiple malignant diseases. However, the biological functions of miR‑199a‑5p and ITGA3 in colorectal cancer (CRC) have rarely been reported. The aim of the present study was to explore the roles of miR‑199a‑5p and ITGA3 in CRC. Immunohistochemistry staining and western blotting were applied to detect the protein expression of ITGA3 in CRC tissues and cells. Reverse transcription‑quantitative PCR was performed to investigate the expression of miR‑199a‑5p and ITGA3 mRNA. HCT‑116 cells were transfected with miR‑199a‑5p mimics, mimics control, short hairpin RNA targeting ITGA3, or pcDNA‑ITGA3 for the functional experiments. Dual luciferase reporter assay was applied to confirm whether miR‑199a‑5p targeted the 3' untranslated region (3'UTR) of ITGA3. The MTT, Transwell and wound healing assays were used to evaluate the proliferation, invasion and migration of CRC cells. Immunofluorescence assay was used to monitor the epithelial‑mesenchymal transition (EMT) biomarker expression. The results demonstrated downregulation of miR‑199a‑5p and upregulation of ITGA3 in CRC tissues and cell lines. miR‑199a‑5p mimics and knockdown of ITGA3 suppressed the proliferation, invasion and migration of CRC cells. Bioinformatics analysis and luciferase reporter assay indicated that miR‑199a‑5p targeted the 3'UTR of the ITGA3 transcript, and overexpression of ITGA3 reversed the tumor‑suppressive effects of miR‑199a‑5p elevation. In addition, the immunofluorescence assay suggested that miR‑199a‑5p mimics suppressed the EMT of CRC cells, whereas the overexpression of ITGA3 restored this effect. In conclusion, miR‑199a‑5p may act as a tumor suppressor by targeting and negatively regulating ITGA3 in CRC.
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1 

Blomme B, Deroanne C, Hulin A, Lambert C, Defraigne JO, Nusgens B, Radermecker M and Colige A: Mechanical strain induces a pro-fibrotic phenotype in human mitral valvular interstitial cells through RhoC/ROCK/MRTF-A and Erk1/2 signaling pathways. J Mol Cell Cardiol. 135:149–159. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Zhao L and Wang Z: MicroRNAs: Game changers in the regulation of α-synuclein in Parkinson's disease. Parkinsons Dis. 2019:17431832019.PubMed/NCBI

3 

Zhao X, Chen GQ and Cao GM: Abnormal expression and mechanism of miR-330-3p/BTG1 axis in hepatocellular carcinoma. Eur Rev Med Pharmacol Sci. 23:6888–6898. 2019.PubMed/NCBI

4 

Yang L, Hong Q, Xu SG, Kuang XY, Di GH, Liu GY, Wu J, Shao ZM and Yu SJ: Downregulation of transgelin 2 promotes breast cancer metastasis by activating the reactive oxygen species/nuclear factor-κB signaling pathway. Mol Med Rep. 20:4045–4258. 2019.PubMed/NCBI

5 

Lin JS, Piper MA, Perdue LA, Rutter C, Webber EM, O'Connor E, Smith N and Whitlock EP: Screening for colorectal cancer: A systematic review for the U.S. Preventive Services Task Force. Agency for Healthcare Research and Quality (US). (Rockville, MD). 2016.

6 

Brenner H, Kloor M and Pox CP: Colorectal cancer. Lancet. 383:1490–1502. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Koliarakis I, Psaroulaki A, Nikolouzakis TK, Kokkinakis M, Sgantzos M, Goulielmos G, Androutsopoulos VP, Tsatsakis A and Tsiaoussis J: Intestinal microbiota and colorectal cancer: A new aspect of research. J BUON. 23:1216–1234. 2018.PubMed/NCBI

8 

Lin F, Zhang P, Zuo Z, Wang F, Bi R, Shang W, Wu A, Ye J, Li S, Sun X, et al: Thioredoxin-1 promotes colorectal cancer invasion and metastasis through crosstalk with S100P. Cancer Lett. 401:1–10. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Nieto MA, Huang RY, Jackson RA and Thiery JP: EMT: 2016. Cell. 166:21–45. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Derynck R and Weinberg RA: EMT and cancer: More than meets the eye. Dev Cell. 49:313–316. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Xu D, Li J, Li RY, Lan T, Xiao C and Gong P: PD-L1 expression is regulated by NF-κB during EMT signaling in gastric carcinoma. Onco Targets Ther. 12:10099–10105. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Szeder B, Tárnoki-Zách J, Lakatos D, Vas V, Kudlik G, Merő B, Koprivanacz K, Bányai L, Hámori L, Róna G, et al: Absence of the Tks4 scaffold protein induces epithelial-mesenchymal transition-like changes in human colon cancer cells. Cells. 8:13432019. View Article : Google Scholar

