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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July 2013 Volume 32 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Targeting heat shock transcription factor 1 for novel hyperthermia therapy (Review)

Yoshiaki Tabuchi, Takashi Kondo
Pages: 3-8
Published online on: 01 May 2013

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Article

Utilization of microRNAs with decreased expression levels in response to X-ray irradiation for fine-tuning radiation-controlled gene regulation

Akihiro Morii, Ryohei Ogawa, Akihiko Watanabe, Zeng-Guo Cui, Ichiro Takasaki, Nobutaka Doi, Takashi Kondo, Hideki Fuse
Pages: 9-16
Published online on: 23 April 2013

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Article

Activation of hepatic stellate cells is suppressed by microRNA-150

Jianjian Zheng, Zhuo Lin, Peihong Dong, Zhongqiu Lu, Shenmeng  Gao, Xiaoqian Chen, Cunzao Wu, Fujun Yu
Pages: 17-24
Published online on: 22 April 2013

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Article

Directed neuronal differentiation of mouse embryonic and induced pluripotent stem cells and their gene expression profiles

Xuesong Chen, Qi Gu, Xiang Wang, Qingwen Ma, Huixiang Tang, Xiaoshuang Yan, Xinbing Guo, Hao Yan, Jie Hao, Fanyi Zeng
Pages: 25-34
Published online on: 08 May 2013

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Article

Connective tissue growth factor induces hepatic progenitor cells to differentiate into hepatocytes

Ai-Ting Yang, Ping Wang, Xiao-Fei Tong, Min Cong, Tian-Hui Liu, Rui  Cong, Peng Wu, Ji-Dong Jia, Bao-En Wang, Hong You
Pages: 35-42
Published online on: 13 May 2013

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Article

Norcantharidin inhibits DNA replication and induces mitotic catastrophe by degrading initiation protein Cdc6

Sansan Chen, Pei Wan, Wen Ding, Fei Li, Chengwu He, Pengliang Chen, Hongwei Li, Zhiming Hu, Wanlong Tan, Jinlong Li
Pages: 43-50
Published online on: 23 April 2013

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Article

miR-129-2 suppresses proliferation and migration of esophageal carcinoma cells through downregulation of SOX4 expression

Min Kang, Yumei Li, Wenqi Liu, Rensheng Wang, Anzhou Tang, Hong Hao, Zhenguo Liu, Hesheng Ou
Pages: 51-58
Published online on: 16 May 2013

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Article

Sex determining region Y-box 2 inhibits the proliferation of colorectal adenocarcinoma cells through the mTOR signaling pathway

Hui Liu, Lutao Du, Zhihua Wen, Yongmei Yang, Juan Li, Zhaogang Dong, Guixi Zheng, Lili Wang, Xin Zhang, Chuanxin Wang
Pages: 59-66
Published online on: 19 April 2013

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Article

Hexane extract of aged black garlic reduces cell proliferation and attenuates the expression of ICAM-1 and VCAM‑1 in TNF-α-activated human endometrial stromal cells

Ki-Hyung Kim, Jin Kyeong Park, Young-Whan Choi, Youn-Han Kim, Eun Na Lee, Ja-Rang Lee, Heui-Soo Kim, Sun-Yong Baek, Bong-Seon Kim, Kyu-Sup Lee, Sik Yoon
Pages: 67-78
Published online on: 25 April 2013

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Article

Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway

Jun Liao, Teng Xu, Jia-Xuan Zheng, Jiu-Mao Lin, Qiao-Yan Cai, De-Biao Yu, Jun Peng
Pages: 79-84
Published online on: 22 April 2013

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Article

Sann-Joong-Kuey-Jian-Tang decreases the protein expression of Mcl‑1 and TCTP and increases that of TNF-α and Bax in BxPC‑3 pancreatic carcinoma cells

Su-Yu Chien, Shou-Jen Kuo, Dar-Ren Chen, Chin-Cheng Su
Pages: 85-92
Published online on: 08 May 2013

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Article

COX-2 regulates E-cadherin expression through the NF-κB/Snail signaling pathway in gastric cancer Corrigendum in /10.3892/ijmm.2022.5083

Zhaofeng Chen, Min Liu, Xiaojun Liu, Shanshan Huang, Linlin Li, Bo Song, Hailong Li, Qian Ren, Zenan Hu, Yongning Zhou, Liang Qiao
Pages: 93-100
Published online on: 10 May 2013

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Article

Downregulation of miR-124 promotes the growth and invasiveness of glioblastoma cells involving upregulation of PPP1R13L

Wei-Hua Zhao, Sheng-Qi Wu, Yang-De Zhang
Pages: 101-107
Published online on: 29 April 2013

