Journal Articles

Open Access

Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review)

Demetrios Petrakis, Denisa Margină, Konstantinos Tsarouhas, Fotios Tekos, Miriana Stan, Dragana Nikitovic, Demetrios Kouretas, Demetrios A. Spandidos, Aristidis Tsatsakis

Pages: 9-19 Published online on: 05 May 2020
Open Access

COVID‑19 in Northern Italy: An integrative overview of factors possibly influencing the sharp increase of the outbreak (Review)

Marina Goumenou, Dimosthenis Sarigiannis, Aristidis Tsatsakis, Ourania Anesti, Anca Oana Docea, Dimitrios Petrakis, Dimitris Tsoukalas, Ronald Kostoff, Valeri Rakitskii, Demetrios A. Spandidos, Michael Aschner, Daniela Calina

Pages: 20-32 Published online on: 16 April 2020
Open Access

Effect of VX‑765 on the transcriptome profile of mice spinal cords with acute injury

Jing Chen, Yu‑Qing Chen, Sai‑Nan Wang, Fei‑Xiang Duan, Yu‑Jiao Shi, Shu‑Qin Ding, Jian‑Guo Hu, He‑Zuo Lü

Pages: 33-42 Published online on: 05 May 2020
Open Access

Dehydrocorydaline inhibits the tumorigenesis of breast cancer MDA‑MB‑231 cells

Ying Huang, Hui Huang, Shiying Wang, Feixiang Chen, Gang Zheng

Pages: 43-50 Published online on: 05 May 2020
Open Access

MicroRNA‑19b inhibitors can attenuate the STAT3 signaling pathway in NPC C666‑1 cells

Li‑Hui Bian, Jing‑Ling Duan, Chen Zhou, Guo‑Wen Shen, Xiao‑Yu Wang, Yang Yang, Xiao‑Ling Zhang, Sheng‑Jun Xiao

Pages: 51-56 Published online on: 04 May 2020
Open Access

High expression of CDCA7 predicts tumor progression and poor prognosis in human colorectal cancer

Siman Li, Jiean Huang, Mengbin Qin, Jinxiu Zhang, Cun Liao

Pages: 57-66 Published online on: 22 April 2020
Open Access

miR‑133b affects cell proliferation, invasion and chemosensitivity in renal cell carcinoma by inhibiting the ERK signaling pathway

Yuan Xu, Yuan Ma, Xiao‑Ling Liu, Sheng‑Li Gao

Pages: 67-76 Published online on: 05 May 2020
Open Access

Low penetrance of hearing loss in two Chinese families carrying the mitochondrial tRNASer(UCN) mutations

Wei Peng, Yi Zhong, Xueyan Zhao, Jie Yuan

Pages: 77-86 Published online on: 30 April 2020

Expression profile of circular RNAs in the peripheral blood of neonates with hypoxic‑ischemic encephalopathy

Xiaohua Dong, Sisi Zhuang, Yun Huang, Xiaojing Yang, Yanrong Fu, Lingling Yu, Yingmin Zhao

Pages: 87-96 Published online on: 23 April 2020
Open Access

7ND protein exerts inhibitory effects on both osteoclast differentiation in vitro and lipopolysaccharide‑induced bone erosion in vivo

Weilin Long, Jingjing Quan, Yiwen Liu, Jing Li, Qimei Gong, Hongwei Jiang

Pages: 97-104 Published online on: 05 May 2020
Open Access

Comprehensive analysis of long non‑coding RNA using an associated competitive endogenous RNA network in Wilms tumor

Zhichao Wang, Huiyan Cheng, Lingli Qi, Dayun Sui

Pages: 105-116 Published online on: 05 May 2020
Open Access

Role of the microRNA‑214/Bax axis in the progression of acute liver failure

Shaohong Wu, Xiaoping Huang, Wei Sun, Li Chen, Yan Huang, Yan Wang, Erping Luo, Ailan Qin, Weifeng Zhao, Jianhe Gan

