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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
February-2019 Volume 43 Issue 2

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

An integrative theory for cancer (Review)

Guopei Luo, Na Liu
Pages: 647-656
Published online on: 28 November 2018

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Review

AngiomiRs: MicroRNAs driving angiogenesis in cancer (Review)

Yarely M. Salinas‑Vera, Laurence A. Marchat, Dolores Gallardo‑Rincón, Erika Ruiz‑García, Horacio Astudillo-De La Vega, Raquel Echavarría‑Zepeda, César López‑Camarillo
Pages: 657-670
Published online on: 27 November 2018

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Review Open Access

Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork (Review)

Hongwei Wang, Mingzhe Li, Zhenzhen Zhang, Haifeng Xue, Xing Chen, Yong Ji
Pages: 671-681
Published online on: 20 November 2018

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Article Open Access

Isorhamnetin alleviates lipopolysaccharide-induced inflammatory responses in BV2 microglia by inactivating NF-κB, blocking the TLR4 pathway and reducing ROS generation

Shin Young Kim, Cheng‑Yun Jin, Cheol Hong Kim, Young Hyun Yoo, Sung Hyun Choi, Gi‑Young Kim, Hyun Min Yoon, Hwan Tae Park, Yung Hyun Choi
Pages: 682-692
Published online on: 20 November 2018

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Article

Rosiglitazone attenuates cell apoptosis through antioxidative and anti-apoptotic pathways in the hippocampi of spontaneously hypertensive rats

Yali Li, Guanghu Yu, Lijuan Liu, Jun Long, Shujie Su, Ting Zhao, Wenjin Liu, Shunji Shen, Xiaolin Niu
Pages: 693-700
Published online on: 19 November 2018

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Article Open Access

Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS

Uddin Md. Nazim, Sang‑Youel Park
Pages: 701-708
Published online on: 21 November 2018

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Article Open Access

Astragaloside IV ameliorates high glucose‑induced renal tubular epithelial‑mesenchymal transition by blocking mTORC1/p70S6K signaling in HK‑2 cells

Xiao Chen, Yang Yang, Chenxu Liu, Zhigao Chen, Dongdong Wang
Pages: 709-716
Published online on: 26 November 2018

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Article Open Access

Ginsenoside Rg1 protects against H2O2‑induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro

Tan‑Zhen Xu, Xiao‑Yan Shen, Ling‑Ling Sun, Ya‑Li Chen, Bi‑Qiong Zhang, Da‑Ke Huang, Wei‑Zu Li
Pages: 717-726
Published online on: 30 November 2018

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Article Open Access

MicroRNA‑100‑5p inhibits osteoclastogenesis and bone resorption by regulating fibroblast growth factor 21

Long Zhou, Han‑Yi Song, Lin‑Lin Gao, Li‑Yu Yang, Shuai Mu, Qin Fu
Pages: 727-738
Published online on: 06 December 2018

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Article Open Access

Role of the long non‑coding RNA‑Annexin A2 pseudogene 3/Annexin A2 signaling pathway in biliary atresia‑associated hepatic injury

Yeletai Nuerzhati, Rui Dong, Zai Song, Shan Zheng
Pages: 739-748
Published online on: 11 December 2018

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Article Open Access

DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats Retraction in /10.3892/ijmm.2026.5734

Zhen‑Dong Zhu, Ji‑Ming Ye, Xue‑Mei Fu, Xue‑Chang Wang, Ji‑Yun Ye, Xin‑Ran Wu, Peng Hua, Yu‑Qiong Liao, Wei Xuan, Jin‑Lan Duan, Wei‑Yuan Li, Hui Fu, Zhong‑Hua Xia, Xuan Zhang
Pages: 749-760
Published online on: 18 December 2018

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Article Open Access

Activating metabotropic glutamate receptor‑7 attenuates visceral hypersensitivity in neonatal maternally separated rats

Limei Shao, Yanbing Liu, Junhua Xiao, Qunying Wang, Fei Liu, Jin Ding
Pages: 761-770
Published online on: 11 December 2018

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Article Open Access

Crude protein from spirulina increases the viability of CCD‑986sk cells via the EGFR/MAPK signaling pathway

Ping Liu, Min‑Kyeong Lee, Jeong‑Wook Choi, Youn‑Hee Choi, Taek‑Jeong Nam
Pages: 771-778
Published online on: 11 December 2018

