Journal Articles

Open Access

SUN2: A potential therapeutic target in cancer (Review)

Xin Chen, Yu Chen, Hui‑Min Huang, Hai‑Di Li, Fang‑Tian Bu, Xue‑Yin Pan, Yang Yang, Wan‑Xia Li, Xiao‑Feng Li, Cheng Huang, Xiao‑Ming Meng, Jun Li

Pages: 1401-1408 Published online on: 27 November 2018
Open Access

Circulating tumor DNA detection: A potential tool for colorectal cancer management (Review)

Huizi Li, Changwen Jing, Jianzhong Wu, Jie Ni, Huanhuan Sha, Xiaoyue Xu, Yuanyuan Du, Rui Lou, Shuchen Dong, Jifeng Feng

Pages: 1409-1416 Published online on: 05 December 2018
Open Access

The prognostic value of S100A10 expression in cancer (Review)

Normastuti Adhini Tantyo, Azrina Saraswati Karyadi, Siti Zulimas Rasman, Marvelmario Reginald Gabriel Salim, Astrella Devina, Anton Sumarpo

Pages: 1417-1424 Published online on: 23 November 2018
Open Access

Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage

Yifeng He, Yu Zhou, Ji Zhang, Fei Yuan, Jun Wang, Lianjun Du, Qi Zhou, Jing Liang, Xiaoyi Ding

Pages: 1425-1434 Published online on: 30 November 2018
Open Access

Sirtuin 7 promotes glioma proliferation and invasion through activation of the ERK/STAT3 signaling pathway

Pengfei Mu, Kun Liu, Qingyuan Lin, Wensheng Yang, Dan Liu, Zhen Lin, Wei Shao, Tianhai Ji

Pages: 1445-1452 Published online on: 06 December 2018
Open Access

miR‑200b and miR‑200c co‑contribute to the cisplatin sensitivity of ovarian cancer cells by targeting DNA methyltransferases

Jue Liu, Xiaobo Zhang, Yuliang Huang, Qunfeng Zhang, Jianbin Zhou, Xiaodi Zhang, Xiaoxu Wang

Pages: 1453-1460 Published online on: 22 November 2018
Open Access

The effects of Tim‑3 activation on T‑cells in gastric cancer progression

Jiangtao Yu, Huanhu Zhang, Shengbo Sun, Shaowei Sun, Leping Li

Pages: 1461-1466 Published online on: 21 November 2018
Open Access

Radium‑223 in patients with metastatic castration‑resistant prostate cancer: Efficacy and safety in clinical practice

Arsela Prelaj, Sara Elena Rebuzzi, Federica Buzzacchino, Chiara Pozzi, Carla Ferrara, Viviana Frantellizzi, Giulia Anna Follacchio, Liana Civitelli, Giuseppe De Vincentis, Silverio Tomao, Vincenzo Bianco

Pages: 1467-1476 Published online on: 30 November 2018
Open Access

Orbital precursor B‑lymphoblastic lymphoma involving the extraocular muscles in a 56‑year‑old male and a review of the literature

Rasmus Ejstrup, Lauge Hjorth Mikkelsen, Mette Klarskov Andersen, Erik Clasen‑Linde, Lise Mette Rahbek Gjerdrum, Setareh Safavi, Steffen Heegaard

Pages: 1477-1482 Published online on: 19 November 2018
Open Access

Diagnosis of mesothelioma with deep learning

Xue Hu, Zebo Yu

Pages: 1483-1490 Published online on: 26 November 2018
Open Access

Overexpression of grainyhead‑like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma

Gang Wang, Jingen Pan, Lu Zhang, Cheng Wang

Pages: 1491-1496 Published online on: 21 November 2018

Serum chromogranin A for the diagnosis of gastroenteropancreatic neuroendocrine neoplasms and its association with tumour expression

Chuan Zhang, Yue Huang, Jiang Long, Xiaochen Yao, Jun Wang, Shimin Zang, Wei Qu, Feng Wang

Pages: 1497-1504 Published online on: 05 December 2018
Open Access

Use of clinical nomograms for predicting survival outcomes in young women with breast cancer

Hui Lin, Fan Zhang, Luanhong Wang, De Zeng

Pages: 1505-1516 Published online on: 28 November 2018
Open Access

Effects and possible mechanism of a picosecond pulsed electric field on angiogenesis in cervical cancer in vitro

Limei Wu, Yutong Wu, Zhengai Xiong, Chenguo Yao, Manman Zeng, Ruizhe Zhang, Yuanyuan Hua

Pages: 1517-1522 Published online on: 30 November 2018
Open Access

Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma

Dan‑Dan Zhao, Jun Yuan, Qi Cheng, Ya‑Ling Qi, Ke Lu, Shan‑Shan Lai, Qian Sun, Yue Zhao, Lei Fang, Mei‑Ling Jin, De‑Cai Yu, Yu‑Dong Qiu, Chao‑Jun Li, Jun Chen, Bin Xue

Pages: 1523-1530 Published online on: 07 December 2018
Open Access

Effect of NOS1 regulating ABCG2 expression on proliferation and apoptosis of cervical cancer cells

Mingde Ding, Hui Zhang, Lei Liu, Ruilan Liang

Pages: 1531-1536 Published online on: 30 November 2018
Open Access

Analysis of PKC‑ζ protein levels in normal and malignant breast tissue subtypes

Tracess Smalley, S. M. Anisul Islam, Christopher Apostolatos, André Apostolatos, Mildred Acevedo‑Duncan

Pages: 1537-1546 Published online on: 04 December 2018
Open Access

Therapeutic effect and adverse reaction of sorafenib in the treatment of advanced renal cancer

Juhui Qiu, Dongjian Liu, Zaichun Yan, Wei Jiang, Qinglei Zhang, Ning Li, Wentao Deng, Kejia Ding

