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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June-2019 Volume 54 Issue 6

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article Open Access

INKA2, a novel p53 target that interacts with the serine/threonine kinase PAK4

Yu‑Yu Liu, Chizu Tanikawa, Koji Ueda, Koichi Matsuda
Pages: 1907-1920
Published online on: 15 April 2019

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Article Open Access

miR‑9 depletion suppresses the proliferation of osteosarcoma cells by targeting p16

Song Gao, Jianchao Wang, Shujian Tian, Jianping Luo
Pages: 1921-1932
Published online on: 12 April 2019

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Article Open Access

Icariin enhances the chemosensitivity of cisplatin‑resistant ovarian cancer cells by suppressing autophagy via activation of the AKT/mTOR/ATG5 pathway

Shaoyan Jiang, Hong Chang, Shaojie Deng, Danyi Fan
Pages: 1933-1942
Published online on: 15 April 2019

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Article Open Access

Immunoglobulin‑like transcript 4 and human leukocyte antigen‑G interaction promotes the progression of human colorectal cancer

Zhaoyang Cai, Lu Wang, Yali Han, Wenwen Gao, Xiaojuan Wei, Rumei Gong, Mingliang Zhu, Yuping Sun, Shuwen Yu
Pages: 1943-1954
Published online on: 22 March 2019

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Article Open Access

The targeting of MTDH by miR‑145‑5p or miR‑145‑3p is associated with prognosis and regulates the growth and metastasis of prostate cancer cells Corrigendum in /10.3892/ijo.2023.5477

Dong Pan, Zhaohui Jia, Wensheng Li, Zhongling Dou
Pages: 1955-1968
Published online on: 12 April 2019

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Article Open Access

Salidroside suppresses the growth and invasion of human osteosarcoma cell lines MG63 and U2OS in vitro by inhibiting the JAK2/STAT3 signaling pathway

Lintuo Huang, Zhengxiang Huang, Wenjun Lin, Lu Wang, Xiongbai Zhu, Xin Chen, Shengwu Yang, Chen Lv
Pages: 1969-1980
Published online on: 10 April 2019

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Article Open Access

Overexpressing miR‑335 inhibits DU145 cell proliferation by targeting early growth response 3 in prostate cancer

Peng Zhang, Xiaojie Yang, Li Wang, Dong Zhang, Qidong Luo, Binxian Wang
Pages: 1981-1994
Published online on: 09 April 2019

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Article Open Access

Harmine induces anticancer activity in breast cancer cells via targeting TAZ

Yu Ding, Jinrong He, Juan Huang, Tong Yu, Xiaoyan Shi, Tianzhu Zhang, Ge Yan, Shanshan Chen, Caixia Peng
Pages: 1995-2004
Published online on: 09 April 2019

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Article Open Access

TGF-β-induced long non-coding RNA MIR155HG promotes the progression and EMT of laryngeal squamous cell carcinoma by regulating the miR-155-5p/SOX10 axis

Weina Cui, Wenxia Meng, Lei Zhao, Huan Cao, Weiwei Chi, Baoshan Wang
Pages: 2005-2018
Published online on: 12 April 2019

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Article Open Access

MAT2B promotes proliferation and inhibits apoptosis in osteosarcoma by targeting epidermal growth factor receptor and proliferating cell nuclear antigen

Yuan Yuan, Yonggang Wang, Zimei Liu, Yong Sun, Yang Yao, Wenxi Yu, Zan Shen
Pages: 2019-2029
Published online on: 27 March 2019

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Article Open Access

Phospho‑STAT1 expression as a potential biomarker for anti‑PD‑1/anti‑PD‑L1 immunotherapy for breast cancer

Yuko Nakayama, Kosaku Mimura, Tomoaki Tamaki, Kensuke Shiraishi, Ley‑Fang Kua, Vivien Koh, Masato Ohmori, Ayako Kimura, Shingo Inoue, Hirokazu Okayama, Yoshiyuki Suzuki, Tadao Nakazawa, Daisuke Ichikawa, Koji Kono
Pages: 2030-2038
Published online on: 10 April 2019

