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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July 2013 Volume 32 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Targeting heat shock transcription factor 1 for novel hyperthermia therapy (Review)

Yoshiaki Tabuchi, Takashi Kondo
Pages: 3-8
Published online on: 01 May 2013

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Article

Utilization of microRNAs with decreased expression levels in response to X-ray irradiation for fine-tuning radiation-controlled gene regulation

Akihiro Morii, Ryohei Ogawa, Akihiko Watanabe, Zeng-Guo Cui, Ichiro Takasaki, Nobutaka Doi, Takashi Kondo, Hideki Fuse
Pages: 9-16
Published online on: 23 April 2013

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Article

Activation of hepatic stellate cells is suppressed by microRNA-150

Jianjian Zheng, Zhuo Lin, Peihong Dong, Zhongqiu Lu, Shenmeng  Gao, Xiaoqian Chen, Cunzao Wu, Fujun Yu
Pages: 17-24
Published online on: 22 April 2013

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Article

Directed neuronal differentiation of mouse embryonic and induced pluripotent stem cells and their gene expression profiles

Xuesong Chen, Qi Gu, Xiang Wang, Qingwen Ma, Huixiang Tang, Xiaoshuang Yan, Xinbing Guo, Hao Yan, Jie Hao, Fanyi Zeng
Pages: 25-34
Published online on: 08 May 2013

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Article

Connective tissue growth factor induces hepatic progenitor cells to differentiate into hepatocytes

Ai-Ting Yang, Ping Wang, Xiao-Fei Tong, Min Cong, Tian-Hui Liu, Rui  Cong, Peng Wu, Ji-Dong Jia, Bao-En Wang, Hong You
Pages: 35-42
Published online on: 13 May 2013

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Article

Norcantharidin inhibits DNA replication and induces mitotic catastrophe by degrading initiation protein Cdc6

Sansan Chen, Pei Wan, Wen Ding, Fei Li, Chengwu He, Pengliang Chen, Hongwei Li, Zhiming Hu, Wanlong Tan, Jinlong Li
Pages: 43-50
Published online on: 23 April 2013

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Article

miR-129-2 suppresses proliferation and migration of esophageal carcinoma cells through downregulation of SOX4 expression

Min Kang, Yumei Li, Wenqi Liu, Rensheng Wang, Anzhou Tang, Hong Hao, Zhenguo Liu, Hesheng Ou
Pages: 51-58
Published online on: 16 May 2013

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Article

Sex determining region Y-box 2 inhibits the proliferation of colorectal adenocarcinoma cells through the mTOR signaling pathway

Hui Liu, Lutao Du, Zhihua Wen, Yongmei Yang, Juan Li, Zhaogang Dong, Guixi Zheng, Lili Wang, Xin Zhang, Chuanxin Wang
Pages: 59-66
Published online on: 19 April 2013

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Article

Hexane extract of aged black garlic reduces cell proliferation and attenuates the expression of ICAM-1 and VCAM‑1 in TNF-α-activated human endometrial stromal cells

Ki-Hyung Kim, Jin Kyeong Park, Young-Whan Choi, Youn-Han Kim, Eun Na Lee, Ja-Rang Lee, Heui-Soo Kim, Sun-Yong Baek, Bong-Seon Kim, Kyu-Sup Lee, Sik Yoon
Pages: 67-78
Published online on: 25 April 2013

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Article

Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway

Jun Liao, Teng Xu, Jia-Xuan Zheng, Jiu-Mao Lin, Qiao-Yan Cai, De-Biao Yu, Jun Peng
Pages: 79-84
Published online on: 22 April 2013

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Article

Sann-Joong-Kuey-Jian-Tang decreases the protein expression of Mcl‑1 and TCTP and increases that of TNF-α and Bax in BxPC‑3 pancreatic carcinoma cells

Su-Yu Chien, Shou-Jen Kuo, Dar-Ren Chen, Chin-Cheng Su
Pages: 85-92
Published online on: 08 May 2013

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Article

COX-2 regulates E-cadherin expression through the NF-κB/Snail signaling pathway in gastric cancer Corrigendum in /10.3892/ijmm.2022.5083

Zhaofeng Chen, Min Liu, Xiaojun Liu, Shanshan Huang, Linlin Li, Bo Song, Hailong Li, Qian Ren, Zenan Hu, Yongning Zhou, Liang Qiao
Pages: 93-100
Published online on: 10 May 2013