Pages: 1547-1550 Published online on: 28 November 2018
Open Access

Higher nuclear EGFR expression is a better predictor of survival in rectal cancer patients following neoadjuvant chemoradiotherapy than cytoplasmic EGFR expression

Ching‑Chieh Yang, Li‑Ching Lin, Yu‑Wei Lin, Yu‑Feng Tian, Chen‑Yi Lin, Ming‑Jen Sheu, Chien‑Feng Li, Ming‑Hong Tai

Pages: 1551-1558 Published online on: 26 November 2018
Open Access

Expression of p53 in ground‑glass nodule of lung cancer and non‑lung cancer patients

Zhihua Teng, Wen Chen, Dongyong Yang, Zhenghua Zhang, Lifei Zhu, Fubing Wu

Pages: 1559-1564 Published online on: 05 December 2018
Open Access

MicroRNA‑885‑5p promotes osteosarcoma proliferation and migration by downregulation of cell division cycle protein 73 homolog expression

Feng‑Qiang Yu, Zeng Wang, Xin‑Wen Wang, Sheng‑Lin Wang, Xiao‑Dong Li, Qing‑Shan Huang, Jian‑Hua Lin

Pages: 1565-1572 Published online on: 06 December 2018
Open Access

miR‑146a‑5p targets interleukin‑1 receptor‑associated kinase 1 to inhibit the growth, migration, and invasion of breast cancer cells

Jing‑Pei Long, Li‑Feng Dong, Fang‑Fang Chen, Yang‑Fan Fan

Pages: 1573-1580 Published online on: 28 November 2018
Open Access

Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells

Wen‑Xue Chen, Jin‑Gao Li, Xiang‑Hui Wan, Xue‑Sen Zou, Shu‑Yi Qi, Yu‑Qing Zhang, Qiu‑Min Weng, Jun‑Yu Li, Wen‑Min Xiong, Chen Xie, Wei‑Liang Cheng

Pages: 1581-1588 Published online on: 28 November 2018
Open Access

Application of remifentanil combined with propofol in the diagnosis of colon cancer with awakening painless digestive endoscopy

Ailan Xian, Chunbin Wang, Ni Guo, Zaixing Wang, Lei Yang, Jie Gao, Longjun Yang

Pages: 1589-1594 Published online on: 06 December 2018
Open Access

NOS1 upregulates ABCG2 expression contributing to DDP chemoresistance in ovarian cancer cells

Xiaoxuan Li, Zhiwei Zou, Jiao Tang, Youhong Zheng, Yu Liu, Yan Luo, Qiuzhen Liu, Yifeng Wang

Pages: 1595-1602 Published online on: 03 December 2018
Open Access

Correlation analysis of IL‑4, IL‑10 and APN levels with postoperative infection of colorectal cancer

Jianyun He, Zhiyan Wang, Sihai Zhang

Pages: 1603-1608 Published online on: 06 December 2018
Open Access

Apatinib enhances the radiosensitivity of the esophageal cancer cell line KYSE‑150 by inducing apoptosis and cell cycle redistribution

Lijun Hu, Fei Sun, Zhiqiang Sun, Xinchu Ni, Jian Wang, Jianlin Wang, Mengyun Zhou, Yue Feng, Ze Kong, Qiu Hua, Jingping Yu

Pages: 1609-1616 Published online on: 06 December 2018
Open Access

SOX2 knockdown inhibits the migration and invasion of basal cell carcinoma cells by targeting the SRPK1‑mediated PI3K/AKT signaling pathway

Zhuo‑Ran Li, Yong Jiang, Jian‑Zhong Hu, Yang Chen, Quan‑Zhong Liu

Pages: 1617-1625 Published online on: 07 December 2018
Open Access

High PD‑L1 expression is associated with a favorable prognosis in patients with esophageal squamous cell carcinoma undergoing postoperative adjuvant radiotherapy

Chenxue Jiang, Yaoyao Zhu, Shuiqin Tang, Gu Zhang, Qingren Lin, Yaping Xu, Jinbiao Shang

Pages: 1626-1634 Published online on: 22 November 2018
Open Access

Melatonin regulates tumor aggressiveness under acidosis condition in breast cancer cell lines

Nathália Martins Sonehara, Jéssica Zani Lacerda, Bruna Victorasso Jardim‑Perassi, Rubens de Paula Jr, Marina Gobbe Moschetta‑Pinheiro, Ynaiá Santos Traba Souza, Júlia Carolina Junqueira de Andrade, Debora Aparecida Pires de Campos Zuccari

Pages: 1635-1645 Published online on: 26 November 2018
Open Access

Let‑7b acts as a tumor suppressor in osteosarcoma via targeting IGF1R

Kai Zhang, Weiwei Wang, Yi Liu, Aijun Guo, Donghui Yang

Pages: 1646-1654 Published online on: 04 December 2018
Open Access

Efficacy and safety of consolidation chemotherapy during the resting period in patients with local advanced rectal cancer

Huan‑Qing Liang, Zhong‑Yi Dong, Zhi‑Jie Liu, Jiao Luo, Qin Zeng, Ping‑Yan Liao, De‑Hua Wu

Pages: 1655-1663 Published online on: 06 December 2018
Open Access

MicroRNA‑504 modulates osteosarcoma cell chemoresistance to cisplatin by targeting p53

Xin Chen, Chen Lv, Xiongbai Zhu, Wenjun Lin, Lu Wang, Zhengxiang Huang, Shengwu Yang, Junying Sun

Pages: 1664-1674 Published online on: 22 November 2018
Open Access

Effects of claudin‑1 downregulation on the physiological processes of gallbladder cancer SGC996 cells

Hao Jin, Qiang Zhang, Shulong Zhang, Huichun Liu, Zhongran Man, Yong Wang

Pages: 1688-1694 Published online on: 21 November 2018
Open Access

Oncogenic value of microRNA‑15b‑5p in hepatocellular carcinoma and a bioinformatics investigation