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Article Open Access

MicroRNA‑93 inhibits chondrocyte apoptosis and inflammation in osteoarthritis by targeting the TLR4/NF‑κB signaling pathway

Yanjie Ding, Laifang Wang, Qing Zhao, Zhenzhen Wu, Lingli Kong
Pages: 779-790
Published online on: 18 December 2018

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Article Open Access

Melatonin regulation of transcription in the reversal of morphine tolerance: Microarray analysis of differential gene expression

Yu‑Che Cheng, Ru‑Yin Tsai, Yen‑Tseng Sung, Ing‑Jung Chen, Tzu‑Yi Tu, Ya‑Yuan Mao, Chih‑Shung Wong
Pages: 791-806
Published online on: 18 December 2018

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Article Open Access

Electro-acupuncture-induced neuroprotection is associated with activation of the IGF-1/PI3K/Akt pathway following adjacent dorsal root ganglionectomies in rats

Tao Hu, Min‑Nan Lu, Bo Chen, Jun Tong, Rui Mao, Shan‑Shan Li, Pin Dai, Ya‑Xin Tan, Yan‑Bin Xiyang
Pages: 807-820
Published online on: 18 December 2018

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Article Open Access

Atorvastatin downregulates HSP22 expression in an atherosclerotic model in vitro and in vivo

Qi Chen, Jian Xiang, Ren Gong, Hai‑Yang Fang, Cong‑Cong Xu, Hong‑Zhou Zhang, Yan‑Qing Wu
Pages: 821-829
Published online on: 03 December 2018

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Article Open Access

Astragaloside IV promotes the proliferation and migration of osteoblast-like cells through the hedgehog signaling pathway Corrigendum in /10.3892/ijmm.2026.5777

Li‑Hua Guo, Yu Cao, Run‑Tao Zhuang, Yan Han, Jun Li
Pages: 830-838
Published online on: 03 December 2018

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Article Open Access

MicroRNA-140-5p aggravates hypertension and oxidative stress of atherosclerosis via targeting Nrf2 and Sirt2

Qing‑Quan Liu, Ke Ren, Su‑Hong Liu, Wei‑Min Li, Chang‑Jun Huang, Xiu‑Hui Yang
Pages: 839-849
Published online on: 26 November 2018

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Article Open Access

Expression of microRNA‑27a in a rat model of osteonecrosis of the femoral head and its association with TGF‑β/Smad7 signalling in osteoblasts

Yuming Bai, Ying Liu, Shengli Jin, Ke Su, Haisen Zhang, Shiyun Ma
Pages: 850-860
Published online on: 30 November 2018

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Article Open Access

The AIB1siRNA-loaded hyaluronic acid-assembled PEI/heparin/Ca2+ nanocomplex as a novel therapeutic strategy in lung cancer treatment

Ying Hao, Yongsheng Gao, Yedan Wu, Changshan An
Pages: 861-867
Published online on: 03 December 2018

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Article Open Access

Expression of FKBP52 in the ovaries of PCOS rats Corrigendum in /10.3892/ijmm.2026.5850

Shiyan Song, Yong Tan
Pages: 868-878
Published online on: 26 November 2018

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Article Open Access

Insulin gene enhancer binding protein 1 induces adipose tissue‑derived stem cells to differentiate into pacemaker‑like cells

Jian Zhang, Mei Yang, An‑Kang Yang, Xi Wang, Yan‑Hong Tang, Qing‑Yan Zhao, Teng Wang, Yu‑Ting Chen, Cong‑Xin Huang
Pages: 879-889
Published online on: 27 November 2018

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Article Open Access

Adipose extracellular matrix promotes skin wound healing by inducing the differentiation of adipose‑derived stem cells into fibroblasts Retraction in /10.3892/ijmm.2024.5430

Zhi‑Qiang Zhou, Yi Chen, Mi Chai, Ran Tao, Yong‑Hong Lei, Yi‑Qing Jia, Jun Shu, Jing Ren, Guo Li, Wen‑Xin Wei, Yu‑Di Han, Yan Han
Pages: 890-900
Published online on: 30 November 2018

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Article Open Access

Baicalin inhibits proliferation and promotes apoptosis of vascular smooth muscle cells by regulating the MEG3/p53 pathway following treatment with ox‑LDL