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Article Open Access

Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma

Nicholas J. Eustace, Joshua C. Anderson, Catherine P. Langford, Hoa Q. Trummell, Patricia H. Hicks, John S. Jarboe, James A. Mobley, Anita B. Hjelmeland, James R. Hackney, Rune T. Pedersen, Kadia Cosby, G. Yancey Gillespie, James A. Bonner, Christopher D. Willey
Pages: 2039-2053
Published online on: 29 March 2019

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Article Open Access

Simvastatin delays castration‑resistant prostate cancer metastasis and androgen receptor antagonist resistance by regulating the expression of caveolin‑1

Yingying Gao, Luo Li, Ting Li, Lei Ma, Mengjuan Yuan, Wei Sun, Hong Lin Cheng, Lingfang Niu, Zhongbo Du, Zhen Quan, Yanru Fan, Jiaxin Fan, Chunli Luo, Xiaohou Wu
Pages: 2054-2068
Published online on: 05 April 2019

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Article Open Access

Antitumor activity of ginsenoside Rg3 in melanoma through downregulation of the ERK and Akt pathways

Lingbin Meng, Rui Ji, Xiaoming Dong, Xiaochun Xu, Ying Xin, Xin Jiang
Pages: 2069-2079
Published online on: 16 April 2019

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Article Open Access

Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells

Shinji Ohkubo, Romina Mancinelli, Selenia Miglietta, Alessandra Cona, Riccardo Angelini, Gianluca Canettieri, Demetrios A. Spandidos, Eugenio Gaudio, Enzo Agostinelli
Pages: 2080-2094
Published online on: 10 April 2019

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Article Open Access

HOXA6 inhibits cell proliferation and induces apoptosis by suppressing the PI3K/Akt signaling pathway in clear cell renal cell carcinoma

Feixiang Wu, Shasha Wu, Hang Tong, Weiyang He, Xin Gou
Pages: 2095-2105
Published online on: 16 April 2019

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Article

Benzyl isothiocyanate suppresses IGF1R, FGFR3 and mTOR expression by upregulation of miR-99a-5p in human bladder cancer cells

Ji-Fan Lin, Te-Fu Tsai, Yi-Chia Lin, Hung-En Chen, Kuang-Yu Chou, Thomas I-Sheng Hwang
Pages: 2106-2116
Published online on: 26 March 2019

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Article

TGF-β1 protects colon tumor cells from apoptosis through XAF1 suppression

Jung Rock Moon, Shin Ju Oh, Chang Kyun Lee, Sung Gil Chi, Hyo Jong Kim
Pages: 2117-2126
Published online on: 09 April 2019

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Article

C‑mannosylation of R‑spondin2 activates Wnt/β‑catenin signaling and migration activity in human tumor cells

Hayato Mizuta, Kenta Kuga, Takehiro Suzuki, Yuki Niwa, Naoshi Dohmae, Siro Simizu
Pages: 2127-2138
Published online on: 01 April 2019

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Article

Droplet digital PCR as a novel system for the detection of microRNA‑34b/c methylation in circulating DNA in malignant pleural mesothelioma

Hiroki Sato, Junichi Soh, Keisuke Aoe, Nobukazu Fujimoto, Shin Tanaka, Kei Namba, Hidejiro Torigoe, Kazuhiko Shien, Hiromasa Yamamoto, Shuta Tomida, Hiroyuki Tao, Kazunori Okabe, Takumi Kishimoto, Shinichi Toyooka
Pages: 2139-2148
Published online on: 01 April 2019

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Article

Potentiation of mitotane action by rosuvastatin: New insights for adrenocortical carcinoma management

Geoffrey Boulate, Larbi Amazit, Annabelle Naman, Atmane Seck, Angelo Paci, Anne Lombes, Eric Pussard, Eric Baudin, Marc Lombes, Ségolène Hescot
Pages: 2149-2156
Published online on: 03 April 2019

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Article

Long non‑coding RNA H19 regulates cell growth and metastasis via the miR‑22‑3p/Snail1 axis in gastric cancer

Li Gan, Lin Lv, Shengtao Liao
Pages: 2157-2168
Published online on: 04 April 2019

