Open Access

Roles of protein tyrosine phosphatases in hepatocellular carcinoma progression (Review)

  • Authors:
    • Yi-Li Chen
    • Ching-Chuan Hsieh
    • Pei-Ming Chu
    • Jing-Yi Chen
    • Yu-Chun Huang
    • Cheng-Yi Chen
  • View Affiliations

  • Published online on: January 19, 2023     https://doi.org/10.3892/or.2023.8485
  • Article Number: 48
  • Copyright : © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Hepatocellular carcinoma (HCC) represents almost 80% of all liver cancers, is the sixth most common cancer and is the second‑highest cause of cancer‑related deaths worldwide. Protein tyrosine phosphatases (PTPs), which are encoded by the largest family of phosphatase genes, play critical roles in cellular responses and are implicated in various signaling pathways. Moreover, PTPs are dysregulated and involved in various cellular processes in numerous cancers, including HCC. Kinases and phosphatases are coordinators that modulate cell activities and regulate signaling responses. There are multiple interacting signaling networks, and coordination of these signaling networks in response to a stimulus determines the physiological outcome. Numerous issues, such as drug resistance and inflammatory reactions in the tumor microenvironment, are implicated in cancer progression, and the role of PTPs in these processes has not been well elucidated. Therefore, the present review focused on discussing the relationship of PTPs with inflammatory cytokines and chemotherapy/targeted drug resistance, providing detailed information on how PTPs can modulate inflammatory reactions and drug resistance to influence progression in HCC.
View Figures
View References

Related Articles

Journal Cover

March-2023
Volume 49 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Hsieh C, Chu P, Chen J, Huang Y and Chen C: Roles of protein tyrosine phosphatases in hepatocellular carcinoma progression (Review). Oncol Rep 49: 48, 2023
APA
Chen, Y., Hsieh, C., Chu, P., Chen, J., Huang, Y., & Chen, C. (2023). Roles of protein tyrosine phosphatases in hepatocellular carcinoma progression (Review). Oncology Reports, 49, 48. https://doi.org/10.3892/or.2023.8485
MLA
Chen, Y., Hsieh, C., Chu, P., Chen, J., Huang, Y., Chen, C."Roles of protein tyrosine phosphatases in hepatocellular carcinoma progression (Review)". Oncology Reports 49.3 (2023): 48.
Chicago
Chen, Y., Hsieh, C., Chu, P., Chen, J., Huang, Y., Chen, C."Roles of protein tyrosine phosphatases in hepatocellular carcinoma progression (Review)". Oncology Reports 49, no. 3 (2023): 48. https://doi.org/10.3892/or.2023.8485