Wen‑Ya Pan, Jiang‑Hui Zeng, Dong‑Yue Wen, Jie‑Yu Wang, Peng‑Peng Wang, Gang Chen, Zhen‑Bo Feng

Pages: 1695-1713 Published online on: 22 November 2018
Open Access

ACTG1 and TLR3 are biomarkers for alcohol‑associated hepatocellular carcinoma

Bing Gao, Shicheng Li, Zhen Tan, Leina Ma, Jia Liu

Pages: 1714-1722 Published online on: 26 November 2018
Open Access

Expression and selective activation of somatostatin receptor subtypes induces cell cycle arrest in cancer cells

Yi Zou, Haiping Tan, Yuanfeng Zhao, Yuan Zhou, Lin Cao

Pages: 1723-1731 Published online on: 28 November 2018
Open Access

MMP‑1 is overexpressed in triple‑negative breast cancer tissues and the knockdown of MMP‑1 expression inhibits tumor cell malignant behaviors in vitro

Qi‑Min Wang, Li Lv, Ying Tang, Li Zhang, Li‑Fen Wang

Pages: 1732-1740 Published online on: 30 November 2018
Open Access

Transcriptome analysis of pancreatic cancer cell response to treatment with grape seed proanthocyanidins

Weihua Wang, Leilei Zhan, Dongqi Guo, Yanju Xiang, Yu Zhang, Muxing Tian, Zhanjiang Han

Pages: 1741-1749 Published online on: 06 December 2018
Open Access

The efficacy and safety of bevacizumab in addition to platinum‑based chemotherapy for the first‑line treatment of patients with advanced nonsquamous non‑small‑cell lung cancer: Final results of AVALANCHE, an observational cohort study

Edina Tolnay, Áron Kristóf Ghimessy, Erzsébet Juhász, Zsuzsanna Sztancsik, György Losonczy, Péter Dombi, Zsuzsanna Vennes, László Helf, Edit Csada, Veronika Sárosi

Pages: 1750-1760 Published online on: 27 November 2018
Open Access

Paeonol‑mediated apoptosis of hepatocellular carcinoma cells by NF‑κB pathway

Qiang Li, Ying Zhang, Jing Sun, Qiyu Bo

Pages: 1761-1767 Published online on: 19 November 2018
Open Access

Expression of 3q oncogene SEC62 in atypical fibroxanthoma‑immunohistochemical analysis of 41 cases and correlation with clinical, viral and histopathologic features

Cornelia S.L. Müller, Léa Kreie, Florian Bochen, Thorsten Pfuhl, Sigrun Smola, Stefan Gräber, Thomas Vogt, Bernhard Schick, Maximilian Linxweiler

Pages: 1768-1776 Published online on: 27 November 2018
Open Access

High ambient radiofrequency radiation in Stockholm city, Sweden

Michael Carlberg, Lena Hedendahl, Tarmo Koppel, Lennart Hardell

Pages: 1777-1783 Published online on: 03 December 2018
Open Access

An atlas for clinical target volume definition, including elective nodal irradiation in definitive radiotherapy of biliary cancer

Silvia Bisello, Matteo Renzulli, Milly Buwenge, Lucia Calculli, Giuseppina Sallustio, Gabriella Macchia, Francesco Deodato, Giancarlo Mattiucci, Silvia Cammelli, Alessandra Arcelli, Lucia Giaccherini, Francesco Cellini, Giovanni Brandi, Sara Guerri, Savino Cilla, Rita Golfieri, Lorenzo Fuccio, Alessio G. Morganti, Alessandra Guido

Pages: 1784-1790 Published online on: 28 November 2018
Open Access

Expression of miR-664 and miR-184 on proliferation, apoptosis and migration of osteosarcoma cells

Pengfei Tao, Jing Feng, Qiong Li, Wei Liu, Lin Yang, Xiaolong Zhao, Huan Ni, Ping Xia

Pages: 1791-1797 Published online on: 20 November 2018
Open Access

Enhanced anticancer effect of oncostatin M combined with salinomycin in CD133+ HepG2 liver cancer cells

Changhao Fu, Lu Wang, Geer Tian, Chen Zhang, Yuanyuan Zhao, Hao Xu, Manman Su, Yi Wang

Pages: 1798-1806 Published online on: 05 December 2018
Open Access

Analyses on K‑ras mutations and fascin expression in patients with cardia cancer

Li Wei, Haiyan Chang, Song Huo

Pages: 1807-1811 Published online on: 22 November 2018
Open Access

Examination of the Biomark assay as an alternative to Oncotype DX for defining chemotherapy benefit

Jinkyoung Kim, Aeree Kim, Chungyeul Kim

Pages: 1812-1818 Published online on: 30 November 2018
Open Access

miR‑7‑5p inhibits cell migration and invasion in glioblastoma through targeting SATB1

Chang‑You Yin, Wei Kong, Jing Jiang, Hao Xu, Wei Zhao

Pages: 1819-1825 Published online on: 28 November 2018
Open Access

MMP-2 expression and correlation with pathology and MRI of glioma

Hui Zhang, Yunxia Ma, Haibao Wang, Liyan Xu, Yongqiang Yu

Pages: 1826-1832 Published online on: 06 December 2018

Clinical features and prognosis of breast cancer with gastric metastasis

Joohyun Hong, Youjin Kim, Jangho Cho, Sung Won Lim, Song Ee Park, Hee Kyung Kim, Hansang Lee, Soo Youn Cho, Ji‑Yeon Kim, Jin Seok Ahn, Young‑Hyuck Im, Yeon Hee Park

Pages: 1833-1841 Published online on: 23 November 2018

Impact of primary tumor location as a predictive factor in patients suffering from colorectal cancer treated with cytotoxic anticancer agents based on the collagen gel droplet‑embedded drug sensitivity test