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Article

Forkhead‑box A1 regulates tumor cell growth and predicts prognosis in colorectal cancer

Young‑Lan Park, Seung‑Hun Kim, Sun‑Young Park, Min‑Woo Jung, Sang‑Yoon Ha, Jung‑Ho Choi, Dae‑Seong Myung, Sung‑Bum Cho, Wan‑Sik Lee, Hyun‑Soo Kim, Young‑Eun Joo
Pages: 2169-2178
Published online on: 04 April 2019

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Article

Toll‑like receptor 4 plays a tumor‑suppressive role in cutaneous squamous cell carcinoma

Erina Mikami, Mitsuhiro Kudo, Ryuji Ohashi, Kiyoko Kawahara, Yoko Kawamoto, Kiyoshi Teduka, Takenori Fujii, Taeko Kitamura, Shoko Kure, Kousuke Ishino, Takashi Sakatani, Ryuichi Wada, Hidehisa Saeki, Zenya Naito
Pages: 2179-2188
Published online on: 17 April 2019

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Article

Targeted therapy based on p53 reactivation reduces both glioblastoma cell growth and resistance to temozolomide

Iris Maria Forte, Paola Indovina, Carmelina Antonella Iannuzzi, Donatella Cirillo, Domenico Di Marzo, Daniela Barone, Francesca Capone, Francesca Pentimalli, Antonio Giordano
Pages: 2189-2199
Published online on: 16 April 2019

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Article

Inflammatory responses induced by Helicobacter pylori on the carcinogenesis of gastric epithelial GES‑1 cells

Jianjun Wang, Yongliang Yao, Qinghui Zhang, Shasha Li, Lijun Tang
Pages: 2200-2210
Published online on: 09 April 2019

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Article

miR‑802 inhibits the aggressive behaviors of non‑small cell lung cancer cells by directly targeting FGFR1 Retraction in /10.3892/ijo.2022.5389

Jiexia Zhang, Jun Li, Shiyue Li, Chengzhi Zhou, Yinyin Qin, Xiaoxiang Li
Pages: 2211-2221
Published online on: 29 March 2019

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Article

Tumor‑suppressive microRNA‑223 targets WDR62 directly in bladder cancer

Satoshi Sugita, Hirofumi Yoshino, Masaya Yonemori, Kazutaka Miyamoto, Ryosuke Matsushita, Takashi Sakaguchi, Toshihiko Itesako, Shuichi Tatarano, Masayuki Nakagawa, Hideki Enokida
Pages: 2222-2236
Published online on: 22 March 2019

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Article

Evaluation of pro‑ and anti‑tumor effects induced by three colony‑stimulating factors, G‑CSF, GM‑CSF and M‑CSF, in bladder cancer cells: Is G‑CSF a friend of bladder cancer cells?

Shunta Hori, Makito Miyake, Sayuri Onishi, Yosuke Morizawa, Yasushi Nakai, Yoshihiro Tatsumi, Kenta Onishi, Kota Iida, Daisuke Gotoh, Yoshitaka Itami, Nobumichi Tanaka, Kiyohide Fujimoto
Pages: 2237-2249
Published online on: 04 April 2019

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Article

CDC20 associated with cancer metastasis and novel mushroom‑derived CDC20 inhibitors with antimetastatic activity

Shujie Cheng, Victor Castillo, Daniel Sliva
Pages: 2250-2256
Published online on: 18 April 2019

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Correction Open Access

[Corrigendum] LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling

Qungen Xiao, Minhai Dong, Fangling Cheng, Feng Mao, Weifeng Zong, Kang Wu, Heping Wang, Ruifan Xie, Baofeng Wang, Ting Lei, Dongsheng Guo
Pages: 2257-2257
Published online on: 02 April 2019

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Correction Open Access

[Corrigendum] Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV

Fengting Liu, Lili Li, Yanxia Li, Xiaofang Ma, Xiyun Bian, Xiaozhi Liu, Guowen Wang, Dianying Zhang
Pages: 2258-2258
Published online on: 18 March 2019

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Journal Cover
April-2026 Volume 68 Issue 4