Yun Liu, Lianqun Jia, Dongyu Min, Yi Xu, Jinquan Zhu, Zengxian Sun
Pages: 901-913
Published online on: 30 November 2018

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Article Open Access

ADAM17 promotes lymph node metastasis in gastric cancer via activation of the Notch and Wnt signaling pathways

Wei Li, Daguang Wang, Xuan Sun, Yang Zhang, Lei Wang, Jian Suo
Pages: 914-926
Published online on: 17 December 2018

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Article Open Access

Construction of a long non‑coding RNA-mediated competitive endogenous RNA network reveals global patterns and regulatory markers in gestational diabetes

Lei Leng, Chengwei Zhang, Lihong Ren, Qiang Li
Pages: 927-935
Published online on: 12 December 2018

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Article Open Access

Genipin protects against H2O2-induced oxidative damage in retinal pigment epithelial cells by promoting Nrf2 signaling

Hailan Zhao, Ruiqing Wang, Mingxia Ye, Lan Zhang
Pages: 936-944
Published online on: 12 December 2018

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Article Open Access

Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF

Jiao Cheng, Hui‑Li Yang, Chun‑Jie Gu, Yu‑Kai Liu, Jun Shao, Rui Zhu, Yin‑Yan He, Xiao‑Yong Zhu, Ming‑Qing Li
Pages: 945-955
Published online on: 10 December 2018

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Article Open Access

Investigation of the neuroprotective effects of crocin via antioxidant activities in HT22 cells and in mice with Alzheimer's disease

Chunyue Wang, Xueying Cai, Wenji Hu, Zhiping Li, Fange Kong, Xia Chen, Di Wang
Pages: 956-966
Published online on: 18 December 2018

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Article Open Access

Corilagin induces apoptosis, autophagy and ROS generation in gastric cancer cells in vitro

Jiajia Xu, Gongye Zhang, Yinping Tong, Jiahui Yuan, Yuanyue Li, Gang Song
Pages: 967-979
Published online on: 18 December 2018

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Article

Akt3 is a target of miR-29c-3p and serves an important function in the pathogenesis of congenital heart disease

Tao Chen, Shu‑Jun Li, Bin Chen, Qiong Huang, Xiang‑Ying Kong, Chen Shen, Hai‑Tao Gu, Xiao‑Wei Wang
Pages: 980-992
Published online on: 30 November 2018

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Article

MicroRNA-323 suppresses nerve cell toxicity in cerebral infarction via the transforming growth factor-β1/SMAD3 signaling pathway

Fengli Che, Huishan Du, Jianchao Wei, Weidong Zhang, Zhe Cheng, Yanna Tong
Pages: 993-1002
Published online on: 07 December 2018

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Article

MicroRNA‑124‑3p attenuates severe community‑acquired pneumonia progression in macrophages by targeting tumor necrosis factor receptor‑associated factor 6

Wei Gao, Hongxia Yang
Pages: 1003-1010
Published online on: 03 December 2018

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Article

Cyr61 decreases Cytarabine chemosensitivity in acute lymphoblastic leukemia cells via NF-κB pathway activation

Yingping Cao, Conglian Wu, Yanfang Song, Zhen Lin, Yanli Kang, Pingxia Lu, Chenqing Zhang, Qinghua Huang, Taisen Hao, Xianjin Zhu, Jianda Hu
Pages: 1011-1020
Published online on: 06 December 2018

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Article

Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells Expression of Concern in /10.3892/ijmm.2026.5922

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Pages: 1021-1032
Published online on: 03 December 2018

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Article

Inhibition of protein kinase CK2 facilitates cellular senescence by inhibiting the expression of HO-1 in articular chondrocytes

Kang Mi Kim, Dong Hyun Sohn, Koanhoi Kim, Young Chul Park
Pages: 1033-1040
Published online on: 04 December 2018

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Article

Astragalus saponins inhibit cell growth, aerobic glycolysis and attenuate the inflammatory response in a DSS-induced colitis model

Hailong Guo, Boshun Wan, Jiansong Wang, Jie Zhang, Wenfei Yao, Zhiyong Shen
Pages: 1041-1048
Published online on: 18 December 2018

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Article

Knockdown of long non-coding RNA HOST2 inhibits the proliferation of triple negative breast cancer via regulation of the let-7b/CDK6 axis