Takumi Ochiai, Kazuhiko Nishimura, Tomoo Watanabe, Masayuki Kitajima, Akinori Nakatani, Kiichi Nagayasu, Naoki Sakuyama, Tsuyoshi Sato, Kenji Kishine, Yu Abe, Isao Nagaoka

Pages: 1842-1850 Published online on: 06 December 2018

Pemetrexed exerts anticancer effects by inducing G0/G1‑phase cell cycle arrest and activating the NOXA/Mcl‑1 axis in human esophageal squamous cell carcinoma cells

Xinying Li, Hongxia Song, Feng Kong, Yanxia Guo, Yuan Chen, Lu Zhang, Dongfang Gao, Xiaofei Zhao, Han Zhang

Pages: 1851-1858 Published online on: 23 November 2018

Decreased expression of ZO‑1 is associated with tumor metastases in liver cancer

Xueli Zhang, Liang Wang, Haitao Zhang, Fang Tu, Yong Qiang, Cuifang Nie

Pages: 1859-1864 Published online on: 27 November 2018

Overexpression of the ASPM gene is associated with aggressiveness and poor outcome in bladder cancer

Zhenglin Xu, Qi Zhang, Frank Luh, Baiye Jin, Xiyong Liu

Pages: 1865-1876 Published online on: 26 November 2018

Caution for simple sequence repeat number variation in the mitochondrial DNA D‑loop to determine cancer‑specific variants

Tokiko Nakai, Akihisa Sakurada, Toshihide Endo, Hiroko Kobayashi, Shinobu Masuda, Makoto Makishima, Mariko Esumi

Pages: 1883-1888 Published online on: 07 December 2018

MicroRNA‑135a induces prostate cancer cell apoptosis via inhibition of STAT6

Bin Xu, Xiaoming Lu, Yuming Zhao, Chunhui Liu, Xiaoming Huang, Shuqiu Chen, Weidong Zhu, Lihua Zhang, Ming Chen

Pages: 1889-1895 Published online on: 04 December 2018

Tanshinone IIA induces apoptosis of ovarian cancer cells in vitro and in vivo through attenuation of PI3K/AKT/JNK signaling pathways

Xian Zhang, Yong Zhou, Ying‑Er Gu

Pages: 1896-1902 Published online on: 21 November 2018

MicroRNA‑139 suppresses hepatocellular carcinoma cell proliferation and migration by directly targeting Topoisomerase I

Pengfei Zhang, Jikai Yin, Lijuan Yuan, Qing Wang, Xilin Du, Rui Dong, Chengguo Wang, Qiangshan Bai, Ling Ji, Guizhi Zhang, Jianguo Lu

Pages: 1903-1913 Published online on: 22 November 2018

High‑fat diets promote colon orthotopic transplantation tumor metastasis in BALB/c mice

Lijuan Xiu, Zhihui Yang, Ying Zhao, Xuan Liu, Jianpeng Jiao, Min Ye, Dazhi Sun, Pinkang Wei

Pages: 1914-1920 Published online on: 21 November 2018

Moesin is an independent prognostic marker for ER‑positive breast cancer

Lifeng Yu, Lin Zhao, Huizhe Wu, Haishan Zhao, Zhaojin Yu, Miao He, Feng Jin, Minjie Wei

Pages: 1921-1933 Published online on: 06 December 2018

Leukemia growth is inhibited by benzoxime without causing any harmful effect in rats bearing RBL‑1 xenotransplants

Yingchun Li, Huihan Wang, Rong Zhang, Guojun Zhang, Ying Yang, Zhuogang Liu

Pages: 1934-1938 Published online on: 30 November 2018

Expression of bone morphogenetic protein 6 in non‑small cell lung cancer and its significance

Wei Xiong, Li Wang, Fenglei Yu

Pages: 1946-1952 Published online on: 30 November 2018

Exosome‑delivered TRPP2 siRNA inhibits the epithelial‑mesenchymal transition of FaDu cells

Chunhui Wang, Lei Chen, Yuanyuan Huang, Kun Li, Anqi Jinye, Taotao Fan, Ren Zhao, Xianming Xia, Bing Shen, Juan Du, Yehai Liu

Pages: 1953-1961 Published online on: 23 November 2018

PI3K/Akt/mTOR signalling pathway activation in patients with ER‑positive, metachronous, contralateral breast cancer treated with hormone therapy

Hirofumi Kanaizumi, Chihiro Higashi, Yumiko Tanaka, Mika Hamada, Wataru Shinzaki, Tatsuya Azumi, Yukihiko Hashimoto, Hiroki Inui, Toshiya Houjou, Yoshifumi Komoike

Pages: 1962-1968 Published online on: 26 November 2018

Coexistence of giant cell tumor of tendon sheath and enchondroma in the middle phalanx of the little finger mimicking a malignant tumor: A case report

Muhammad Phetrus Johan, Tadahiko Kubo, Taisuke Furuta, Tomohiko Sakuda, Nobuo Adachi

Pages: 1969-1973 Published online on: 28 November 2018

Association of the invasiveness of colon cancer with the expression of C/EBPα

Wei Li, Liang‑Jun Jiang, Xiao‑Jun Zhou, Xian‑Zhou Lu, Long‑Fei Liu, Song Wang

Pages: 1974-1979 Published online on: 23 November 2018

A multicenter single‑arm Phase II clinical trial of second‑line FOLFIRI plus panitumumab after first‑line treatment with FOLFOX plus panitumumab for initial RAS wild‑type colorectal cancer with evaluation of circulating tumor DNA: A protocol study

Hiromichi Maeda, Naoki Nagata, Takeshi Nagasaka, Koji Oba, Hideyuki Mishima, Takeshi Kato, Kazuhiro Yoshida, Kei Muro, Junichi Sakamoto