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article Open Access

Overcoming acquired doxorubicin resistance of ovarian carcinoma cells by verapamil‑mediated promotion of DNA damage‑driven cytotoxicity

Elvira Mukinovic, Sina Federmann, Larissa Messling, Marlena Sekeres, Julia Mann, Lena Abbey, Matthias U. Kassack, Gerhard Fritz
Article Number: 48
Published online on: 24 February 2026

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Review Open Access

IL‑6: A key player in the EGFR‑TKI‑resistant tumor microenvironment and its therapeutic implications (Review)

Qi Wei, Chengming Huang, Yuanyuan Zhang, Hao Zeng, Chang Qi, Sihan Tan, Weimin Li, Panwen Tian, Yalun Li
Article Number: 47
Published online on: 20 February 2026

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Review

Mechanisms of chemoresistance in diffuse large B‑cell lymphoma and novel therapeutic strategies (Review)

Mengdi Wan, Xi Wang, Bin Luo, Huangming Hong, Yizhun Zhu, Tongyu Lin
Article Number: 46
Published online on: 20 February 2026

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Article Open Access

lncRNA AL445238.2‑USP4 axis regulates cell survival and stemness in colon cancer

Hualong Lin, Jieni Feng, Peirui Chen, Jialin Hu, Linjia Zhu, Shaofei Yuan
Article Number: 45
Published online on: 20 February 2026

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Review Open Access

Beyond the membrane: Internalization and compartmentalization of insulin‑like growth factor 1 receptor signaling in cancer pathogenesis and treatment (Review)

Tiehong Zhang, Ling Li, Chunling Du
Article Number: 44
Published online on: 18 February 2026

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Review Open Access

Role and underlying mechanisms of miR‑200 family in breast cancer (Review)

Jiaqi Liu, Hua Du, Yingxu Shi
Article Number: 43
Published online on: 16 February 2026

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Review Open Access

Role of SPAG6 in regulating physiological functions and tumorigenesis (Review)

Yu Luo, Qibing Yan, Pohao Zhang, Hui Xu, Rong Zhang, Ruihe Wang, Yongkang Wu
Article Number: 42
Published online on: 12 February 2026

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Correction Open Access

[Corrigendum] Podoplanin‑mediated TGF‑β‑induced epithelial‑mesen‑ chymal transition and its correlation with bHLH transcription factor DEC in TE‑11 cells

Yunyan Wu, Qiang Liu, Xu Yan, Yukio Kato, Makiko Tanaka, Sadaki Inokuchi, Tadashi Yoshizawa, Satoko Morohashi, Hiroshi Kijima
Article Number: 41
Published online on: 11 February 2026

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Review Open Access

Emerging roles of RNA m6A modification in multiple myeloma pathogenesis and treatment resistance (Review)

Yasen Maimaitiyiming, Shuoyang Hu, Die Bai, Yingchao Guan, Na Bu, Wenhui Hao, Mayila Maimaiti
Article Number: 40
Published online on: 10 February 2026

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Correction Open Access

[Corrigendum] The p85α regulatory subunit of PI3K mediates cAMP‑PKA and retinoic acid biological effects on MCF7 cell growth and migration

Caterina F. Donini, Erika Di Zazzo, Candida Zuchegna, Marina Di Domenico, Sonia D'Inzeo, Arianna Nicolussi, Enrico V. Avvedimento, Anna Coppa, Antonio Porcellini
Article Number: 39
Published online on: 02 February 2026

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Review Open Access

Advances in the study of the breast carcinoma exosomal microRNAs: From basic mechanisms to clinical applications (Review)

Zhi-Min Chen, Peng Huang, Dun-Yang Yang, Shu Lin, Si-Qing Cai
Article Number: 38
Published online on: 30 January 2026

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Retraction Open Access

[Retracted] Matrix metalloproteinase‑1 promotes prostate tumor growth and metastasis

Sai Murali Krishna Pulukuri, Jasti S. Rao
Article Number: 37
Published online on: 19 January 2026

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Journal Cover
May-2026 Volume 68 Issue 5