Pages: 117-126 Published online on: 05 May 2020
Open Access

High glucose contributes to the polarization of peritoneal macrophages to the M2 phenotype in vivo and in vitro

Jieshan Lin, Qingyu Kong, Wenke Hao, Wenxue Hu

Pages: 127-134 Published online on: 05 May 2020
Open Access

miR‑10a‑5p inhibits osteogenic differentiation of bone marrow‑derived mesenchymal stem cells

Yingjie Zhang, Lishu Zhou, Zhaoqiang Zhang, Fei Ren, Liangjiao Chen, Zedong Lan

Pages: 135-144 Published online on: 04 May 2020
Open Access

p53/PGC‑1α‑mediated mitochondrial dysfunction promotes PC3 prostate cancer cell apoptosis

Jiuling Li, Yany Li, Lanlan Chen, Bingbing Yu, Yanan Xue, Rui Guo, Jing Su, Yanan Liu, Liankun Sun

Pages: 155-164 Published online on: 05 May 2020
Open Access

MicroRNA‑125a‑mediated regulation of the mevalonate signaling pathway contributes to high glucose‑induced proliferation and migration of vascular smooth muscle cells

Dan Ye, Guo‑Hua Lou, Ai‑Chun Li, Feng‑Qin Dong, Guo‑Ping Chen, Wei‑Wei Xu, Yan‑Ning Liu, Shen‑Jiang Hu

Pages: 165-174 Published online on: 16 April 2020
Open Access

Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury

Chunyan Wang, Wenlin Yuan, Anmin Hu, Juan Lin, Zhengyuan Xia, Catherine F. Yang, Yalan Li, Zhongjun Zhang

Pages: 175-184 Published online on: 04 May 2020

Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer

Chun‑Chao Chang, Kuo‑Ching Chao, Chi‑Jung Huang, Chih‑Sheng Hung, Yen‑Chieh Wang

Pages: 185-192 Published online on: 22 April 2020
Open Access

Identification of novel USH2A mutations in patients with autosomal recessive retinitis pigmentosa via targeted next‑generation sequencing

Xiong Zhu, Xiao Li, Wanli Tian, Yeming Yang, Kuanxiang Sun, Shuzhen Li, Xianjun Zhu

Pages: 193-200 Published online on: 22 April 2020
Open Access

PNU282987 inhibits amyloid‑β aggregation by upregulating astrocytic endogenous αB‑crystallin and HSP‑70 via regulation of the α7AChR, PI3K/Akt/HSF‑1 signaling axis

Zhenkui Ren, Zhihui Dong, Peng Xie, Ju Lv, Yumei Hu, Zhizhong Guan, Chunlin Zhang, Wenfeng Yu

Pages: 201-208 Published online on: 05 May 2020
Open Access

Ischemic postconditioning attenuates the inflammatory response in ischemia/reperfusion myocardium by upregulating miR‑499 and inhibiting TLR2 activation

Xin‑Yue Zhang, Zheng Huang, Qing‑Jie Li, Guo‑Qiang Zhong, Jian‑Jun Meng, Dong‑Xiao Wang, Rong‑Hui Tu

Pages: 209-218 Published online on: 30 April 2020
Open Access

Urethral meatus stricture BOO stimulates bladder smooth muscle cell proliferation and pyroptosis via IL‑1β and the SGK1‑NFAT2 signaling pathway

Wang Kai, Chen Lin, Yang Jin, He Ping‑Lin, Liu Xun, Amend Bastian, Stenzl Arnulf, Xing Sha‑Sha, Luo Xu, Cui Shu

Pages: 219-226 Published online on: 24 April 2020
Open Access

Elevated plasma levels of exosomal BACE1‑AS combined with the volume and thickness of the right entorhinal cortex may serve as a biomarker for the detection of Alzheimer's disease

Dewei Wang, Ping Wang, Xianli Bian, Shunliang Xu, Qingbo Zhou, Yuan Zhang, Mao Ding, Min Han, Ling Huang, Jianzhong Bi, Yuxiu Jia, Zhaohong Xie

