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Article

Trop2 is a potential biomarker for the promotion of EMT in human breast cancer

  • Authors:
    • Wei Zhao
    • Xingwang Kuai
    • Xueyi Zhou
    • Lizhou Jia
    • Jinsong Wang
    • Xiaobing Yang
    • Zhidan Tian
    • Xiaolei Wang
    • Qian Lv
    • Bin Wang
    • Youcai Zhao
    • Wenbin Huang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Oncology, Huai'an Hospital Affiliated of Xuzhou Medical College and Huai'an Second People's Hospital, Huai'an, Jiangsu 223002, P.R. China, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China
  • Pages: 759-766
    |
    Published online on: June 14, 2018
       https://doi.org/10.3892/or.2018.6496
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Abstract

Trop2 is considered to have an important function in tumor metastasis and the promotion of epithelial‑mesenchymal transition (EMT). E‑cadherin is a crucial factor in intercellular adhesion and EMT transformation. In the present study, we detected the expression of Trop2 and E‑cadherin in breast cancer (BC) to better define their prognostic value. The mRNA expression levels of these two genes in 20 cases of fresh BC tissues were detected by quantitative real‑time polymerase chain reaction (qRT‑PCR). We also detected the expression levels of these two genes by immunohistochemistry (IHC) in 312 BC tissues, and the correlations between the expression of these two genes and the clinicopathological characteristics in BC patients were analyzed. The mRNA and protein expression levels of the two genes in BC cell lines were studied by qRT‑PCR and western blotting. The results indicated that Trop2+/E‑cadherin‑ was expressed in BC tissues more than that in the matched adjacent tissues. The protein expression results obtained via IHC were similar to the mRNA expression results. Trop2+/E‑cadherin‑ that was expressed in BC was associated with lymph node status, metastasis, tumor‑node‑metastasis (TNM) stage, and ER‑/PR‑/HER2‑ expression. BC patients that expressed Trop2+/E‑cadherin‑ had poor overall survival rates. The results of Trop2 and E‑cadherin expression levels obtained in the BC cell lines were the same as those obtained in the BC tissues. Overall, Trop2 has a potential role in the promotion of EMT in BC and it could be considered as a therapeutic target in the future.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Zeichner SB, Terawaki H and Gogineni K: A review of systemic treatment in metastatic triple-negative breast cancer. Breast Cancer (Auckl). 10:25–36. 2016.PubMed/NCBI

3 

Abdel-Fatah TMA, Agarwal D, Liu DX, Russell R, Rueda OM, Liu K, Xu B, Moseley PM, Green AR, Pockley AG, et al: SPAG5 as a prognostic biomarker and chemotherapy sensitivity predictor in breast cancer: A retrospective, integrated genomic, transcriptomic, and protein analysis. Lancet Oncol. 17:1004–1018. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Cetin I and Topcul M: Triple negative breast cancer. Asian Pac J Cancer Prev. 15:2427–2431. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Park YH, Jung HH, Ahn JS and Im YH: Statin induces inhibition of triple negative breast cancer (TNBC) cells via PI3K pathway. Biochem Biophys Res Commun. 439:275–279. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Ma CX, Cai S, Li S, Ryan CE, Guo ZF, Schaiff WT, Lin L, Hoog J, Goiffon RJ, Prat A, et al: Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models. J Clin Invest. 122:1541–1552. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Jitariu AA, Cimpean AM, Ribatti D and Raica M: Triple negative breast cancer: The kiss of death. Oncotarget. 8:46652–46662. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Zhao W, Zhu H, Zhang S, Yong H, Wang W, Zhou Y, Wang B, Wen J, Qiu Z, Ding G, et al: Trop2 is overexpressed in gastric cancer and predicts poor prognosis. Oncotarget. 7:6136–6145. 2016.PubMed/NCBI

9 

McDougall AR, Tolcos M, Hooper SB, Cole TJ and Wallace MJ: Trop2: From development to disease. Dev Dyn. 244:99–109. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Li Z, Jiang X and Zhang W: TROP2 overexpression promotes proliferation and invasion of lung adenocarcinoma cells. Biochem Biophys Res Commun. 470:197–204. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Cubas R, Zhang S, Li M, Chen C and Yao Q: Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer. 9:2532010. View Article : Google Scholar : PubMed/NCBI

12 

Guerra E, Trerotola M, Dell' Arciprete R, Bonasera V, Palombo B, El-Sewedy T, Ciccimarra T, Crescenzi C, Lorenzini F, Lorenzini F, et al: A bicistronic CYCLIN D1-TROP2 mRNA chimera demonstrates a novel oncogenic mechanism in human cancer. Cancer Res. 68:8113–8121. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Wu Y, Zhang L, Zhang L, Wang Y, Li H, Ren XB, Wei F, Yu WW, Liu T, Wang X, et al: Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma. Int J Oncol. 46:2586–2594. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Bai ZT, Wu ZR, Xi LL, Li X, Chen P, Wang FQ, Meng WB, Zhou WC, Wu XA, Yao XJ, et al: Inhibition of invasion by N-trans-feruloyloctopamine via AKT, p38MAPK and EMT related signals in hepatocellular carcinoma cells. Bioorg Med Chem Lett. 27:989–993. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Yang Y, Zhang J, Yan Y, Cai H, Li M, Sun K, Wang J, Liu X, Wang J and Duan X: Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer. Oncotarget. 8:8057–8068. 2017.PubMed/NCBI