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Article

Downregulation of miR-124 promotes the growth and invasiveness of glioblastoma cells involving upregulation of PPP1R13L

Wei-Hua Zhao, Sheng-Qi Wu, Yang-De Zhang
Pages: 101-107
Published online on: 29 April 2013

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Article

α-lipoic acid protects dopaminergic neurons against MPP+-induced apoptosis by attenuating reactive oxygen species formation

Da-Wei Li, Guang-Ren Li, Yan Lu, Zhi-Qiang Liu, Ming Chang, Ming Yao, Wei Cheng, Lin-Sen Hu
Pages: 108-114
Published online on: 24 April 2013

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Article

Effect of L-homocysteine on endothelial cell-cell junctions following F-actin stabilization through tropomyosin-1 overexpression

Maciej Gagat, Dariusz Grzanka, Magdalena Izdebska, Alina Grzanka
Pages: 115-129
Published online on: 22 April 2013

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Article

Inhibition of arginine ADP-ribosyltransferase 1 reduces the expression of poly(ADP-ribose) polymerase-1 in colon carcinoma

Yi Tang, Ya-Lan Wang, Lian Yang, Jian-Xia Xu, Wei Xiong, Ming Xiao, Ming Li
Pages: 130-136
Published online on: 08 May 2013

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Article

The Rb1 gene inhibits the viability of retinoblastoma cells by regulating homologous recombination

Ying Yang, Sijia Tian, Bryce Brown, Pei Chen, Huan Hu, Lei Xia, Jing Zhang, Xiaoxiao Cai, Zhao Chen, Xueke Pan, Jian Ge, Keming Yu, Jing Zhuang
Pages: 137-143
Published online on: 10 May 2013

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Article

Mutations of the SCN4B-encoded sodium channel β4 subunit in familial atrial fibrillation

Ruo-Gu Li, Qian Wang, Ying-Jia Xu, Min Zhang, Xin-Kai Qu, Xu Liu, Wei-Yi Fang, Yi-Qing Yang
Pages: 144-150
Published online on: 22 April 2013

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Article

Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathway

Jie Yu, Xiaopeng Hu, Zhengdong Yang, Hiroshi Takemori, Yanhong Li, Huan Zheng, Shicong Hong, Qiuhong Liao, Xiuying Wen
Pages: 151-157
Published online on: 10 May 2013

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Article

Assessment of cardiac inflammation and remodeling during the development of streptozotocin-induced diabetic cardiomyopathy in vivo: A time course analysis

P. M. Becher, D. Lindner, M. Fröhlich, K. Savvatis, D. Westermann, C. Tschöpe
Pages: 158-164
Published online on: 02 May 2013

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Article

Expression and distribution of Src in the nucleus of myocytes in cardiac hypertrophy

Ping Chen, Faqian Li, Zeqing Xu, Zhanyu Li, Xian Ping Yi
Pages: 165-173
Published online on: 14 May 2013

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Article

An incompletely penetrant novel MAFB (p.Ser56Phe) variant in autosomal dominant multicentric carpotarsal osteolysis syndrome

Gabriel C. Dworschak, Markus Draaken, Alina Hilger, Mark Born, Heiko Reutter, Michael Ludwig
Pages: 174-178
Published online on: 10 May 2013

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Article

Crude extract of Ceriporia lacerata has a protective effect on dexamethasone-induced cytotoxicity in INS-1 cells via the modulation of PI3K/PKB activity

Ji-Hye Kim, Yu-Kyoung Park, Ji-Eun Kim, Sam-Pin Lee, Byoung-Cheon Kim, Byeong-Churl Jang
Pages: 179-186
Published online on: 26 April 2013

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Article

Nicorandil inhibits hypoxia-induced apoptosis in human pulmonary artery endothelial cells through activation of mitoKATP and regulation of eNOS and the NF-κB pathway

Hui Wang, Xiangrong Zuo, Qiang Wang, Yanzhe Yu, Lijun Xie, Hong Wang, Hongcheng Wu, Weiping Xie
Pages: 187-194
Published online on: 13 May 2013

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Article

Identification of common gene networks responsive to mild hyperthermia in human cancer cells

Ayako Kariya, Yoshiaki Tabuchi, Tatsuya Yunoki, Takashi Kondo
Pages: 195-202
Published online on: 30 April 2013