Pages: 1980-1985 Published online on: 27 November 2018

BRCA1 mutation in breast cancer patients: Analysis of prognostic factors and survival

Joanna Huszno, Zofia Kołosza, Ewa Grzybowska

Pages: 1986-1995 Published online on: 28 November 2018

miR‑885‑5p suppresses osteosarcoma proliferation, migration and invasion through regulation of β‑catenin

Yan Liu, Zili Bao, Wanqing Tian, Guicheng Huang

Pages: 1996-2004 Published online on: 28 November 2018
Open Access

[Corrigendum] miR‑23b suppresses lung carcinoma cell proliferation through CCNG1

Hongsheng Han, Zhenxian Zhang, Xueqin Yang, Wenfeng Yang, Chengwei Xue, Xiaoli Cao

Pages: 2005-2005 Published online on: 04 December 2018

Role of RNA‑binding protein 5 in the diagnosis and chemotherapeutic response of lung cancer (Review)

Yanling Xu, Zhenzhong Su, Junyao Li, Qi Wang, Guangping Meng, Yu Zhang, Wen Yang, Jie Zhang, Peng Gao

Pages: 2013-2019 Published online on: 10 December 2018

Anaplastic lymphoma kinase fusions: Roles in cancer and therapeutic perspectives (Review)

Zhifa Cao, Qian Gao, Meixian Fu, Nan Ni, Yuting Pei, Wen‑Bin Ou

Pages: 2020-2030 Published online on: 20 December 2018

Targeting the BDNF/TrkB pathway for the treatment of tumors (Review)

Lingbin Meng, Baoqiong Liu, Rui Ji, Xin Jiang, Xuebo Yan, Ying Xin

Pages: 2031-2039 Published online on: 20 December 2018
Open Access

Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma

Tian Liu, Jing Liu, Qiuyue Chen, Shengjian Jin, Sisi Mi, Wenhua Shao, Yasusei Kudo, Sien Zeng, Guangying Qi

Pages: 2040-2046 Published online on: 17 December 2018
Open Access

Lost expression of cell adhesion molecule 1 is associated with bladder cancer progression and recurrence and its overexpression inhibited tumor cell malignant behaviors

Yegang Chen, Li Liu, Zhanjun Guo, Yi Wang, Yongjiao Yang, Xiaoqiang Liu

Pages: 2047-2056 Published online on: 18 December 2018
Open Access

Pancreatic stellate cells facilitate pancreatic cancer cell viability and invasion

Shang‑Long Liu, Shou‑Gen Cao, Ying Li, Bo Sun, Dong Chen, Dong‑Sheng Wang, Yan‑Bing Zhou

Pages: 2057-2062 Published online on: 10 December 2018
Open Access

Tumor suppressor role of microRNA‑545 in oral squamous cell carcinoma

Guangyi Yuan, Haoming Wu, Yu Du, Fanglin He

Pages: 2063-2068 Published online on: 11 December 2018
Open Access

Neoadjuvant chemoradiotherapy followed by liver transplantation is a promising treatment for patients with unresectable hilar cholangiocarcinoma: A case report

Jun Wang, Halmurat Obulkasim, Xiaoping Zou, Baorui Liu, Yafu Wu, Xingyu Wu, Yitao Ding

Pages: 2069-2074 Published online on: 28 December 2018
Open Access

CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines

Yicui Piao, Hongyu Guo, Zhibo Qu, Biao Zheng, Yong Gao

Pages: 2075-2080 Published online on: 14 December 2018
Open Access

Identification of novel lncRNAs involved in the pathogenesis of childhood acute lymphoblastic leukemia

Sheng Li, Hongliang Bian, Yizhi Cao, Chenxia Juan, Qian Cao, Guoping Zhou, Yongjun Fang

Pages: 2081-2090 Published online on: 14 December 2018
Open Access

Circular RNA hsa_circ_0078602 may have potential as a prognostic biomarker for patients with hepatocellular carcinoma

Peisi Kou, Chenyue Zhang, Jiamao Lin, Haiyong Wang

Pages: 2091-2098 Published online on: 21 December 2018
Open Access

Genomic amplification of HPV, h‑TERC and c‑MYC in liquid‑based cytological specimens for screening of cervical intraepithelial neoplasia and cancer

Wenting Ji, Weihua Lou, Zubei Hong, Lihua Qiu, Wen Di

Pages: 2099-2106 Published online on: 12 December 2018
Open Access

DLC2 operates as a tumor suppressor gene in breast cancer via the RhoGTPase pathway

Zheng Yang, Hanrui Chen, Man Shu, Yunjian Zhang, Ling Xue, Yuan Lin

Pages: 2107-2116 Published online on: 28 December 2018
Open Access

M3, a natural lignan xyloside, exhibits potent anticancer activity in HCT116 cells

Weidong Shen, Yu Zhao, Haijiao Chen, Ting Zhang, Shenbao Wu, Pengfei Liu

Pages: 2117-2122 Published online on: 12 December 2018
Open Access

Distribution of cancer stem cells in two human brain gliomas

Lilei Peng, Jie Fu, Weijun Wang, Florence M. Hofman, Thomas C. Chen, Ligang Chen

Pages: 2123-2130 Published online on: 12 December 2018
Open Access

Expression profile and biological function of miR‑455‑5p in colorectal carcinoma

Jinqiu Wang, Yang Lu, Yiyong Zeng, Leming Zhang, Kongliang Ke, Yu Guo

Pages: 2131-2140 Published online on: 21 December 2018
Open Access

Dissected peripancreatic tissue margin is a critical prognostic factor and is associated with a K‑ras gene mutation in pancreatic ductal adenocarcinoma

Nobuyuki Nishizawa, Yusuke Kumamoto, Hiroshi Katoh, Hideki Ushiku, Keigo Yokoi, Toshimichi Tanaka, Satoru Ishii, Kazuharu Igarashi, Hiroshi Tajima, Takashi Kaizu, Tsutomu Yoshida, Makoto Saegusa, Masahiko Watanabe, Keishi Yamashita