Pages: 227-238 Published online on: 05 May 2020
Open Access

Petatewalide B alleviates oxygen‑glucose deprivation/reoxygenation‑induced neuronal injury via activation of the AMPK/Nrf2 signaling pathway

Sun Young Park, Min Hyun Cho, Mei Li, Ke Li, Geuntae Park, Young‑Whan Choi

Pages: 239-246 Published online on: 16 April 2020
Open Access

Ginsenoside Rb1 reduces H2O2‑induced HUVEC dysfunction by stimulating the sirtuin‑1/AMP‑activated protein kinase pathway

Zhenda Zheng, Min Wang, Cailian Cheng, Dinghui Liu, Lin Wu, Jieming Zhu, Xiaoxian Qian

Pages: 247-256 Published online on: 28 April 2020
Open Access

Excessive production of mitochondrion‑derived reactive oxygen species induced by titanium ions leads to autophagic cell death of osteoblasts via the SIRT3/SOD2 pathway

Siqian Wang, Jingyuan Yang, Tingting Lin, Shengbing Huang, Jianfeng Ma, Xin Xu

Pages: 257-264 Published online on: 24 April 2020
Open Access

Hypoxia/reoxygenation activates the JNK pathway and accelerates synovial senescence

Yubiao Zhang, Siqi Zhou, Weisong Cai, Guangtao Han, Jianping Li, Mao Chen, Haohuan Li

Pages: 265-276 Published online on: 30 April 2020
Open Access

Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2

Wei Wu, Yuqiang Shang, Shiling Dai, Chunjun Yu, Jie Wang

Pages: 277-285 Published online on: 24 April 2020
Open Access

Identification, characterization and microRNA expression profiling of side population cells in human oral squamous cell carcinoma Tca8113 cell lines

Wei Luo, Rong‑Sen Liu, Ling‑Ling E, Yang Bai, Xiang‑Pan Kong, Hua‑Wei Liu, Hao Wu, Hong‑Chen Liu

Pages: 286-296 Published online on: 16 April 2020
Open Access

Mutation spectrum analysis of 29 causative genes in 43 Chinese patients with congenital hypothyroidism

Huijuan Wang, Xiaohong Kong, Yanrui Pei, Xuemei Cui, Yijie Zhu, Zixuan He, Yanxia Wang, Lirong Zhang, Lixia Zhuo, Chao Chen, Xiaoli Yan

Pages: 297-309 Published online on: 16 April 2020
Open Access

Ginkgolide B inhibits hydrogen peroxide‑induced apoptosis and attenuates cytotoxicity via activating the PI3K/Akt/mTOR signaling pathway in H9c2 cells

Jin Liu, Peng Wu, Zhihui Xu, Jun Zhang, Jiabao Liu, Zhijian Yang

Pages: 310-316 Published online on: 30 April 2020
Open Access

Phosphorylated GSK‑3β protects stress‑induced apoptosis of myoblasts via the PI3K/Akt signaling pathway

Meixi Liu, Xia Huang, Yihong Tian, Xiao Yan, Fang Wang, Junbo Chen, Qi Zhang, Qiang Zhang, Xiao Yuan

Pages: 317-327 Published online on: 30 April 2020
Open Access

MicroRNA‑138‑5p regulates the development of spinal cord injury by targeting SIRT1

Jinchuan Chen, Rujie Qin

Pages: 328-336 Published online on: 16 April 2020
Open Access

Combination of HSP90 and autophagy inhibitors promotes hepatocellular carcinoma apoptosis following incomplete thermal ablation

Fen Chen, Haiyang Xie, Haiwei Bao, Laurencia Violetta, Shusen Zheng

Pages: 337-343 Published online on: 21 April 2020
Open Access

Ginsenoside metabolite 20(S)‑protopanaxadiol promotes neural stem cell transition from a state of proliferation to differentiation by inducing autophagy and cell cycle arrest

Shali Chen, Ji He, Xiyuan Qin, Tiao Luo, Aparna Pandey, Jijia Li, Suyou Liu, Junli Luo, Qi Wang, Zhiyong Luo