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article Open Access

Smoking promotes colorectal cancer via the CKAP2L/AREG axis

Shasha Wu, Feixiang Wu, Xiaoqing Li, Zhihang Jiang, Fuqiang Liu, Zheng Jiang
Article Number: 59
Published online on: 13 March 2026

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Diverse roles of SERPINE1 in regulating cellular proliferation and invasion

Wei Wang, Pengfei Zhao, Tian Wang, Weijing Wu, Jing Li, Qiang Huang, Jing Momo
Article Number: 58
Published online on: 13 March 2026

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Therapeutic implications of targeting cancer testis antigen MAGEA1 in cervical cancer

Ayoung Kim, Jina Kim, Woori Kwak, Kyumin Mo, Soohyun Choe, Minyeong Jeon, Jisun Lee, Jun-Won Yun, Hyunho Yoon
Article Number: 57
Published online on: 12 March 2026

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Review Open Access

Enolase 1: A paradigm of metabolic enzyme moonlighting in tumorigenesis (Review)

Xiaochen Ni, Mingsi Zhang, Kaiyuan Zhang, Chuhang Wang, Jianing Guo, Wei Fan, Linfeng Zheng, Tao Jiang, Guangji Zhang
Article Number: 56
Published online on: 12 March 2026

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Correction Open Access

[Corrigendum] Influence of MLH1 on colon cancer sensitivity to poly(ADP‑ribose) polymerase inhibitor combined with irinotecan

Lucio Tentori, Carlo Leonetti, Alessia Muzi, Annalisa Susanna Dorio, Manuela Porru, Susanna Dolci, Federica Campolo, Patrizia Vernole, Pedro Miguel Lacal, Françoise Praz, Grazia Graziani
Article Number: 55
Published online on: 09 March 2026

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Review Open Access

Pancreatic cancer EMT‑targeted therapy: Molecular mechanisms and clinical translation (Review)

Guirui Zhang, Yongmo Wu, Mingzhen Wei, Shupeng Huang, Qinghao Wang, Zhengyi Xie, Sisi Liu, Jin Wang
Article Number: 54
Published online on: 06 March 2026

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Retraction Open Access

[Retracted] Design, synthesis and preclinical evaluation of NRC‑AN‑019

Kompella Amala, A.k.S. Bhujanga Rao, Bharathi Gorantla, Christopher S.  Gondi, Jasti S. Rao
Article Number: 53
Published online on: 04 March 2026

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Article Open Access

FOXM1 inhibitor, RCM‑1, enhances venetoclax mediated apoptosis through downregulation of ATP2B4 in rhabdomyosarcoma

Nawal Merjaneh, Ying-Wei Lan, Zicheng Deng, Johnny Donovan, Guolun Wang, Jonathan Do, Tiffany Juan, Xiaomei Xia, Vladimir V. Kalinichenko, Tanya V. Kalin
Article Number: 52
Published online on: 04 March 2026

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Correction Open Access

[Corrigendum] Leptin promotes breast cancer cell migration and invasion via IL‑18 expression and secretion

Kuangfa Li, Lan Wei, Yunxiu Huang, Yang Wu, Min Su, Xueli Pang, Nian Wang, Feihu Ji, Changli Zhong, Tingmei Chen
Article Number: 51
Published online on: 26 February 2026

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Article Open Access

RNA‑binding protein DAZAP1 promotes gastric cancer metastasis by enhancing NOTCH1 and JAG1 mRNA stability

Siyang Peng, Yidong Chen, Jieke Wu, Xiaodong Huang, Linjie Hong, Yanci Xie, Yuting Lei, Xiangyang Wei, Ping Yang, Jieming Zhang, Qiong Yang, Guangnan Liu, Aimin Li, Side Liu, Jiaying Li, Weiyu Dai, Yanfeng Hu, Jing Wang, Jing Xiong, Jide Wang
Article Number: 50
Published online on: 26 February 2026

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Retraction Open Access

[Retracted] Knockdown of MALAT1 inhibits osteosarcoma progression via regulating the miR‑34a/cyclin D1 axis

Guangchao Duan, Chuanlin Zhang, Changke Xu, Chao Xu, Lei Zhang, Yan Zhang
Article Number: 49
Published online on: 24 February 2026

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