Pages: 2141-2150 Published online on: 17 December 2018
Open Access

Effect of STAT3 decoy oligodeoxynucleotides mediated by ultrasound-targeted microbubbles combined with ultrasound on the growth of squamous cell carcinoma of the esophagus

Yan Zhang, Meiwu Zhang, Xiaoxiang Fan, Dafeng Mao, Shuyi Lv, Ping Chen

Pages: 2151-2158 Published online on: 10 December 2018
Open Access

Emerging role of long non‑coding RNA MALAT1 in predicting clinical outcomes of patients with digestive system malignancies: A meta‑analysis

Chao Wang, Qiaoling Zhang, Yuhuan Hu, Jianshen Zhu, Jinyou Yang

Pages: 2159-2170 Published online on: 28 December 2018
Open Access

Overexpression of SIRT4 inhibits the proliferation of gastric cancer cells through cell cycle arrest

Yiwang Hu, Jiahao Lin, Yao Lin, Xuxu Chen, Guanbao Zhu, Guoyu Huang

Pages: 2171-2176 Published online on: 28 December 2018
Open Access

Associations in tumor infiltrating lymphocytes between clinicopathological factors and clinical outcomes in estrogen receptor‑positive/human epidermal growth factor receptor type 2 negative breast cancer

Yuichiro Miyoshi, Tadahiko Shien, Akiko Ogiya, Naoko Ishida, Kieko Yamazaki, Rie Horii, Yoshiya Horimoto, Norikazu Masuda, Hiroyuki Yasojima, Touko Inao, Tomofumi Osako, Masato Takahashi, Nobumoto Tomioka, Yumi Wanifuchi‑Endo, Mitsuchika Hosoda, Hiroyoshi Doihara, Hiroko Yamashita

Pages: 2177-2186 Published online on: 19 December 2018
Open Access

Irradiated endothelial cells modulate the malignancy of liver cancer cells

Sung Dae Kim, Joo Mi Yi, Moon‑Taek Park

Pages: 2187-2196 Published online on: 14 December 2018
Open Access

CRISPR/Cas9‑mediated cervical cancer treatment targeting human papillomavirus E6

Takahiro Yoshiba, Yasushi Saga, Masashi Urabe, Ryosuke Uchibor, Shigeki Matsubara, Hiroyuki Fujiwara, Hiroaki Mizukami

Pages: 2197-2206 Published online on: 10 December 2018
Open Access

Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico‑pathological and molecular (next generation sequencing) study of 22 cases

Nikola Hájková, Ivana Tichá, Jan Hojný, Kristýna Němejcová, Michaela Bártů, Romana Michálková, Michal Zikán, David Cibula, Jan Laco, Tomáš Geryk, Gábor Méhes, Pavel Dundr

Pages: 2207-2214 Published online on: 20 December 2018
Open Access

miR‑140‑5p inhibits cell proliferation and invasion in colorectal carcinoma by targeting SOX4

Zhongsong Zhao, Weiwei Liu, Jianhua Li

Pages: 2215-2220 Published online on: 14 December 2018
Open Access

miR-21 promotes cell migration and invasion of hepatocellular carcinoma by targeting KLF5

Jian Wang, Yanfeng Chu, Mei Xu, Xiumei Zhang, Yumei Zhou

Pages: 2221-2227 Published online on: 18 December 2018
Open Access

Identification of potential biomarkers of lung adenocarcinoma brain metastases via microarray analysis of cDNA expression profiles

Haiyang Su, Zhenyang Lin, Weicheng Peng, Zhiqiang Hu

Pages: 2228-2236 Published online on: 14 December 2018
Open Access

MicroRNA‑155 affects oxidative damage through regulating autophagy in endothelial cells

Huifen Chen, Mi Yang Liu Gao, Li Zhang, Fa Lian He, Yan Kun Shi, Xing Hua Pan, Hong Wang

Pages: 2237-2243 Published online on: 21 December 2018
Open Access

Prognostic evaluation of patients with resectable lung cancer using systemic inflammatory response parameters

Jie Zhu, Lian Lian, Hualong Qin, Wen‑Jie Wang, Rui Ren, Meng‑Dan Xu, Kai Chen, Weiming Duan, Fei‑Ran Gong, Min Tao, Qiaoming Zhi, Meng‑Yao Wu, Wei Li

Pages: 2244-2256 Published online on: 20 December 2018
Open Access

Oncogenic miR‑744 promotes prostate cancer growth through direct targeting of LKB1

Minglei Zhang, Hai Li, Yun Zhang, Hongyan Li

Pages: 2257-2265 Published online on: 11 December 2018
Open Access

Correlation of ERK/MAPK signaling pathway with proliferation and apoptosis of colon cancer cells

Gang Zhou, Jing Yang, Peng Song

Pages: 2266-2270 Published online on: 20 December 2018
Open Access

Expression of miR‑21 and miR‑138 in colon cancer and its effect on cell proliferation and prognosis

Changxuan You, Liming Jin, Qi Xu, Bo Shen, Xuelong Jiao, Xuewu Huang

Pages: 2271-2277 Published online on: 21 December 2018
Open Access

Effects of compound Kushen injection on pathology and angiogenesis of tumor tissues

Hongyan Wang, Haiyan Hu, Hua Rong, Xuwei Zhao

Pages: 2278-2282 Published online on: 21 December 2018
Open Access

Identification of imatinib‑resistant long non‑coding RNAs in gastrointestinal stromal tumors

Jingyi Yan, Didi Chen, Xiaolei Chen, Xuecheng Sun, Qiantong Dong, Zhou Du, Tingting Wang

Pages: 2283-2295 Published online on: 11 December 2018
Open Access

Correlation of SOX9 and NM23 genes with the incidence and prognosis of prostate cancer