Pages: 353-361 Published online on: 21 April 2020
Open Access

Immunotherapy of Bacillus Calmette‑Guérin by targeting macrophages against bladder cancer in a NOD/scid IL2Rg‑/‑ mouse model

Qing‑Long Tan, Chang‑Yuan Zhou, Lin Cheng, Min Luo, Chun‑Ping Liu, Wen‑Xing Xu, Xian Zhang, Xing Zeng

Pages: 362-370 Published online on: 22 April 2020
Open Access

IgE and IgG4 responses to shrimp allergen tropomyosin and its epitopes in patients from coastal areas of northern China

Junpu Li, Zhiwei Li, Deyu Kong, Shaoshen Li, Yang Yu, Huiqiang Li

Pages: 371-379 Published online on: 21 April 2020
Open Access

HBV DNA integrates into upregulated ZBTB20 in patients with hepatocellular carcinoma

Zebao He, Jiansheng Zhu, Jinggang Mo, Haihong Zhao, Qiuyue Chen

Pages: 380-386 Published online on: 16 April 2020
Open Access

The sympathetic transmitter norepinephrine inhibits VSMC proliferation induced by TGFβ by suppressing the expression of the TGFβ receptor ALK5 in aorta remodeling

Zhipeng Hu, Bowen Li, Zhiwei Wang, Xiaoping Hu, Min Zhang, Ruoshi Chen, Qi Wu, Fangyuan Jia

Pages: 387-397 Published online on: 22 April 2020
Open Access

Mammalian STE20‑like kinase 1 regulates pancreatic cancer cell survival and migration through Mfn2‑mediated mitophagy

Yongli Hu, Bing Wang, Lie Wang, Zhenran Wang, Zhiyuan Jian, Lin Deng

Pages: 398-404 Published online on: 28 April 2020
Open Access

BPA disrupts 17‑estradiol‑mediated hepatic protection against ischemia/reperfusion injury in rat liver by upregulating the Ang II/AT1R signaling pathway

Yili Zhang, Yu Shi, Zeyu Li, Liankang Sun, Mei Zhang, Liang Yu, Shengli Wu

Pages: 416-422 Published online on: 16 April 2020
Open Access

Integrated analysis of a lncRNA‑mRNA network reveals a potential mechanism underlying necrotizing enterocolitis

Wenjuan Chen, Xiangyun Yan, Tian Tian, Ru Yan, Xingyun Wang, Zhangbin Yu, Yingzheng Li, Le Zhang, Shuping Han

Pages: 423-435 Published online on: 21 April 2020
Open Access

Vitamin C decreases VEGF expression levels via hypoxia‑inducible factor‑1α dependent and independent pathways in lens epithelial cells

Lin Zhao, Jianming Wang, Yi Zhang, Lijun Wang, Miao Yu, Feng Wang

Pages: 436-444 Published online on: 30 April 2020
Open Access

Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons

Man Yang, Naqi Lian, Yang Yu, Yaoqi Wang, Keliang Xie, Yonghao Yu

Pages: 445-453 Published online on: 05 May 2020
Open Access

Upregulation of microRNA‑1 inhibits proliferation and metastasis of breast cancer

Jing Peng, Chenwei Yuan, Ziping Wu, Yan Wang, Wenjin Yin, Yanping Lin, Liheng Zhou, Jinsong Lu

Pages: 454-464 Published online on: 04 May 2020
Open Access

WAVE3 upregulation in esophageal squamous cell carcinoma and its effect on the migration of human esophageal cancer cell lines in vitro

Xuebing Li, Jie Geng, Zhenzhen Ren, Chao Xiong, Yuqing Li, Hongchun Liu

Pages: 465-473 Published online on: 05 May 2020
Open Access

MicroRNA‑21 serves an important role during PAOO‑facilitated orthodontic tooth movement

Yuanyuan Zhang, Yulou Tian, Xiaofeng Yang, Zhenjin Zhao, Cuijuan Feng, Yang Zhang