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Article

α-lipoic acid protects dopaminergic neurons against MPP+-induced apoptosis by attenuating reactive oxygen species formation

Da-Wei Li, Guang-Ren Li, Yan Lu, Zhi-Qiang Liu, Ming Chang, Ming Yao, Wei Cheng, Lin-Sen Hu
Pages: 108-114
Published online on: 24 April 2013

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Article

Effect of L-homocysteine on endothelial cell-cell junctions following F-actin stabilization through tropomyosin-1 overexpression

Maciej Gagat, Dariusz Grzanka, Magdalena Izdebska, Alina Grzanka
Pages: 115-129
Published online on: 22 April 2013

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Article

Inhibition of arginine ADP-ribosyltransferase 1 reduces the expression of poly(ADP-ribose) polymerase-1 in colon carcinoma

Yi Tang, Ya-Lan Wang, Lian Yang, Jian-Xia Xu, Wei Xiong, Ming Xiao, Ming Li
Pages: 130-136
Published online on: 08 May 2013

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Article

The Rb1 gene inhibits the viability of retinoblastoma cells by regulating homologous recombination

Ying Yang, Sijia Tian, Bryce Brown, Pei Chen, Huan Hu, Lei Xia, Jing Zhang, Xiaoxiao Cai, Zhao Chen, Xueke Pan, Jian Ge, Keming Yu, Jing Zhuang
Pages: 137-143
Published online on: 10 May 2013

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Article

Mutations of the SCN4B-encoded sodium channel β4 subunit in familial atrial fibrillation

Ruo-Gu Li, Qian Wang, Ying-Jia Xu, Min Zhang, Xin-Kai Qu, Xu Liu, Wei-Yi Fang, Yi-Qing Yang
Pages: 144-150
Published online on: 22 April 2013

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Article

Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathway

Jie Yu, Xiaopeng Hu, Zhengdong Yang, Hiroshi Takemori, Yanhong Li, Huan Zheng, Shicong Hong, Qiuhong Liao, Xiuying Wen
Pages: 151-157
Published online on: 10 May 2013

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Article

Assessment of cardiac inflammation and remodeling during the development of streptozotocin-induced diabetic cardiomyopathy in vivo: A time course analysis

P. M. Becher, D. Lindner, M. Fröhlich, K. Savvatis, D. Westermann, C. Tschöpe
Pages: 158-164
Published online on: 02 May 2013

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Article

Expression and distribution of Src in the nucleus of myocytes in cardiac hypertrophy

Ping Chen, Faqian Li, Zeqing Xu, Zhanyu Li, Xian Ping Yi
Pages: 165-173
Published online on: 14 May 2013

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Article

An incompletely penetrant novel MAFB (p.Ser56Phe) variant in autosomal dominant multicentric carpotarsal osteolysis syndrome

Gabriel C. Dworschak, Markus Draaken, Alina Hilger, Mark Born, Heiko Reutter, Michael Ludwig
Pages: 174-178
Published online on: 10 May 2013

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Article

Crude extract of Ceriporia lacerata has a protective effect on dexamethasone-induced cytotoxicity in INS-1 cells via the modulation of PI3K/PKB activity

Ji-Hye Kim, Yu-Kyoung Park, Ji-Eun Kim, Sam-Pin Lee, Byoung-Cheon Kim, Byeong-Churl Jang
Pages: 179-186
Published online on: 26 April 2013

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Article

Nicorandil inhibits hypoxia-induced apoptosis in human pulmonary artery endothelial cells through activation of mitoKATP and regulation of eNOS and the NF-κB pathway

Hui Wang, Xiangrong Zuo, Qiang Wang, Yanzhe Yu, Lijun Xie, Hong Wang, Hongcheng Wu, Weiping Xie
Pages: 187-194
Published online on: 13 May 2013

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Article

Identification of common gene networks responsive to mild hyperthermia in human cancer cells

Ayako Kariya, Yoshiaki Tabuchi, Tatsuya Yunoki, Takashi Kondo
Pages: 195-202
Published online on: 30 April 2013

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Article

Induction of thymic stromal lymphopoietin expression in 16-HBE human bronchial epithelial cells by 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3

Dan Zhang, Chenghua Peng, Haijin Zhao, Yang Xia, Dandan Zhang, Hangming Dong, Jiafu Song, Liqin Zhou, Shaoxi Cai, Fei Zou
Pages: 203-210
Published online on: 18 April 2013

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Article

Differential effects of insulin and dexamethasone on pulmonary surfactant-associated genes and proteins in A549 and H441 cells and lung tissue

Zdenek Rucka, Petr Vanhara, Irena Koutna, Lenka  Tesarova, Michaela Potesilova, Stanislav Stejskal, Pavel Simara, Jan  Dolezel, Vaclav Zvonicek, Oldrich Coufal, Ivan Capov
Pages: 211-218
Published online on: 25 April 2013