Ming Xi, Song Wan, Wei Hua, Yulin Zhou, Wencong Jiang, Jianxin Hu

Pages: 2296-2302 Published online on: 12 December 2018
Open Access

A potential novel therapy for FGFR1‑amplified pancreatic cancer with bone metastasis, screened by next‑generation sequencing and a patient‑derived xenograft model

Zhonghai Guan, Huanrong Lan, Dan Sun, Xuanwei Wang, Ketao Jin

Pages: 2303-2307 Published online on: 28 December 2018
Open Access

Immunohistochemical analysis of matrix metalloproteinase‑9 predicts papillary thyroid carcinoma prognosis

Xingkai Liu, Chang Su, Jing Xu, Dan Zhou, He Yan, Wei Li, Guihui Chen, Nan Zhang, Dahai Xu, Haixia Hu

Pages: 2308-2316 Published online on: 19 December 2018
Open Access

MicroRNA‑197‑3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma

Jun‑Sheng Ni, Hao Zheng, Zhi‑Ping Huang, Yong‑Gang Hong, Yang‑Liu Ou, Yuan‑Ping Tao, Meng‑Chao Wang, Zhen‑Guang Wang, Yuan Yang, Wei‑Ping Zhou

Pages: 2317-2327 Published online on: 18 December 2018
Open Access

The tumor suppressor OVCA1 is a short half‑life protein degraded by the ubiquitin‑proteasome pathway

Yingwei Lin, Fandou Kong, Yan Li, Yinghui Wang, Ling Song, Chunyan Zhao

Pages: 2328-2334 Published online on: 19 December 2018
Open Access

Tumor microenvironment classification based on T‑cell infiltration and PD‑L1 in patients with mismatch repair‑proficient and ‑deficient colorectal cancer

Shousheng Liu, Pengfei Kong, Xiaopai Wang, Lin Yang, Chang Jiang, Wenzhuo He, Qi Quan, Jinsheng Huang, Qiankun Xie, Xiaojun Xia, Bei Zhang, Liangping Xia

Pages: 2335-2343 Published online on: 12 December 2018
Open Access

Comparison of laryngeal mask airway and endotracheal intubation in gynecological cancer operation

Zhenghuan Song, Jing Tan, Jia Fang, Qingming Bian, Lianbing Gu

Pages: 2344-2350 Published online on: 07 December 2018
Open Access

Systematic tracking of altered modules identifies the key biomarkers involved in chronic lymphocytic leukemia

Xin Lu, Zhen Wu, Xue‑Ying Zhao, Chun‑Feng Li, Shi‑Feng Kan

Pages: 2351-2355 Published online on: 07 December 2018
Open Access

Knockdown of SNHG12 suppresses tumor metastasis and epithelial‑mesenchymal transition via the Slug/ZEB2 signaling pathway by targeting miR‑218 in NSCLC

Yan Wang, Shuxin Liang, Yang Yu, Yankui Shi, Hailiang Zheng

Pages: 2356-2364 Published online on: 28 December 2018
Open Access

Prognostic value of serum IL-8 and IL-10 in patients with ovarian cancer undergoing chemotherapy

Lixia Zhang, Weiwei Liu, Xinbo Wang, Xiaoli Wang, Hong Sun

Pages: 2365-2369 Published online on: 18 December 2018
Open Access

ALK‑G1269A mutation in epithelioid inflammatory myofibroblastic sarcoma after progression on crizotinib: A case report

Xiaojing Xu, Hong Li, Ke Peng, Yiyi Yu, Lingli Chen, Yong Fang, Yihong Sun, Yingyong Hou, Tianshu Liu

Pages: 2370-2376 Published online on: 21 December 2018
Open Access

Integrative analysis of gene expression profiles reveals distinct molecular characteristics in oral tongue squamous cell carcinoma

Ranran Wang, Xiao Zhou, Hui Wang, Bo Zhou, Shanshan Dong, Qi Ding, Mingjing Peng, Xiaowu Sheng, Jianfeng Yao, Rongfu Huang, Yong Zeng, Ying Long

Pages: 2377-2387 Published online on: 21 December 2018
Open Access

Effects of respiratory motion on volumetric and positional difference of GTV in lung cancer based on 3DCT and 4DCT scanning

Shijiang Wang, Dongping Shang, Xue Meng, Xindong Sun, Yan Ma, Jinming Yu

Pages: 2388-2392 Published online on: 18 December 2018
Open Access

Plastin3 is associated with epithelial‑mesenchymal transition and poor prognosis in gastric cancer

Junji Kurashige, Takehiro Yokobori, Kosuke Mima, Genta Sawada, Yusuke Takahashi, Hiroki Ueo, Yuki Takano, Tae Matsumura, Ryutaro Uchi, Hidetoshi Eguchi, Tomoya Sudo, Keishi Sugimachi, Masaki Mori, Hideo Baba, Koshi Mimori

Pages: 2393-2399 Published online on: 11 December 2018
Open Access

MicroRNA-372 functions as a tumor suppressor in cell invasion, migration and epithelial-mesenchymal transition by targeting ATAD2 in renal cell carcinoma

Shiqi Ji, Xiaolin Su, Haijian Zhang, Zhixing Han, Yuqian Zhao, Qingjun Liu

Pages: 2400-2408 Published online on: 28 December 2018
Open Access

Effect of fibroblast co‑culture on the proliferation, viability and drug response of colon cancer cells

Byumseok Koh, Hyojin Jeon, Dahee Kim, Dukjin Kang, Kwang Rok Kim

Pages: 2409-2417 Published online on: 14 December 2018

Clinical significance of melanoma cell adhesion molecule CD146 and VEGFA expression in epithelial ovarian cancer