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Article

Induction of thymic stromal lymphopoietin expression in 16-HBE human bronchial epithelial cells by 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3

Dan Zhang, Chenghua Peng, Haijin Zhao, Yang Xia, Dandan Zhang, Hangming Dong, Jiafu Song, Liqin Zhou, Shaoxi Cai, Fei Zou
Pages: 203-210
Published online on: 18 April 2013

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Article

Differential effects of insulin and dexamethasone on pulmonary surfactant-associated genes and proteins in A549 and H441 cells and lung tissue

Zdenek Rucka, Petr Vanhara, Irena Koutna, Lenka  Tesarova, Michaela Potesilova, Stanislav Stejskal, Pavel Simara, Jan  Dolezel, Vaclav Zvonicek, Oldrich Coufal, Ivan Capov
Pages: 211-218
Published online on: 25 April 2013

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Article

Differential expression of miRNAs in the nervous system of a rat model of bilateral sciatic nerve chronic constriction injury

Haixia Li, Le Shen, Chao Ma, Yuguang Huang
Pages: 219-226
Published online on: 14 May 2013

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Article

Cell viability, collagen synthesis and cytokine expression in human osteoblasts following incubation with generated wear particles using different bone cements

Christoph Schulze, Katrin Lochner, Anika Jonitz, Robert Lenz, Oliver Duettmann, Doris Hansmann, Rainer Bader
Pages: 227-234
Published online on: 16 May 2013

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Article

Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity

Kasthuri Bai Magalingam, Ammu Radhakrishnan, Nagaraja Haleagrahara
Pages: 235-240
Published online on: 10 May 2013

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Article

Chrysanthemum zawadskii extract protects osteoblastic cells from highly reducing sugar-induced oxidative damage

Kwang Sik Suh, Sang Youl Rhee, Woon Won Jung, Nam Jae Kim, Young Pyo Jang, Hye Jin Kim, Min Kyoung Kim, Young Kil Choi, Young Seol Kim
Pages: 241-250
Published online on: 08 May 2013

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Article

Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by the combination of Coriolus versicolor and Ganoderma lucidum

Tze-Chen Hsieh, Joseph M. Wu
Pages: 251-257
Published online on: 10 May 2013

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Journal Cover
April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

DUSP26: Unveiling a critical molecular mediator and therapeutic target in developmental dysplasia of the hip‑associated secondary osteoarthritis

Enbo Wang, Haixiang Zhang, Dechao Wu, Sadik Ali, Xianglu Ji
Article Number: 105
Published online on: 26 February 2026

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Review Open Access

mTOR signaling pathway in primary Sjögren's syndrome: Pathogenesis and potential therapeutic targets (Review)

Rongxiu Huo, Yanting Yang, Chengcheng Wei, Yang Yang, Danli Meng, Jinying Lin, Xinxiang Huang
Article Number: 104
Published online on: 25 February 2026

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Article Open Access

Bumetanide‑blocked SLC12A2 exerts a protective effect in experimental diabetic retinopathy

Yuting Zhang, Xiuli Wang, Qinyue Xie, Yue Huang, Dongjia Huang, Ziqing Liu, Tong Xu, Man Ni, Hongwei Yang
Article Number: 103
Published online on: 25 February 2026

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Article Open Access

Peroxisome proliferator‑activated receptor α regulates acesulfame‑K‑induced NAFLD via hepatic PLCβ: Foe and friend

Peng-Yao Lin, Jia-Rong Xie, Tian-Chen Qian, Shi-Song Wang, Si-Yi Yu, Wen-Bo Shi, Ying Wang, Lu-Ze Cen, Qing-Jing Zhu, Yi-Yang Zheng, Hui Gao, Rong Fang, Zhao-Xia Xia, Ai-Ming Liu, Lei Xu
Article Number: 102
Published online on: 25 February 2026

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Retraction Open Access

[Retracted] A novel role for Livin in the response to ultraviolet B radiation and pterygium development

Shuang-Qing Wu, Qi-Bin Xu, Wen-Yan Sheng, Lin-Ya Su, Li-Wei Zhu
Article Number: 101
Published online on: 24 February 2026

