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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
February-2017 Volume 39 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

The role of sphingolipid signalling in diabetes‑associated pathologies (Review)

Mei Li Ng, Carol Wadham, Olga A. Sukocheva
Pages: 243-252
Published online on: 11 January 2017

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Review

PI3K/AKT signaling mediated by G protein‑coupled receptors is involved in neurodegenerative Parkinson's disease (Review)

Noriko Nakano, Satoru Matsuda, Mayuko Ichimura, Akari Minami, Mako Ogino, Toshiyuki Murai, Yasuko Kitagishi
Pages: 253-260
Published online on: 16 December 2016

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Review

Roles of oncogenes and tumor-suppressor genes in osteoclastogenesis (Review)

Akari Minami, Mako Ogino, Noriko Nakano, Mayuko Ichimura, Atsuko Nakanishi, Toshiyuki Murai, Yasuko Kitagishi, Satoru Matsuda
Pages: 261-267
Published online on: 04 January 2017

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Article Open Access

Construction of an miRNA-regulated drug-pathway network reveals drug repurposing candidates for myasthenia gravis

Yuze Cao, Xiaoyan Lu, Jianjian Wang, Huixue Zhang, Zhaojun Liu, Si Xu, Tianfeng Wang, Shangwei Ning, Bo Xiao, Lihua Wang
Pages: 268-278
Published online on: 11 January 2017

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Article Open Access

miR-628-3p regulates osteoblast differentiation by targeting RUNX2: Possible role in atrophic non-union

Hua Chen, Xinran Ji, Fei She, Yuan Gao, Peifu Tang
Pages: 279-286
Published online on: 28 December 2016

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Article Open Access

Transcriptome reveals the overexpression of a kallikrein gene cluster (KLK1/3/7/8/12) in the Tibetans with high altitude-associated polycythemia

Kang Li, Luobu Gesang, Zeng Dan, Lamu Gusang
Pages: 287-296
Published online on: 14 December 2016

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Article Open Access

Ulinastatin post-treatment attenuates lipopolysaccharide-induced acute lung injury in rats and human alveolar epithelial cells

Yunpeng Luo, Wen Che, Mingyan Zhao
Pages: 297-306
Published online on: 13 December 2016

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Article Open Access

Matrine induces the apoptosis of fibroblast-like synoviocytes derived from rats with collagen-induced arthritis by suppressing the activation of the JAK/STAT signaling pathway

Yongsheng Yang, Qiumei Dong, Rongheng Li
Pages: 307-316
Published online on: 29 December 2016

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Article Open Access

IL-1β impedes the chondrogenic differentiation of synovial fluid mesenchymal stem cells in the human temporomandibular joint

Wenjing Liu, Yangpeng Sun, Yiqing He, Hong Zhang, Youhua Zheng, Yu Yao, Zhiguang Zhang
Pages: 317-326
Published online on: 15 December 2016

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Article Open Access

Alterations in splenic function and gene expression in mice with depressive-like behavior induced by exposure to corticosterone

Heqin Zhan, Feng Huang, Fulin Yan, Zhenghang Zhao, Jixia Zhang, Taizhen Cui, Fan Yang, Guangfan Hai, Xiaoman Jia, Yongji Shi
Pages: 327-336
Published online on: 05 January 2017

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Article Open Access

Redistribution of adrenomedullary nicotinic acetylcholine receptor subunits and the effect on circulating epinephrine levels in a murine model of acute asthma

Xi Chen, Juntao Feng, Chengping Hu, Qingwu Qin, Yuanyuan Li, Ling Qin
Pages: 337-346
Published online on: 23 December 2016

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Article Open Access

The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration

Cuicui Li, Lei Chang, Zhiquan Chen, Zhongzhong Liu, Yanfeng Wang, Qifa Ye
Pages: 347-356
Published online on: 11 January 2017

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Article Open Access

Effect of Annexin A1 gene on the proliferation and invasion of esophageal squamous cell carcinoma cells and its regulatory mechanisms

Gaohua Han, Kaijin Lu, Junxing Huang, Jun Ye, Shengbin Dai, Yunyao Ye, Lixin Zhang
Pages: 357-363
Published online on: 28 December 2016

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Article Open Access

Identification of antibiotic resistance genes in the multidrug-resistant Acinetobacter baumannii strain, MDR-SHH02, using whole-genome sequencing

Hualiang Wang, Jinghua Wang, Peijuan Yu, Ping Ge, Yanqun Jiang, Rong Xu, Rong Chen, Xuejie Liu
Pages: 364-372
Published online on: 30 December 2016