16 

Cong N, Du P, Zhang A, Shen F, Su J, Pu P, Wang T, Zjang J, Kang C and Zhang Q: Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma. Oncol Rep. 29:1579–1587. 2013. View Article : Google Scholar : PubMed/NCBI

17 

He R, Zhang FH and Shen N: LncRNA FEZF1-AS1 enhances epithelial-mesenchymal transition (EMT) through suppressing E-cadherin and regulating WNT pathway in non-small cell lung cancer (NSCLC). Biomed Pharmacother. 95:331–338. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Zhang J, Chen XY, Huang KJ, Wu WD, Jiang T, Cao J, Zhou LS, Qiu ZJ and Huang C: Expression of FoxM1 and the EMT-associated protein E-cadherin in gastric cancer and its clinical significance. Oncol Lett. 12:2445–2450. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Wang ZS, Shen Y, Li X, Zhou CZ, Wen YG, Jin YB and Li JK: Significance and prognostic value of Gli-1 and Snail/E-cadherin expression in progressive gastric cancer. Tumour Biol. 35:1357–1363. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Chandra Mangalhara K, Manvati S, Saini SK, Ponnusamy K, Agarwal G, Abraham SK and Bamezai RNK: ERK2-ZEB1-miR-101-1 axis contributes to epithelial-mesenchymal transition and cell migration in cancer. Cancer Lett. 391:59–73. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Ahmed NS, Ghatak S, El Masry MS, Gnyawali SC, Roy S, Amer M, Everts H, Sen CK and Khanna S: Epidermal E-Cadherin dependent β-catenin pathway is phytochemical inducible and accelerates anagen hair cycling. Mol Ther. 25:2502–2512. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Garcia-Pedrero JM, Garcia-Cabo P, Ángeles Villaronga M, Hermida-Prado F, Granda-Diaz R, Allonca E and Rodrigo JP: Prognostic significance of E-cadherin and β-catenin expression in HPV-negative oropharyngeal squamous cell carcinomas. Head Neck. 39:2293–2300. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Su SC, Hsieh MJ, Yang WE, Chung WH, Reiter RJ and Yang SF: Cancer metastasis: Mechanisms of inhibition by melatonin. J Pineal Res. 62:2017. View Article : Google Scholar

25 

Pearlman RL, Montes de Oca MK, Pal HC and Afaq F: Potential therapeutic targets of epithelial-mesenchymal transition in melanoma. Cancer Lett. 391:125–140. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Hao Y, Yang X, Zhang D, Luo J and Chen R: Long noncoding RNA LINC01186, regulated by TGF-β/SMAD3, inhibits migration and invasion through Epithelial-Mesenchymal-Transition in lung cancer. Gene. 608:1–12. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Lin H, Zhang H, Wang J, Lu M, Zheng F, Wang C, Tang X, Xu N, Chen R, Zhang D, et al: A novel human Fab antibody for Trop2 inhibits breast cancer growth in vitro and in vivo. Int J Cancer. 134:1239–1249. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao W, Kuai X, Zhou X, Jia L, Wang J, Yang X, Tian Z, Wang X, Lv Q, Wang B, Wang B, et al: Trop2 is a potential biomarker for the promotion of EMT in human breast cancer. Oncol Rep 40: 759-766, 2018.
APA
Zhao, W., Kuai, X., Zhou, X., Jia, L., Wang, J., Yang, X. ... Huang, W. (2018). Trop2 is a potential biomarker for the promotion of EMT in human breast cancer. Oncology Reports, 40, 759-766. https://doi.org/10.3892/or.2018.6496
MLA
Zhao, W., Kuai, X., Zhou, X., Jia, L., Wang, J., Yang, X., Tian, Z., Wang, X., Lv, Q., Wang, B., Zhao, Y., Huang, W."Trop2 is a potential biomarker for the promotion of EMT in human breast cancer". Oncology Reports 40.2 (2018): 759-766.
Chicago
Zhao, W., Kuai, X., Zhou, X., Jia, L., Wang, J., Yang, X., Tian, Z., Wang, X., Lv, Q., Wang, B., Zhao, Y., Huang, W."Trop2 is a potential biomarker for the promotion of EMT in human breast cancer". Oncology Reports 40, no. 2 (2018): 759-766. https://doi.org/10.3892/or.2018.6496
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao W, Kuai X, Zhou X, Jia L, Wang J, Yang X, Tian Z, Wang X, Lv Q, Wang B, Wang B, et al: Trop2 is a potential biomarker for the promotion of EMT in human breast cancer. Oncol Rep 40: 759-766, 2018.
APA
Zhao, W., Kuai, X., Zhou, X., Jia, L., Wang, J., Yang, X. ... Huang, W. (2018). Trop2 is a potential biomarker for the promotion of EMT in human breast cancer. Oncology Reports, 40, 759-766. https://doi.org/10.3892/or.2018.6496
MLA
Zhao, W., Kuai, X., Zhou, X., Jia, L., Wang, J., Yang, X., Tian, Z., Wang, X., Lv, Q., Wang, B., Zhao, Y., Huang, W."Trop2 is a potential biomarker for the promotion of EMT in human breast cancer". Oncology Reports 40.2 (2018): 759-766.
Chicago
Zhao, W., Kuai, X., Zhou, X., Jia, L., Wang, J., Yang, X., Tian, Z., Wang, X., Lv, Q., Wang, B., Zhao, Y., Huang, W."Trop2 is a potential biomarker for the promotion of EMT in human breast cancer". Oncology Reports 40, no. 2 (2018): 759-766. https://doi.org/10.3892/or.2018.6496
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