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Discovery of novel cancer therapeutic targets and drugs

Lead Editor: Professor FUWEN YUAN, Shanghai University of Traditional Chinese Medicine, China

Guest Editors:
  • Dr Fengjing Jia ,  Shanghai University of Traditional Chinese Medicine ,  China

Despite significant progress made towards the identification of novel therapeutic targets and the discovery of potent chemotherapeutic agents, cancer incidence and mortality are rapidly growing worldwide, and it is one of the leading causes of death. Targeted therapies are one of the primary treatment strategies for cancers, especially after the cancer progresses to metastasis status. However, the intrinsic off-target toxicity of the current anticancer drugs as well as the rapid genetic evolution of cancer cells limited the therapeutic efficiency and led to the cancer eventually developing drug resistance. Thus, the identification of novel cancer therapeutic targets and the screening and development of cancer-targeted drugs are urgently needed. The aim of this special issue is to invite submissions of original articles and reviews tackling the discovery of novel cancer therapeutics targets and new drugs with potential anticancer activities. Studies employing in vitro cancer cell models and in vivo animal models with mechanism studies are welcome.


Submission deadline: 16/03/2026 | Views:
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December-2025 Volume 30 Issue 6

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Journal Metrics

Impact Factor: 2.2

CiteScore: 4.6

CiteScore Rank: Q2: #178/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.568

SCImago Journal Rank (SJR): 0.663

Article Open Access

SBEM confers paclitaxel resistance in breast cancer via DUSP16‑mediated MAPK/AMPK pathway activation

Liang Liu, Ning Lu, Xiaomei Liu, Qingting Yi, Shengnan Li, Jie Wen, Huijuan Sun, Yuanming Du
Article Number: 607
Published online on: 21 October 2025

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Article Open Access

Role and molecular mechanisms of hypoxia‑derived exosomal miR‑301a on gemcitabine resistance in pancreatic cancer

Weiwei Qu, Wanyi Tan, Mengjie Ye, Weixiang Tang, Lijun Zhang, Guangtao Luo
Article Number: 606
Published online on: 21 October 2025

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Case Report

Multiple primary malignant neoplasms and long‑term survival: A case report

Biao Xie, Ke Huang, Shuibo Zhu
Article Number: 605
Published online on: 21 October 2025

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Article Open Access

m6A RNA methylation regulator‑associated genes drive metastasis and immune cell infiltration in skin cutaneous melanoma

Yi Geng, Sijia Zhao, Tianxiang Geng, Xiu-Lian Xu, Xiaodie Zhang
Article Number: 604
Published online on: 21 October 2025

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Article Open Access

Analysis of the efficacy and prognostic factors of gemcitabine combined with oxaliplatin in non‑Hodgkin lymphoma

Xiaobo Zhang, Guang Li, Feng Liu, Rui Shi, Jing Wen, Wen Wu, Jinqian Dai
Article Number: 603
Published online on: 21 October 2025

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Article Open Access

Stimulator of interferon genes signaling network‑driven prognostic signature for pancreatic cancer: Hub gene discovery with multimodal validation

Wenjing Yu, Junqun Liao, Jiayan Li, Yongquan Wu
Article Number: 602
Published online on: 21 October 2025

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Article Open Access

Gamma Knife consolidation therapy improves prognosis in patients with advanced epidermal growth factor receptor‑mutant lung adenocarcinoma treated with first‑generation epidermal growth factor receptor‑tyrosine kinase inhibitors

Bin Xu, Donghui Lu, Dongmei Wang, Huan Ma, Zhijie Li, Lijie Zhang, Meiqin Liu, Donglai Lv
Article Number: 601
Published online on: 17 October 2025

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Article Open Access

Identification of EFNA3 as candidate prognosis marker and potential therapeutic target for adrenocortical carcinoma

Yanghao Tai, Xinzhe Liu, Yifan Zhou, Jiwen Shang
Article Number: 600
Published online on: 17 October 2025

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Article Open Access

Inhibition of apoptosis in breast cancer cells by si‑FoxO3a through the protein digestion and absorption signaling pathway

