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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
February-2019 Volume 43 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

An integrative theory for cancer (Review)

Guopei Luo, Na Liu
Pages: 647-656
Published online on: 28 November 2018

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Review

AngiomiRs: MicroRNAs driving angiogenesis in cancer (Review)

Yarely M. Salinas‑Vera, Laurence A. Marchat, Dolores Gallardo‑Rincón, Erika Ruiz‑García, Horacio Astudillo-De La Vega, Raquel Echavarría‑Zepeda, César López‑Camarillo
Pages: 657-670
Published online on: 27 November 2018

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Review Open Access

Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork (Review)

Hongwei Wang, Mingzhe Li, Zhenzhen Zhang, Haifeng Xue, Xing Chen, Yong Ji
Pages: 671-681
Published online on: 20 November 2018

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Article Open Access

Isorhamnetin alleviates lipopolysaccharide-induced inflammatory responses in BV2 microglia by inactivating NF-κB, blocking the TLR4 pathway and reducing ROS generation

Shin Young Kim, Cheng‑Yun Jin, Cheol Hong Kim, Young Hyun Yoo, Sung Hyun Choi, Gi‑Young Kim, Hyun Min Yoon, Hwan Tae Park, Yung Hyun Choi
Pages: 682-692
Published online on: 20 November 2018

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Article

Rosiglitazone attenuates cell apoptosis through antioxidative and anti-apoptotic pathways in the hippocampi of spontaneously hypertensive rats

Yali Li, Guanghu Yu, Lijuan Liu, Jun Long, Shujie Su, Ting Zhao, Wenjin Liu, Shunji Shen, Xiaolin Niu
Pages: 693-700
Published online on: 19 November 2018

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Article Open Access

Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS

Uddin Md. Nazim, Sang‑Youel Park
Pages: 701-708
Published online on: 21 November 2018

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Article Open Access

Astragaloside IV ameliorates high glucose‑induced renal tubular epithelial‑mesenchymal transition by blocking mTORC1/p70S6K signaling in HK‑2 cells

Xiao Chen, Yang Yang, Chenxu Liu, Zhigao Chen, Dongdong Wang
Pages: 709-716
Published online on: 26 November 2018

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Article Open Access

Ginsenoside Rg1 protects against H2O2‑induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro

Tan‑Zhen Xu, Xiao‑Yan Shen, Ling‑Ling Sun, Ya‑Li Chen, Bi‑Qiong Zhang, Da‑Ke Huang, Wei‑Zu Li
Pages: 717-726
Published online on: 30 November 2018

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Article Open Access

MicroRNA‑100‑5p inhibits osteoclastogenesis and bone resorption by regulating fibroblast growth factor 21

Long Zhou, Han‑Yi Song, Lin‑Lin Gao, Li‑Yu Yang, Shuai Mu, Qin Fu
Pages: 727-738
Published online on: 06 December 2018

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Article Open Access

Role of the long non‑coding RNA‑Annexin A2 pseudogene 3/Annexin A2 signaling pathway in biliary atresia‑associated hepatic injury

Yeletai Nuerzhati, Rui Dong, Zai Song, Shan Zheng
Pages: 739-748
Published online on: 11 December 2018

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Article Open Access

DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen‑Dong Zhu, Ji‑Ming Ye, Xue‑Mei Fu, Xue‑Chang Wang, Ji‑Yun Ye, Xin‑Ran Wu, Peng Hua, Yu‑Qiong Liao, Wei Xuan, Jin‑Lan Duan, Wei‑Yuan Li, Hui Fu, Zhong‑Hua Xia, Xuan Zhang
Pages: 749-760
Published online on: 18 December 2018

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Article Open Access

Activating metabotropic glutamate receptor‑7 attenuates visceral hypersensitivity in neonatal maternally separated rats

Limei Shao, Yanbing Liu, Junhua Xiao, Qunying Wang, Fei Liu, Jin Ding
Pages: 761-770
Published online on: 11 December 2018