13 

Zhang HD, Jiang LH, Sun DW, Li J and Ji ZL: The role of miR-130a in cancer. Breast Cancer. 24:521–527. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Mellis D and Caporali A: MicroRNA-based therapeutics in cardiovascular disease: Screening and delivery to the target. Biochem Soc Trans. 46:11–21. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Di Leva G, Garofalo M and Croce CM: MicroRNAs in cancer. Annu Rev Pathol. 9:287–314. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Li Y, Zhang G, Wu B, Yang W and Liu Z: miR-199a-5p represses protective autophagy and overcomes chemoresistance by directly targeting DRAM1 in acute myeloid leukemia. J Oncol. 2019:56134172019. View Article : Google Scholar : PubMed/NCBI

17 

Qu D, Yang Y and Huang X: miR-199a-5p promotes proliferation and metastasis and epithelial-mesenchymal transition through targeting PIAS3 in cervical carcinoma. J Cell Biochem. 120:13562–13572. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Dai BH, Geng L, Wang Y, Sui CJ, Xie F, Shen RX, Shen WF and Yang JM: microRNA-199a-5p protects hepatocytes from bile acid-induced sustained endoplasmic reticulum stress. Cell Death Dis. 4:e6042013. View Article : Google Scholar : PubMed/NCBI

19 

Ahmadi A, Khansarinejad B, Hosseinkhani S, Ghanei M and Mowla SJ: miR-199a-5p and miR-495 target GRP78 within UPR pathway of lung cancer. Gene. 620:15–22. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Zhu QD, Zhou QQ, Dong L, Huang Z, Wu F and Deng X: MiR-199a-5p inhibits the growth and metastasis of colorectal cancer cells by targeting ROCK1. Technol Cancer Res Treat. 17:15330346187755092018. View Article : Google Scholar : PubMed/NCBI

21 

Kim BK, Yoo HI, Kim I, Park J and Kim YS: FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer. BMB Rep. 48:360–366. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Weber C, Alon R, Moser B and Springer TA: Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: Implications for transendothelial chemotaxis. J Cell Biol. 134:1063–1073. 1996. View Article : Google Scholar : PubMed/NCBI

23 

Desgrosellier JS and Cheresh DA: Integrins in cancer: Biological implications and therapeutic opportunities. Nat Rev Cancer. 10:9–22. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Sun CC, Qu XJ and Gao ZH: Arginine-glycine-aspartate-binding integrins as therapeutic and diagnostic targets. Am J Ther. 23:e198–e207. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Nagata M, Noman AA, Suzuki K, Kurita H, Ohnishi M, Ohyama T, Kitamura N, Kobayashi T, Uematsu K, Takahashi K, et al: ITGA3 and ITGB4 expression biomarkers estimate the risks of locoregional and hematogenous dissemination of oral squamous cell carcinoma. BMC Cancer. 13:4102013. View Article : Google Scholar : PubMed/NCBI

26 

Jiao Y, Li Y, Liu S, Chen Q and Liu Y: ITGA3 serves as a diagnostic and prognostic biomarker for pancreatic cancer. Onco Targets Ther. 12:4141–4152. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Zhang H, Cui X, Cao A, Li X and Li L: ITGA3 interacts with VASP to regulate stemness and epithelial-mesenchymal transition of breast cancer cells. Gene. 734:1443962020. View Article : Google Scholar : PubMed/NCBI

28 

Li GF, Li ZB, Zhuang SJ and Li GC: Inhibition of microRNA-34a protects against propofol anesthesia-induced neurotoxicity and cognitive dysfunction via the MAPK/ERK signaling pathway. Neurosci Lett. 675:152–159. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Heo G, Kang D, Park C, Kim SJ, Choo J, Lee Y, Yoo JW, Jung Y, Lee J, Kim ND, et al: Pro-apoptotic effect of the novel benzylidene derivative MHY695 in human colon cancer cells. Oncol Lett. 18:3256–3264. 2019.PubMed/NCBI

30 

Fu J, Wu L, Ge C, Xu T, Li D, Fu W, Wang L and Du J: De-escalating chemotherapy for stage II colon cancer? Therap Adv Gastroenterol. 12:17562848198675532019. View Article : Google Scholar : PubMed/NCBI