Yuedong Zhang, Hongwei Zhang, Huiqing Kang, Wenjie Huo, Yu Zhou, Yuchao Zhang
Pages: 1049-1057
Published online on: 26 November 2018

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Article

MicroRNA-497 inhibits multiple myeloma growth and increases susceptibility to bortezomib by targeting Bcl-2 Corrigendum in /10.3892/ijmm.2019.4297

Faqing Tian, Yong Zhan, Wei Zhu, Juheng Li, Meiqin Tang, Xiaohui Chen, Jian Jiang
Pages: 1058-1066
Published online on: 07 December 2018

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Article

Cryptotanshinone induces reactive oxygen species‑mediated apoptosis in human rheumatoid arthritis fibroblast‑like synoviocytes

Hu‑Nan Sun, Ying‑Hua Luo, Ling‑Qi Meng, Xian‑Ji Piao, Yue Wang, Jia‑Ru Wang, Hao Wang, Yi Zhang, Jin‑Qian Li, Wan‑Ting Xu, Yang Liu, Yu Zhang, Tong Zhang, Ying‑Hao Han, Mei‑Hua Jin, Gui‑Nan Shen, Yan‑Qing Zang, Long‑Kui Cao, Dong‑Jie Zhang, Cheng‑Hao Jin
Pages: 1067-1075
Published online on: 03 December 2018

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Article

Hyaluronic acid-chitosan nanoparticles encoding CrmA attenuate interleukin-1β induced inflammation in synoviocytes in vitro

Bo Qiu, Xiong‑Feng Xu, Rong‑Hui Deng, Gan‑Qing Xia, Xi‑Fu Shang, Pang‑Hu Zhou
Pages: 1076-1084
Published online on: 26 November 2018

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Article

Dynamic expression of SMAD3 is critical in osteoblast differentiation of PDMCs

Hsi‑Ting Lin, Shao‑Kuan Chen, Jiun‑Wen Guo, I‑Chang Su, Chi‑Jung Huang, Chih‑Cheng Chien, Chih‑Ju Chang
Pages: 1085-1093
Published online on: 26 November 2018

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Article

Downregulation of Blimp1 inhibits the maturation of bone marrow-derived dendritic cells

Jiansheng Xiao, Ji Zhang, Xing Li, Xiaomin Dai, Jing Wang, Ying He, Lai Wei, Jun Shi, Nianqiao Gong
Pages: 1094-1104
Published online on: 26 November 2018

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Article

Lysine demethylase 3a in craniofacial and neural development during Xenopus embryogenesis

Hyun‑Kyung Lee, Tayaba Ismail, Chowon Kim, Youni Kim, Jeen‑Woo Park, Oh‑Shin Kwon, Beom‑Sik Kang, Dong‑Seok Lee, Taejoon Kwon, Tae Joo Park, Hyun‑Shik Lee
Pages: 1105-1113
Published online on: 11 December 2018

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Journal Cover
September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Mechanisms and therapeutic strategies of pyroptosis in sepsis‑induced acute lung injury (Review)

Wenyu Wu, Nuoran Li, Guoshu Deng, Suyi Yang, Ruifeng Zeng, Rui Chen, Jun Li
Article Number: 264
Published online on: 22 July 2026

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Review Open Access

Gut‑bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review)

Fuchao Chen, Jingyue Sun, Xiao Wang
Article Number: 263
Published online on: 21 July 2026

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Expression of Concern Open Access

[Expression of Concern] Exposure to acoustic stimuli promotes the development and differentiation of neural stem cells from the cochlear nuclei through the clusterin pathway

Tao Xue, Li Wei, Ding-Jun Zha, Li Qiao, Lian-Jun Lu, Fu-Quan Chen, Jian-Hua Qiu
Article Number: 262
Published online on: 20 July 2026

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Article Open Access

Cepharanthine inhibits tick‑borne encephalitis virus infection through modulation of the stress and inflammation response

Wan-Da Tang, Lan-Juan Zhao
Article Number: 261
Published online on: 16 July 2026

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Article Open Access

circCACNA1D drives pulmonary fibrosis by regulating pyruvate kinase M2 dimer‑tetramer switching