Ping Zhou, Tingchuan Xiong, Jingxin Chen, Fen Li, Tingting Qi, Jianlin Yuan

Pages: 2418-2424 Published online on: 17 December 2018

Efficacy of cytokine‑induced killer cells targeting CD40 and GITR

Kaja D. Biederbick, Ingo G.H. Schmidt‑Wolf

Pages: 2425-2430 Published online on: 18 December 2018

Metformin attenuates hypoxia‑induced resistance to cisplatin in the HepG2 cell line

Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai

Pages: 2431-2440 Published online on: 24 December 2018

Effects of Beclin 1 overexpression on aggressive phenotypes of colon cancer cells

Mei‑Ying Zhang, Li‑Yuan Wang, Shuang Zhao, Xiao‑Chong Guo, Ying‑Qi Xu, Zhi‑Hong Zheng, Hang Lu, Hua‑Chuan Zheng

Pages: 2441-2450 Published online on: 10 December 2018

MicroRNA‑543 suppresses liver cancer growth and induces apoptosis via the JAK2/STAT3 signaling pathway

Dianhui Xiu, Dawei Wang, Jing Wang, Fujian Ji, Wenlei Zhang

Pages: 2451-2456 Published online on: 17 December 2018

Long non‑coding RNA LOC541471: A novel prognostic biomarker for head and neck squamous cell carcinoma

Hua Wu, Da Hai Yu, Mian Hua Wu, Teng Huang

Pages: 2457-2464 Published online on: 14 December 2018

WZY‑321, a novel evodiamine analog, inhibits glioma cell growth in an autophagy‑associated manner

Guan Sun, Chuang Zhang, Hongmao Song, Jun Guo, Min Li, Ying Cao

Pages: 2465-2472 Published online on: 18 December 2018

The role of the fat mass and obesity‑associated protein in the proliferation of pancreatic cancer cells

Xiaodong Tang, Shuanghai Liu, Dawei Chen, Zhenguo Zhao, Jiahua Zhou

Pages: 2473-2478 Published online on: 28 December 2018

Synchronous primary sigmoid colon cancer and primary thyroid cancer followed by a malignant tumor of the kidney: Case report of multiple primary cancer and review of the literature

Cheng Peng, Zequn Li, Huijie Gao, Xueqing Zou, Xiao Wang, Changkuo Zhou, Jun Niu

Pages: 2479-2484 Published online on: 24 December 2018

Expression of coxsackie and adenovirus receptor is correlated with inferior prognosis in liver cancer patients

Xue Yang, Shuangshuang Li, Huiju Wang, Wanyuan Chen, Xiaozhou Mou, Shibing Wang

Pages: 2485-2490 Published online on: 24 December 2018

miR‑16 regulates proliferation and apoptosis of pituitary adenoma cells by inhibiting HMGA2

Yingying Niu, Hongbo Zhou, Yancui Liu, Yunfeng Wang, Jinding Xie, Chong Feng, Ning An

Pages: 2491-2497 Published online on: 28 December 2018

Nonylphenol promotes the proliferation of colorectal cancer COLO205 cells by upregulating the expression of protein kinase C ζ

Xuefeng Yang, Handong Huang, Maijian Wang, Xingbin Zheng, Ming Xie, Jie Xu

Pages: 2498-2506 Published online on: 18 December 2018

Effect on macrophage proliferation of a novel polysaccharide from Lactarius deliciosus (L. ex Fr.) Gray

Yiling Hou, Meng Wang, Daqun Zhao, Lu Liu, Xiang Ding, Wanru Hou

Pages: 2507-2515 Published online on: 28 December 2018

Inflammatory biomarkers in prognostic analysis for patients with glioma and the establishment of a nomogram

Tong Yang, Ping Mao, Xianhai Chen, Xuan Niu, Gaofeng Xu, Xiaobin Bai, Wanfu Xie

Pages: 2516-2522 Published online on: 24 December 2018

Metformin selectively targets 4T1 tumorspheres and enhances the antitumor effects of doxorubicin by downregulating the AKT and STAT3 signaling pathways

Yun‑Suk Kwon, So‑Young Chun, Hong‑Yan Nan, Kyung‑Soo Nam, Chuhee Lee, Soyoung Kim

Pages: 2523-2530 Published online on: 12 December 2018

Differences in colorectal cancer surveillance epidemiology and screening in the WHO European Region

Emma Altobelli, Leonardo Rapacchietta, Ciro Marziliano, Giuseppe Campagna, Valerio F. Profeta, Roberto Fagnano

Pages: 2531-2542 Published online on: 19 December 2018

Epigenetic treatment‑mediated modulation of PD‑L1 predicts potential therapy resistance over response markers in myeloid malignancies: A molecular mechanism involving effectors of PD‑L1 reverse signaling

Hongbin Liu, Yunshan Hu, Rafael Rimoldi, Chloe Von Hagt, Edmund W.C. Khong, Nora Lee, Shaun Flemming, Andrew Spencer, Anthony E. Dear

Pages: 2543-2550 Published online on: 17 December 2018

Changes in renal function following nedaplatin‑containing chemotherapy in patients with urothelial carcinoma unfit for cisplatin

Masayuki Nagasawa, Susumu Kageyama, Tetsuya Yoshida, Yuki Okinaka, Shigehisa Kubota, Akinori Wada, Kenichi Kobayashi, Keiji Tomita, Ryosuke Murai, Teruhiko Tsuru, Kazuyoshi Johnin, Mitsuhiro Narita, Akihiro Kawauchi

Pages: 2551-2556 Published online on: 20 December 2018

Dendritic cell subpopulations in nasopharyngeal cancer

Johan S. Nilsson, Milad Abolhalaj, Kristina Lundberg, Malin Lindstedt, Lennart Greiff

Pages: 2557-2561 Published online on: 14 December 2018
Journal Cover

February 2019
Volume 17 Issue 2

Print ISSN: 1792-1074
Online ISSN: 1792-1082

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