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Article Open Access

Crude protein from spirulina increases the viability of CCD‑986sk cells via the EGFR/MAPK signaling pathway

Ping Liu, Min‑Kyeong Lee, Jeong‑Wook Choi, Youn‑Hee Choi, Taek‑Jeong Nam
Pages: 771-778
Published online on: 11 December 2018

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Article Open Access

MicroRNA‑93 inhibits chondrocyte apoptosis and inflammation in osteoarthritis by targeting the TLR4/NF‑κB signaling pathway

Yanjie Ding, Laifang Wang, Qing Zhao, Zhenzhen Wu, Lingli Kong
Pages: 779-790
Published online on: 18 December 2018

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Article Open Access

Melatonin regulation of transcription in the reversal of morphine tolerance: Microarray analysis of differential gene expression

Yu‑Che Cheng, Ru‑Yin Tsai, Yen‑Tseng Sung, Ing‑Jung Chen, Tzu‑Yi Tu, Ya‑Yuan Mao, Chih‑Shung Wong
Pages: 791-806
Published online on: 18 December 2018

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Article Open Access

Electro-acupuncture-induced neuroprotection is associated with activation of the IGF-1/PI3K/Akt pathway following adjacent dorsal root ganglionectomies in rats

Tao Hu, Min‑Nan Lu, Bo Chen, Jun Tong, Rui Mao, Shan‑Shan Li, Pin Dai, Ya‑Xin Tan, Yan‑Bin Xiyang
Pages: 807-820
Published online on: 18 December 2018

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Article Open Access

Atorvastatin downregulates HSP22 expression in an atherosclerotic model in vitro and in vivo

Qi Chen, Jian Xiang, Ren Gong, Hai‑Yang Fang, Cong‑Cong Xu, Hong‑Zhou Zhang, Yan‑Qing Wu
Pages: 821-829
Published online on: 03 December 2018

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Article Open Access

Astragaloside IV promotes the proliferation and migration of osteoblast-like cells through the hedgehog signaling pathway

Li‑Hua Guo, Yu Cao, Run‑Tao Zhuang, Yan Han, Jun Li
Pages: 830-838
Published online on: 03 December 2018

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Article Open Access

MicroRNA-140-5p aggravates hypertension and oxidative stress of atherosclerosis via targeting Nrf2 and Sirt2

Qing‑Quan Liu, Ke Ren, Su‑Hong Liu, Wei‑Min Li, Chang‑Jun Huang, Xiu‑Hui Yang
Pages: 839-849
Published online on: 26 November 2018

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Article Open Access

Expression of microRNA‑27a in a rat model of osteonecrosis of the femoral head and its association with TGF‑β/Smad7 signalling in osteoblasts

Yuming Bai, Ying Liu, Shengli Jin, Ke Su, Haisen Zhang, Shiyun Ma
Pages: 850-860
Published online on: 30 November 2018

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Article Open Access

The AIB1siRNA-loaded hyaluronic acid-assembled PEI/heparin/Ca2+ nanocomplex as a novel therapeutic strategy in lung cancer treatment

Ying Hao, Yongsheng Gao, Yedan Wu, Changshan An
Pages: 861-867
Published online on: 03 December 2018

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Article Open Access

Expression of FKBP52 in the ovaries of PCOS rats

Shiyan Song, Yong Tan
Pages: 868-878
Published online on: 26 November 2018

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Article Open Access

Insulin gene enhancer binding protein 1 induces adipose tissue‑derived stem cells to differentiate into pacemaker‑like cells

Jian Zhang, Mei Yang, An‑Kang Yang, Xi Wang, Yan‑Hong Tang, Qing‑Yan Zhao, Teng Wang, Yu‑Ting Chen, Cong‑Xin Huang
Pages: 879-889
Published online on: 27 November 2018

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Article Open Access

Adipose extracellular matrix promotes skin wound healing by inducing the differentiation of adipose‑derived stem cells into fibroblasts Retraction in /10.3892/ijmm.2024.5430