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Article Open Access

Microarray analysis of circular RNA expression patterns in polarized macrophages

Yingying Zhang, Yao Zhang, Xueqin Li, Mengying Zhang, Kun Lv
Pages: 373-379
Published online on: 11 January 2017

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Article

Cytoprotective effects of esculetin against oxidative stress are associated with the upregulation of Nrf2-mediated NQO1 expression via the activation of the ERK pathway

Min Ho Han, Cheol Park, Dae‑Sung Lee, Su‑Hyun Hong, Il‑Whan Choi, Gi‑Young Kim, Sung Hyun Choi, Jung‑Hyun Shim, Jung‑Il Chae, Young Hyun Yoo, Yung Hyun Choi
Pages: 380-386
Published online on: 16 December 2016

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Article

5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells

Kunihiro Ueta, Junkoh Yamamoto, Tohru Tanaka, Yoshiteru Nakano, Takehiro Kitagawa, Shigeru Nishizawa
Pages: 387-398
Published online on: 28 December 2016

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Article

Morin exerts cytoprotective effects against oxidative stress in C2C12 myoblasts via the upregulation of Nrf2-dependent HO-1 expression and the activation of the ERK pathway Corrigendum in /10.3892/ijmm.2025.5555

Moon Hee Lee, Min Ho Han, Dae-Sung Lee, Cheol Park, Su-Hyun Hong, Gi-Young Kim, Sang Hoon Hong, Kyoung Seob Song, Il-Whan Choi, Hee-Jae Cha, Yung Hyun Choi
Pages: 399-406
Published online on: 23 December 2016

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Article

Wheat-bran autolytic peptides containing a branched-chain amino acid attenuate non-alcoholic steatohepatitis via the suppression of oxidative stress and the upregulation of AMPK/ACC in high-fat diet-fed mice

Takumi Kawaguchi, Takato Ueno, Yoichi Nogata, Masako Hayakawa, Hironori Koga, Takuji Torimura
Pages: 407-414
Published online on: 14 December 2016

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Article

High-resolution melting analysis for rapid and sensitive NOTCH1 screening in chronic lymphocytic leukemia

Jing-Jing Xu, Fei-Rong Yao, Min Jiang, You-Tao Zhang, Feng Guo
Pages: 415-422
Published online on: 05 January 2017

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Article

BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury

Yin Yang, Chunyang Guo, Bo Liao, Junjun Cao, Chen Liang, Xijing He
Pages: 423-429
Published online on: 27 December 2016

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Article

Inhibitory effects of alpha-lipoic acid on oxidative stress in the rostral ventrolateral medulla in rats with salt-induced hypertension

Yu‑Peng Huang, Hong‑Yan Jin, Hui‑Ping Yu
Pages: 430-436
Published online on: 30 December 2016

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Article

Resistance of interleukin-6 to the extracellular inhibitory environment promotes axonal regeneration and functional recovery following spinal cord injury

Gang Yang, Wen-Yuan Tang
Pages: 437-445
Published online on: 05 January 2017

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Article

ISG15 inhibits cancer cell growth and promotes apoptosis

Mei-Juan Zhou, Fang-Zhi Chen, Han-Chun Chen, Xin-Xing Wan, Xi Zhou, Qian Fang, Dian-Zheng Zhang
Pages: 446-452
Published online on: 30 December 2016

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Article

Hepatic inflammatory cytokine production can be regulated by modulating sphingomyelinase and ceramide synthase 6

Min Hee Kim, Hee Kyung Ahn, Eun‑Ji Lee, Su‑Jeong Kim, Ye‑Ryung Kim, Joo‑Won Park, Woo‑Jae Park
Pages: 453-462
Published online on: 22 December 2016

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Article

Identification of potential drug targets based on a computational biology algorithm for venous thromboembolism

Ruiqiang Xie, Lei Li, Lina Chen, Wan Li, Binbin Chen, Jing Jiang, Hao Huang, Yiran Li, Yuehan He, Junjie Lv, Weiming He
Pages: 463-471
Published online on: 14 December 2016

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Article

Effect of glucosamine on expression of type II collagen, matrix metalloproteinase and sirtuin genes in a human chondrocyte cell line

Mamoru Igarashi, Koji Sakamoto, Isao Nagaoka
Pages: 472-478
Published online on: 28 December 2016

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Article

HPIP silencing inhibits TGF-β1-induced EMT in lung cancer cells

Shaomin Shi, Jianjun Zhao, Jing Wang, Donghui Mi, Zhongsen Ma
Pages: 479-483
Published online on: 05 January 2017