Liying Sun, Zhongxu Wang, Yanxi Liu, Jiaxin Lv, Xiaotong Shao, Haoming Tang, Cheng Hu, Liang Cao, Yundong Zhao, Shuang Chen
Article Number: 599
Published online on: 17 October 2025

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Review Open Access

CCL2/CCR2 signaling pathway in tumorigenesis and metastasis (Review)

Ya Zhang, Bin Fan, Hang Yang, Gangxian Chen, Zhou Huang, Ying Li, Xiang Ma, Tiying Wang, Weiquan Wang, Linhao Cai, Lei Han, Yan Liu, Dongqi Li, Xianwei Chen, Yihao Yang, Zuozhang Yang
Article Number: 598
Published online on: 17 October 2025

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Article Open Access

Mechanistic role of the ILK‑S100A4 axis in modulating invasion and EMT in salivary adenoid cystic carcinoma

Yang Yang, Jia-Xin Luo, Yuan-Yang Li, Ke-Hong Guo, Lin Ye, Dan Zhao
Article Number: 597
Published online on: 16 October 2025

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Case Report Open Access

Submandibular adenoid cystic carcinoma presenting with liver metastasis as the initial symptom: A case report

Tianyi Li, Tingyao Ma, Yue Zhao, Shujing Zhang, Guoliang Yang, Xuelian Wang, Xudong Wang, Mingzhu Wang, Xi Zhao, Hongfei Liu, Jun Wu, Xiaoli Zhao, Xiaohong Chen
Article Number: 596
Published online on: 15 October 2025

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Case Report Open Access

Esophageal perforation in a patient with lung cancer after administration of bevacizumab combined with radiotherapy and chemotherapy: A case report

Qiang Jia, Yun-Long Zhou, Lan-Ying Duan, Hui-Chao Li, Gaowu Hu
Article Number: 595
Published online on: 15 October 2025

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Case Report

Gastrointestinal metastasis in prostate cancer and therapeutic implications: A case report

Marie-Anne Audisio, Anh-Tuan Nguyen, Evelyne Peroux, Jean-Laurent Lamboley, David Lussato, Marie Pautas, Hugo Picchi, Audrey Le Roy, Aline Barhli, Marie Dusaud, Hélène Vanquaethem, Antoine Schernberg, Carole Helissey
Article Number: 594
Published online on: 15 October 2025

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Review Open Access

Advancements in research on the role of the key glycolytic enzyme hexokinase 2 in the regulation of tumor immune evasion (Review)

Yiyang Qian, Xiaodan Zhu, Dong Niu, Quan Tang, Chunhui Jin
Article Number: 593
Published online on: 14 October 2025

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Review Open Access

Cellular senescence in cancer: Unveiling dual roles, tumor microenvironment dynamics and therapeutic innovations (Review)

Yatsu Lam, Jiaming Gu, Peihao Yin
Article Number: 592
Published online on: 14 October 2025

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Article Open Access

A novel defined cuproptosis‑related signature score to predict prognosis and immunotherapy efficacy in pancreatic cancer

Weiyu Ge, Yongchao Wang, Daiyuan Shentu, Ming Yue, Yanling Wang
Article Number: 591
Published online on: 14 October 2025

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Article Open Access

Multi‑omics and experimental validation unveil BDNF as a diagnostic biomarker and therapeutic target in endoplasmic reticulum stress‑driven lung adenocarcinoma: Therapeutic potential of Esketamine

Xiujuan Deng, Yujun Tan, Guangbo Tan, Heli Ning
Article Number: 590
Published online on: 14 October 2025

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Review Open Access

Role of signaling pathways in lung cancer development and advances in targeted therapies (Review)

Zhang Tao, Weiwei Shao, Haiyang Zhou, Shujing Xia, Jie Zeng, Jing Ren, Xueyang Wang, Hua Zhu
Article Number: 589
Published online on: 14 October 2025

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Article Open Access

Bortezomib overcomes TRAIL resistance in Burkitt's lymphoma by enhancing apoptosis via reactive oxygen species‑mediated DR5 upregulation and MAPK pathway activation

Jiajie Chen, Yujia You, Wei Zhao, Yichuan Zhou, Shiqi Pu, Xiaoyu Bai, Ping Yang, Minhui Li
Article Number: 588
Published online on: 14 October 2025