Zhi‑Qiang Zhou, Yi Chen, Mi Chai, Ran Tao, Yong‑Hong Lei, Yi‑Qing Jia, Jun Shu, Jing Ren, Guo Li, Wen‑Xin Wei, Yu‑Di Han, Yan Han
Pages: 890-900
Published online on: 30 November 2018

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Article Open Access

Baicalin inhibits proliferation and promotes apoptosis of vascular smooth muscle cells by regulating the MEG3/p53 pathway following treatment with ox‑LDL

Yun Liu, Lianqun Jia, Dongyu Min, Yi Xu, Jinquan Zhu, Zengxian Sun
Pages: 901-913
Published online on: 30 November 2018

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Article Open Access

ADAM17 promotes lymph node metastasis in gastric cancer via activation of the Notch and Wnt signaling pathways

Wei Li, Daguang Wang, Xuan Sun, Yang Zhang, Lei Wang, Jian Suo
Pages: 914-926
Published online on: 17 December 2018

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Article Open Access

Construction of a long non‑coding RNA-mediated competitive endogenous RNA network reveals global patterns and regulatory markers in gestational diabetes

Lei Leng, Chengwei Zhang, Lihong Ren, Qiang Li
Pages: 927-935
Published online on: 12 December 2018

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Article Open Access

Genipin protects against H2O2-induced oxidative damage in retinal pigment epithelial cells by promoting Nrf2 signaling

Hailan Zhao, Ruiqing Wang, Mingxia Ye, Lan Zhang
Pages: 936-944
Published online on: 12 December 2018

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Article Open Access

Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF

Jiao Cheng, Hui‑Li Yang, Chun‑Jie Gu, Yu‑Kai Liu, Jun Shao, Rui Zhu, Yin‑Yan He, Xiao‑Yong Zhu, Ming‑Qing Li
Pages: 945-955
Published online on: 10 December 2018

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Article Open Access

Investigation of the neuroprotective effects of crocin via antioxidant activities in HT22 cells and in mice with Alzheimer's disease

Chunyue Wang, Xueying Cai, Wenji Hu, Zhiping Li, Fange Kong, Xia Chen, Di Wang
Pages: 956-966
Published online on: 18 December 2018

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Article Open Access

Corilagin induces apoptosis, autophagy and ROS generation in gastric cancer cells in vitro

Jiajia Xu, Gongye Zhang, Yinping Tong, Jiahui Yuan, Yuanyue Li, Gang Song
Pages: 967-979
Published online on: 18 December 2018

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Article

Akt3 is a target of miR-29c-3p and serves an important function in the pathogenesis of congenital heart disease

Tao Chen, Shu‑Jun Li, Bin Chen, Qiong Huang, Xiang‑Ying Kong, Chen Shen, Hai‑Tao Gu, Xiao‑Wei Wang
Pages: 980-992
Published online on: 30 November 2018

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Article

MicroRNA-323 suppresses nerve cell toxicity in cerebral infarction via the transforming growth factor-β1/SMAD3 signaling pathway

Fengli Che, Huishan Du, Jianchao Wei, Weidong Zhang, Zhe Cheng, Yanna Tong
Pages: 993-1002
Published online on: 07 December 2018

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Article

MicroRNA‑124‑3p attenuates severe community‑acquired pneumonia progression in macrophages by targeting tumor necrosis factor receptor‑associated factor 6

Wei Gao, Hongxia Yang
Pages: 1003-1010
Published online on: 03 December 2018

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Article

Cyr61 decreases Cytarabine chemosensitivity in acute lymphoblastic leukemia cells via NF-κB pathway activation

Yingping Cao, Conglian Wu, Yanfang Song, Zhen Lin, Yanli Kang, Pingxia Lu, Chenqing Zhang, Qinghua Huang, Taisen Hao, Xianjin Zhu, Jianda Hu
Pages: 1011-1020
Published online on: 06 December 2018