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Article Open Access

Endothelial UNC5B regulates blood‑retinal barrier homeostasis

Yujia Yao, Suyu Wang, Jiajun Li, Qianzi Jin, Ziyi Chen, Qin Jiang, Keran Li
Article Number: 100
Published online on: 20 February 2026

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Review Open Access

Metabolic hubs in reproduction: The regulatory network of lipid droplets in gamete and embryo physiology (Review)

Liuzhu Pan, Zongzhuang Wen, Yi Jin
Article Number: 99
Published online on: 17 February 2026

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Review Open Access

The role and mechanism of IL‑35 in myasthenia gravis (Review)

Jing Mao, Lin-Ming Zhang, Yan-Lin Zhu, Shu-Ji Gao, Ming-Wei Liu
Article Number: 98
Published online on: 17 February 2026

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Article Open Access

miRNA‑378a‑5p attenuates the development of abdominal aortic aneurysm via ABLIM1‑MKL1 signaling pathways

Jing Wang, Yujia Zou, Yani Wang, Zheming Yang, Daoshen Liu, Xiaolin Su, Haixu Song, Kai Xu, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 97
Published online on: 16 February 2026

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Review Open Access

Dysregulated post‑translational modifications in granulosa cells drive ovarian dysfunction and potential infertility applications (Review)

Yufei Zhong, Yunfei Zou, Zhuoyuan Yang, Junjun Wang, Zezheng Pan, Jiugeng Feng
Article Number: 96
Published online on: 16 February 2026

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Review Open Access

Microglia‑mediated neuroinflammation in intracerebral hemorrhage: Pathological mechanisms and implications for therapeutic development (Review)

Xuehui Fan, Changzhi Pu, Luyi Zhong, Oucheng Wang, Binyi Zhao, Dongyi Liao, Xue Bai, Guiquan Chen, Guoqiang Yang
Article Number: 95
Published online on: 16 February 2026

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Correction Open Access

[Corrigendum] Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs

Qing-Yong Chen, Li-Qun Xu, De-Min Jiao, Qing-Hua Yao, Yan-Yi Wang, Hui-Zhen Hu, Yu-Quan Wu, Jia Song, Jie Yan, Li-Jun Wu
Article Number: 94
Published online on: 12 February 2026

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Article Open Access

Orcinol glucoside ameliorates pulmonary fibrosis by suppressing hyaluronic acid synthesis and macrophage M2 polarization via targeting hyaluronic acid synthase 2

Caizi Li, Xinglinzi Tang, Xiaoru Luo, Xin Lai, Jing Yang, Zheng Xu, Gulizeba Muhetaer, Yizi Xie, Xiufang Huang, Hang Li
Article Number: 93
Published online on: 10 February 2026

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Review Open Access

Helicobacter pylori and hyperglycemia fuel gastric cancer glycolysis: Mechanisms and targeted intervention (Review)

Youjia Liu, Fang Wang, Ya Deng, Yanxia Hu, Feihong Shu, Jie Yu, Guoyou Gou, Min Wen, Chen Luo, Xianmin Lu, Qian Du, Jingyu Xu, Rui Xie
Article Number: 92
Published online on: 09 February 2026

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Review Open Access

Targeting the gut‑bone axis through exercise: A novel approach to osteoporosis prevention and treatment (Review)

Jingjing Wu, Siqi Zhang, Junjie Wu, Yuhang Luan, Xingchen Yao, Boyan Xu, Yiting Wang, Yingyue Sheng, Yuzheng Xue, Yilin Ren
Article Number: 91
Published online on: 09 February 2026

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Review Open Access

Chorus line in oral squamous cell carcinoma: How stromal and immune players orchestrate tumor progression (Review)

Eliano Cascardi, Mario Della Mura, Nicoletta Sgarro, Silvia Minei, Gerardo Cazzato, Eugenio Maiorano, Lorenzo Lo Muzio, Maria Eleonora Bizzoca, Fábio França Vieira E Silva, Eleonora Lo Muzio, Mario Dioguardi, Andrea Ballini
Article Number: 90
Published online on: 09 February 2026

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Correction Open Access

[Corrigendum] Hsa_circularRNA_0079201 suppresses chondrocyte proliferation and endochondral ossification by regulating the microRNA‑140‑3p/SMAD2 signaling pathway in idiopathic short stature 

Xijuan Liu, Chen Yan, Xueqiang Deng, Jingyu Jia
Article Number: 89
Published online on: 09 February 2026