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Article Open Access

Prognostic role and mutational characteristics of N6‑methyladenosine‑related genes in lung adenocarcinoma

Jiahao Yang, Xiangpeng Chu, Zihao Chen, Yi Long, Jinghua Chen
Article Number: 587
Published online on: 14 October 2025

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Retraction Open Access

[Retracted] Nerve growth factor and its receptors on onset and diagnosis of ovarian cancer

Xiaolin Yu, Zhaoxia Liu, Rui Hou, Yijun Nie, Rensheng Chen
Article Number: 586
Published online on: 13 October 2025

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Case Report

Severe fluoropyrimidine toxicity in a patient with rectal adenocarcinoma with DPYD c.2846A>T heterozygous mutation: A case report

Sezai Tunc, Ogur Karhan
Article Number: 585
Published online on: 13 October 2025

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Article

Prognostic value of the postoperative CALLY index in T1/T2 clear cell renal cell carcinoma

Hiroshi Hirata, Nakanori Fujii, Takanori Tokunaga, Kosuke Shimizu, Keita Kobayashi, Koji Shiraishi
Article Number: 584
Published online on: 10 October 2025

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Review

Role and mechanistic study of long non‑coding RNA maternally expressed gene 3 in gastric cancer (Review)

Buyun Jia, Hui Cheng, Peizheng Yang, Xiangyu Wang, Shanshan Li, Jinghui Wang
Article Number: 583
Published online on: 10 October 2025

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Article Open Access

Survival and recurrence characteristics of patients with esophageal cancer with a pathological complete response after neoadjuvant immunochemotherapy followed by surgery: A multicenter propensity score matching study

Feng Wang, Xiangyang Yu, Dongjie Yan, Lei Yang, Jianfei Zhu, Ran Yang, Yi Han
Article Number: 582
Published online on: 10 October 2025

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Article

Machine learning‑based programmed cell death‑related index to predict prognosis and immunotherapy response in skin cutaneous melanoma

Xinyi Wang, Yuzhi Zheng, Shan Yang, Hongli Si, Wenqiu Chen, Siyuan Shen
Article Number: 581
Published online on: 09 October 2025

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Correction Open Access

[Corrigendum] UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells

Yan Qing Gong, Ding Peng, Xiang Hui Ning, Xin Yu Yang, Xue Song Li, Li Qun Zhou, Ying Lu Guo
Article Number: 580
Published online on: 09 October 2025

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Article Open Access

Dynamic changes in tumor blood flow during chemotherapy: Implications in customized treatment for pancreatic cancer

Hiromitsu Maehira, Takeru Maekawa, Yoshihisa Tsuji, Haruki Mori, Nobuhito Nitta, Takeshi Sonoda, Reiko Otake, Soichiro Tani, Katsushi Takebayashi, Masatsugu Kojima, Sachiko Kaida, Toru Miyake, Masaji Tani
Article Number: 579
Published online on: 08 October 2025

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Review Open Access

Abnormal metabolic networks participate in invasion and migration of tumors of the digestive system (Review)

Jianxin Li, Weidong Zhang
Article Number: 578
Published online on: 08 October 2025

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Article Open Access

A clinical feature‑based nomogram for the personalized prediction of radioactive iodine therapy outcomes in patients with papillary thyroid carcinoma

Jingjia Cao, Huazhen Liang, Xiang Li, Xin Guan, Hao Xu
Article Number: 577
Published online on: 07 October 2025

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Review Open Access

Immune checkpoint biology in hepatocellular carcinoma (Review)

Ching-Hua Hsieh, Pei-Chin Chuang
Article Number: 576
Published online on: 07 October 2025

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Article Open Access

Preoperative PD‑1+CD4+ lymphocytes reflect immunological and physical frailty and are associated with postoperative infectious complications following gastrectomy for gastric cancer

Naoyuki Uehata, Hironori Tsujimoto, Nozomi Ito, Toru Kubo, Hiromi Miyazaki, Hiroyuki Horiguchi, Keita Kouzu, Seiichiro Fujishima, Takafumi Suzuki, Risa Kariya, Asuma Ide, Yoshihisa Yaguchi, Hideki Ueno
Article Number: 575
Published online on: 07 October 2025