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Article

Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Pages: 1021-1032
Published online on: 03 December 2018

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Article

Inhibition of protein kinase CK2 facilitates cellular senescence by inhibiting the expression of HO-1 in articular chondrocytes

Kang Mi Kim, Dong Hyun Sohn, Koanhoi Kim, Young Chul Park
Pages: 1033-1040
Published online on: 04 December 2018

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Article

Astragalus saponins inhibit cell growth, aerobic glycolysis and attenuate the inflammatory response in a DSS-induced colitis model

Hailong Guo, Boshun Wan, Jiansong Wang, Jie Zhang, Wenfei Yao, Zhiyong Shen
Pages: 1041-1048
Published online on: 18 December 2018

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Article

Knockdown of long non-coding RNA HOST2 inhibits the proliferation of triple negative breast cancer via regulation of the let-7b/CDK6 axis

Yuedong Zhang, Hongwei Zhang, Huiqing Kang, Wenjie Huo, Yu Zhou, Yuchao Zhang
Pages: 1049-1057
Published online on: 26 November 2018

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Article

MicroRNA-497 inhibits multiple myeloma growth and increases susceptibility to bortezomib by targeting Bcl-2 Corrigendum in /10.3892/ijmm.2019.4297

Faqing Tian, Yong Zhan, Wei Zhu, Juheng Li, Meiqin Tang, Xiaohui Chen, Jian Jiang
Pages: 1058-1066
Published online on: 07 December 2018

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Article

Cryptotanshinone induces reactive oxygen species‑mediated apoptosis in human rheumatoid arthritis fibroblast‑like synoviocytes

Hu‑Nan Sun, Ying‑Hua Luo, Ling‑Qi Meng, Xian‑Ji Piao, Yue Wang, Jia‑Ru Wang, Hao Wang, Yi Zhang, Jin‑Qian Li, Wan‑Ting Xu, Yang Liu, Yu Zhang, Tong Zhang, Ying‑Hao Han, Mei‑Hua Jin, Gui‑Nan Shen, Yan‑Qing Zang, Long‑Kui Cao, Dong‑Jie Zhang, Cheng‑Hao Jin
Pages: 1067-1075
Published online on: 03 December 2018

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Article

Hyaluronic acid-chitosan nanoparticles encoding CrmA attenuate interleukin-1β induced inflammation in synoviocytes in vitro

Bo Qiu, Xiong‑Feng Xu, Rong‑Hui Deng, Gan‑Qing Xia, Xi‑Fu Shang, Pang‑Hu Zhou
Pages: 1076-1084
Published online on: 26 November 2018

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Article

Dynamic expression of SMAD3 is critical in osteoblast differentiation of PDMCs

Hsi‑Ting Lin, Shao‑Kuan Chen, Jiun‑Wen Guo, I‑Chang Su, Chi‑Jung Huang, Chih‑Cheng Chien, Chih‑Ju Chang
Pages: 1085-1093
Published online on: 26 November 2018

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Article

Downregulation of Blimp1 inhibits the maturation of bone marrow-derived dendritic cells

Jiansheng Xiao, Ji Zhang, Xing Li, Xiaomin Dai, Jing Wang, Ying He, Lai Wei, Jun Shi, Nianqiao Gong
Pages: 1094-1104
Published online on: 26 November 2018

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Article

Lysine demethylase 3a in craniofacial and neural development during Xenopus embryogenesis

Hyun‑Kyung Lee, Tayaba Ismail, Chowon Kim, Youni Kim, Jeen‑Woo Park, Oh‑Shin Kwon, Beom‑Sik Kang, Dong‑Seok Lee, Taejoon Kwon, Tae Joo Park, Hyun‑Shik Lee
Pages: 1105-1113
Published online on: 11 December 2018

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Journal Cover
January-2026 Volume 57 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

FK506‑binding proteins as emerging bridges linking proteostasis to multi‑system pathogenesis and therapeutic strategies (Review)