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Review Open Access

Post‑translational modifications in diabetic kidney disease (Review)

Mengfei He, Zihang Wang, Zhuang Miao, Yu Zhao, Lingling Wei, Lijie Zhang, Ruili Yin, Yan Wang, Longyan Yang
Article Number: 88
Published online on: 09 February 2026

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Review Open Access

Role of vascular smooth muscle cell pathobiology in sepsis‑induced vasoplegia (Review)

Hang Ruan, Xiao-Yan Shen, Shi-Yan Liu, Shu-Sheng Li
Article Number: 87
Published online on: 06 February 2026

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Review Open Access

Signalling pathways regulated by FSTL1 in inflammation and potential therapeutic applications (Review)

Changliang Ma, Jingxin Li, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Wencui Li, Zhiqin Deng, Zhe Zhao
Article Number: 86
Published online on: 05 February 2026

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Article Open Access

Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling

Qin Deng, Zhongzhong Liu, Qifa Ye, Jia Liu, Zhihui Fu, Xingjian Zhang, Jun Luo, Zhongshan Lu, Pengpeng Yue, Jiansheng Xiao, Qi Xiao
Article Number: 85
Published online on: 05 February 2026

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Review Open Access

Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)

Wei Li, Wen-Hong Wang, Yi Song, Xu-Jiong Li, Yan Li, Xia Wang, Ting-Ting Tian, Xiao Huang, Li Zhao
Article Number: 84
Published online on: 04 February 2026

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Correction Open Access

[Corrigendum] p57KIP2‑mediated inhibition of human trophoblast apoptosis and promotion of invasion in vitro

Guo-Qian He, Guang-Yu Liu, Wen-Ming Xu, Hui-Juan Liao, Xing-Hui Liu, Guo-Lin He
Article Number: 83
Published online on: 04 February 2026

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Review Open Access

Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)

Yongchun Liang, Xinbiao Fan, Xiaofei Geng, Yunfeng Jia, Wenyu Shang, Xitong Sun, Jun Ge, Guijun Ye, Boyu Zhu, Zheng Zhang, Yuxin Kang, Xiaoyu Shan, Junping Zhang
Article Number: 82
Published online on: 03 February 2026

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Review Open Access

IMP metabolic mechanisms and IMPDH targeting strategies in tumor metabolic reprogramming and therapy (Review)

Hao Zhu, Hao Wang, Xia Li, Weisong Zhang, Yihao Wang, Qingze Tan, Dongxu Ying, Zhan Shi, Jianxiang Song
Article Number: 81
Published online on: 03 February 2026

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Article Open Access

Ebastine targets HER2/HER3 signaling and cancer stem cell traits to overcome trastuzumab resistance in HER2‑positive breast cancer

Eunsun Jung, Ji Young Kim, Dongmi Ko, Juyeon Seo, Sang Yoon Lee, Daeun Lee, Subeen Kim, Minsu Park, Seongjae Kim, Soeun Park, Kyoungmin Lee, Yong Koo Kang, Kee Dal Nam, Yoon-Jae Kim, Jae Hong Seo
Article Number: 80
Published online on: 02 February 2026

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Correction Open Access

[Corrigendum] Inhibition of acid‑sensing ion channel 1a attenuates acid‑induced activation of autophagy via a calcium signaling pathway in articular chondrocytes

Wen-Fan Gao, Ya-Yun Xu, Jin-Fang Ge, Fei-Hu Chen
Article Number: 79
Published online on: 02 February 2026

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Review Open Access

Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)

Lu Xu, Wei Jiang, Lin Song, Jing Wang, Jiangquan Yu, Ruiqiang Zheng
Article Number: 78
Published online on: 30 January 2026

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Correction Open Access

[Corrigendum] Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

Fanlan Meng, Jun Li, Xiao Yang, Xiaoyong Yuan, Xin Tang
Article Number: 77
Published online on: 29 January 2026

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Review Open Access

Spatial metabolomics: A new tool for unravelling the metabolic disorders and heterogeneity in diabetic kidney disease (Review)

Hanfei Li, Yuxi Li, Bo Zhang, Wenhao Cheng, Guowei Ma, Jin Rong, Shiru Duan, Di Feng, Tingting Zhao
Article Number: 76
Published online on: 29 January 2026

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Journal Cover
May-2026 Volume 57 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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