A potential role for astaxanthin in the treatment of bone diseases (Review)

  • Authors:
    • Maria Teresa Valenti
    • Massimiliano Perduca
    • Maria Grazia Romanelli
    • Monica Mottes
    • Luca Dalle Carbonare
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  • Published online on: June 26, 2020     https://doi.org/10.3892/mmr.2020.11284
  • Pages: 1695-1701
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Abstract

Alterations in molecular signaling impair cellular functions and induce degenerative diseases. Among the factors affecting intracellular signaling pathways, oxidative stress serves an important role. Astaxanthin (3,3'‑dihydroxy‑β, β‑carotene-4,4'‑dione), a pigment found in aquatic organisms, belongs to the xanthophylls family. Astaxanthin exerts a strong antioxidant activity and is widely used in food, cosmetic and pharmaceutical industries. Oxidative stress damages bone homeostasis by producing reactive oxygen species and increasing the production of pro‑resorption cytokines, such as interleukin (IL)‑1, tumor necrosis factor‑α and IL‑6. Therefore, antioxidant molecules can counteract the negative effects of oxidative stress on bone. Accordingly, previous studies have demonstrated that supplementation of astaxanthin in bone contributes to the restoration of bone homeostasis. The present review summarizes the negative effects of oxidative stress in bone and explores the role of astaxanthin in counteracting skeletal injuries consequent to oxidative stress.
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September-2020
Volume 22 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Valenti M, Perduca M, Romanelli M, Mottes M and Dalle Carbonare L: A potential role for astaxanthin in the treatment of bone diseases (Review). Mol Med Rep 22: 1695-1701, 2020.
APA
Valenti, M., Perduca, M., Romanelli, M., Mottes, M., & Dalle Carbonare, L. (2020). A potential role for astaxanthin in the treatment of bone diseases (Review). Molecular Medicine Reports, 22, 1695-1701. https://doi.org/10.3892/mmr.2020.11284
MLA
Valenti, M., Perduca, M., Romanelli, M., Mottes, M., Dalle Carbonare, L."A potential role for astaxanthin in the treatment of bone diseases (Review)". Molecular Medicine Reports 22.3 (2020): 1695-1701.
Chicago
Valenti, M., Perduca, M., Romanelli, M., Mottes, M., Dalle Carbonare, L."A potential role for astaxanthin in the treatment of bone diseases (Review)". Molecular Medicine Reports 22, no. 3 (2020): 1695-1701. https://doi.org/10.3892/mmr.2020.11284