Zhi Li, Xiaolei Liu, Hesong Zeng
Article Number: 30
Published online on: 24 November 2025

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Retraction Open Access

[Retracted] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues

Jin-Long Chen, Fang Chen, Ting-Ting Zhang, Nai-Fu Liu
Article Number: 29
Published online on: 24 November 2025

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Article Open Access

METTL3 inhibits LINC00312 to suppress osteoporosis progression in a YTHDF2‑dependent manner

Yang Wang, Yihao Tian, Gang Yao
Article Number: 28
Published online on: 20 November 2025

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Review Open Access

Decoding structural birth defects through genomic landscapes: Innovative frameworks for diagnosis (Review)

Ruihao Xu, Haoming Ren, Zhengwei Yuan, Wanqi Huang, Hui Gu
Article Number: 27
Published online on: 20 November 2025

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Article Open Access

MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice

Dan Chen, Hui-Min Zhao, Xiao-Lin Sun, Zhi-Xuan Xing, Sheng-Peng Li, Shuai-Chao Li, Ya-Xian Wu, Qing-Feng Pang, Jian-Feng Huang
Article Number: 26
Published online on: 18 November 2025

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Article Open Access

Synergistic effects of Akebia saponin D and Semaglutide on diabetic nephropathy and osteoporosis via the Klotho‑p53 signaling axis

Qian Zhang, Dan Wang, Hongxia Jia, Zongji Zheng, Liyan Lin, Linna Li, Ling Wang, Yaoming Xue
Article Number: 25
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer

Ke Li, Conghu Yuan
Article Number: 24
Published online on: 17 November 2025

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Article

Comparative analysis of pan MHC‑I epitopes immunoreactivity on Hantaan virus nucleocapsid protein

Zhikui Li, Weijie Ding, Yubo Sun, Chenfeng Tian, Shuaishuai Fu, Fei Shi, Zhenchi Fang, Yuanzhe Li, Jianchang Li, Sirui Cai, Haobo Kang, Baozeng Sun, Junqi Zhang, Yuanjie Sun, Shuya Yang, Yusi Zhang, Chunmei Zhang, Yun Zhang, Xiyang Zhang, Kun Yang, Dongbo Jiang
Article Number: 23
Published online on: 14 November 2025

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Article Open Access

Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy

Boya Zhang, Defeng Kong, Siji Chen, Xuewu Sun, Hao Cheng
Article Number: 22
Published online on: 14 November 2025

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Article Open Access

Targeting p38 MAPK signaling pathway: 
Quercetin as a novel therapy for TMJ synovitis

Mosha Cheng, Yuhe Guan, Xiaotao Xin, Xin Yi, Yi Liu
Article Number: 21
Published online on: 13 November 2025

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Review Open Access

Lipid droplets in astrocytes: Key organelles for CNS homeostasis and disease (Review)

Yuchen Wang, Boxuan Wang, Jinchao Hou, Xiaodong Huo, Chenlin Liu, Ruili Guan, Honggang Chen, Yang Zhou, Jianbin Zhang, Congcong Zhuang, Yuankang Zou
Article Number: 20
Published online on: 13 November 2025

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Review Open Access

Copper dyshomeostasis and cardiovascular disease: Molecular mechanisms and new strategies for targeted intervention with cuproptosis (Review)

Peiyu Li, Yinghui Li, Qian Meng, Jie Wang, Kun Wang, Sumin Yang
Article Number: 19
Published online on: 13 November 2025

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Article Open Access

Elevated FTO alleviates sepsis‑induced acute kidney injury by regulating macrophage inflammatory phenotypes

Xiaona Chen, Ziqi Sun, Jiabo Chen, Jinquan Zhang, Zeyu Liu, Zhengzheng Yan, Quan Li, Zhixia Chen
Article Number: 18
Published online on: 12 November 2025

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Correction Open Access

[Corrigendum]  Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

Bo Meng, Yisong Wang, Bin Li
Article Number: 17
Published online on: 10 November 2025

