Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target

  • Authors:
    • Zujun Sun
    • Qi Liu
    • Dongxia Ye
    • Kaichuang Ye
    • Zhenhua Yang
    • Dong Li
  • View Affiliations

  • Published online on: November 2, 2017     https://doi.org/10.3892/or.2017.6073
  • Pages:209-216
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Abstract

Mesenchymal-epithelial transition factor (c-Met) is the only high affinity receptor for hepatocyte growth factor (HGF), and is frequently activated in many human cancers. However, little is known about the role of the HGF/c-Met signaling pathway in the progression of human oral squamous cell carcinoma (OSCC). This study evaluated the role of the HGF/c-Met signaling pathway in the progression of human OSCC. We found that the expression of c-Met was significantly increased in human OSCC tissues than in normal mucosa adjacent to the tumor (P<0.05), but was not correlated with clinicopathological parameters. Additionally, the selective c-Met inhibitor JNJ was found to inhibit cell viability and migration and promote apoptosis in OSCC cell lines, and also blocked the activation AKT, ERK1/2, and NF-κB p65; thus, suggesting that HGF/c-Met signaling may play an important role in the tumorigenic properties of OSCC cells via the AKT, ERK1/2, and NF-κB pathways. Collectively, these results indicated that HGF/c-Met signaling may serve essential roles in the progression of human OSCC, and may thus be a basis for the development of novel therapeutic approaches in the treatment of OSCC.

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January 2018
Volume 39 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
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APA
Sun, Z., Liu, Q., Ye, D., Ye, K., Yang, Z., & Li, D. (2018). Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target. Oncology Reports, 39, 209-216. https://doi.org/10.3892/or.2017.6073
MLA
Sun, Z., Liu, Q., Ye, D., Ye, K., Yang, Z., Li, D."Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target". Oncology Reports 39.1 (2018): 209-216.
Chicago
Sun, Z., Liu, Q., Ye, D., Ye, K., Yang, Z., Li, D."Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target". Oncology Reports 39, no. 1 (2018): 209-216. https://doi.org/10.3892/or.2017.6073