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Case Report Open Access

Primary retroperitoneal squamous cell carcinoma: A case report

Fang Zhang, Yuan Gui, Jing Zhang
Article Number: 574
Published online on: 06 October 2025

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Case Report

Papillary thyroid carcinoma with metastasis to the femur as a rare cause of femoral fracture: A case report

Jiahua Chen, Mi Zhang
Article Number: 573
Published online on: 06 October 2025

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Retraction Open Access

[Retracted] Effect of interventional embolotherapy on FHIT and p16 expression in hepatocellular carcinoma patients

Wei Xu, Xiaogai Qi, Xia Wang, Jize Sun
Article Number: 572
Published online on: 06 October 2025

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Article Open Access

GBP5 as a prognostic biomarker associated with immune cell infiltration, migration and invasion in clear cell renal cell carcinoma

Xiaobao Cheng, Shujiang Ye, Xiang Xu, Shuo Yang, Wei Zhao, Zhenquan Lu, Caiyong Lai
Article Number: 571
Published online on: 03 October 2025

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Article Open Access

FBXL22, a circadian‑regulated immune biomarker with pan‑cancer prognostic value and therapeutic potential in prostate cancer

Jin Liu, Maoyuan Feng, Jian Zhou, Shijie Yang, Yue Shi, Wenping Li
Article Number: 570
Published online on: 03 October 2025

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Article Open Access

Deciphering site‑specific histopathological parameters with potential clinical value in head and neck squamous cell carcinomas

Sofia-Eleni Tzorakoleftheraki, Vassiliki Kotoula, Georgios Karakatsoulis, Konstantinos Markou, Stavroula Pervana, Konstantinos Vlachtsis, Sofia Chrisafi, Amanda Psyrri, George Fountzilas, Prodromos Hytiroglou, Triantafyllia Koletsa
Article Number: 569
Published online on: 03 October 2025

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Article Open Access

Non‑surgical breast‑conserving treatment using Kochi oxydol‑radiation therapy for unresectable carcinomas II for patients with stage 0 to IIIC breast cancer

Akihiro Hori, Taiju Shimbo, Jun Ikenaga, Takaaki Itami, Mari Mukai, Kazuma Kobata, Takashi Ogawa, Ayaka Kihara, Mio Nakata, Yuuki Yoshino, Satoshi Takeno, Kanabu Nawa, Hiroto Yoshioka, Keiji Nihei, Hironori Akiyama, Ken Yoshida, Kosei Kimura, Mitsuhiko Iwamoto
Article Number: 568
Published online on: 02 October 2025

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Review Open Access

Pathogenic role and therapeutic targets of nuclear factor‑κB signaling pathway in cancer (Review)

Xing Li, Lu Chen, Ming Zeng, Jialun Deng, Fan Chen, Lingying Yu, Mingyue Ao
Article Number: 567
Published online on: 02 October 2025

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Case Report Open Access

Multimodal treatment for multifocal metastatic maxillary adenoid cystic carcinoma: A case report

Bin He, Jie Shi, Qing-Yan Yan, Ling Zhang
Article Number: 566
Published online on: 01 October 2025

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Review Open Access

Roles of β‑catenin protein in non‑small cell lung cancer (Review)

Lina Peng, Ran Gao, Liping Han, Tian Fu, Cuixia Bian
Article Number: 565
Published online on: 01 October 2025

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Article Open Access

Application value and safety of trilaciclib in first‑line chemotherapy combined with immunotherapy for extensive‑stage small cell lung cancer: A real‑world study

Yanping Cui, Hongjuan Zhang, Lizhi Wang, Xingyi Lou
Article Number: 564
Published online on: 01 October 2025

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Case Report Open Access

Multicentric Castleman disease detected during the evaluation of tongue cancer: A case report

Yuta Yasui, Satoshi Shimohama, Manabu Yamada, Kenichiro Suga, Masafumi Nishikawa, Seiji Asoda
Article Number: 563
Published online on: 01 October 2025

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Case Report Open Access

Sequential microwave ablation combined with radioactive iodine‑125 seed implantation successfully cured multiple metastases of gallbladder cancer: A case report