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation

Rui Zhang
Article Number: 75
Published online on: 27 January 2026

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Review Open Access

MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review)

Liping Liang, Xiaoyan Liu, Bang Li, Huyi Lei, Zibo Tang, Shijie Mai, Chenghai Yang, Yongjian Zhou, Shaoheng Zhang, Le Liu
Article Number: 74
Published online on: 27 January 2026

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Review Open Access

Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review)

Yang Liu, Yongfeng Li, Heng Ma, Shichang Deng, Chao Cheng
Article Number: 73
Published online on: 26 January 2026

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Retraction Open Access

[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG  

Shan Cai, Chao-Jia Shi, Jian-Xiang Lu, Yan-Pei Wang, Tian Yuan, Xiang-Peng Wang
Article Number: 72
Published online on: 26 January 2026

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Review Open Access

Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review)

Fei Tang, Dong Liu, Shi-Chao Zhu, Hui-Min Zhou, Xue-Wen Qiu
Article Number: 71
Published online on: 22 January 2026

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Review Open Access

MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review)

Pablo Michael Navarro‑Rodríguez, Ramón Francisco Bajeca‑Serrano, Francisco Javier Turrubiates‑Hernández, Hazael Ramiro Ceja‑Gálvez, Jorge Hernández‑Bello, Cristian Oswaldo Hernández‑Ramírez, Saúl Ramírez‑de Los Santos, José Francisco Muñoz‑Valle
Article Number: 70
Published online on: 22 January 2026

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Article Open Access

Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen, Ke Xu, Mei-Hua Chen
Article Number: 69
Published online on: 21 January 2026

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Review Open Access

Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)

Yuxing Li, Yujiao Gong, Jiaxing Zhao, Rensen Ran
Article Number: 68
Published online on: 21 January 2026

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Review Open Access

Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)

Ruo-Mei Cui, Mai Zheng, Jian-Bin Hong, Zheng-Xiang Wang, Yu-Fang Cun, Shu-Ji Gao, Yan-Lin Zhu, Zi-Bin Yang, Ming-Wei Liu
Article Number: 67
Published online on: 21 January 2026

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Expression of Concern Open Access

[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Article Number: 66
Published online on: 21 January 2026

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Review Open Access

Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Yaling Dai, Qiuling Huang, Mengquan Tan, Zhifu Wang, Cai Jiang, Zheng Liu, Shenghang Zhang, Siyuan Song
Article Number: 65
Published online on: 21 January 2026

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Article

Deciphering the CAF‑LCN2 axis: Key to overcoming anti‑PD‑L1 immunotherapy resistance in lung cancer

Dan Xiao, Jing Yang, Jianying Zhou, Zhenzhen Hu, Ting Zhang
Article Number: 64
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhang
Article Number: 63
Published online on: 19 January 2026

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Review Open Access

Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Review Open Access

Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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Review Open Access

ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Review Open Access

Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Review Open Access

Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Review Open Access

Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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Review Open Access

The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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Journal Cover
April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Role of vascular smooth muscle cell pathobiology in sepsis‑induced vasoplegia (Review)

Hang Ruan, Xiao-Yan Shen, Shi-Yan Liu, Shu-Sheng Li
Article Number: 87
Published online on: 06 February 2026

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Signalling pathways regulated by FSTL1 in inflammation and potential therapeutic applications (Review)

Changliang Ma, Jingxin Li, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Wencui Li, Zhiqin Deng, Zhe Zhao
Article Number: 86
Published online on: 05 February 2026

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Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling

Qin Deng, Zhongzhong Liu, Qifa Ye, Jia Liu, Zhihui Fu, Xingjian Zhang, Jun Luo, Zhongshan Lu, Pengpeng Yue, Jiansheng Xiao, Qi Xiao
Article Number: 85
Published online on: 05 February 2026

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Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)

Wei Li, Wen-Hong Wang, Yi Song, Xu-Jiong Li, Yan Li, Xia Wang, Ting-Ting Tian, Xiao Huang, Li Zhao
Article Number: 84
Published online on: 04 February 2026

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[Corrigendum] p57KIP2‑mediated inhibition of human trophoblast apoptosis and promotion of invasion in vitro

Guo-Qian He, Guang-Yu Liu, Wen-Ming Xu, Hui-Juan Liao, Xing-Hui Liu, Guo-Lin He
Article Number: 83
Published online on: 04 February 2026

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Published online on: 29 January 2026

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