Yujie Wang, Xiaoting Li, Meirong Wang, Nailiang Zhai, Mengqi Jiang, Bo Liu, Changjun Lv, Songzi Zhang, Xiaodong Song, Jinjin Zhang
Article Number: 260
Published online on: 15 July 2026

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Review Open Access

Recent progress and therapeutic strategies in the treatment of cervical neuroendocrine neoplasms (Review)

Yanpeng Tian, Yu Zhang, Liling Wang, Zhongkang Li, Xiaotong Xu, Shouze Liu, Shenyu Yang, Xiangyang Ren, Menghan Xu, Xingzi Chang, Xianghua Huang, Qian Zhao, Ruixia Guo
Article Number: 259
Published online on: 15 July 2026

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Review Open Access

Neurofibromin in bone disease: Mechanisms and therapeutic implications (Review)

Shuhong Zhang, Ge Yang
Article Number: 258
Published online on: 14 July 2026

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Review Open Access

Exercise‑induced exosomal noncoding RNAs: Molecular signaling cascades in bone remodeling and translational applications in sports‑related bone injuries (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 257
Published online on: 14 July 2026

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Review Open Access

Targeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review)

Tianhao Xie, Kang Hu, Shu Pan, Xin Tong, Haitong Huang, Hao Ding, Jun Zhao
Article Number: 256
Published online on: 13 July 2026

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Article Open Access

Tubular PFKFB3 drives diabetic kidney fibrosis via lactate‑dependent H4K12 lactylation and HIPK2 transactivation

Mingkun Xu, Linhang Fu, Yulong Zhang, Xiuli Guo, Han Wu, Sijing Gao, Fei Xiao, Li Xu
Article Number: 255
Published online on: 13 July 2026

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Retraction Open Access

[Retracted] p73 participates in WWOX-mediated apoptosis in leukemia cells

Donghong Lin, Zhaolei Cui, Lingying Kong, Feng Cheng, Jianping Xu, Fenghua Lan
Article Number: 254
Published online on: 13 July 2026

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Article Open Access

Role of hyperthermia in overcoming HPV‑mediated MHC‑Ⅰ downregulation and promoting immune surveillance

Hanyu Wang, Hongxin Lang, Yaoxing Guo, Te Sun, Yuansong Bai, Tao Zhang, Rui-Qun Qi
Article Number: 253
Published online on: 10 July 2026

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Review Open Access

Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review)

Ruhui Yang, Haimin Zeng, Qi Xiao, Yining Xie, Yi Long, Xiang Chen
Article Number: 252
Published online on: 09 July 2026

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Expression of Concern Open Access

[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Article Number: 251
Published online on: 08 July 2026

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Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization

Yaohan Xu, Jing Pan, Jie Chen, Yutao Zhu, Miaolian Cai, Zeyu Ma, Siji Chen, Tianze Yu, Yushu Wei, Jingying Pan, Kunliang Luo, Yinjing Song, Stijn Van Der Veen, Hao Cheng
Article Number: 250
Published online on: 08 July 2026

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Review Open Access

Protective effects of Astragaloside IV on various liver diseases: From chemistry to herbal medicines (Review)

Jialu Shi, Xiaoyu Zhou, Jiabin Wu, Liru Zeng, Xia Wang, Wei Li, Xiao Huang, Xiaoyu Deng, Wenhong Wang
Article Number: 249
Published online on: 07 July 2026

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GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review)

Hang Ruan, Meipeng Zhu, Shi-Yan Liu, Li-Juan Zou, Shu-Sheng Li
Article Number: 248
Published online on: 07 July 2026

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Review Open Access

FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)

Changzhong Qian, Zhenyu Zhang, Xian Wu, Huibo Ti, Junjie Wu, Zhengdong Yuan, Xia Li, Feng-Lai Yuan
Article Number: 247
Published online on: 06 July 2026

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Retraction Open Access

[Retracted] β‑catenin signaling induces the osteoblastogenic differentiation of human pre‑osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression

Bo Liu, Song Wu, Lihua Han, Chaoyue Zhang
Article Number: 246
Published online on: 06 July 2026

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Article Open Access

Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging

Yanfang Du, Congyu Zhou, Yanpeng Tian, Zhongkang Li, Xianghua Huang
Article Number: 245
Published online on: 03 July 2026

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Review Open Access

TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

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Correction Open Access

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

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Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

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Article Open Access

FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

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Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