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Article

Differential expression of miRNAs in the nervous system of a rat model of bilateral sciatic nerve chronic constriction injury

Haixia Li, Le Shen, Chao Ma, Yuguang Huang
Pages: 219-226
Published online on: 14 May 2013

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Article

Cell viability, collagen synthesis and cytokine expression in human osteoblasts following incubation with generated wear particles using different bone cements

Christoph Schulze, Katrin Lochner, Anika Jonitz, Robert Lenz, Oliver Duettmann, Doris Hansmann, Rainer Bader
Pages: 227-234
Published online on: 16 May 2013

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Article

Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity

Kasthuri Bai Magalingam, Ammu Radhakrishnan, Nagaraja Haleagrahara
Pages: 235-240
Published online on: 10 May 2013

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Article

Chrysanthemum zawadskii extract protects osteoblastic cells from highly reducing sugar-induced oxidative damage

Kwang Sik Suh, Sang Youl Rhee, Woon Won Jung, Nam Jae Kim, Young Pyo Jang, Hye Jin Kim, Min Kyoung Kim, Young Kil Choi, Young Seol Kim
Pages: 241-250
Published online on: 08 May 2013

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Article

Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by the combination of Coriolus versicolor and Ganoderma lucidum

Tze-Chen Hsieh, Joseph M. Wu
Pages: 251-257
Published online on: 10 May 2013

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

miR‑205: A dual regulator of angiogenesis in health and disease (Review)

Maria Oltra, Miriam Martínez‑Santos, Maria Ybarra, Maria Pires, Chiara Ceresoni, Clara Gomis‑Coloma, Cristina Medina‑Trillo, Javier Sancho, Jorge Barcia
Article Number: 51
Published online on: 29 December 2025

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Astragaloside IV: A multipotent phytochemical for treating fibrotic diseases (Review)

Mingyu Wu, Ke Li, Jiabin Wu, Qiuyu Zhang, Xiaotong Ma, Wei Dai, Haoyang Gao, Xianyi Ding, Wenhong Wang, Weihua Xiao
Article Number: 50
Published online on: 24 December 2025

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Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

Yue-Chen Liu, Jia-Wei Zhao, Xiong-Tao Yue, Qi-Jie Chen, Shan-Jie Rong, Shi-Wei Liu, Fei Sun, Chun-Liang Yang, Cong-Yi Wang
Article Number: 49
Published online on: 24 December 2025

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Role of SIRT3 in digestive system diseases and therapeutic prospects (Review)

Jiajia Li, Qian Liu, Shun Yao, Xin Li, Li Zhang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 48
Published online on: 22 December 2025

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Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling

Jin-Hwa Kim, Sang-Hyup Lee, Sang-Yoon Kim, Jeong-Won Kim, Ji-Soo Jeong, Eun-Hye Chung, Su-Ha Lee, Chang-Yeop Kim, Bong-Keun Choi, Je-Won Ko, Tae-Won Kim
Article Number: 47
Published online on: 22 December 2025

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A comprehensive review on pain: Model, target, therapy, and prospect (Review)

Chenyu Chang, Xutao Wu, Kejia Liu, Lei Wang, Mozili Adu, Qingyuan Lin, Huilian Huang, Qinge Ma, Rongrui Wei, Xiaoyun Wang, Wenmin Liu
Article Number: 46
Published online on: 17 December 2025

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Retraction Open Access

[Retracted] Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia
Article Number: 45
Published online on: 15 December 2025

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Review Open Access

Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review)

Quanquan Zhou, Ge‑Lin Zhang, Weitong Sun, Jiayi Cai, Li-Hua Yu
Article Number: 44
Published online on: 10 December 2025

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Article Open Access

Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

Yiyang Pan, Feng Yang, Liucan Wang, Tianshu Yang, Guangsheng Du, Cong Xu, Hua Yang, Min Yu, Weidong Xiao
Article Number: 43
Published online on: 10 December 2025

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Review Open Access

Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou, Kunming Wen
Article Number: 42
Published online on: 08 December 2025

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Review Open Access

Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review)

Qian Yu, Yu Kuang, Jie He, Li Yang, Xinjie Li, Hao Yu
Article Number: 41
Published online on: 08 December 2025

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Retraction Open Access

[Retracted] MicroRNA‑493‑5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Guannan Wang, Xiaosan Fang, Meng Han, Xiaoming Wang, Qiang Huang
Article Number: 40
Published online on: 08 December 2025

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Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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Article Open Access

STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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Article Open Access

HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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Article Open Access

FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Review Open Access

Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Review Open Access

Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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