31 

Luo W, Gao F, Li S and Liu L: FoxM1 promotes cell proliferation, invasion, and stem cell properties in nasopharyngeal carcinoma. Front Oncol. 8:4832018. View Article : Google Scholar : PubMed/NCBI

32 

Dhamija S and Diederichs S: From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis. Int J Cancer. 139:269–280. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Xu TJ, Qiu P, Zhang YB, Yu SY, Xu GM and Yang W: MiR-148a inhibits the proliferation and migration of glioblastoma by targeting ITGA9. Hum Cell. 32:548–556. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Norouzinia M, Azodi MZ, Seyfi DN, Kardan A, Naseh A and Akbari Z: Predication of hub target genes of differentially expressed microRNAs contributing to infection in gastric non-cancerous tissue. Gastroenterol Hepatol Bed Bench. 12 (Suppl 1):S44–S50. 2019.PubMed/NCBI

35 

Zhang W, Xu J, Wang K, Tang X and He J: miR1393p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A. Oncol Rep. 42:1699–1708. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Dai X, Liang Z, Liu L, Guo K, Xu S and Wang H: Silencing of MALAT1 inhibits migration and invasion by sponging miR13p in prostate cancer cells. Mol Med Rep. 20:3499–3508. 2019.PubMed/NCBI

37 

Ye K, Xu C and Hui T: MiR-34b inhibits the proliferation and promotes apoptosis in colon cancer cells by targeting Wnt/β-catenin signaling pathway. Biosci Rep. 39:BSR201917992019. View Article : Google Scholar : PubMed/NCBI

38 

Yuan Y, Li N, Zeng L, Shen Z and Jiang C: Pathogenesis investigation of miR-199-5p in oral submucous fibrosis based on bioinformatics analysis. Oral Dis. 25:456–465. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Chao CC, Wu PH, Huang HC, Chung HY, Chou YC, Cai BH and Kannagi R: Downregulation of miR-199a/b-5p is associated with GCNT2 induction upon epithelial-mesenchymal transition in colon cancer. FEBS Lett. 591:1902–1917. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Song B, Du J, Feng Y, Gao YJ and Zhao JS: Co-expressed differentially expressed genes and long non-coding RNAs involved in the celecoxib treatment of gastric cancer: An RNA sequencing analysis. Exp Ther Med. 12:2455–2468. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Ura H, Denno R, Hirata K, Yamaguchi K and Yasoshima T: Separate functions of alpha2beta1 and alpha3beta1 integrins in the metastatic process of human gastric carcinoma. Surg Today. 28:1001–1006. 1998. View Article : Google Scholar : PubMed/NCBI

42 

Kurokawa A, Nagata M, Kitamura N, Noman AA, Ohnishi M, Ohyama T, Kobayashi T, Shingaki S, Takagi R; Oral and Maxillofacial Pathology; Surgery Group, : Diagnostic value of integrin alpha3, beta4, and beta5 gene expression levels for the clinical outcome of tongue squamous cell carcinoma. Cancer. 112:1272–1281. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tian L, Chen M, He Q, Yan Q and Zhai C: MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer. Mol Med Rep 22: 2307-2317, 2020.
APA
Tian, L., Chen, M., He, Q., Yan, Q., & Zhai, C. (2020). MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer. Molecular Medicine Reports, 22, 2307-2317. https://doi.org/10.3892/mmr.2020.11323
MLA
Tian, L., Chen, M., He, Q., Yan, Q., Zhai, C."MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer". Molecular Medicine Reports 22.3 (2020): 2307-2317.
Chicago
Tian, L., Chen, M., He, Q., Yan, Q., Zhai, C."MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer". Molecular Medicine Reports 22, no. 3 (2020): 2307-2317. https://doi.org/10.3892/mmr.2020.11323
Copy and paste a formatted citation
x
Spandidos Publications style
Tian L, Chen M, He Q, Yan Q and Zhai C: MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer. Mol Med Rep 22: 2307-2317, 2020.
APA
Tian, L., Chen, M., He, Q., Yan, Q., & Zhai, C. (2020). MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer. Molecular Medicine Reports, 22, 2307-2317. https://doi.org/10.3892/mmr.2020.11323
MLA
Tian, L., Chen, M., He, Q., Yan, Q., Zhai, C."MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer". Molecular Medicine Reports 22.3 (2020): 2307-2317.
Chicago
Tian, L., Chen, M., He, Q., Yan, Q., Zhai, C."MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer". Molecular Medicine Reports 22, no. 3 (2020): 2307-2317. https://doi.org/10.3892/mmr.2020.11323
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