Beneficial effects of grape seed proanthocyanidin extract on arterial remodeling in spontaneously hypertensive rats via protecting against oxidative stress

  • Authors:
    • Ying Liang
    • Jian Wang
    • Haiqing Gao
    • Quanzhen Wang
    • Jun Zhang
    • Jie Qiu
  • View Affiliations

  • Published online on: September 1, 2016     https://doi.org/10.3892/mmr.2016.5699
  • Pages: 3711-3718
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Abstract

Arterial remodeling is a pathogenic occurrence during hypertension and, in turn, is closely associated with the development and complications of hypertension. Grape seed proanthocyanidin extract (GSPE) has been reported to exhibit a protective effect on cardiovascular disease, however its effect on arterial remodeling remains to be fully elucidated. In the present study, the effects of GSPE on arterial remodeling were analyzed by treating spontaneously hypertensive rats (SHRs) with GSPE (250 mg/kg·day). Arterial remodeling was quantified through morphological methods; thoracic aortas were stained with hematoxylin-eosin or sirius red‑victoria blue. The arterial ultrastructure was imaged using transmission electron microscopy. The content of nitric oxide (NO) and endothelin‑1 (ET‑1) were examined to determine endothelial function. Oxidative stress was assessed by malondialdehyde (MDA) levels and the activities of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). Administration of GSPE markedly alleviated hypertension‑induced arterial remodeling, which was not associated with blood pressure control. ET‑1 production was reduced, while NO production was increased in the GSPE group, which exhibited improved endothelial function. In addition, treatment with GSPE significantly ameliorated oxidative stress by improving SOD and CAT activities and reducing MDA formation. In conclusion, GSPE may attenuate hypertension‑induced arterial remodeling by repressing oxidative stress and is recommended as a potential anti‑arterial remodeling agent for patients with hypertensive vascular diseases.
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October-2016
Volume 14 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Liang Y, Wang J, Gao H, Wang Q, Zhang J and Qiu J: Beneficial effects of grape seed proanthocyanidin extract on arterial remodeling in spontaneously hypertensive rats via protecting against oxidative stress. Mol Med Rep 14: 3711-3718, 2016.
APA
Liang, Y., Wang, J., Gao, H., Wang, Q., Zhang, J., & Qiu, J. (2016). Beneficial effects of grape seed proanthocyanidin extract on arterial remodeling in spontaneously hypertensive rats via protecting against oxidative stress. Molecular Medicine Reports, 14, 3711-3718. https://doi.org/10.3892/mmr.2016.5699
MLA
Liang, Y., Wang, J., Gao, H., Wang, Q., Zhang, J., Qiu, J."Beneficial effects of grape seed proanthocyanidin extract on arterial remodeling in spontaneously hypertensive rats via protecting against oxidative stress". Molecular Medicine Reports 14.4 (2016): 3711-3718.
Chicago
Liang, Y., Wang, J., Gao, H., Wang, Q., Zhang, J., Qiu, J."Beneficial effects of grape seed proanthocyanidin extract on arterial remodeling in spontaneously hypertensive rats via protecting against oxidative stress". Molecular Medicine Reports 14, no. 4 (2016): 3711-3718. https://doi.org/10.3892/mmr.2016.5699