Pages: 474-482 Published online on: 04 May 2020
Open Access

MicroRNA‑93 promotes angiogenesis and attenuates remodeling via inactivation of the Hippo/Yap pathway by targeting Lats2 after myocardial infarctionω

Chengjie Ma, Peipei Peng, Yan Zhou, Tianya Liu, Lijuan Wang, Chen Lu

Pages: 483-493 Published online on: 21 April 2020
Open Access

Identification of key miRNAs and genes for mouse retinal development using a linear model

Yishen Wang, Xiao Wang, Yukang Jiang, Ruyuan Liu, Di Cao, Jianying Pan, Yan Luo

Pages: 494-506 Published online on: 21 April 2020
Open Access

Heptapeptide HP3 acts as a potent inhibitor of experimental imiquimod‑induced murine psoriasis and impedes the trans‑endothelial migration of mononuclear cells

Ernesto A. Vázquez‑Sánchez, José S. Mendoza‑Figueroa, Guadalupe Gutiérrez‑Gonzalez, Luis A. Zapi‑Colín, Azael Torales‑Cardeña, Paola E. Briseño‑Lugo, Iván  Díaz‑Toalá, Juan C. Cancino‑Diaz, Sonia M. Pérez‑Tapia, Mario   E. Cancino‑Diaz, Fernando Gómez‑Chávez, Sandra Rodríguez‑Martínez

Pages: 507-515 Published online on: 05 May 2020
Open Access

A novel heterozygous mutation in the HMBS gene in a patient with acute intermittent porphyria and posterior reversible encephalopathy syndrome

Yang Yang, Xiyun Chen, Huijuan Wu, Hua Peng, Wenjing Sun, Bin He, Zhengang Yuan

Pages: 516-524 Published online on: 04 May 2020
Open Access

3‑N‑Butyphthalide improves learning and memory in rats with vascular cognitive impairment by activating the SIRT1/BDNF pathway

Ayong Tian, Wan Li, Qing Zai, Hui Li, Rong‑Wei Zhang

Pages: 525-533 Published online on: 04 May 2020

miR‑96 exerts an oncogenic role in the progression of cervical cancer by targeting CAV‑1

Yong Chen, Changqing Liu, Bingfan Xie, Shangqiu Chen, Yuan Zhuang, Shaoxia Zhang

Pages: 543-550 Published online on: 30 April 2020

A HGF‑derived peptide suppresses EMT in human lens epithelial cells via the TGF‑β/Smad and Akt/mTOR signaling pathways

Xiaobo Huang, Yulan Wang, Pei Zhang, Haidong Zou

Pages: 551-558 Published online on: 28 April 2020

Hypoxia‑inducible factor‑1α regulates Lipin1 differently in pre‑adipocytes and mature adipocytes

Yoshitaka Kihira, Yoshino Fujimura, Shuhei Tomita, Toshiaki Tamaki, Eiji Sato

Pages: 559-565 Published online on: 16 April 2020

Juglone potentiates BRAF inhibitor‑induced apoptosis in melanoma through reactive oxygen species and the p38‑p53 pathway

Zheng Li, Xiao Liu, Ming Li, Jingxiu Chai, Shan He, Jinfeng Wu, Jinhua Xu

Pages: 566-574 Published online on: 28 April 2020

Effect of SIRT1 activators and inhibitors on CD44+/CD133+‑enriched non‑small cell lung cancer cells

Zuhal Eroglu, Ceren Erdem, Gulperi Oktem, Vildan Bozok Cetintas, Zekeriya Duzgun

Pages: 575-581 Published online on: 04 May 2020

Anti‑inflammatory effects of the NF‑κB inhibitor dehydroxymethylepoxyquinomicin on ARPE‑19 cells

Yoshimasa Ando, Yasuhiko Sato, Akihiko Kudo, Takayo Watanabe, Akito Hirakata, Annabelle A. Okada, Kazuo Umezawa, Hiroshi Keino

Pages: 582-590 Published online on: 04 May 2020
Journal Cover

July-2020
Volume 22 Issue 1

Print ISSN: 1791-2997
Online ISSN: 1791-3004

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