Open Access

The human microbiome links to prostate cancer risk and treatment (Review)

  • Authors:
    • Bowen Xia
    • Jingwei Wang
    • Dongxu Zhang
    • Xiaopeng Hu
  • View Affiliations

  • Published online on: May 4, 2023     https://doi.org/10.3892/or.2023.8560
  • Article Number: 123
  • Copyright: © Xia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Prostate cancer (Pca) is the second most common cancer type worldwide. Microorganisms colonized in different body parts may affect the development/progression and treatment of Pca through direct or indirect interactions. The composition of microorganisms in different colonization sites and their effects on Pca may differ. In recent years, several studies have focused on the differences in the microbiota of patients with Pca, and dysbiosis may affect the inflammatory status, hormone levels and microbial metabolites leading to Pca progression. However, little is known about the interaction between Pca treatment and microorganisms; for example, how androgen deprivation therapy and androgen receptor axis‑targeting therapeutics for Pca affect microbiota composition and metabolism, and how the microbiota affects treatment response in patients with Pca remain to be understood. The present review explored the current studies on the relevance of microbiota to Pca progression and treatment to provide direction for future microbiome‑Pca research. Due to the complexity of the potential interconnections between Pca and the microbiota, further investigation is critical.
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June-2023
Volume 49 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Xia B, Wang J, Zhang D and Hu X: The human microbiome links to prostate cancer risk and treatment (Review). Oncol Rep 49: 123, 2023
APA
Xia, B., Wang, J., Zhang, D., & Hu, X. (2023). The human microbiome links to prostate cancer risk and treatment (Review). Oncology Reports, 49, 123. https://doi.org/10.3892/or.2023.8560
MLA
Xia, B., Wang, J., Zhang, D., Hu, X."The human microbiome links to prostate cancer risk and treatment (Review)". Oncology Reports 49.6 (2023): 123.
Chicago
Xia, B., Wang, J., Zhang, D., Hu, X."The human microbiome links to prostate cancer risk and treatment (Review)". Oncology Reports 49, no. 6 (2023): 123. https://doi.org/10.3892/or.2023.8560