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Review Open Access

Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation (Review)

Jing Wang, Qin Zhao, Shuwan Zhang, Jia Liu, Xingyue Fan, Bin Han, Yaqin Hou, Xiaopeng Ai
Article Number: 16
Published online on: 05 November 2025

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High‑fat diet and cognitive dysfunction: Mechanistic insights into diet‑induced neurodegeneration (Review)

Min You, Fan Wu, Feng Xiong, Xue-Fei Hu, Huan Wu, Li Zhou, Hong-Xing Zhang
Article Number: 15
Published online on: 05 November 2025

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Article Open Access

ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model

Shuang Dou, Zhijun Li, Boyao Zheng, Zhenyu Ren, Hai Wang, Qing Zuo, Fang Fang, Yuehong Zhuang
Article Number: 14
Published online on: 05 November 2025

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Review Open Access

Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review)

Chaowei Zhang, Yuxuan Han, Weiyi Yao, Qing Hong, Na Chen
Article Number: 13
Published online on: 04 November 2025

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Review Open Access

β‑hydroxybutyric acid as a potential therapeutic metabolite for type 2 diabetes mellitus (Review)

Xianyi Ding, Jiabin Wu, Lian Wang, Ke Li, Haoyang Gao, Mingyu Wu, Qiuyu Zhang, Ruonan Han, Wenhong Wang, Weihua Xiao
Article Number: 12
Published online on: 03 November 2025

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Review

Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)

Xunjie Jian, Chang Cheng, Wenjie Lu, Hui Peng, Diqi Yang
Article Number: 11
Published online on: 03 November 2025

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Review Open Access

Interpretation of the molecular mechanism and therapeutic potential of microRNA‑155 in cardiovascular and cerebrovascular diseases (Review)

Xitong Zhao, Pengqin Wang
Article Number: 10
Published online on: 03 November 2025

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Expression of Concern Open Access

[Expression of Concern]  CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 9
Published online on: 29 October 2025

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Article Open Access

TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF‑κB pathway

Linlin Xiao, Man Qu, Lulu Chen, Mingli Xiang, Qian Long, Jianguo Liu, Xiaoyan Guan, Chengcheng Liao
Article Number: 8
Published online on: 27 October 2025

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Review Open Access

Harnessing copper: Innovative approaches to combat neurodegenerative diseases and cancer (Review)

Tao Duan, Hanhai Mao, Xingyue Jiang, Ying Tian, Jidong Zhang, Jun Tan
Article Number: 7
Published online on: 27 October 2025

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Retraction Open Access

[Retracted] Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma

Guanen Qiao, Chenguang Dai, Yang He, Junjie Shi, Chunfang Xu
Article Number: 6
Published online on: 27 October 2025

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Review Open Access

Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review)

Yiming Shao, Ke Song, Ruixin Yu, He Xiao, Chengjun Li, Yuling Deng, Yuan Zhang, Yixing Ren
Article Number: 5
Published online on: 24 October 2025

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Article Open Access

Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer

Chuanxi Lai, Xiya Jia, Yiyi Chen, Kangke Chen, Fei Wang, Qiqi Zhang, Xiaonan Xiang, Zhe-Sheng Chen, Lingna Xu, Sheng Dai
Article Number: 4
Published online on: 23 October 2025

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Article Open Access

Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis

Weichao Sun, Yi Liao, Jianguo Feng, Jianhui Liang, Qifei He, Yinxing Cui, Dixi Huang, Houyin Shi, Wei You, Wei Sun, Qian Yi
Article Number: 3
Published online on: 23 October 2025

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Review

Importance of B cells (Review)

Zhiyuan Liu, Haoran Dai, Xiaoyu Cui, Yeping Liu, Zhaocheng Dong
Article Number: 2
Published online on: 22 October 2025

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Retraction Open Access

[Retracted] Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
Article Number: 1
Published online on: 22 October 2025

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February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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Article Open Access

HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Review Open Access

Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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