Wenjun Li, Yanwei Chen, Shuangshuang Zhao, Maohui An, Huajiao Zhao, Yun Cai, Jiayan Bao, Jiwen Qian, Baoding Chen
Article Number: 562
Published online on: 01 October 2025

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Article Open Access

Signature of immune infiltration‑related ferroptosis genes to predict the prognosis of patients with osteosarcoma

Ling-Rong Zeng, Guang-Hui Zhu, Hai-Bo Mei, Ge Yang
Article Number: 561
Published online on: 01 October 2025

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Article Open Access

Anticancer effects of the Kiperin Purple Collagen complex: Evidence from HCT116 and MIA PaCa‑2 cell models

Lutfiye Karcioglu Batur, Cuneyd Yavas, Nezih Hekim
Article Number: 560
Published online on: 01 October 2025

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Expression of Concern Open Access

[Expression of Concern] microRNA‑99a is downregulated and promotes proliferation, migration and invasion in non‑small cell lung cancer A549 and H1299 cells

Changjin Chen, Ziyi Zhao, Yu Liu, Dezhi Mu
Article Number: 559
Published online on: 01 October 2025

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Article Open Access

Leucine‑rich repeat‑containing G protein‑coupled receptor 4 promotes proliferation, invasion and migration, and inhibits apoptosis in non‑small cell lung cancer cells

Xiaoyu Duan, Xiangsen Liu, Yuchen Shan, Songfu Zhou, Ming Lou, Zhaojia Gao, Kai Yuan
Article Number: 558
Published online on: 30 September 2025

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Retraction Open Access

[Retracted] Treatment with a selenium‑platinum compound induced T‑cell acute lymphoblastic leukemia/lymphoma cells apoptosis through the mitochondrial signaling pathway

Feifei Wu, Wei Cao, Huaping Xu, Mingxia Zhu, Jing Wang, Xiaoyan Ke
Article Number: 557
Published online on: 29 September 2025

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Article Open Access

Serum fucosylated receptor expression‑enhancing protein 5 as a biomarker for early stage pancreatic cancer

Kazuyuki Sogawa, Riko Yonekubo, Momori Shimizu, Satoshi Muraoka, Jun Adachi, Shigetsugu Takano, Hirotaka Takizawa, Masayuki Ohtsuka, Takeshi Tomonaga
Article Number: 556
Published online on: 26 September 2025

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Case Report Open Access

Primary squamous thyroid cancer: A case report

Shuchang Dong, Xuewen Wang, Ziwen Zhou, Lingjun Feng, Qingliang Xu
Article Number: 555
Published online on: 26 September 2025

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Article Open Access

Transarterial infusion chemotherapy for severe hepatic dysfunction and poor performance status in diffuse hepatic metastasis: A case report

Xiao-Chun Chen, Xian-Qin Li, Yi Liu, Xu Zhang, Chuan Lin, Zhi-Ping Yuan
Article Number: 554
Published online on: 25 September 2025

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Article Open Access

Real‑world investigation for camrelizumab combined with apatinib in patients with advanced hepatocellular carcinoma

Liyang Yin, Yuanyuan Shi, Ruijia An, Yajing Hao, Haoran Huo, Jiadong Xue, Ruifeng Qin, Zengjiang Yuan
Article Number: 553
Published online on: 25 September 2025

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Article Open Access

Impact of SAMHD1 and phosphorylated ATM levels on the progression and prognosis of patients with soft tissue sarcoma

Yun Jae Kim, Young Jae Moon, Ae Ri Ahn, Ho Sung Park, Myoung Ja Chung, Woo Sung Moon, Kyu Yun Jang, Kyoung Min Kim
Article Number: 552
Published online on: 24 September 2025

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Article Open Access

Methionine‑MAT2A‑SAM axis controls lipid levels by regulating ACSL4

Chaoyi Xia, Jingshu Min
Article Number: 551
Published online on: 24 September 2025

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Article Open Access

Favorable survival of patients with nasopharyngeal carcinoma associated with metachronous multiple primary cancers: A retrospective study

Xin Huang, Ying Kong, Tianyu Wu, Zhen Meng, Min Kang
Article Number: 550
Published online on: 23 September 2025