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Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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Correction Open Access

[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

Jun Li, Weichun Guo, Min Xiong, Heng Han, Jie Chen, Dan Mao, Bing Tang, Hualong Yu, Yun Zeng
Article Number: 238
Published online on: 01 July 2026

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Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review)

Mei Wu, Yan Li
Article Number: 237
Published online on: 30 June 2026

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Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

Qing Li, Mingrong Cheng, Weiwei Li, Xiaoyue Wang, Xiaoqing Liu, Yujie Yan
Article Number: 236
Published online on: 30 June 2026

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Review Open Access

ABCG2 transporter: Structural and functional associations with gout (Review)

Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Usman Nazir, Jiamen Sun, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi
Article Number: 235
Published online on: 30 June 2026

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Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

Keyue Zhang, Tong Li, Huan Liu, Huibo Ti, Zhenyu Zhang, Zhengdong Yuan, Junjie Wu, Xielin Yan, Zixin Luo, Haiting Hu, Xingchen Yao, Shuwen Shi, Xian Wu, Feng-Lai Yuan, Xiao Chen
Article Number: 234
Published online on: 30 June 2026

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Correction Open Access

[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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October-2026 Volume 58 Issue 4

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Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Energy stress activates AMPK to suppress ferroptosis in neurodegenerative proteinopathies

Yuanyuan Yong, Yuxin Hu, Qian Feng, Xiaogang Zhou, Lu Yu, Dalian Qin, Jianing Mi, Jianming Wu, Jianxin Liu, Anguo Wu
Article Number: 274
Published online on: 31 July 2026

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Brazilin attenuates methylglyoxal‑induced endothelial injury by enhancing eIF5A hypusination and inhibiting the AMPK/mTOR‑mediated autophagy/apoptosis axis in vitro and in vivo

Yu Liang, Jinxiang Chen, Haiyang Li, Junjing Xiong, Jingcan You, Liqun Wang, Jianbo Wu, Youkun Zheng, Mao Luo
Article Number: 273
Published online on: 30 July 2026

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Post‑translational modifications in atherosclerosis: Roles, mechanisms and therapeutic potential (Review)

Xiaoxiang Xu, Fei Ma, Wei Yu
Article Number: 272
Published online on: 30 July 2026

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Role of extracellular matrix in liver fibrosis regression and regeneration (Review)

Yuanzhi Zhou, Zeyuan Qiang, Yang Duan, Jiwei Huang, Haichuan Wang
Article Number: 271
Published online on: 29 July 2026

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Correction Open Access

[Corrigendum] Circulating microRNA profiles and the identification of miR‑593 and miR‑511 which directly target the PROP1 gene in children with combined pituitary hormone deficiency

Yanyan Hu, Qian Wang, Zengmin Wang, Fengxue Wang, Xiaobo Guo, Guimei Li
Article Number: 270
Published online on: 29 July 2026

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Unveiling the role of spatial transcriptomics in the analysis of the tumor immune microenvironment (Review)

Jialin Jiang, Xinyu Tu, Yi Cao, Qun Yan, Buqing Sai, Jian Ma
Article Number: 269
Published online on: 28 July 2026

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Expression of Concern Open Access

[Expression of Concern] Luteolin protects mice from severe acute pancreatitis by exerting HO‑1‑mediated anti‑inflammatory and antioxidant effects

Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang
Article Number: 268
Published online on: 27 July 2026

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Article Open Access

circRNA_013145‑miR‑185‑5p‑RhoA axis: A novel mechanism in the pathophysiology of diabetes‑induced erectile dysfunction

Wenhan Huang, Xin Lv, Jiahua Qian, Yihao Chen, Yuhe Si, Jingwei Wang, Jianxiong Ma
Article Number: 267
Published online on: 24 July 2026

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Review Open Access

Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review)

Jinyi Hou, Yaotan Li, Shijia Lin, Qingqing Liu, Huijuan Zheng, Weijing Liu, Yaoxian Wang, Liang Peng, Zhen Wang
Article Number: 266
Published online on: 23 July 2026

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Review Open Access

Effects of cuproptosis and its application in inflammatory bowel disease (Review)

Li Chen, Francis Atim Akanyibah, Jing Guan, Bing Pei, Bo Wang, Fei Mao
Article Number: 265
Published online on: 23 July 2026

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