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Article Open Access

Protein arginine methyltransferase 7 regulates the cell cycle and promotes the progression of prostate cancer

Hongyuan Wan, Hangshen Zhou, Jiandong Gui, Dongjie Yang, Rong Wang, Jiang Ni, Sheng Wu, Yan Qin, Qiaowei Qi, Lijie Zhu, Ninghan Feng, Yuanyuan Mi
Article Number: 549
Published online on: 23 September 2025

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Case Report Open Access

Adrenal cyst misdiagnosed with cystic renal cell carcinoma: A case report

Xin Huang, Mengyu Zhang, Yijun Zhan, Ce Chen, Xinhua Zhang, Yaozhong Xu
Article Number: 548
Published online on: 23 September 2025

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Correction Open Access

[Corrigendum] Characteristics of primary side population cervical cancer cells

Zhen-Tong Wei, Xiao-Wei Yu, Jia-Xue He, Yan Liu, Song-Ling Zhang
Article Number: 547
Published online on: 23 September 2025

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Article Open Access

Clinicopathological characteristics and treatment of patients with colorectal neuroendocrine carcinoma: A retrospective study of 157 cases

Meng Dai, Shuang Sun, Xin Liu, Hulun Li
Article Number: 546
Published online on: 23 September 2025

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Peripheral blood tumor marker levels can indicate the location of lung cancer metastasis

Jiahao Wang, Xiaobo Wang, Yingjia Mao, Hongmei Niu, Fuqian Zhao, Daofu Shen, Lei Wang
Article Number: 545
Published online on: 23 September 2025

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Retrospective comparisons of the dosimetric differences between coplanar and non‑coplanar volume‑modulated arc therapy in patients with pediatric brainstem glioma

Zhanquan Lei, Junjie Jing, Yuequan Shi, Bo Gao, Kongfeng Shao, Yiqun Liu, Junjin Yan
Article Number: 544
Published online on: 22 September 2025

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Preoperative peripheral blood routine indicators as predictors of prognosis and diagnosis in glioma under the 2021 World Health Organization classification

Qing Yang, Jiaying Ni, Jiandong Zhu, Xiao Fan, Xing Cheng, Yun Yu, Zhumei Shi, Yingyi Wang, Yongping You
Article Number: 543
Published online on: 22 September 2025

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Case Report Open Access

Efficacy of combined immunotherapy and chemotherapy in recurrent non‑small cell lung cancer during durvalumab maintenance therapy: A case report

Yuki Maze, Takahiro Mitsumura, Hiroshi Nakahama, Tatsuya Kato, Yui Takahashi, Yuichiro Nei, Shigeo Hanada, Atsushi Miyamoto, Hironori Uruga, Takeshi Fujii, Meiyo Tamaoka
Article Number: 542
Published online on: 22 September 2025

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Efficacy and safety of fruquintinib combined with immunotherapy in later‑line treatment of metastatic colorectal cancer

Ying Peng, Sheng Li, Liangjun Zhu
Article Number: 541
Published online on: 22 September 2025

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Prognostic value of M2 macrophage‑related genes and their importance in the immunotherapy response in hepatocellular carcinoma

Aiping Wang, Xiaojing Li, Zi Wang, Lan Chen
Article Number: 540
Published online on: 22 September 2025

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Histone acetyltransferase 1 promotes ovarian cancer progression by regulating cell proliferation and the cell cycle

Xiao Han, Ling Liu, Jing Li, Yunxiao Zhi, Lanlan Zhao, Limin Yuan, Xuezhe Ouyang, Jie Liu
Article Number: 539
Published online on: 22 September 2025

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Retraction Open Access

[Retracted] MicroRNA‑320a downregulation mediates human liver cancer cell proliferation through the Wnt/β‑catenin signaling pathway

Caicheng Lu, Zengwei Liao, Minxian Cai, Guirong Zhang
Article Number: 538
Published online on: 22 September 2025

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January-2026 Volume 31 Issue 1

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Impact Factor: 2.2

CiteScore: 4.6

CiteScore Rank: Q2: #178/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.568

SCImago Journal Rank (SJR): 0.663

Article

Survival outcomes and prognostic factors in temporal bone malignancies: A retrospective cohort of 20 patients

Liming Gao, Wenyang Zhang, Ting Ye, Rui Guo, Yin Xia
Article Number: 25
Published online on: 06 November 2025

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Real‑world performance of the machine learning‑based prediction of chemotherapy‑associated adverse effects in lung cancer

Sha Huang, Zhengwei Huang, Zhoujian Sun, Tianao Xie, Xingyu Zhu, Sheng Lu, Zhengxing Huang, Jian Hu, Zhengfu He
Article Number: 24
Published online on: 06 November 2025

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Long non‑coding RNA RP11‑196G11.6 inhibits neuroblastoma progression by regulating the miR‑376a‑3p/RYBP signaling axis

Jie Zhang, Kai Huang, Jianwu Zhou, Wenge Liao, Fei Li, Zhenzhen Zhao, Shan Wang
Article Number: 23
Published online on: 06 November 2025

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Review

Cervical cancer immune microenvironment: Mechanisms of HPV‑mediated immune evasion and advances in immunotherapy (Review)

Xiaojing Zhou, Ren An, Xiangjuan Li
Article Number: 22
Published online on: 05 November 2025

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Mesenchymal stem cell‑derived exosomes: Regulators of progression and suppression in pancreatic cancer (Review)

Haoyan Zhuang, Xuewen Shi
Article Number: 21
Published online on: 04 November 2025

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Advancements in research regarding the influence of the tumor microenvironment on the proliferation and metastasis of osteosarcoma (Review)

Tao Shi, Jianping Kang, Qiyang Wang, Jiamei Song, Xiaofeng He
Article Number: 20
Published online on: 04 November 2025

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Enhanced expression of CXCL1 in renal cell carcinoma facilitates tumor cell malignancy via PI3K/AKT‑dependent mechanisms

Shiliang Gui, Hongrui Zhang, Huiting Xiao, Chen Liu, Yuhang Wang, Baotian Wang, Hongbin Qiu
Article Number: 19
Published online on: 03 November 2025

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Case Report Open Access

Photodynamic therapy with local‑targeted perfusion for recurrent tracheal adenoid cystic carcinoma achieving 12‑year survival: A case report

Luoqi Yang, Lu Wang, Hongwu Wang, Heng Zou
Article Number: 18
Published online on: 03 November 2025

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Retraction Open Access

[Retracted] Tunicamycin inhibits progression of glioma cells through downregulation of the MEG‑3‑regulated wnt/β‑catenin signaling pathway

Xin Li, Lei Xue, Qin Peng
Article Number: 17
Published online on: 03 November 2025

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Article Open Access

Non‑targeted metabolomics reveals diagnostic biomarker in the plasma of patients with lung cancer

Yan Liu, Yangmin Li, Haijun Hou, Yanyan Dong, Haitong Tian, Yanan Zhao, Ke Li, Jiayuan Zhou, Fujie Song, Yan Li
Article Number: 16
Published online on: 31 October 2025

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Primary pulmonary angiosarcoma: A case study with genetic insights and potential therapeutic targets

Yanling Zhu, Chunfang Guo
Article Number: 15
Published online on: 31 October 2025

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Review Open Access

Progress in the treatment of esophageal neuroendocrine carcinoma (Review)

Jie Shi, Bin He, Heng Di Zhang, Chao Yang Jiang, Ling Zhang
Article Number: 14
Published online on: 31 October 2025

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Sensitive cell‑free DNA assay for accurate detection of RAS and BRAF mutations in liquid biopsies of patients with metastatic colorectal cancer: Final results of the multicentric ColoBEAM study

Alexandre Harlé, Céline Gavoille, Olivier Bouché, Meher Ben Abdelghani, Jérome Plaza, Dominique Spaeth, Axelle Boudrant, François Ghiringhelli, Anne-Laure Villing, Christophe Borg, Marie Rouyer, Marie Husson, Pauline Gilson, Julia Salleron, Aurélien Lambert, Jean-Louis Merlin
Article Number: 13
Published online on: 30 October 2025

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Article

Single‑center retrospective study of factors associated with early discontinuation of tumor‑treating fields therapy in glioblastoma

Kohei Suzuki, Koichiro Sato, Shohei Nagasaka, Ryo Miyaoka, Takeshi Saito, Yoshiteru Nakano, Nayuta Higa, Toshiaki Akahane, Akihide Tanimoto, Ryosuke Hanaya, Junkoh Yamamoto
Article Number: 12
Published online on: 29 October 2025

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Review Open Access

Clinical value of emerging peripheral blood protein biomarkers in prostate cancer (Review)

Mengli Chen, Feng Wang, Weixi Wang, Kangle Feng, Kaihua Xiang, Xubo Gong, Zhihua Tao, Weiwei Liu
Article Number: 11
Published online on: 29 October 2025

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Intratumoral and peritumoral radiomics of MRI predict pathological differentiation in patients with rectal cancer

Huanhui Liu, Hanjing Zhang, Qian Zou, Jianquan Yang
Article Number: 10
Published online on: 29 October 2025

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Retraction Open Access

[Retracted] Peritumoral activated hepatic stellate cells are associated with hepatic recurrence for resectable colorectal adenocarcinoma liver metastasis following resection

Li Deng, Taiyuan Li, Yuanyuan Liao, Shuang Liu, Zhen Xie, Zhixiang Huang, Hua Dai, Jianfeng Li, Xiong Lei
Article Number: 9
Published online on: 27 October 2025

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Case Report Open Access

Combined BRAF/MEK inhibition for BRAF‑mutant melanoma brain metastases in pregnancy: A case report

Jaroslav Melus, Michaela Jezberova, Silvia Mikulajova, Katarina Komaromy Gerincova, Martin Karlik, Igor Straka, Marek Krivosik, Peter Valkovic, Gabriela Timarova
Article Number: 8
Published online on: 24 October 2025

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Case Report Open Access

Synchronous rectal and endometrial cancer: A case report and literature review

Zhuofan Li, Li Peng, Qing Su, Beige Zong
Article Number: 7
Published online on: 24 October 2025

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Article

Predictive significance of thoracic skeletal muscle nutritional status for radiotherapy survival in elderly patients with esophageal squamous cell carcinoma

Shuqin Liu, Qi Li, Dongmei Luo, Caixia Jia, Dingqiang Peng, Guihong Liu
Article Number: 6
Published online on: 24 October 2025

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Review Open Access

Ribosome‑binding protein 1: A multidimensional regulator of cancer progression and a novel target for precision therapy (Review)

Ho Huang, Jia Ouyang
Article Number: 5
Published online on: 23 October 2025

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Case Report Open Access

Brain metastasis of ovarian cancer >20 years after initial diagnosis: A case report

Chihiro Ishizawa, Kazunari Miyazawa, Misaki Tani, Kazuaki Neriishi, Yukari Kambe, Akira Tsuchiya
Article Number: 4
Published online on: 23 October 2025

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Article Open Access

Investigating the roles of microRNAs associated with cancer stem cells, drug resistance, metastasis and recurrence in hepatocellular carcinoma: A systematic review, network analysis and experimental verification

Yuanyuan Jiang, Xiaoning Zhu, Qinghua Peng, Paniz Zarghami Dastjerdi, Mengyun Peng, Ding Zheng, Xiaodong Wang, Yoke Kqueen Cheah, Jing Wang
Article Number: 3
Published online on: 23 October 2025

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Case Report Open Access

Advanced dual primary male breast cancer and lung cancer: A case report and literature review

Xiaoxiao Xing, Junyi Li, Yue Wang, Shiyun Zhang, Jun Li, Yun Wang, Dongpo Zhang, Daixiang Liao
Article Number: 2
Published online on: 22 October 2025

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Retraction Open Access

[Retracted] Tumor necrosis factor‑related apoptosis‑inducing ligand inhibits proliferation and induces apoptosis of prostate and bladder cancer cells

Lin Hao, Yan Zhao, Zhi-Gang Li, Hou-Guang He, Qing Liang, Zhi-Guo Zhang, Zhen-Duo Shi, Pei-Ying Zhang, Cong-Hui Han
Article Number: 1
Published online on: 22 October 2025

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